Construction and Validation of a Nomogram for The Prediction of Overall Survival in Intrahepatic Cholangiocarcinoma

Abstract Objective: This study aimed to establishand validates a nomogram to predict the overall survival (OS) of patients with intrahepatic cholangiocarcinoma (ICC).Patients and methods: The ICC patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. Then, the independent prognosis-related factors were obtained from the training set using the Cox regression model for the establishment of a nomogram.Results: We identified 3675 eligible patients with a median survival time of 9 months (0–153 months). According to multivariate analysis, age, sex, marital status, grade, T stage, N stage, M stage, surgery, chemotherapy and radiotherapy were identified as the factors to independently predictthe prognosis for ICC (all P<0.05). Thereafter, the above factors were incorporated for the construction of a nomogram. In comparison with the AJCC 8th TNM classification system and the SEER summary stage system, our constructed nomogram showed higher ability in discrimination, as revealed by the C-index (all P<0.001).Besides, the internal as well as external calibration curve analysis demonstrated that the predicted results were highly consistent with the actual ones. On the other hand, our nomogram outperformed the AJCC 8th TNM classification system and the SEER summary stage system in predicting the 3- and 5-year OS, as suggested by time-independent area under the curve (tAUC) values.Conclusion: Our constructed nomogram performs well, indicating its potential as an efficient approach to evaluate the prognosis of ICC patients.

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Prognostic Factors for Overall Survival in Advanced Intrahepatic Cholangiocarcinoma Treated with Yttrium-90 Radioembolization

Journal of Clinical Medicine ◽

10.3390/jcm9010056 ◽

2019 ◽

Vol 9 (1) ◽

pp. 56 ◽

Cited By ~ 3

Author(s):

Michael Köhler ◽

Fabian Harders ◽

Fabian Lohöfer ◽

Philipp M. Paprottka ◽

Benedikt M. Schaarschmidt ◽

...

Keyword(s):

Overall Survival ◽

Prognostic Factors ◽

Liver Disease ◽

Surgical Resection ◽

Intrahepatic Cholangiocarcinoma ◽

Tumor Volume ◽

Cox Regression ◽

Tertiary Care ◽

Liver Volume ◽

Total Liver Volume

Purpose: To evaluate factors associated with survival following transarterial 90Y (yttrium) radioembolization (TARE) in patients with advanced intrahepatic cholangiocarcinoma (ICC). Methods: This retrospective multicenter study analyzed the outcome of three tertiary care cancer centers in patients with advanced ICC following resin microsphere TARE. Patients were included either after failed previous anticancer therapy, including relapse after surgical resection, or for having a minimum of 25% of total liver volume affected by ICC. Patients were stratified and response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria at 3 months. Kaplan–Meier analysis was performed to analyze survival followed by cox regression to determine independent prognostic factors for survival. Results: 46 patients were included (19 male, 27 female), median age 62.5 years (range 29–88 years). A total of 65% of patients had undergone previous therapy, while 63% had a tumor volume > 25% of the entire liver volume. Median survival was 9.5 months (95% CI: 6.1–12.9 months). Due to loss in follow-up, n = 37 patients were included in the survival analysis. Cox regression revealed the extent of liver disease to one or both liver lobes being associated with survival, irrespective of tumor volume (p = 0.041). Patients with previous surgical resection of ICC had significantly decreased survival (3.9 vs. 12.8 months, p = 0.002). No case of radiation-induced liver disease was observed. Discussion: Survival after 90Y TARE in patients with advanced ICC primarily depends on disease extent. Only limited prognostic factors are associated with a general poor overall survival.

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Definitive radiotherapy in the management of node-positive bladder cancer: A National Cancer Data Base (NCDB) analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.2_suppl.394 ◽

2016 ◽

Vol 34 (2_suppl) ◽

pp. 394-394

Author(s):

William Allen Stokes ◽

Chad G Rusthoven ◽

Norman Yeh ◽

Brian D. Kavanagh

Keyword(s):

Overall Survival ◽

Bladder Cancer ◽

Cox Regression ◽

External Beam Radiotherapy ◽

Disease Free Survival ◽

Guideline Recommendation ◽

Related Factors ◽

Definitive Radiotherapy ◽

Cancer Data ◽

Node Positive

394 Background: The survival impact of definitive radiotherapy (RT) in lymph node positive (N+) non-metastatic (M0) bladder cancer is unclear, as reflected in the National Comprehensive Cancer Network (NCCN) guideline recommendation for chemotherapy (CT) with or without RT in this population. We conducted the present analysis of the NCDB to determine whether RT at a definitive dose would be associated with improved overall survival (OS) in patients with N+ bladder cancer. Methods: NCDB was queried for subjects diagnosed from 1998-2012 with cN1-3 M0 cancer of the urinary bladder who did not undergo cystectomy. Definitive RT included external beam radiotherapy to the pelvis or bladder regions to a cumulative dose of ≥ 54Gy (per NCCN guideline for gross nodal disease). Cox regression was used to assess the association of definitive RT with overall survival while controlling for patient-related, tumor-related, and treatment-related factors. Results: 3,298 N+ subjects not undergoing cystectomy were identified, of whom 840 (25.5%) received any RT and 392 (11.9%) received ≥ 54Gy. In the entire cohort, multivariate analysis adjusting for age, year, sex, race, location, income, comorbidity, histology, grade, T-stage, N-stage, and receipt of chemotherapy demonstrated an OS benefit (HR for death 0.69; 95%CI 0.59-0.82; p < 0.01) with cumulative RT dose ≥ 54Gy. On subgroup analysis, this OS benefit persisted both among the 1905 patients (331 receiving ≥ 54Gy) undergoing CT (HR 0.66; 95%CI 0.46-0.95; p = 0.02) and among the 1393 patients (61 receiving ≥ 54Gy) not undergoing CT (HR 0.67; 95%CI 0.55-0.82; p < 0.01). Conclusions: In the largest analysis to date of definitive radiotherapy for N+ bladder cancer, receipt of a definitive RT dose was associated with improved OS, irrespective of receipt of CT. Intermediate oncologic endpoints including locoregional control and disease-free survival were unavailable for analysis. With a minority of N+ subjects receiving any radiotherapy, this intervention appears to be underutilized among these patients.

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Development and Validation of Nomograms to Predict Prognosis of Oral and Oropharyngeal Mucoepidermoid Carcinoma: A SEER-Based Study

10.21203/rs.3.rs-125136/v1 ◽

2020 ◽

Author(s):

muyuan liu ◽

Litian Tong ◽

Manbin Xu ◽

Xiang Xu ◽

Bin Liang ◽

...

Keyword(s):

Overall Survival ◽

Prognostic Factors ◽

Mucoepidermoid Carcinoma ◽

Cox Regression ◽

Seer Database ◽

Disease Specific Survival ◽

Cox Regression Analysis ◽

T Stage ◽

N Stage ◽

Disease Specific

Abstract Background: Due to the low incidence of mucoepidermoid carcinoma, there lacks sufficient studies for determining optimal treatment and predicting prognosis. The purpose of this study was to develop prognostic nomograms, to predict overall survival and disease-specific survival (DSS) of oral and oropharyngeal mucoepidermoid carcinoma patients, using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. Methods: Clinicopathological and follow-up data of patients diagnosed with oral and oropharyngeal mucoepidermoid carcinoma between 2004 and 2017 were collected from the SEER database. The Kaplan-Meier method with the log-rank test was employed to identify single prognostic factors. Multivariate Cox regression was utilized to identify independent prognostic factors. C-index, area under the ROC curve (AUC) and calibration curves were used to assess performance of the prognostic nomograms. Results: A total of 1230 patients with oral and oropharyngeal mucoepidermoid carcinoma were enrolled in the present study. After multivariate Cox regression analysis, age, sex, tumor subsite, T stage, N stage, M stage, grade and surgery were identified as independent prognostic factors for overall survival. T stage, N stage, M stage, grade and surgery were identified as independent prognostic factors for disease-specific survival. Nomograms were constructed to predict the overall survival and disease-specific survival based on the independent prognostic factors. The fitted nomograms possessed excellent prediction accuracy, with a C-index of 0.899 for OS prediction and 0.893 for DSS prediction. Internal validation by computing the bootstrap calibration plots, using the validation set, indicated excellent performance by the nomograms. Conclusion: The prognostic nomograms developed, based on individual clinicopathological characteristics, in the present study, accurately predicted the overall survival and disease-specific survival of patients with oral and oropharyngeal mucoepidermoid carcinoma.

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Gastric neuroendocrine neoplasias: manifestations and comparative outcomes

Endocrine Related Cancer ◽

10.1530/erc-18-0582 ◽

2019 ◽

Vol 26 (9) ◽

pp. 751-763 ◽

Cited By ~ 1

Author(s):

S Felder ◽

H Jann ◽

R Arsenic ◽

T Denecke ◽

V Prasad ◽

...

Keyword(s):

Survival Data ◽

Classification System ◽

Cox Regression ◽

Clinical Course ◽

Tnm Classification ◽

Careful Analysis ◽

Low Grade ◽

Tertiary Referral Centre ◽

Cox Regression Analysis ◽

Grade 3

Although gastric neuroendocrine neoplasias (gNEN) are an orphan disease, their incidence is rising. The heterogeneous clinical course powers the ongoing discussion of the most appropriate classification system and management. Prognostic relevance of proposed classifications was retrospectively analysed in 142 patients from a single tertiary referral centre. Baseline, management and survival data were acquired for statistical analyses. The distribution according to the clinicopathological typification was gNEN-1 (n = 86/60.6%), gNEN-2 (n = 7/4.9%), gNEN-3 (n = 24/16.9%) and gNEN-4 (n = 25/17.6%), while hypergastrinemia-associated gNEN-1 and -2 were all low-grade tumours (NET-G1/2), formerly termed sporadic gNEN-3 could be subdivided into gNEN-3 with grade 1 or 2 and gNEN-4 with grade 3 (NEC-G3). During follow-up 36 patients died (25%). The mean overall survival (OS) of all gNEN was 14.2 years. The OS differed statistically significant across all subgroups with either classification system. According to UICC 2017 TNM classification, OS differed for early and advanced stages, while WHO grading indicated poorer prognosis for NEC-G3. Cox regression analysis confirmed the independent prognostic validity of either classification system for survival. Particularly careful analysis of the clinical course of gNEN-1 (ECLomas, gastric carcinoids) confirmed their mostly benign, but recurrent and extremely slowly progressive behaviour with low risk of metastasis (7%) and an efficient long-term control by repetitive endoscopic procedures. Our study provides evidence for the validity of current classifications focusing on typing, grading and staging. These are crucial tools for risk stratification, especially to differentiate gNEN-1 as well as sporadic gNET and gNEC (gNEN-3 vs -4).

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Influence of Lymphangio (L), Vascular (V), and Perineural (Pn) Invasion on Recurrence and Survival of Resected Intrahepatic Cholangiocarcinoma

Journal of Clinical Medicine ◽

10.3390/jcm10112426 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2426

Author(s):

Fabian Bartsch ◽

Lisa-Katharina Heuft ◽

Janine Baumgart ◽

Maria Hoppe-Lotichius ◽

Rabea Margies ◽

...

Keyword(s):

Overall Survival ◽

Intrahepatic Cholangiocarcinoma ◽

Vascular Invasion ◽

Tumor Recurrence ◽

Perineural Invasion ◽

Tnm Classification ◽

Recurrence Free Survival ◽

Extrahepatic Recurrence ◽

Free Survival ◽

Rare Malignancy

(1) Background: Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy. Besides tumor, nodal, and metastatic status, the UICC TNM classification describes further parameters such as lymphangio- (L0/L1), vascular (V0/V1/V2), and perineural invasion (Pn0/Pn1). The aim of this study was to analyze the influence of these parameters on recurrence and survival. (2) Methods: All surgical explorations for patients with ICC between January 2008 and June 2018 were collected and further analyzed in our institutional database. Statistical analyses focused on perineural, lymphangio-, and vascular invasion examined histologically and their influence on tumor recurrence and survival. (3) Results: Of 210 patients who underwent surgical exploration, 150 underwent curative-intended resection. Perineural invasion was present in 41, lymphangioinvasion in 21, and vascular invasion in 37 patients (V1 n = 34, V2 n = 3). Presence of P1, V+ and L1 was significantly associated with positivity of each other of these factors (p < 0.001, each). None of the three parameters showed direct influence on tumor recurrence in general, but perineural invasion influenced extrahepatic recurrence significantly (p = 0.019). Whereas lymphangio and vascular invasion was neither associated with overall nor recurrence-free survival, perineural invasion was significantly associated with a poor 1-, 3- and 5-year overall survival (OS) of 80%, 35%, and 23% for Pn0 versus 75%, 23%, and 0% for Pn1 (p = 0.027). Concerning recurrence-free survival (RFS), Pn0 showed a 1-, 3- and 5-year RFS of 42%, 18%, and 16% versus 28%, 11%, and 0% for Pn1, but no significance was reached (p = 0.091). (4) Conclusions: Whereas lymphangio- and vascular invasion showed no significant influence in several analyses, the presence of perineural invasion was associated with a significantly higher risk of extrahepatic tumor recurrence and worse overall survival.

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A Novel Clinical-Radiomics Model Based on Sarcopenia and Radiomics for Predicting the Prognosis of Intrahepatic Cholangiocarcinoma After Radical Hepatectomy

Frontiers in Oncology ◽

10.3389/fonc.2021.744311 ◽

2021 ◽

Vol 11 ◽

Author(s):

Liming Deng ◽

Bo Chen ◽

Chenyi Zhan ◽

Haitao Yu ◽

Jiuyi Zheng ◽

...

Keyword(s):

Intrahepatic Cholangiocarcinoma ◽

Clinical Decision Making ◽

Cox Regression ◽

Area Under The Curve ◽

Psoas Muscle ◽

Staging System ◽

Predictive Performance ◽

Arterial Phase ◽

Neutrophil Lymphocyte Ratio ◽

Staging Systems

BackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignant tumor with a poor prognosis. This study aimed to establish a novel clinical-radiomics model for predicting the prognosis of ICC after radical hepatectomy.MethodsA clinical-radiomics model was established for 82 cases of ICC treated with radical hepatectomy in our hospital from May 2011 to December 2020. Radiomics features were extracted from venous-phase and arterial-phase images of computed tomography. Kaplan-Meier survival analysis was generated to compare overall survival (OS) between different groups. The independent factors were identified by univariate and multivariate Cox regression analyses. Nomogram performance was evaluated regarding discrimination, calibration, and clinical utility. C-index and area under the curve (AUC) were utilized to compare the predictive performance between the clinical-radiomics model and conventional staging systems.ResultsThe radiomics model included five features. The AUC of the radiomics model was 0.817 in the training cohort, and 0.684 in the validation cohort. The clinical-radiomics model included psoas muscle index, radiomics score, hepatolithiasis, carcinoembryonic antigen, and neutrophil/lymphocyte ratio. The reliable C-index of the model was 0.768, which was higher than that of other models. The AUC of the model for predicting OS at 1, and 3 years was 0.809 and 0.886, which was significantly higher than that of the American Joint Committee on Cancer 8th staging system (0.594 and 0.619), radiomics model (0.743 and 0.770), and tumor differentiation (0.645 and 0.628). After stratification according to the constructed model, the median OS was 59.8 months for low-risk ICC patients and 10.1 months for high-risk patients (p < 0.0001).ConclusionThe clinical-radiomics model integrating sarcopenia, clinical features, and radiomics score was accurate for prognostic prediction for mass-forming ICC patients. It provided an individualized prognostic evaluation in patients with mass-forming ICC and could helped surgeons with clinical decision-making.

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Prognostic Nomogram and a Risk Classification System for Predicting Overall Survival of Elderly Patients with Fibrosarcoma: A Population-Based Study

Journal of Oncology ◽

10.1155/2021/9984217 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Fengkai Yang ◽

Hangkai Xie ◽

Yucheng Wang

Keyword(s):

Overall Survival ◽

Elderly Patients ◽

Classification System ◽

Cox Regression ◽

Predictive Accuracy ◽

Risk Classification ◽

Seer Database ◽

Training Set ◽

Decision Curve Analysis ◽

Validation Set

Background. The objective of this study was to develop a nomogram model and risk classification system to predict overall survival in elderly patients with fibrosarcoma. Methods. The study retrospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database relating to elderly patients diagnosed with fibrosarcoma between 1975 and 2015. Independent prognostic factors were identified using univariate and multivariate Cox regression analyses on the training set to construct a nomogram model for predicting the overall survival of patients at 3, 5, and 10 years. The receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the discrimination and predictive accuracy of the model. Decision curve analysis was used for assessing the clinical utility of the model. Result. A total of 357 elderly fibrosarcoma patients from the SEER database were included in our analysis, randomly classified into a training set (252) and a validation set (105). The multivariate Cox regression analysis of the training set demonstrated that age, surgery, grade, chemotherapy, and tumor stage were independent prognostic factors. The ROC showed good model discrimination, with AUC values of 0.837, 0.808, and 0.806 for 3, 5, and 10 years in the training set and 0.769, 0.779, and 0.770 for 3, 5, and 10 years in the validation set, respectively. The calibration curves and decision curve analysis showed that the model has high predictive accuracy and a high clinical application. In addition, a risk classification system was constructed to differentiate patients into three different mortality risk groups accurately. Conclusion. The nomogram model and risk classification system constructed by us help optimize patients’ treatment decisions to improve prognosis.

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Prognostic impact of tumor deposits in colorectal cancer with lymph nodes metastasis.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e15051 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e15051-e15051

Author(s):

Fangqi Liu ◽

Jiang Zhao ◽

Li Yang ◽

Ji Zhu ◽

Ye Xu

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Cancer Patients ◽

Classification System ◽

Tnm Classification ◽

Prognostic Impact ◽

Training Cohort ◽

Tnm System ◽

Lymph Nodes Metastasis ◽

Colorectal Cancer Patients

e15051 Background:The TNM classification system was widely used in managing many kinds of cancer including colorectal cancer. However, there is one undefined aspect that is the value of tumor deposits (TDs) in the condition of TDs and lymph nodes metastasis (LNM) coexisting. This research aims to clarify the prognostic impact of TDs in colorectal cancer especially for the condition of TDs combined with LNM. Methods: An analysis was performed to evaluate the prognostic significance of TDs in stage Ⅰ to Ⅳ colorectal cancer patients from 2010 to 2013 using Surveillance Epidemiology and End Results (SEER) database as a training cohort (N = 65, 537). An additional 3, 719 patients from Fudan University Shanghai Cancer Center were enrolled between 2006 and 2014 as a test cohort to validate the results. Results: TDs were observed in 6.32% of patients in training cohort and 14.7% in test cohort. A significantly reduced overall survival was observed for TDs positive in LNM positive and negative colorectal cancer patients (hazard ratio [HR], 1.65; 95% CI, 1.54 to 1.76). Further analysis combining TDs with LNM shows that there is no considerable difference in the impact on overall survival between N1 and N1c or between N1 with TDs (N1TD) and N2. The 3-year survival rate was 82.3%, 72.0%, 69.9%, 55.7%, 52.1%, 39.4% for N0, N1, N1c, N1TD, N2 and N2 with TDs (N2TD) respectively. Similar results were observed in the test cohort. Conclusions: These results support the 7th and 8th TNM system in which N1c was integrated into pathological N classification. However, LNM with positive TDs should be also considered into the TNM classification system because of the high prognostic impact of TDs, which was not mentioned in the current TNM system.

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High platelet-to-lymphocyte ratio is associated with poor prognosis in patients with unresectable intrahepatic cholangiocarcinoma receiving gemcitabine plus cisplatin

BMC Cancer ◽

10.1186/s12885-020-07390-3 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Gunn Huh ◽

Ji Kon Ryu ◽

Jung Won Chun ◽

Joo Seong Kim ◽

Namyoung Park ◽

...

Keyword(s):

Overall Survival ◽

Intrahepatic Cholangiocarcinoma ◽

Roc Analysis ◽

Cox Regression ◽

Cox Proportional Hazards ◽

Time Dependent ◽

Platelet To Lymphocyte Ratio ◽

Cox Regression Analysis ◽

Lymphocyte Ratio ◽

The Impact

Abstract Background Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR), have emerged as prognostic markers in various cancers. The aim of this study was to explore the impact of SIR markers on the survival outcomes of unresectable intrahepatic cholangiocarcinoma (IHC) patients. Methods Patients with histologically confirmed, unresectable IHC treated with gemcitabine plus cisplatin (GP) chemotherapy in a single tertiary hospital from 2012 to 2016 were retrospectively reviewed. Progression-free survival (PFS) and overall survival (OS) were determined using unadjusted Kaplan-Meier and adjusted Cox-proportional-hazards analysis. Time-dependent receiver operating characteristic (ROC) analysis was performed to compare the performance of the SIR markers in predicting OS. Results A total of 137 patients received a median of six cycles (interquartile range [IQR], 3–11) of GP chemotherapy with a median observation time of 9.9 months (range, 1.8–54.7 months). The median PFS and OS of all patients were 7.8 months and 9.9 months, respectively. Among the SIR markers, high PLR (> 148) and high NLR (> 5) were associated with a short PFS (Hazard ratio [HR] 1.828, P = 0.006; HR 1.738, P = 0.030, respectively) and short OS (HR 2.332, P < 0.001; HR 2.273, P < 0.001, respectively). Low LMR (< 3.5) and low AGR (< 1.2) were associated with a short OS (HR 2.423, P < 0.001; HR 1.768, P = 0.002, respectively). In multivariable cox-regression analysis, high PLR (HR 1.766, P = 0.009) and distant lymph node (LN) metastasis (HR 2.085, P = 0.001) were associated with a short PFS. High PLR (HR 1.856, P = 0.002) was an independent predictor of a short OS, along with distant LN metastasis (HR 1.929; P < 0.001), low LMR (HR 1.691; P = 0.041), and low level of serum albumin (< 3.5 g/dL) (HR 1.632; P = 0.043). Time-dependent ROC analysis revealed that the area under the curve of PLR for predicting overall survival was greater than that of NLR, LMR, and AGR at most time points. Conclusions High PLR was an independent prognostic factor of a short PFS and OS in patients with unresectable IHC receiving GP chemotherapy.

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An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma

Cancer Research and Treatment ◽

10.4143/crt.2019.423 ◽

2020 ◽

Vol 52 (2) ◽

pp. 469-480 ◽

Cited By ~ 1

Author(s):

Liang Chen ◽

Hongyuan Fu ◽

Tongyu Lu ◽

Jianye Cai ◽

Wei Liu ◽

...

Keyword(s):

Light Chain ◽

Intrahepatic Cholangiocarcinoma ◽

Cox Regression ◽

Area Under The Curve ◽

Clinical Information ◽

Cancer Antigen 125 ◽

Curative Intent ◽

Cox Regression Analysis ◽

Neutrophil Lymphocyte Ratio ◽

Effective Models

PurposeMicrotubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy.Materials and MethodsFrom August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry.ResultsThe 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively.ConclusionThe nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.

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