scholarly journals Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age

2020 ◽  
Vol 150 (11) ◽  
pp. 2977-2984
Author(s):  
Mariane M Luiz ◽  
Roberta Máximo ◽  
Dayane C Oliveira ◽  
Paula C Ramírez ◽  
Aline F de Souza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Activities Of Daily Living ◽  
Vitamin D Deficiency ◽  
Daily Living ◽  
Clinical Characteristics ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency compromises muscle function and is related to the etiology of several clinical conditions that can contribute to the development of disability. However, there are few epidemiological studies investigating the association between vitamin D deficiency and the incidence of disability. Objectives We aimed to assess whether vitamin D deficiency is associated with the incidence of disability in basic activities of daily living (BADL) and to verify whether there are sex differences in this association. Methods A 4-y follow-up study was conducted involving individuals aged 50 y or older who participated in ELSA (English Longitudinal Study of Ageing). The sample consisted of 4814 participants free of disability at baseline according to the modified Katz Index. Vitamin D was assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations and the participants were classified as sufficient (>50 nmol/L), insufficient (>30 to ≤50 nmol/L), or deficient (≤30 nmol/L). Sociodemographic, behavioral, and clinical characteristics were also investigated. BADL were re-evaluated after 2 and 4 y of follow-up. The report of any difficulty to perform ≥1 BADL was considered as an incident case of disability. Poisson models stratified by sex and controlled for sociodemographic, behavioral, and clinical characteristics were carried out. Results After 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). However, insufficient serum 25(OH)D was not a risk factor for the incidence of BADL disability in either men or women. Conclusions Independently of sex, deficient serum 25(OH)D concentrations were associated with increased risk of incidence of BADL disability in adults >50 y old and should be an additional target of clinical strategies to prevent disability in these populations.

scholarly journals 25-Hydroxyvitamin D deficiency is a risk factor for atherosclerotic cardiovascular disease: a prospective study

2021 ◽  
Author(s):  
Shan Su ◽  
Liting Wang ◽  
Xulei Tang ◽  
Nan Zhao ◽  
Conghui Guan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Glucose Metabolism ◽  
Vitamin D Deficiency ◽  
Atherosclerotic Cardiovascular Disease ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Ascvd Risk

Abstract Background Vitamin D, a fat-soluble vitamin, play a protective role in the cardiovascular system. Increasing evidence has suggested that the vitamin D deficiency is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). The aim of the present study was to investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D] and the risk of ASCVD in Chinese, especially in people with type 2 diabetes mellitus(T2DM). Methods Based on the "REACTION" study conducted in 2011, 9014 residents aged 40 to 75 in Lanzhou, Gansu province were followed up from 2014 to 2016. A total of 7061 subjects with complete data from the two surveys in present study were analyzed. Baseline population was classified into four groups based on 25(OH)D quartiles, comparing the different 25(OH)D groups of ASCVD incidence after follow-up, multivariate Cox proportional hazards regression modelling was used to estimate associations between 25(OH)D levels and the risk of ASCVD and to further analyze the relationship between ASCVD risk and 25(OH)D levels in different glucose metabolism status. Results Among 7,061 subjects aged 40 to 75 years, the median serum 25(OH)D level was 15.91ng/ml, and the prevalence of vitamin D deficiency was 75.1%, merely 2.0% of those with vitamin D sufficiency. During the follow-up period of 3.3 years, 216 cases of ASCVD events were recorded. The cumulative incidence of ASCVD from lowest of 25(OH)D levels to the highest were 4.1%, 3.0%, 3.1% and 2.0%, respectively. Cox regression analysis indicated that the individuals in quartile 1 but not quartile 2 or 3 of 25(OH)D level had significantly higher rate of ASCVD than that in highest quartile, additionally, 10 ng/ml per increase in serum 25(OH)D at baseline, the ASCVD risk was reduced by 24%[hazard ratio(HR):0.761, 95% confident interval(CI):0.590- 0.980, P <0.05]. When the effects of 25(OH)D on ASCVD risk was assessed in different glucose metabolism status, the results showed that the low 25(OH)D plus T2DM was associated with high risk of ASCVD after adjustment of confounding risk factors (HR: 2.284, 95% CI: 1.242-4.202, P <0.05).The risk of ASCVD decreased by 35% as serum 25(OH)D increased by 10 ng/ml, which remained significant after stepwise adjustments ( P <0.05). Conclusions Serum 25(OH)D is independently and inversely associated with the risk of ASCVD in Chinese.Increasing vitamin D levels can effectively reduce the risk of ASCVD incidence, especially in T2DM populations.

Using Activities of Daily Living Assessments to Measure the Effectiveness of Vitamin D Supplements in Elderly Long-Stay Patients

1987 ◽  
Vol 50 (2) ◽  
pp. 60-62 ◽  
Author(s):  
D Corless ◽  
M Ellis ◽  
E Dawson ◽  
F Fraser ◽  
S Evans ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly Patients ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Controlled Trial ◽  
Double Blind ◽  
Hydroxyvitamin D ◽  
Low Concentrations ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

Selected activities of daily living were used to measure improvement in independence of long-stay elderly patients known to have low concentrations of plasma 25-hydroxyvitamin D. This was a double-blind random controlled trial lasting between 8 and 40 weeks. No significant changes were found in either group.

scholarly journals Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Kazuhiko Arima ◽  
Satoshi Mizukami ◽  
Takayuki Nishimura ◽  
Yoshihito Tomita ◽  
Hiroki Nakashima ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Muscle Weakness ◽  
Elderly Individuals ◽  
Musculoskeletal Conditions ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Osteoporosis Fracture

Abstract Background Vitamin D deficiency is associated with osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. Elderly individuals are more likely to present with poor musculoskeletal conditions. Recently, several epidemiological studies have assessed the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and musculoskeletal conditions in elderly individuals. Main text Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Numerous studies have shown a positive association between serum 25(OH)D levels and bone mineral density. Only a few studies have reported an association between serum 25(OH)D levels and quantitative ultrasound (QUS) parameters. Low serum 25(OH)D level may be a risk factor for hip fracture. However, data on the association between vitamin D deficiency and the incidence of non-hip fracture are contrasting. Falls are a major cause of mortality and morbidity in older adults. Several prospective population-based cohort studies have shown that low 25(OH)D levels are associated with an increased risk of falls. Reduced muscle strength and physical performance are risk factors for adverse events, including disability, institutionalization, and mortality. The role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly individuals is still controversial. Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of disability among older adults. Data on the association between serum 25(OH)D levels and OA are contrasting. Conclusion Some studies have shown that vitamin D deficiency may be a risk factor for poor musculoskeletal conditions, such as osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. However, other studies did not find an association between serum 25(OH)D levels and musculoskeletal conditions.

scholarly journals Are Indian obese children and adolescents at increased risk for Vitamin D deficiency?

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Aashima Dabas ◽  
T. Aravind ◽  
Sangeeta Yadav ◽  
Mukta Mantan ◽  
Smita Kaushik
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Indian Children ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
High Risk Factor ◽  
25 Hydroxyvitamin D ◽  
Obese Subjects

Objectives: Obesity has been mentioned as a high risk factor for Vitamin D deficiency (VDD) requiring supplementation in Indian children. Material and Methods: Forty obese and age-matched non-obese subjects (age 5–18 years) were assessed for lifestyle parameters, metabolic profile, and serum 25-hydroxyvitamin D (25OHD). VDD was defined as serum 25OHD < 12 ng/mL. Results: Mean 25OHD was comparable among obese and controls (15.0 ± 9.95 and 15.1 ± 4.79 ng/mL; P = 0.97) with VDD seen in 82% of cases and 85% of controls. Pubertal cases had lower 25OHD values than prepubertal obese cases (10.78 ± 4.69 and 17.2 ± 11 ng/mL; P = 0.06). Mean duration of physical activity (<2 h/week) and screen time (>2 h/day) was similar across prepubertal and pubertal groups and between obese and controls. Obesity was not associated with risk for VDD among cases and controls (odds ratio 0.83, 95% C.I. 0.25–2.7, P = 0.76). Conclusion: Obese pubertal subjects were more at risk for VDD than prepubertal subjects. Routine Vitamin D supplementation to obese Indian children may be considered during adolescence.

scholarly journals Severe vitamin D deficiency is a risk factor for renal hyperfiltration

2018 ◽  
Vol 108 (6) ◽  
pp. 1342-1351 ◽  
Author(s):  
Jong Hyun Jhee ◽  
Ki Heon Nam ◽  
Seong Yeong An ◽  
Min-Uk Cha ◽  
Misol Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Glomerular Filtration Rate ◽  
Vitamin D Deficiency ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Hydroxyvitamin D ◽  
Severe Vitamin ◽  
25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015. Overall, 33,210 subjects with normal renal function were included in the final analysis. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL. RHF was defined as estimated glomerular filtration rate with residual in the >95th percentile after adjustment for age, sex, height, weight, and history of hypertension or diabetes. Results The mean ± SD age of subjects was 48.1 ± 15.9 y, and the number of women was 18,779 (56.5%). Estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis (β: −0.02; 95% CI: −0.02, −0.01; P < 0.001). Furthermore, 1637 (4.9%) subjects were categorized into the RHF group, and the prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficiency group (5.8% compared with 5.0%, P < 0.001). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (OR: 2.41; 95% CI, 1.72, 3.43; P < 0.001). Conclusions Severe vitamin D deficiency is significantly associated with increasing prevalence of RHF in a relatively healthy adult population.

scholarly journals Factors Associated with Vitamin D Deficiency and Inadequacy among Women of Childbearing Age in the United States

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Guixiang Zhao ◽  
Earl S. Ford ◽  
James Tsai ◽  
Chaoyang Li ◽  
Janet B. Croft
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
The United States ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Hydroxyvitamin D ◽  
Supplement Use ◽  
Increased Risk ◽  
25 Hydroxyvitamin D ◽  
Dietary Supplement Use

Objective. To examine the prevalence and correlates of vitamin D deficiency and inadequacy among US women of childbearing age. Methods. Data from 1,814 female participants (20–44 y) in the 2003–2006 NHANES were analyzed to estimate the age-adjusted prevalence and prevalence ratios with 95% confidence intervals (CIs) for vitamin D deficiency (defined as serum 25-hydroxyvitamin D [25(OH)D] <12.0 ng/mL) and inadequacy (defined as 25(OH)D: 12.0–<20.0 ng/mL). Results. The age-adjusted prevalence was 11.1% (95% CI: 8.8–14.0%) for vitamin D deficiency and 25.7% (95% CI: 22.3–29.5%) for vitamin D inadequacy. Race/ethnicity other than non-Hispanic white and obesity were associated with increased risks, whereas dietary supplement use, milk consumption of ≥1 time/day, and potential sunlight exposure during May-October were associated with decreased risks for both vitamin D deficiency and inadequacy (). Current smoking and having histories of diabetes and cardiovascular disease were also associated with an increased risk for vitamin D deficiency (). Conclusions. Among women of childbearing age, periconceptional intervention programs may focus on multiple risk factors for vitamin D deficiency and inadequacy to ultimately improve their vitamin D nutrition.

scholarly journals Deficiency in 25-Hydroxyvitamin D and 30-Day Mortality in Patients With Severe Sepsis and Septic Shock

2014 ◽  
Vol 23 (5) ◽  
pp. e72-e79 ◽  
Author(s):  
Megan A. Rech ◽  
Todd Hunsaker ◽  
Jennifer Rodriguez
Keyword(s):  
Vitamin D ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Vitamin D Deficiency ◽  
Odds Ratio ◽  
Medical Center ◽  
Academic Medical Center ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Background Vitamin D has immunomodulating properties. Objective To determine if vitamin D deficiency within 30 days of admission to the intensive care unit in patients with sepsis might be associated with increased all-cause 30-day mortality. Methods In a retrospective cohort study at a large, tertiary, urban, academic medical center, records of patients who had 25-hydroxyvitamin D levels measured within 30 days of admission for severe sepsis or septic shock from June 2006 to April 2011 were examined. Patients were considered deficient in vitamin D if its serum concentration was 15 ng/mL or less. The primary outcome of interest was 30-day mortality. Results Among the 121 patients in the sample, 65 (54%) were vitamin D deficient. Baseline demographics were similar between vitamin D deficient and nondeficient groups, except that the vitamin D deficient group had more African Americans (P = .01). All-cause 30-day mortality was significantly higher in patients deficient in vitamin D (37% vs 20%; P = .04) and remained higher at 90 days (51% vs 25%, P = .005). In multivariate analysis, age (odds ratio, 1.04; 95% CI 1.01–1.07; P = .01) and vitamin D deficiency (odds ratio, 2.7; 95% CI, 1.39–18.8; P = .02) were independently associated with increased 30-day mortality. Conclusion Patients deficient in vitamin D within 30 days of hospital admission for severe sepsis or septic shock may be at increased risk for all-cause 30-day mortality.

scholarly journals Gestational vitamin D deficiency and autism spectrum disorder

BJPsych Open ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 85-90 ◽  
Author(s):  
Anna A. E. Vinkhuyzen ◽  
Darryl W. Eyles ◽  
Thomas H. J. Burne ◽  
Laura M. E. Blanken ◽  
Claudia J. Kruithof ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critical Period ◽  
Autism Spectrum ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D ◽  
Spectrum Disorders ◽  
Clinical Records

BackgroundThere is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.AimsTo determine the association between gestational vitamin D status and ASD.MethodBased on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases).ResultsIndividuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P=0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only.ConclusionsMid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny.

High Prevalence of Vitamin D Deficiency in Allogeneic Stem Cell Transplant Recipients.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2138-2138
Author(s):  
Richard W Joseph ◽  
Krishna V. Komanduri ◽  
R. M Saliba ◽  
Amin Alousi ◽  
S. Giralt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Stem Cell Transplant ◽  
Sun Exposure ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Allogeneic Transplant ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Abstract Vitamin D deficiency has long been understood to place patients at increased risk for reduced bone density and the development of pathological fractures. In addition to these classical manifestations, a wide body of emerging evidence suggests that Vitamin D deficiency may also increase the risk of illnesses associated with inflammation, including cardiovascular disease, infectious disease, autoimmune disease, and many common cancers. Our own in vitro data has confirmed that Vitamin D receptors are sharply upregulated on activated T cells and that physiologic calcitriol concentrations appear to have direct immunomodulatory functions (Joseph and Komanduri, unpublished). Vitamin D sufficiency is estimated by measuring 25-hydroxyvitamin D (25-OH D or calcidiol), and although there is no consensus on the optimal levels, many clinicians define sufficiency as &gt;30 ng/ml, insufficiency as 20–30 ng/ml, and deficiency as &lt;20 ng/ml. As one of the main sources of Vitamin D is through exposure to sunlight, allogeneic stem cell transplant (SCT) patients are at especially high risk of developing Vitamin D deficiency secondary to prolonged hospitalizations and standard recommendations to avoid sun exposure due to their increased risk of photosensitivity. To our knowledge, there are no large studies describing the incidence of Vitamin D deficiency in allogeneic SCT patients. We initially conducted a pilot study to assess Vitamin D levels in a group of allogeneic SCT recipients approximately assessed at approximately post-SCT day +100 (n=71) and found that only 18% of patients were sufficient, while the incidence of deficiency and insufficiency were to be 62%, and 20% respectively. To further elucidate if the deficiency was present pre-transplant or occurred post-transplant because of hospitalization and avoidance of sun exposure, we then assessed pre-transplant 25-hydroxyvitamin D levels in a larger group of allogeneic SCT recipients (n=108), and found that only 8% had normal baseline levels, while the vast majority were deficient (71%) or demonstrated insufficiency (21%). The baseline characteristics of this population are shown in the table below. Although this pilot study was not designed to assess the clinical significance of Vitamin D deficiency in the allogeneic transplant population, we believe that the unexpectedly high incidence of Vitamin D deficiency in SCT recipients deserves further study. Given the increasing epidemiologic and laboratory data implicating the Vitamin D axis in inflammation, we plan to assess traditional clinical outcomes associated with deficiency (including bone density and fracture rates) as well as immunological endpoints (GVHD and infection incidence) in future longitudinal studies. In conclusion, the incidence of Vitamin D deficiency in the allogeneic transplant setting is very high and additional studies are warranted to determine the clinical consequences associated with deficiency, and the potential therapeutic benefits of Vitamin D repletion in SCT recipients.

Preoperative Vitamin D Deficiency is a Risk Factor for Postthyroidectomy Hypoparathyroidism: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Author(s):  
Konstantina D Vaitsi ◽  
Panagiotis Anagnostis ◽  
Stavroula Veneti ◽  
Theodosios S Papavramidis ◽  
Dimitrios G Goulis
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Pubmed Central ◽  
Hydroxyvitamin D ◽  
Study Selection ◽  
Postoperative Hypoparathyroidism ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Abstract Context Whether preoperative vitamin D deficiency (VDD) contributes to postoperative hypoparathyroidism (hypoPT) risk is unknown. Objective This work aimed to meta-analyze the best available evidence regarding the association between preoperative vitamin D status and hypoPT risk. Methods A comprehensive literature search was conducted in PubMed, CENTRAL, and Scopus databases, up to October 31, 2020. Study selection included patients undergoing thyroidectomy with preoperative vitamin D status and postoperative hypoPT data. Two researchers independently extracted data from eligible studies. Data were expressed as risk ratio (RR) with 95% CI. The I2 index was employed for heterogeneity. Results Thirty-nine studies were included in the quantitative analysis (61 915 cases with transient and 5712 with permanent hypoPT). Patients with VDD demonstrated a higher risk for transient hypoPT compared with those with preoperative vitamin D sufficiency (RR 1.92, 95% CI, 1.50-2.45, I2 = 85%). These results remained significant for patients with preoperative 25-hydroxyvitamin D concentrations less than or equal to 20 ng/mL (mild VDD; RR 1.46, 95% CI, 1.10-1.94, I2 = 88%) and less than or equal to 10 ng/mL (severe VDD; RR 1.98, 95% CI 1.42-2.76, I2 = 85%). The risk of permanent hypoPT was increased only in cases with severe VDD (RR 2.45, 95% CI, 1.30-4.63, I2 = 45%). No difference was evident in subgroup analysis according to study design or quality. Conclusion Patients with preoperative VDD are at increased risk of transient hypoPT following thyroidectomy. The risk for permanent hypoPT is increased only for those with severe VDD.

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