Helicobacter Pylori Infection in Iran: Demographic, Endoscopic and Pathological Factors

Abstract Background: Helicobacter pylori infection is the most important risk factor for Gastritis and Peptic Ulcer. But other factors except H. pylori play roles in its pathogenesis. In current study we compare the clinical manifestation and endoscopic and histopathology findings in patients with and without H. pylori infection.Methods: In this cross-sectional study, 233 of patients with dyspepsia who referred for endoscopy were studied about presence of H. pylori infection. During endoscopy 5 biopsies were taken from each individual. The criteria for presence of H. pylori infection was the presence and recognition of bacteria in pathologic specimen which was done for all patient. These two groups of patient were compared with their demographic, background, endoscopic and pathologic findings. Results: From 233 cases, 154 (66.1%) cases were non-smoker, 201 (86.3%) cases were not alcohol user, 153 (65.7%) cases used tap water and the most common symptom was reported in 157 individual (67.4%) was epigastria pain. There was a significant relation between the number of family member, marital status and presence of H. pylori infection. Also there is a significant relation between endoscopic findings and pathologic findings in patients with H. pylori.Conclusions: the results of current studt demonstrated that H. pylori infection was not associated with sex, alcohol and NSAID drugs. According to the role of H. pylori in pathophysiology of peptic ulcer was clarified, also in this study there were a significant difference in endoscopic and pathological findings H. pylori.

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Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors

BMC Gastroenterology ◽

10.1186/s12876-021-01931-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Seyedeh Amineh Hojati ◽

Sara Kokabpeyk ◽

Salma Yaghoubi ◽

Farahnaz Joukar ◽

Mehrnaz Asgharnezhad ◽

...

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Epigastric Pain ◽

Tap Water ◽

Clinical Manifestations ◽

Gastrointestinal Symptoms ◽

Common Symptom ◽

Pathological Findings ◽

Significant Difference ◽

H Pylori

Abstract Background Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed to compare the clinical manifestations and endoscopic and histopathological findings of patients with and without H. pylori infection. Methods In this cross-sectional study, 233 patients with dyspepsia, referred for endoscopy, were examined regarding the presence of H. pylori infection. During an endoscopic exam, 5 biopsy specimens were taken from the stomach. The criteria for the presence of H. pylori infection was the presence and identification of bacteria in pathology. Two groups of H. pylori-positive and H. pylori-negative patients were compared regarding their demographic, endoscopic, and pathological findings. Results Of 233 patients, 154 (66.1%) were non-smokers, 201 (86.3%) were not alcohol users, and 153 (65.7%) used tap water. The most common symptom, reported in 157 (67.4%) patients, was epigastric pain. There was a significant difference between patients with and without H. pylori infection in terms of the educational status, occupational status, family history of gastrointestinal cancer, and some gastrointestinal symptoms. Also, there was a significant relationship between the endoscopic and pathological findings of patients with H. pylori. Conclusions The results of the present study revealed that H. pylori infection was not associated with sex, alcohol consumption, or non-steroidal anti-inflammatory drug use. The role of H. pylori in the pathophysiology of peptic ulcer was clarified. Also, there was a significant difference in the endoscopic and pathological findings of patients with H. pylori.

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Epidemiology of upper gastrointestinal bleeding and Helicobacter pylori infection: review of 3,488 Thai patients

Asian Biomedicine ◽

10.5372/1905-7415.0901.373 ◽

2017 ◽

Vol 9 (1) ◽

pp. 87-93

Author(s):

Sakolwan Suchartlikitwong ◽

Kamolyut Lapumnuaypol ◽

Rungsun Rerknimitr ◽

Duangporn Werawatganon

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Gastrointestinal Bleeding ◽

Upper Gastrointestinal Bleeding ◽

Helicobacter Pylori Infection ◽

Exclusion Criteria ◽

Common Causes ◽

Mucosal Lesions ◽

H Pylori ◽

Upper Gastrointestinal

Abstract Background The current epidemiology of upper gastrointestinal bleeding (UGIB) in Thailand is poorly understood and the reported prevalence of Helicobacter pylori infection is outdated. Objectives To investigate the etiologies of UGIB and prevalence of H. pylori infection in Thailand, including its association with UGIB. Methods We retrieved information regarding patients attending the endoscopic unit of King Chulalongkorn Memorial Hospital from June 2007 to January 2013. A database search using keywords “upper gastrointestinal bleeding” and “iron deficiency” was used. From 4,454 diagnoses, after exclusion criteria, 3,488 patients (2,042 male (58.5%) and 1,446 female (41.5%); mean age 63.3 ± 15.94 years, range 13–103 years) were included. Results The three most common causes of UGIB were peptic ulcer (38.2%), nonulcer-mucosal lesions (23.4%), and esophageal-related causes (20.4%). The 5 year-incidence of H. pylori was 25%–30%. The overall prevalence was 27%. The prevalence of H. pylori infection was found to decrease with age from 43.8% at <40 years to 21.7% at >79 years old. H. pylori infection was significantly associated with duodenal and gastroduodenal ulcers. Cirrhosis and nonulcer-mucosal lesions were significantly unrelated to H. pylori infection. Patients with concurrent cirrhosis with peptic ulcer were found to be negative for H. pylori infection. Conclusion Peptic ulcer is the leading cause of UGIB in Thailand. However, its incidence is declining. Patients who presented to hospital with UGIB were older, compared with those a decade ago. H. pylori infection plays an important role in UGIB and its incidence was stable during the past 5 years.

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Helicobacter pylori infection reduces the risk of gastroesophageal reflux disease

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-193-9-96-101 ◽

2021 ◽

pp. 96-101

Author(s):

R. I. Khlynova ◽

O. M. Khromtsova ◽

R. B. Berdnikov ◽

I. B. Khlynov

Keyword(s):

Helicobacter Pylori ◽

Gastroesophageal Reflux Disease ◽

Gastric Mucosa ◽

Gastroesophageal Reflux ◽

Observational Study ◽

Reflux Disease ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Biopsy Specimens ◽

H Pylori

The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.

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Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400002 ◽

2010 ◽

Vol 128 (4) ◽

pp. 187-191 ◽

Cited By ~ 13

Author(s):

Aurea Cristina Portorreal Miranda ◽

Rodrigo Strehl Machado ◽

Edina Mariko Koga da Silva ◽

Elisabete Kawakami

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Sao Paulo ◽

Helicobacter Pylori Infection ◽

Socioeconomic Level ◽

São Paulo ◽

Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic ◽

H Pylori

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

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DIAGNOSTIC ACCURACY OF UREA BREATH TEST FOR HELICOBACTER PYLORI INFECTION IN CHILDREN WITH DYSPEPSIA IN COMPARISON TO HISTOPATHOLOGY

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032016000200011 ◽

2016 ◽

Vol 53 (2) ◽

pp. 108-112 ◽

Cited By ~ 4

Author(s):

Naser HONAR ◽

Alireza MINAZADEH ◽

Nader SHAKIBAZAD ◽

Mahmood HAGHIGHAT ◽

Forough SAKI ◽

...

Keyword(s):

Helicobacter Pylori ◽

Carbon Isotope ◽

Sensitivity And Specificity ◽

Breath Test ◽

Close Association ◽

Urea Breath Test ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Predictive Values ◽

H Pylori

ABSTRACT Background - Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective - In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods - This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results - The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion - Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.

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The Magnitude and associated factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji Hospital, Southeast Ethiopia

10.21203/rs.3.rs-25765/v1 ◽

2020 ◽

Author(s):

Dagaga Goboto Kenea ◽

Mesfin Negawo ◽

Firaol Kitila Lemessa ◽

Solomon Tejineh

Keyword(s):

Helicobacter Pylori ◽

Alcohol Drinking ◽

Intestinal Parasites ◽

Helicobacter Pylori Infection ◽

P Value ◽

Cross Sectional ◽

Gastrointestinal Complications ◽

Ulcer Disease ◽

Southeast Ethiopia ◽

H Pylori

Abstract Background: Helicobacter pylori infection is the most common chronic bacterial infection and there were approximately 4.4 billion individuals with H pylori infection worldwide. Among those, hundreds of millions of people develop peptic ulcer disease during their lifetime and still tens of millions might progress to gastric cancer. Hence, early information is very important to prevent upper gastrointestinal complications. Consequently, the current study aimed to assess the magnitude and associated risk factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji hospital, Southeast Ethiopia.Methods: A hospital-based cross-sectional study involving 348 adult dyspeptic patients attending Bokoji hospital was carried out from July 16 to October 31, 2019. About 50 mg of fresh stool and 60 µl of capillary blood were collected from each dyspeptic patient and analyzed for detection of Helicobacter pylori antigens, presence of intestinal parasites and ABO blood grouping respectively. Data were entered using Epi Info 7 and Statistical analysis was done using SPSS version 21 and a p-value less than 0.05 was considered as statistically significant.Results: The overall magnitude of Helicobacter pylori infection was 47.7%. The magnitude of H. pylori infection was almost two times higher in patients who do not have a habit of handwashing after toilet visit than those who wash their hand's habit of handwashing after visiting toilet (AOR 2.241, 95% CI (1.410, 3.563) and alcohol drinking habit (AOR 1.796, 95% CI (1.087, 2.968). Conclusions: The magnitude of H. pylori was high in the study area and associated with handwashing habits after toilet use and alcohol drinking habits. Therefore, the community could be educated on the handwashing habit to minimize H. pylori infections.

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Follow-up analysis and histopathological study of gastric mucosa in patients with Helicobacter pylori infection

Journal of International Medical Research ◽

10.1177/03000605211055397 ◽

2021 ◽

Vol 49 (12) ◽

pp. 030006052110553

Author(s):

Guang Zhao ◽

Zhishang Zhang ◽

Baohui Li ◽

Silin Huang ◽

Wensi Li ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastric Mucosa ◽

Intraepithelial Neoplasia ◽

Mucosal Damage ◽

Helicobacter Pylori Infection ◽

Gastric Mucosal Damage ◽

Histopathological Study ◽

Significant Difference ◽

H Pylori

Objective To investigate the histomorphological characteristics of the gastric mucosa and the prognosis in patients with Helicobacter pylori infection. Methods Progressive damage to the gastric mucosa was examined by immunohistochemistry in 2294 patients with H. pylori infection and follow-up information was analyzed. Results H. pylori initially colonized the mucus layer covered by the gastric mucosa epithelium, then selectively adhered to and destroyed the surface mucus cells causing intra-gastric and extra-gastric lesions. Gastric mucosal damage induced by H. pylori was divided into five stages according to the depth of H. pylori invasion and degree of lesion deterioration: mucilaginous, surface mucocellular, lamina propria lesion, mucosal atrophy, and intraepithelial neoplasia stages. Morphological follow-up analysis revealed no significant difference in 6-month curative effects between stage I and stage II, but significant differences were found between stages II and III, stages III and IV, and between stages IV and stage V, respectively. Conclusions This novel staging strategy may be a valuable tool for diagnosing and predicting the results of gastric mucosal damage induced by H. pylori infection.

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Relationship between mucosal levels of Helicobacter pylori-specific IgA, interleukin-8 and gastric inflammation

Clinical Science ◽

10.1042/cs0960409 ◽

1999 ◽

Vol 96 (4) ◽

pp. 409-414 ◽

Cited By ~ 4

Author(s):

Q. B. ZHANG ◽

G. ETOLHI ◽

J. B. DAWODU ◽

C. G. GEMMELL ◽

R. I. RUSSELL

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Inverse Correlation ◽

Interleukin 8 ◽

Antral Mucosa ◽

Significant Difference ◽

Iga Antibodies ◽

Iga Response ◽

Non Ulcer Dyspepsia ◽

H Pylori

Mucosal IgA is important in local immune defence. Helicobacter pylori induces a specific IgA response in antral mucosa, but its immunopathology is unknown. Interleukin-8 (IL-8) has been suggested to be important in H. pylori-induced inflammation. Current information on the relationship between H. pylori-induced IgA and mucosal inflammation is limited. To investigate possible associations between mucosal-specific IgA, the toxinogenicity of H. pylori, mucosal levels of IL-8 and gastric inflammation, 52 endoscoped patients were studied. These comprised 28 patients with peptic ulcer and 24 with non-ulcer dyspepsia. Of these patients, 38 had H. pylori infection: 28 with peptic ulcer and 10 with non-ulcer dyspepsia. Antral biopsies were taken for histology, H. pylori culture and measurement of mucosal levels of IL-8 (pg/mg) and specific IgA (A450×1000) by ELISA. Mucosal H. pylori IgA was detectable in 35 out of 38 patients with H. pylori infection, with a median (interquartile) level of 220 (147, 531) units. There was no significant difference in mucosal levels of the IgA antibodies between patients infected with cytotoxin-positive or cagA-positive strains of H. pylori and those with toxin-negative or cagA-negative strains. The IgA levels in those patients with severe neutrophil infiltration were lower than in those with mild or moderate infiltration (P< 0.05). There was a weak inverse correlation between antral mucosal IgA and IL-8 in infected patients (r = -0.36; P = 0.04). H. pylori infection induced a significant local mucosal IgA response in most infected patients. The level of IgA antibodies does not appear to be correlated with the toxinogenicity of H. pylori. However, patients with severe active inflammation appear to have decreased levels of IgA. An inverse correlation between mucosal IL-8 and IgA may suggest that IL-8-induced inflammation compromises the mucosal IgA defence and renders the mucosa susceptible to further damage.

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Frequency of Helicobacter pylori infection in patients of acne vulgaris

10.53350/pjmhs211561411 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1411-1414

Author(s):

Z. Khalid ◽

H. B. A. Kalhoro ◽

A. Ashraf ◽

H. Mughal ◽

K. Bukhsh ◽

...

Keyword(s):

Helicobacter Pylori ◽

Acne Vulgaris ◽

Serum Levels ◽

Cross Sectional Study ◽

Helicobacter Pylori Infection ◽

Pathology Laboratory ◽

Cross Sectional ◽

Dermatology Department ◽

H Pylori ◽

Very High

Background: Acne vulgaris is a common complaint throughout the world, contributing to both morbidity and healthcare costs. Helicobacter pylori (HP) infection is also a world heath problem, and recent evidence suggests that two conditions may be related. However, there is insignificant evidence to support a casual association of HP infection and acne vulgaris. Aim: To determine the frequency of helicobacter pylori infection in patients of acne vulgaris Study design: Descriptive, cross-sectional study. Settings and duration: Dermatology Department, Liaquat University of medical and health Sciences (LUMHS), Civil Hospital, Hyderabad from 22nd August 2017 to 21st February 2018 Methods: A total of 135 patients, 13 to 30 years of age of both genders with acne vulgaris were included in this study. Patients with H Pylori infection positive without acne vulgaris, family history helicobacter pylori infection, chronic smoker or alcoholics were excluded. Patients were subjected to relevant investigations i.e. HP antibody titer, for that blood sample of each patient was sent to institutional pathology laboratory for measuring of serum levels of anti H. Pylori IgG antibodies where each report was prepared by consultant pathologist. Results: Mean age was 23.33 ± 4.14 years. Out of these 135 patients, 48 (35.56%) were females and 87 (64.44%) were males with female to male ratio of 1:1.8. Frequency of helicobacter pylori infection in patients of acne vulgaris was seen in 107 (79.26%) patients. Conclusion: This study concluded that frequency of helicobacter pylori infection in patients of acne vulgaris is very high and these patients should be screened for helicobacter pylori infection Keywords: Acne, helicobacter pylori, association

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Helicobacter Pylori infection among dyspepsia patients in suburbs of Riyadh, Saudi Arabia

Journal of the Pakistan Medical Association ◽

10.47391/jpma.01-082 ◽

2020 ◽

pp. 1-12

Author(s):

Talal Shakhs Alghamdi ◽

Tahir Ansari ◽

Atif Ali Bashir ◽

Mohammed Ali Batais ◽

Mohammed Fahad Aldhahi ◽

...

Keyword(s):

Helicobacter Pylori ◽

Saudi Arabia ◽

Helicobacter Pylori Infection ◽

Gi Endoscopy ◽

Endoscopic Findings ◽

Current Prevalence ◽

Significant Difference ◽

H Pylori ◽

Upper Gastrointestinal

Abstract Objective: The objective of the study was to determine the current prevalence of Helicobacter pylori infection among Dyspepsia patients and correlate this with Endoscopic findings. Methodology: A retrospective, descriptive facility-based study conducted from June to December 2017 to estimate the prevalence of Helicobacter pylori among dyspepsia patients from Majmaah, Sudair, Zulfi and Shaqra areas of Riyadh region, Saudi Arabia. Four years data from January 2012 to December 2016 were reviewd by a checklist and analyzed by SPSS. Results: Out of 1398 dyspepsia patients, 485 (34.7%) were positive, and 913 (65.3%) were negative for H-Pylori infection. Majority of patients (81.7%) had gastritis, out of which, 39.9% of gastritis patients were H-pylori positive. The frequency of H-pylori infection was significantly higher among patients with gastritis (p < 0.001). There was no statistically significant difference in the frequency of H-pylori infection among patients with erosion, ulcer, polyp and cancer (p > 0.05). Conclusion: The prevalence of H.Pylori was low as compared to other governorates in the kingdom and regional countries. Gastritis was dominating finding on upper gastrointestinal (GI) endoscopy. Keywords: Helicobacter pylori, Prevalence, Dyspepsia, Riyadh region

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