scholarly journals Association between respiratory and heart rate fluctuations and death occurrence in dying cancer patients: Continuous measurement with a non-wearable monitor

Author(s):  
Sakiko Fukui ◽  
Kasumi Ikuta ◽  
Isseki Maeda ◽  
Satoshi Hattori ◽  
Yutaka Hatano ◽  
...  

Abstract Background The present study aimed to explore the association between impending death and continual changes in respiratory and heart rates measured by a non-wearable monitor every minute for the final 2 weeks of dying cancer patients. Methods In this longitudinal study, we enrolled patients in a palliative-care-unit and continuously measured their respiratory/heart rates by a monitor, capturing their other vital signs and clinical status from medical records. Result A dataset was created with 240 patient-days from every minute data to death (345,600 data) among 24 patients for 3–14 days to death. We analyzed this 240 patient-day data. After confirming the associations between the value of death day (n = 24) or other days (2–14 days before death, n = 216) and the mean, maximum, minimum, and variance of respiratory and heart rates every 24 hours by univariate analyses, we conducted a repeated measures logistic regression analysis using a generalized estimating equation. Finally, the maximum respiratory rate and mean heart rate were significantly associated with death at 24, 48, and 72 hours later, other than the respiratory rate of the last 24 hours. Conclusion The maximum respiratory rate and mean heart rate measured every minute by a monitor can warn imminent death during the last days of life among dying patients. Our findings can help for family caregivers and care staff to aware imminent death among dying patients at home or in facilities, in collaboration with palliative care professionals.

2021 ◽  
Author(s):  
Sakiko Fukui ◽  
Kasumi Ikuta ◽  
Isseki Maeda ◽  
Satoshi Hattori ◽  
Yutaka Hatano ◽  
...  

Abstract Background: The cancer deaths at home and in care facilities are increasing worldly. If we can identify imminent death using a monitoring device and inform it to family members and care staff, it will help them, even in the absence of healthcare professionals at all times. We examined the association between impending death and continual changes in respiratory and heart rates measured by a non-wearable monitor every minute for the final 2 weeks of dying cancer patients. In this longitudinal study, we enrolled patients in a palliative-care-unit and continuously measured their respiratory/heart rates by a monitor, capturing their other vital signs and clinical status from medical records.Result: A dataset was created with 240 patient-days from every minute data to death (345,600 data) among 24 patients for 3-14 days to death. We analyzed this 240 patient-day data. After confirming the associations between the value of death day (n=24) or other days (2–14 days before death, n=216) and the mean, maximum, minimum, and variance of respiratory and heart rates every 24 hours by univariate analyses, we conducted a repeated measures logistic regression analysis using a generalized estimating equation. Finally, the maximum respiratory rate and mean heart rate were significantly associated with death at 24, 48, and 72 hours later, other than the respiratory rate of the last 24 hours.Conclusion: The maximum respiratory rate and mean heart rate measured every minute by a monitor can warn imminent death during the last days of life among dying patients. Our findings can help for caregivers to aware imminent death among dying patients at home or in facilities, in collaboration with palliative care professionals.


2006 ◽  
Vol 31 (6) ◽  
pp. 485-492 ◽  
Author(s):  
Cristina de Miguel Sánchez ◽  
Sofía Garrido Elustondo ◽  
Alicia Estirado ◽  
Fernando Vicente Sánchez ◽  
Cristina García de la Rasilla Cooper ◽  
...  

2010 ◽  
Vol 12 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Wei-Shu Lai ◽  
Co-Shi Chantal Chao ◽  
Wan-Ping Yang ◽  
Ching-Huey Chen

Background: Dyspnea is a frequent and devastating symptom among advanced cancer patients for which improved and low-cost palliative techniques are needed.Methods: A one-group repeated measures research design investigated the efficacy of guided imagery (GI) with theta music (θM) on dyspnea in advanced cancer patients. The intervention consisted of four periods: (a) pretest; (b) intervention with peaceful non-θM; (c) intervention with 10 min of GI with θM (GI/θM), with the first and last 3 min being θM only (i.e., the middle 4 min was GI/θM); and (d) posttest. Dyspnea outcome was measured with the Modified Borg Scale (MBS) for self-reported evaluation of dyspneic symptoms. Physiological parameters measured were pulse oxygen saturation (SpO2), end-tidal CO2(EtCO2), heart rate (HR), and respiratory rate (RR). Posttest qualitative data were obtained via interview for subjective patient experience.Results: Participants included 53 patients, 33% with lung cancer. GI/θM produced a significant decrease in MBS scores; 90% of the subjects gave positive qualitative reviews of GI/θM. SpO2did not change significantly over time. GI/θM significantly increased EtCO2, decreased RR, and decreased HR.Discussion: This study demonstrates that GI/θM is a useful intervention for palliative care of patients with dyspnea. θM alone was demonstrated to be effective, while soothing non-θM was not effective. GI/θM was more effective than θM alone. GI/θM should be considered low-cost end-of-life palliative care for dyspnea.


1995 ◽  
Vol 4 (3) ◽  
pp. 233-238 ◽  
Author(s):  
LL Chlan

BACKGROUND: Although mechanically ventilated patients experience numerous stressors, they have not been included in music therapy stress reduction and relaxation studies. OBJECTIVE: To examine selected psychophysiologic responses of mechanically ventilated patients to music. METHODS: A two-group experimental design with pretest, posttest, and repeated measures was used. Twenty mechanically ventilated patients were randomized to a music-listening group or a nonmusic (headphones only) group. Physiologic dependent measures--heart rate and rhythm, respiratory rate, systolic and diastolic blood pressure, oxygen saturation, and airway pressure--were collected at timed intervals. Psychologic data were collected before and after intervention using the Profile of Mood States. RESULTS: Using repeated measures analysis of variance, results for heart rate and respiratory rate over time and over time between groups were significant. Between-group differences were significant for respiratory rate. Significant differences were found via t test for the music group's Profile of Mood States scores. No adverse cardiovascular responses were noted for either group. CONCLUSIONS: Data indicated that music listening decreased heart rate, respiratory rate, and Profile of Mood States scores, indicating relaxation and mood improvement.


Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 89
Author(s):  
Woori Bae ◽  
Kyunghoon Kim ◽  
Bongjin Lee

To effectively use vital signs as indicators in children, the magnitude of deviation from expected vital sign distribution should be determined. The purpose of this study is to derive age-specific centile charts for the heart rate and respiratory rate of the children who visited the emergency department. This study used the Korea’s National Emergency Department Information System dataset. Patients aged <16 years visiting the emergency department between 1 January 2016 and 31 December 2017 were included. Heart rate and respiratory rate centile charts were derived from the population with normal body temperature (36 to <38 °C). Of 1,901,816 data points retrieved from the database, 1,454,372 sets of heart rates and 1,458,791 sets of respiratory rates were used to derive centile charts. Age-specific centile charts and curves of heart rates and respiratory rates showed a decline in heart rate and respiratory rate from birth to early adolescence. There were substantial discrepancies in the reference ranges of Advanced Paediatric Life Support and Pediatric Advanced Life Support guidelines. Age-based heart rate and respiratory rate centile charts at normal body temperature, derived from children visiting emergency departments, serve as new evidence-based data and can be used in follow-up studies to improve clinical care for children.


1997 ◽  
Vol 200 (4) ◽  
pp. 661-675 ◽  
Author(s):  
R M Bevan ◽  
I L Boyd ◽  
P J Butler ◽  
K Reid ◽  
A J Woakes ◽  
...  

The South Georgian shag (Phalacrocorax georgianus) shows a remarkable diving ability comparable to that of penguins, yet nothing is known of the physiology of these birds. In this study, heart rates and abdominal temperatures were recorded continuously in four free-ranging South Georgian shags using an implanted data-logger. A time&shy;depth recorder was also attached to the back of the implanted birds to record their diving behaviour. The diving behaviour of the birds was essentially similar to that reported in other studies, with maximum dive durations for individual birds ranging between 140 and 287 s, and maximum depths between 35 and 101 m. The birds, while at the nest, had a heart rate of 104.0&plusmn;13.1 beats min-1 (mean &plusmn; s.e.m.) and an abdominal temperature of 39.1&plusmn;0.2 &deg;C. During flights of 221&plusmn;29 s, heart rate and abdominal temperature rose to 309.5&plusmn;18.0 beats min-1 and 40.1&plusmn;0.3 &deg;C, respectively. The mean heart rate during diving, at 103.7&plusmn;13.7 beats min-1, was not significantly different from the resting values, but the minimum heart rate during a dive was significantly lower at 64.8&plusmn;5.8 beats min-1. The minimum heart rate during a dive was negatively correlated with both dive duration and dive depth. Abdominal temperature fell progressively during a diving bout, with a mean temperature at the end of a bout of 35.1&plusmn;1.7 &deg;C. The minimum heart rate during diving is at a sub-resting level, which suggests that the South Georgian shag responds to submersion with the 'classic' dive response of bradycardia and the associated peripheral vasoconstriction and utilisation of anaerobic metabolism. However, the reduction in abdominal temperature may reflect a reduction in the overall metabolic rate of the animal such that the bird can remain aerobic while submerged.


2016 ◽  
Vol 59 (2) ◽  
pp. 201-207 ◽  
Author(s):  
Francesco Fazio ◽  
Francesca Arfuso ◽  
Elisabetta Giudice ◽  
Claudia Giannetto ◽  
Giuseppe Piccione

Abstract. The effects of time after birth and of twinning on rectal temperature (RT), heart rate (HR), respiratory rate (RR) and body weight (BW) values were evaluated in five singleton Comisana lambs (three males and two females), five singleton Maltese Kids (three males and two females), four couples of twin Comisana lambs (four males and four females) and four couples of twin Maltese kids (four males and four females) during the first month of life. For all kids and lambs, RT, HR, RR and BW were recorded after 1 and 24 h from birth and every 2 days until the 30th day of life. The application of two-way repeated measures analysis of variance (ANOVA) showed a statistically significant effect of time (P < 0.0001) on RT, HR, RR and BW values in all lambs and kids during the first month of life. Any significant effect of twinning (P > 0.05) on all studied parameters was found in lambs, whereas statistically significant differences in BW, RT and HR values (P < 0.01) were found between twin and singleton kids throughout the first month of life. The results obtained in this study make a contribution to the knowledge of homeostatic, cardiorespiratory and thermoregulatory adaptations occurring in singleton lambs and kids and in twin lambs and kids during the first 30 days of life. Our findings indicate that the BW, RT, HR and RR values, whose homeostasis is still evolving in newborn, should be interpreted dynamically as a function of the period of postnatal adaptation and also of twinning.


1966 ◽  
Vol 14 (1) ◽  
pp. 47-57
Author(s):  
H.W. Vos

Effort and time spent in machine milking using pipeline vs. bucket milking methods were compared in a conventional cowshed and in a 2-level milking parlour. In each case 2 units were used and cows were machine-stripped. In the cowshed data were obtained for each of 6 milkers milking 20 low-yielding cows; in the parlour each of 3 milkers milked 21 moderate yielding cows. Total energy expenditure (measured at one milking only for each of the cowshed milkers) averaged 5.0 kcal./min., but considerable variation was shown between workers. In the cowshed mean heart rate was similar for the 2 milking methods but in the parlour heart rates were higher for bucket than pipeline milking; the former also involved greater increase in effort in carrying the filled cans and in cleaning the milking equipment. Milking time for the bucket method exceeded that for the pipeline method by 18% and 9% in cowshed and parlour respectively. Practical aspects are discussed. R.B.S. (Abstract retrieved from CAB Abstracts by CABI’s permission)


1991 ◽  
Vol 69 (4) ◽  
pp. 1117-1120 ◽  
Author(s):  
Denis Chabot ◽  
Max Bayer ◽  
André de Roos

Data on heart rate can be analyzed in terms of beats per unit of time (heart rate) or its reciprocal, time per beat (interbeat interval). We show that counting beats (including fractions), averaging interbeat intervals, and measuring the time for a fixed number of beats are correct techniques to measure heart activity within observation periods. QRS counts are less precise, but not systematically biased. Conversely, averaging instantaneous heart rates always overestimates true heart rate. Arithmetic means across trials of equal duration are correct only when heart activity for each trial is expressed as mean heart rate. For observation periods with equal numbers of beats, heart activity for each trial must be expressed as mean interbeat interval. A literature survey showed that biased techniques were frequently used to calculate heart rate, and that about half of the studies did not provide sufficient information on the methods used.


2020 ◽  
Author(s):  
Jeppe H. Christensen ◽  
Gabrielle H. Saunders ◽  
Michael Porsbo ◽  
Niels H. Pontoppidan

AbstractWe investigate the longitudinal association between multidimensional characteristics of everyday ambient sound and continuous mean heart rate. We used in-market data from hearing aid users who logged ambient acoustics via smartphone-connected hearing aids and continuous heart rate from their own wearables.We find that ambient acoustic characteristics explain approximately 4% of the fluctuation in mean heart rate throughout the day. Specifically, increases in ambient sound pressure intensity are significantly related to increases in mean heart rates, corroborating prior laboratory and short-term real-world data. In addition, however, and not previously recognized, increases in the ambient sound quality - that is, the difference between sound signal and noise - are associated with decreases in mean heart rates.Our findings document a mixed influence of everyday sounds on cardiovascular stress, and that the relationship is more complex than is seen from examination of sound intensity alone. Thus, our findings highlight the relevance of ambient environmental sound in models of human ecophysiology.


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