scholarly journals Vitamin D Toxicity in A Pediatric Toxicological Referral Center: A Cross-Sectional Study from Iran

2020 ◽  
Author(s):  
Fariba Farnaghi ◽  
Hossein Hassanian-Moghaddam ◽  
Nasim Zamani ◽  
Narges Gholami ◽  
Latif Gachkar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Population ◽  
Demographic Data ◽  
Essential Element ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Benign Condition ◽  
Significant Difference ◽  
Vitamin D Toxicity

Abstract Background: Vitamin D is an essential element for body health whose supplements are generally administered to prevent vitamin D deficiency. Since these supplements are available at homes, vitamin D toxicity may happen in children.Methods: All children younger than 12 years who presented to the pediatric emergency department of Loghman Hakim Hospital, Tehran, Iran with history of ingestion ofvitamin D supplements more than 1500 IU/day were enrolled. Patients’ demographic data, on-presentation signs and symptoms, laboratory findings, treatments given, and outcome were evaluated.Result: Fifteenpatients presented during the study period. Their mean age was 46.53 ±10.14 months and 12 (80%) were girls. All of them had unintentionally ingested vitamin D. Mean ingested dose was 406700.7±227400.1 IU. In eight patients (53.3%), 25 Hydroxyvitamin D level was more than 100 ng/mL. One patient experienced hypercalcemia while all of them were asymptomatic and discharged without complications. There was no significant difference between patients with and without high levels of 25 OH vitamin D regarding lab tests, toxicity course, and outcome.Conclusion: It seems that acute vitamin D toxicity is a benign condition in our pediatric population which may be due to high prevalence of vitamin D deficiency in Iran.

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

scholarly journals Association of Vitamin D Status and Cardio-Metabolic Risk Factors in Children and Adolescents: The CASPIAN-V Study

2020 ◽  
Author(s):  
Mostafa Qorbani ◽  
Motahar Heidari-Beni ◽  
Hanieh-Sadat Ejtahed ◽  
Gita Shafiee ◽  
Farid Goodarzi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Communicable Disease ◽  
Pediatric Population ◽  
Surveillance Program ◽  
Cross Sectional ◽  
Low Hdl ◽  
25 Hydroxy Vitamin D ◽  
And Control

Abstract Background: Metabolic syndrome (MetS) starts from early life, and is one of the important underlying factors for non-communicable disease (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing risk of pediatric MetS. Objective: This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents. Methods: This cross-sectional nationwide study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, physical examination was conducted, and blood samples were collected. Serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using direct competitive immunoassay chemiluminescene method.Results: 2596 students with mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n=276), and 60.5% (n=1570), respectively. Prevalence of MetS was higher in vitamin D deficient group. Students with deficient vitamin D level had higher odds of MetS (OR: 4.25, 95%CI: 2.26-7.98), abdominal obesity (OR: 2.24, 95%CI: 1.61-3.12), low HDL-C (OR: 1.65, 95%CI: 1.18-2.30) and high fasting blood sugar (OR: 2.56, 95%CI: 1.43-4.57) in comparison to those with sufficient level of vitamin D.Conclusion: Vitamin D deficiency was associated with increased odds of MetS and its components in Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.

scholarly journals KNOWLEDGE AND PRACTICES REGARDING VITAMIN D DEFICIENCY AMONG WOMEN ATTENDING IMAM HUSSEIN MEDICAL CITY IN KARBALA 2018

2019 ◽  
pp. 39-43
Author(s):  
SARAH JAFAR AL-GHRAIBAWI ◽  
SAAD IBRAHIM AL-GHABBAN ◽  
RIYADH DHEYHOOD AL-ZUBAIDY
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Public Awareness ◽  
Sun Exposure ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Medical City ◽  
The Mean ◽  
Socio Demographic Factors

Objective: Vitamin D deficiency is a global health problem. It is significantly associated with skeletal and non-skeletal problems. Prevention can be maintained mainly by effective sun exposure or supplementation and to lesser extent by dietary intake. To determine the magnitude of knowledge and practice of women towards vitamin D deficiency. Methods: A cross-sectional study, purposive sample of 442 women were approached who attended consultants’ clinics of Imam Hussein Medical City in Karbala. Data collection done between March 2 and June 30, 2018 through direct interviews using a special questionnaire prepared for the purpose of the study. Results: Less than half (45.2%) of the women had heard about vitamin D; their source of information was from relatives and friends then from health care provider. The mean score for the participants’ knowledge about VDD was 4.25 out of 9.0 (47%). It has a significant association with higher educational levels and urban residence. There is no significant difference regarding age, marital status or occupation. The mean score for the participants’ practice about vitamin D deficiency was 2.53 out of 5 (50.71%). There is no influence of practice score by socio-demographic factors. Conclusion: Overall knowledge towards vitamin D deficiency was suboptimal. Improving practices towards VD is directly related to increase knowledge about it that indicates the need to increase public awareness about the problem, encourage appropriate way of sun exposure, consumption of vitamin D rich food and taking supplementation when sun exposure is difficult.

Frequency of Vitamin D deficiency in Coronary artery disease patients following up in tertiary care cardiac center in Lahore

2021 ◽  
Vol 15 (10) ◽  
pp. 2559-2560
Author(s):  
Attaullah Khan Niazi ◽  
Muhammed Muneeb ◽  
Kanza Sana Umer ◽  
Ammar Hameed Khan ◽  
Kiran Manzar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Demographic Data ◽  
Tertiary Care ◽  
Cross Sectional ◽  
Artery Disease ◽  
Cardiac Center

Aim: To find out frequency of Vit. D deficiency in Coronary artery disease following up in tertiary care cardiac center Method: It is Purposive Cross-sectional study, Duration study period of two months in which 228 patients attended out clinic and underwent admission at department of cardiology & cardiovascular surgery, Data collection tool (a struc-tured questionnaire) consists of demographic data, Vitamin d3 level, details of medications and co-angulation factors, ECG findings and expected Echocardiogram findings Result: The subjects were severely deficient in vitamin D and its levels were inversely correlated with most of the com-ponents of metabolic syndrome. A Vitamin D deficiency is stirring the Pakistan rural population regardless of their age, gender, and the results of this study’s result have showed that this vitamin D deficiency is crucial in Pakistan. However, large scale studies are required to verify our findings. Keywords: Cardiovascular disease, Vitamin D. deficiency, Coronary artery disease, Malnutrition

scholarly journals Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study

2021 ◽  
Author(s):  
Vinita Singh ◽  
Neelam Tamar ◽  
Zamir Lone ◽  
Esha Das ◽  
Rajshree Sahu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Menstrual Cycle ◽  
Vitamin D Deficiency ◽  
Cycle Length ◽  
Menstrual Disorders ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Menstrual Irregularities ◽  
25 Hydroxy Vitamin D

Background: Research examining the role of vitamin D deficiency and the development of menstrual disorders in women is of widespread interest. Studies have been published showing that supplementation with high-dose vitamin D can lead to the restoration of the menstrual cycle. We lack adequate information regarding the effect of vitamin D levels on the physiology of menstruation and further on fertility in women of reproductive age due to the contradictory results reported by studies. Objective: To study the association of 25-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity. Materials and Methods: In this cross-sectional study, serum vitamin D levels of 166 women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = 83) between April-June 2019 were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = 83). Results: A decreased level of vitamin D was associated with a 13.3 times odds of an irregular cycle (OR (95% CI): 13.30 (5.79-30.60), p < 0.001). 25-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < 0.001) in mean vitamin D levels among the females with irregular cycles vs. regular cycles. Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed. Key words: Menstrual disturbances, Ovulation, Reproductive period, Vitamin D deficiency, Dietary supplements, Polycystic ovarian syndrome.

scholarly journals Vitamin D Deficiency in HCV Antiviral Treatment Responders versus Non-Responders

2019 ◽  
Vol 8 (1) ◽  
pp. 45-49
Author(s):  
Rana M Arif ◽  
Fahad Aman Khan ◽  
Imran Khan ◽  
Muzammil Aslam Kataria ◽  
Jawed Iqbal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Vitamin D Deficiency ◽  
Antiviral Treatment ◽  
Study Data ◽  
P Value ◽  
Hcv Rna ◽  
Cross Sectional ◽  
Significant Difference

Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease (CLD). Pakistan has a high burden of infectious diseases, including HCV. Its prevalence varies according to geographic regions in the country from about 2·4% to 6·5%. The objective of the study was to compare the frequency of vitamin D deficiency in responders and non-responders of antiviral treatment for chronic hepatitis C.Material and Methods: This comparative cross-sectional study was conducted in Hepatitis Clinic, Jinnah hospital, Lahore from 20th May to 20th November 2013. After ethical approval, participants were selected by using purposive non-probability sampling, 52 responder patients i.e. who were labeled negative for HCV RNA by PCR after 12 weeks of antiviral treatment and 52 non-responder patients were included in this study. Data was collected by using pretested structured questionnaire. Vitamin D3 levels were measured by ELISA and a cut-off value of below 30ng/ml was labeled as Vitamin D deficiency. SPSS version 21 was used to analyze data with p value less than 0.05 taken as statistically significant.Results: Out of 104 patients (mean age 35±8.1 years), 61.5% were males and 38.5 % were females. There was a significant difference in frequency of vitamin D deficiency in treatment responder group when compared to non-responders (p = 0.016). Mean level of vitamin D was 21.8±10.8ng/ml in responders whereas it was 15.6±7.5 in non-responders with a statistically significant difference (p = 0.001).Conclusion: This study concludes that there is a significant vitamin D deficiency among treatment non-responders as compared to treatment responders in patients with chronic hepatitis C.

scholarly journals Vitamin D status in 3-6-year-old children of Mananthavady ICDS block in Wayanad, Kerala, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1226
Author(s):  
Arif Mohamed Khan ◽  
T. G. Sindhu ◽  
M. Vijayakumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cross Sectional Study ◽  
Tribal Community ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
High Prevalence ◽  
25 Oh Vitamin D ◽  
Kerala State

Background: Despite plenty of sunlight, vitamin D deficiency has been reported in both urban and rural population in India. This study was conducted to estimate the prevalence of Vitamin D deficiency in children between 3-6 years of age group belonging to Mananthavady ICDS block of Wayanad and to identify the sociodemographic variables affecting its level.Methods: This descriptive cross-sectional study was conducted from December 2014 to June 2015. 140 children were selected from 20 Anganawadis in Mananthavady ICDS block in Wayanad district of Kerala state by random methods. After taking relevant history and conducting detailed clinical examinations, blood samples were taken to assess 25(OH) Vitamin D, calcium, phosphorous and alkaline phosphatase levels. Statistical analysis was done using PASW software. Calculations of means were done using descriptive statistics and comparative analysis was done using independent T test.Results: Out of the 140 children 51 belonged to tribal community. The mean 25(OH) Vitamin D level was 22.7ng/ml. 47.1% of the population had deficient, 35% insufficient and 17.9% adequate Vitamin D levels. There was no statistically significant difference in Vitamin D levels between children of tribal and non-tribal community. There was significant increase in Vitamin D levels during summer when compared to that of winter and autumn seasons.Conclusions: There is a high prevalence of vitamin D deficiency among the rural children of 3-6-year age of Mananthavadi ICDS block. The Vitamin D levels were almost equal between the tribal and non-tribal children. Vitamin D levels are significantly higher during summer when compared to other seasons.

scholarly journals The Relationship of Vitamin D Deficiency with Severity and Outcome of Acute Stroke

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Reza Ebrahimi Rad ◽  
Mohammadreza Zarbakhsh ◽  
Samira Sarabi
Keyword(s):  
Vitamin D ◽  
Acute Stroke ◽  
Vitamin D Deficiency ◽  
Clinical Severity ◽  
Stroke Severity ◽  
Cross Sectional ◽  
Nihss Score ◽  
Increased Risk ◽  
Significant Difference ◽  
The Relationship

Abstract Background: There are currently conflicting results regarding the link between vitamin D deficiency and increased risk for stroke and its poor prognosis. The present study aimed to assess the relationship between vitamin D deficiency and prognosis of acute stroke. Methods: This bi-center cross-sectional study was performed on 140 consecutive patients who referred to two general hospitals in Iran with the diagnosis of acute stroke. The levels of 25-hydroxy vitamin D were evaluated by Electrochemiluminescence (ECL) technique. Clinical severity of stroke on admission as well as on discharge time were evaluated using the National Institutes of Health Stroke Scale (NIHSS) or Modified Rankin (mRS) tools. Results: Mean serum level of vitamin D was 25.51 ± 18.87 ng/mL, ranging from 3.0 to 98.6 ng/ml. There was a significant difference between the two groups (with and without vitamin D deficiency) in terms of stroke severity and disability, as reflected by mRS (P=0.003) and NIHSS evaluation (14.24 ± 9.23 versus 9.73 ± 7.36, P=0.003). Also, regarding patients’ clinical condition, the mean NIHSS score in those with deficient and normal levels of vitamin D was 14.24 ± 9.23 and 9.73 ± 7.36, respectively with NIHSS score > 5 in 76.1% and 61.5%, respectively (P = 0.003). Conclusion: According to the results of study, vitamin D status can be related to the severity of stroke. However, considering the cross-sectional design of our study, it could not point out the causality between vitamin D deficiency and acute stroke and further studies are warranted. It is not possible to draw any conclusions in terms of causality. Further studies are required in order to assess the relationship between the serum vitamin D levels and stroke severity.

Effect of Vitamin D Deficiency on Voice

2017 ◽  
Vol 26 (3) ◽  
pp. 865-872 ◽  
Author(s):  
Abdul-Latif Hamdan ◽  
Georges Ziade ◽  
Doja Sarieddine ◽  
Dollen Tabri ◽  
Fatima Allaw ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Acoustic Analysis ◽  
Demographic Data ◽  
Vocal Fatigue ◽  
Perceptual Evaluation ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Purpose The purpose of this article was to investigate the relationship between low level of vitamin D, phonatory symptoms, and acoustic findings. Method A total of 38 subjects presenting to the endocrinology clinic were enrolled in 2 groups: 19 with vitamin D deficiency who were not on treatment, and 19 with normal vitamin D level who were on treatment. Demographic data included age, gender, and history of smoking. All patients were asked about the presence or absence of dysphonia, degree of phonatory effort, and vocal fatigue. Acoustic analysis and perceptual evaluation using the grade, roughness, breathiness, asthenia, and strain scale were performed on all subjects. Results The mean age of the total group was 47.29 ± 13.52 years. The difference in the mean and frequency of phonatory effort, vocal fatigue, and dysphonia, and in the mean of the acoustic variables, perceptual parameters, and the score of the Voice Handicap Index-10 was not statistically significant between patients with low vitamin D levels compared with controls. Conclusion The results of this study revealed no significant difference in the prevalence of phonatory symptoms in patients with vitamin D deficiency compared with patients with no vitamin D deficiency. A larger study is needed to substantiate the difference in the prevalence of phonatory systems between the 2 groups.

scholarly journals Vitamin D Level in Predialysis Chronic Kidney Disease Patients Stage 3 to 5 and Predictors of its Deficiency

2021 ◽  
pp. 64-72
Author(s):  
Mohamed G. Mohamed ◽  
Hanaa I. Okda ◽  
Hossam A. Hodeib ◽  
Mostafa T. Gabr
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Ckd Stage ◽  
Significant Difference

Background: Vitamin D deficiency is commonly encountered in patients with chronic kidney disease (CKD) with or without undergoing dialysis. This study was conducted to assess vitamin D level in patients diagnosed with predialysis CKD stage 3 – 5, and to determine the predictors of its deficiency in such patients. Materials and Methods: This cross-sectional study included 75 patients who were divided into three equal groups of CKD-3, CKD-4 and CKD-5. All cases were subjected to detailed history taking, physical examination and measurement of estimated glomerular filtration rate (eGFR) according to Cockcroft-Gault formula. In addition, laboratory investigations included CBC, renal function tests, serum ferritin, intact parathyroid hormone (iPTH) and vitamin D level. Results: Patient demographics and other co-morbidities were comparable among the three groups. Serum vitamin D had mean values of 24.84, 20.52 and 11.24 ng/ml in patients with stages III, IV and V respectively, with significant difference between the three groups. Vitamin D deficiency was more common in CKD-5 cases. On the contrary, serum parathyroid hormone and ferritin were significantly higher levels, in patients with higher stages. There was statistically significant positive correlation of serumvitamin D with eGFR, Hb, calcium and albumin. On the other hand, serum vitamin D was negatively correlated with phosphate, PTH, urea andcreatinine. Conclusion: It is evident that higher stages of CKD are associated with more vitamin D deficiency.

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