Risk Factors and clinical features of deterioration of COVID-19 Patients in Zhejiang, China: a single-centered, retrospective study
Abstract BackgroundA severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection swept through Wuhan and spread across China and overseas from December 2019. To identify predictors associated with disease progression, we evaluate clinical risk factors of exacerbation of SARS-CoV2 infection. Methoda retrospective analysis was used for PCR-confirmed COVID-19 (coronavirus disease 2019) diagnosed hospitalized cases between January 19, 2019 and February 19, 2020 in Zhejiang, China. We systematically analyzed the clinical characteristics of the patients and predictors of clinical deterioration.Result100 patients with COVID-19 were included, with median age of 54 years. Among them, 49 cases (49%) were severe and critical cases. Age (P=0.0001), gender (P=0.0031), BMI (P=0.0339), hypertension (P<0.0001), IL6 (P=0.0001), IL10 (P<0.0001), T lymphocyte count (P=0.0001), B lymphocyte count (P=0.0001), White blood cell count (P=0.0002), d2 dimer (P=0.005), PCT (P=0.0039), CRP (P<0.0001), AST (P=0.0484) and artificial liver therapy (P=0.0148), glucocorticoid therapy (P<0.0001) were associated with the severity of the disease. Age and overweigh were independent risk factors for disease severity. ConclusionDeterioration among covid-19 infected patients occurred rapidly after hospital admission, it is necessary to pay attention to these patients. In our cohort, we found that several factors resulted in increased severity. Among these factors, Early detection and reversal of these indicators may reduce the progression of the disease. In addition, early treatment with low doses of glucocorticoids and necessary liver therapy may help reduce mortality in critically ill patients.