scholarly journals 25-Hydroxyvitamin D deficiency is a risk factor for atherosclerotic cardiovascular disease: a prospective study

2021 ◽  
Author(s):  
Shan Su ◽  
Liting Wang ◽  
Xulei Tang ◽  
Nan Zhao ◽  
Conghui Guan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Glucose Metabolism ◽  
Vitamin D Deficiency ◽  
Atherosclerotic Cardiovascular Disease ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Ascvd Risk

Abstract Background Vitamin D, a fat-soluble vitamin, play a protective role in the cardiovascular system. Increasing evidence has suggested that the vitamin D deficiency is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). The aim of the present study was to investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D] and the risk of ASCVD in Chinese, especially in people with type 2 diabetes mellitus(T2DM). Methods Based on the "REACTION" study conducted in 2011, 9014 residents aged 40 to 75 in Lanzhou, Gansu province were followed up from 2014 to 2016. A total of 7061 subjects with complete data from the two surveys in present study were analyzed. Baseline population was classified into four groups based on 25(OH)D quartiles, comparing the different 25(OH)D groups of ASCVD incidence after follow-up, multivariate Cox proportional hazards regression modelling was used to estimate associations between 25(OH)D levels and the risk of ASCVD and to further analyze the relationship between ASCVD risk and 25(OH)D levels in different glucose metabolism status. Results Among 7,061 subjects aged 40 to 75 years, the median serum 25(OH)D level was 15.91ng/ml, and the prevalence of vitamin D deficiency was 75.1%, merely 2.0% of those with vitamin D sufficiency. During the follow-up period of 3.3 years, 216 cases of ASCVD events were recorded. The cumulative incidence of ASCVD from lowest of 25(OH)D levels to the highest were 4.1%, 3.0%, 3.1% and 2.0%, respectively. Cox regression analysis indicated that the individuals in quartile 1 but not quartile 2 or 3 of 25(OH)D level had significantly higher rate of ASCVD than that in highest quartile, additionally, 10 ng/ml per increase in serum 25(OH)D at baseline, the ASCVD risk was reduced by 24%[hazard ratio(HR):0.761, 95% confident interval(CI):0.590- 0.980, P <0.05]. When the effects of 25(OH)D on ASCVD risk was assessed in different glucose metabolism status, the results showed that the low 25(OH)D plus T2DM was associated with high risk of ASCVD after adjustment of confounding risk factors (HR: 2.284, 95% CI: 1.242-4.202, P <0.05).The risk of ASCVD decreased by 35% as serum 25(OH)D increased by 10 ng/ml, which remained significant after stepwise adjustments ( P <0.05). Conclusions Serum 25(OH)D is independently and inversely associated with the risk of ASCVD in Chinese.Increasing vitamin D levels can effectively reduce the risk of ASCVD incidence, especially in T2DM populations.

scholarly journals Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age

2020 ◽  
Vol 150 (11) ◽  
pp. 2977-2984
Author(s):  
Mariane M Luiz ◽  
Roberta Máximo ◽  
Dayane C Oliveira ◽  
Paula C Ramírez ◽  
Aline F de Souza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Activities Of Daily Living ◽  
Vitamin D Deficiency ◽  
Daily Living ◽  
Clinical Characteristics ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency compromises muscle function and is related to the etiology of several clinical conditions that can contribute to the development of disability. However, there are few epidemiological studies investigating the association between vitamin D deficiency and the incidence of disability. Objectives We aimed to assess whether vitamin D deficiency is associated with the incidence of disability in basic activities of daily living (BADL) and to verify whether there are sex differences in this association. Methods A 4-y follow-up study was conducted involving individuals aged 50 y or older who participated in ELSA (English Longitudinal Study of Ageing). The sample consisted of 4814 participants free of disability at baseline according to the modified Katz Index. Vitamin D was assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations and the participants were classified as sufficient (&gt;50 nmol/L), insufficient (&gt;30 to ≤50 nmol/L), or deficient (≤30 nmol/L). Sociodemographic, behavioral, and clinical characteristics were also investigated. BADL were re-evaluated after 2 and 4 y of follow-up. The report of any difficulty to perform ≥1 BADL was considered as an incident case of disability. Poisson models stratified by sex and controlled for sociodemographic, behavioral, and clinical characteristics were carried out. Results After 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). However, insufficient serum 25(OH)D was not a risk factor for the incidence of BADL disability in either men or women. Conclusions Independently of sex, deficient serum 25(OH)D concentrations were associated with increased risk of incidence of BADL disability in adults &gt;50 y old and should be an additional target of clinical strategies to prevent disability in these populations.

scholarly journals Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Kazuhiko Arima ◽  
Satoshi Mizukami ◽  
Takayuki Nishimura ◽  
Yoshihito Tomita ◽  
Hiroki Nakashima ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Muscle Weakness ◽  
Elderly Individuals ◽  
Musculoskeletal Conditions ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Osteoporosis Fracture

Abstract Background Vitamin D deficiency is associated with osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. Elderly individuals are more likely to present with poor musculoskeletal conditions. Recently, several epidemiological studies have assessed the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and musculoskeletal conditions in elderly individuals. Main text Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Numerous studies have shown a positive association between serum 25(OH)D levels and bone mineral density. Only a few studies have reported an association between serum 25(OH)D levels and quantitative ultrasound (QUS) parameters. Low serum 25(OH)D level may be a risk factor for hip fracture. However, data on the association between vitamin D deficiency and the incidence of non-hip fracture are contrasting. Falls are a major cause of mortality and morbidity in older adults. Several prospective population-based cohort studies have shown that low 25(OH)D levels are associated with an increased risk of falls. Reduced muscle strength and physical performance are risk factors for adverse events, including disability, institutionalization, and mortality. The role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly individuals is still controversial. Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of disability among older adults. Data on the association between serum 25(OH)D levels and OA are contrasting. Conclusion Some studies have shown that vitamin D deficiency may be a risk factor for poor musculoskeletal conditions, such as osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. However, other studies did not find an association between serum 25(OH)D levels and musculoskeletal conditions.

scholarly journals Severe vitamin D deficiency is a risk factor for renal hyperfiltration

2018 ◽  
Vol 108 (6) ◽  
pp. 1342-1351 ◽  
Author(s):  
Jong Hyun Jhee ◽  
Ki Heon Nam ◽  
Seong Yeong An ◽  
Min-Uk Cha ◽  
Misol Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Glomerular Filtration Rate ◽  
Vitamin D Deficiency ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Hydroxyvitamin D ◽  
Severe Vitamin ◽  
25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015. Overall, 33,210 subjects with normal renal function were included in the final analysis. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL. RHF was defined as estimated glomerular filtration rate with residual in the >95th percentile after adjustment for age, sex, height, weight, and history of hypertension or diabetes. Results The mean ± SD age of subjects was 48.1 ± 15.9 y, and the number of women was 18,779 (56.5%). Estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis (β: −0.02; 95% CI: −0.02, −0.01; P < 0.001). Furthermore, 1637 (4.9%) subjects were categorized into the RHF group, and the prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficiency group (5.8% compared with 5.0%, P < 0.001). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (OR: 2.41; 95% CI, 1.72, 3.43; P < 0.001). Conclusions Severe vitamin D deficiency is significantly associated with increasing prevalence of RHF in a relatively healthy adult population.

scholarly journals Association of Serum 25-Hydroxyvitamin D Concentrations with All-Cause and Cause-Specific Mortality Among Adult Patients with Existing Cardiovascular Disease

2021 ◽  
Author(s):  
Lei Dai ◽  
Man Liu ◽  
Liangkai Chen
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Respiratory Disease ◽  
Adult Patients ◽  
Hydroxyvitamin D ◽  
Specific Mortality ◽  
25 Hydroxyvitamin D ◽  
Reduced Risk ◽  
Cvd Mortality

Abstract Background:Vitamin D insufficiency and deficiency are common in patients with cardiovascular disease (CVD). We aimed to prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adult patients with existing CVD.Methods:We included 37,080 patients with CVD from the UK Biobank study, a prospective cohort of half a million participants aged 40–69 years. We defined patients with CVD as those who suffered coronary heart disease, atrial fibrillation, heart failure, or stroke. The associations of serum 25(OH)D concentration with all-cause and cause-specific mortality were examined by using multivariable Cox regression models and competing risk analyses.Results:Among 37,080 patients with CVD at baseline, 57.5% were subjected to vitamin D deficiency (i.e., 25[OH]D <50 nmol/L). During a median follow-up of 8.9 years, 3920 total deaths occurred, including 1411 deaths from CVD, 1497 deaths from cancer, 368 deaths from respiratory disease, and 644 other-cause deaths. We observed non-linear inverse associations for all-cause, cancer, respiratory disease, and other-cause mortality (P-nonlinearity <0.001) and approximately linear inverse associations for CVD mortality (P-nonlinearity = 0.069). Among CVD patients with vitamin D deficiency, per 10 nmol/L increment in serum 25(OH)D concentrations was associated with an 11% reduced risk for all-cause mortality and 10% reduced risk for CVD mortality.Conclusion:Among patients with existing CVD, increasing levels in serum 25(OH)D were independently associated with a decreased risk of all-cause and cause-specific mortality. These findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.

Vitamin D Deficiency Contributed to Mozart’s death

2011 ◽  
Vol 26 (2) ◽  
pp. 117-117 ◽  
Author(s):  
William B Grant ◽  
Stefan Pilz
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Deficiency ◽  
Cause Of Death ◽  
Wolfgang Amadeus Mozart ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Serum

Dawson’s recent extensive bibliographic review of the cause of death of Wolfgang Amadeus Mozart found that there were a number of hypotheses including poisoning, infection, cardiovascular disease, and renal disease and its complications. Overlooked in any of the papers hypothesizing about his death was a discussion of the likely role of very low serum 25-hydroxyvitamin D [25(OH)D] level in contributing to his untimely death.

scholarly journals Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Lei Dai ◽  
Man Liu ◽  
Liangkai Chen
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Respiratory Disease ◽  
Adult Patients ◽  
Hydroxyvitamin D ◽  
Specific Mortality ◽  
25 Hydroxyvitamin D ◽  
Reduced Risk ◽  
Cvd Mortality

Background: Vitamin D insufficiency and deficiency are common in patients with cardiovascular disease (CVD). We aimed to prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adult patients with existing CVD.Methods: We included 37,079 patients with CVD from the UK Biobank study, a prospective cohort of half a million participants aged 40–69 years. We defined patients with CVD as those who suffered coronary heart disease, atrial fibrillation, heart failure, or stroke. The associations of serum 25(OH)D concentration with all-cause and cause-specific mortality were examined by using multivariable Cox regression models and competing risk analyses.Results: Among 37,079 patients with CVD at baseline, 57.5% were subjected to vitamin D deficiency (i.e., 25[OH]D &lt;50 nmol/L). During a median follow-up of 11.7 years, 6,319 total deaths occurred, including 2,161 deaths from CVD, 2,230 deaths from cancer, 623 deaths from respiratory disease, and 1,305 other-cause deaths. We observed non-linear inverse associations for all-cause, cancer, respiratory disease, and other-cause mortality (P-non-linearity &lt;0.01) and approximately linear inverse associations for CVD mortality (P-non-linearity = 0.074). Among CVD patients with vitamin D deficiency, per 10 nmol/L increment in serum 25(OH)D concentrations was associated with an 12% reduced risk for all-cause mortality and 9% reduced risk for CVD mortality.Conclusion: Among patients with existing CVD, increasing levels in serum 25(OH)D were independently associated with a decreased risk of all-cause and cause-specific mortality. These findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.

Abstract P137: Walking Impairment and Vitamin D Deficiency in the Elderly, National Health and Nutrition Examination Survey 2001 to 2004

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Lea Moukarzel ◽  
Danlin Mao ◽  
Luis H Eraso
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
The Elderly ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
Health And Nutrition ◽  
History Of ◽  
25 Hydroxyvitamin D

Introduction: Vitamin D deficiency has been reported in 36% of otherwise healthy adults and 57% of inpatients in the US. Vitamin D deficiency (< 15 ng/ml) is linked to increased muscle weakenss, cardiovascular disease and abnormal bone mineral metabolism. The elderly are more prone to vitamin D deficiency because of decrease dietary intake, diminished sunlight exposure and reduced skin thickness among other risk factors. We hypothesized that walking impairment in subjects older than 60 years old is associated to abnormal serum levels of 25-hydroxyvitaminD levels independent of traditional cardiovascular risk factors. Methods: A multivariable adjustment was performed using the National Health and Nutrition Examination Survey database and a graded association was present between serum 25-hydroxyvitaminD levels and walking impairment. We analyzed data from 2,322 participants of the NHANES 2001-2004 survey ages 60 years or older who responded to the walking impairment (WI) questionnaire and had serum 25-hydroxyvitamin D levels measured. Walking impairment was defined as an affirmative answer to the question: “have you had pain in either leg while walking?” A 25 hydroxyvitamin D deficiency level was defined as a serum level of 15ng/dl or less. PAD was defined as an ABI of less than 0.9 in either leg. Results: The prevalence of individuals 60 year or older with walking impairment due to leg pain in the United States is 25 % (S.E, 1.3). Mexican Americans (31.43%) had a higher prevalence of WI than Whites (24.28%) or African Americans (28.67%). Walking impairment was also statistically significant among those with a history of diabetes mellitus, cardiovascular disease, and peripheral arterial disease. Results also showed that C-reactive protein and alkaline phosphates were higher among those with walking impairment. A multivariable adjustment was performed and a graded association was present between serum 25-hydroxyvitaminD levels and walking impairment. An odds ratio of 1.526186(p= 0.013) for walking impairment was present among vitamin D deficient subjects after adjusting for age, gender, and race-ethnicity. The association remained after further adjusting for C-reactive protein, chronic kidney disease, smoking, history of diabetes, PAD, and history of cardiovascular disease (O.R. =1.416255, p=0.045). Conclusion: Walking impairment is associated with 25-hydroxyvitaminD deficiency in the elderly independent of traditional cardiovascular risk factors. These results warrant further studies to determine if vitamin D supplementation improves functional capacity and reduces cardiovascular disease in the elderly.

Depressed Serum 25-Hydroxyvitamin D Levels Increase Hospital Stay and Alter Glucose Homeostasis in First-ever Ischemic Stroke

2019 ◽  
Vol 16 (4) ◽  
pp. 340-347
Author(s):  
Yuge Wang ◽  
Yanqiang Wang ◽  
Bingjun Zhang ◽  
Yinyao Lin ◽  
Sha Tan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Hospital Stay ◽  
Functional Outcome ◽  
Vitamin D Deficiency ◽  
Glucose Homeostasis ◽  
Clinical Severity ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Deficiency Group

Background and Objective: Vitamin D deficiency is internationally recognized among the potentially modifiable risk factors for ischemic cardio-cerebrovascular diseases. However, the association between vitamin D deficiency and stroke morbidity or mortality remains insufficiently known. Our aim is to investigate their relevance to 25-hydroxyvitamin D [25(OH) D] levels and clinical severity and outcome after 3 months in first-ever ischemic stroke. Methods: Retrospective analysis of 356 consecutive patients in first-ever ischemic stroke between 2013 and 2015. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome after 3 months of onset was evaluated using the modified Rankin scale (mRS). Results: Among the 356 enrolled patients, HbA1c was higher in insufficiency/deficiency group than that in the sufficiency group (6.3 ± 1.7 vs. 5.9 ± 1.1, p =0.015). The hospital stay was longer in insufficiency/deficiency group than that in the sufficiency group (11 (8-17) vs. 9.5 (7-13), p = 0.035). There was a significant inversed trend between serum 25(OH) D levels and hospital stay (OR 0.960, P = 0.031), using logistic regression. Conclusions: 25(OH)D levels are associated with glucose homeostasis, 25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke. Vitamin D deficiency did not predict functional outcome in the span of 3 months.

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