Long COVID: A Protocol for Systematic Review and Meta-analysis of Symptomatology and Treatment Approaches

2021 ◽  
Author(s):  
Emmanuel Okechukwu Nna ◽  
Michael Abel Alao ◽  
Canice Anyachukwu ◽  
Adanze Onyenonachi Asinobi ◽  
Babatunde Ogunbosi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Quality Assessment ◽  
Observational Studies ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Treatment Approaches ◽  
Pooled Prevalence ◽  
Registration Number

Abstract Background:The burden of SAR COV-2 infection is not limited to the acute viraemia and its symptomatology but extends far beyond to include the long COVID, also known as post-COVID-19 syndrome,which may soon reach public health significance. We set out to produce a protocol for reliable and accurate systematic review and meta-analysis of the symptomatology and treatment approaches of long COVID globally.Methods:We developed a search strategy using MeSH terms, text words and entry terms. Nine databases will be searched: PubMed, Embase, CINAHL, AJOL, Google Scholar, Web of Science, Cochrane Library, Researchgate and Scopus. Only observational studies retrievable in the English Language will be included. The primary measurable outcome is the pooled prevalence of the symptoms of long COVID. The secondary outcomes include the summary effect sizes of the treatment approaches to the long COVID; the geographic, race, gender and age variations in symptomatology, and the quality of life of patients with long COVID. Identified studies will be screened, deduplicated, selected and data items extracted using DistillerSR software. All studies will be assessed for methodological, clinical and statistical heterogeneity. Assessment of meta-bias in the selected studies will be performed using the NIH Quality assessment tool for observational studies. Publication bias will be assessed using the funnel plot and Egger’s regression intercept. The pooled prevalence will be expressed with SE and 95% CI. The strength of evidence from this analysis will be assessed using the NIH Quality Assessment for Systematic Reviews and Meta-analysis.Discussion: This analysis will map globally the symptoms of long COVID and its correlates, exploring the influences of geographic locations, race, age and gender, thereby enabling a severity index on a global scale. It will examine in detail the treatment approaches to the long COVID and their impacts on the quality of life of patients. The evidence from this study will inform health policies toward the management of post-COVID-19 syndrome. The outcome of this study will be published in peer-reviewed scientific journal.Trial Registration Number:This protocol is registered with PROSPERO, registration number CRD42021236457

scholarly journals Prevalence and Risk Factors for Spasticity After Stroke: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Huangling Zeng ◽  
Jian Chen ◽  
Yang Guo ◽  
Sheng Tan
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Observational Studies ◽  
Hemorrhagic Stroke ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Stroke Patients ◽  
Pooled Prevalence ◽  
Severe Spasticity

Background: Spasticity is a common sequela of stroke. The incidence of poststroke spasticity (PSS) has not been systematically reviewed in recent years, and some risk factors remain debated. This systematic review and meta-analysis was conducted to determine the prevalence and risk factors for PSS.Methods: We searched electronic databases (PubMed, Embase, Cochrane Library, CNKI, WANFANG and CBM) inception to May 12, 2020. Observational studies summarizing the incidence or risk factors for PSS were included. Only cohort studies were enrolled in meta-analysis. For risk factors examined in at least three different studies, we combined effects into odds ratios (OR) and 95% confidence intervals (CI).Results: One thousand four hundred sixty-seven studies were retrieved and 23 were involved in meta-analysis. The pooled prevalence of spasticity after stroke was 25.3% and that after the first-ever stroke was 26.7%. The incidence of spasticity after the first-ever stroke with paresis was 39.5%. The prevalence of disabling or severe spasticity (MAS ≥ 3) in stroke patients with paresis was 9.4% (95% CI 0.056–0.133), and severe spasticity was 10.3% (95% CI 0.058–0.149). Moderate to severe paresis (OR = 6.573, 95% CI 2.579–16.755, I2 = 0.0%), hemorrhagic stroke (OR = 1.879, 95% CI 1.418–2.490, I2 = 27.3%) and sensory disorder were risk factors for PSS.Conclusions: The incidence of PSS was significantly higher in stroke patients with paresis. Patients with moderate to severe paresis and sensory disorder should be closely followed up. The role of hemorrhagic stroke in predicting PSS remains to be further explored.

scholarly journals Tuina for spasticity of poststroke: protocol of a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e038705
Author(s):  
Qiongshuai Zhang ◽  
Guangcheng Ji ◽  
Fang Cao ◽  
Yihan Sun ◽  
Guanyu Hu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Short Form ◽  
Meta Analysis ◽  
Biomedical Literature ◽  
Primary Data ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Quality Of Life Scale

IntroductionSpasticity is a common complication of poststroke, tuina is a widely used rehabilitation treatment, although there is a lack of supportive evidence on efficacy and safety for patients with poststroke spasticity. The aim of this systematic review is to assess and synthesis evidence of efficacy and safety of tuina for spasticity of poststroke.Methods and analysisA comprehensive electronic search of EMBASE, MEDLINE, Cochrane Library, Web of Science, Wiley, Springer, PEDro, Chinese Science Citation Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific and Journal Database (VIP), Wanfang Database (Wanfang), Japanese medical database (CiNii), Korean Robotics Institute Summer Scholars and Thailand Thai-Journal Citation Index Centre will be conducted to search literatures of randomised controlled trials of tuina for spasticity of poststroke survivors range from the establishment to 1 January 2020.There is no time of publication limitations. The primary outcome will be measured with the Modified Ashworth Scale, and the second outcome will include Fugl-Meyer Assessment Scale, surface electromyogram RMS value, the Modified Barthel Index, Stroke Specific Quality of Life Scale, quality of life 36-Item Short-Form Health Survey and Visual Analogue Scale. Cochrane Handbook for Systematic Reviews of Interventions will be used to assess the risk of bias, and GRADE will be used to access the confidence in cumulative evidence. The protocol will be conducted according to approach and Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015.Ethics and disseminationEthical approval will not be required, for no primary data of individual patients were collected. We will publish the findings in a peer-reviewed journal.PROSPERO registration numberCRD42020163384.

Global epidemiology of acromegaly: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Salvatore Crisafulli ◽  
Nicoletta Luxi ◽  
Janet Sultana ◽  
Andrea Fontana ◽  
Federica Spagnolo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Meta Analysis ◽  
Geographic Area ◽  
Cochrane Library ◽  
Pooled Prevalence ◽  
Global Epidemiology ◽  
Study Heterogeneity ◽  
Quality Assessments

Objective: To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies. Methods: MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31st January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived performing a random-effects meta-analysis. Results: A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95%CI: 4.4-7.9) per 100,000 persons, while the incidence rate (IR) was 0.38 (95%CI: 0.32-0.44) cases per 100,000 person-years. For both prevalence and IR, a considerable between-study heterogeneity was found (I2= 99.3% and 86.0%, respectively). The quality of study reporting was rated as medium for 20 studies and low for 12 studies. Conclusions: Although the largest amount of heterogeneity was due to the high precision of the studies’ estimates, data source and geographic area could represent relevant study-levels factors which could explain about 50% of the total between-study variability. Large-scale high quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.

scholarly journals Quality of life in children with kidney transplant: Systematic review

2018 ◽  
Vol 71 (suppl 6) ◽  
pp. 2818-2823
Author(s):  
Noélia Souza Santos Araújo ◽  
Rogério Rodrigues Floriano Pereira ◽  
Dayana Fram ◽  
Paula Hino ◽  
Maria Cristina Barbosa Longo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Kidney Transplant ◽  
Observational Studies ◽  
Pediatric Patients ◽  
Social Conditions ◽  
Cochrane Library ◽  
Healthy Children ◽  
Review Of The Literature

ABSTRACT Objective: To identify in the literature studies that evaluate the quality of life in pediatric patients with kidney transplant through use of specific, validated instruments in Pediatrics. Method: Systematic review of the literature with searches conducted in the following databases: Medline, PubMed, LILACS, CINAHL, SciELO and Cochrane Library. Main keywords: Quality of life, Kidney transplantation and Pediatrics. Results: A total of 366 studies were selected and eight observational studies were included that evaluated the quality of life of children with kidney transplant by means of evaluation instruments of quality of life. Conclusion: The quality of life of children with kidney transplant is inferior compared to healthy children. The post-transplant period presents better results compared to pre-transplant children. The identification of mental, physical and social conditions related to the quality of life of this population allows for better planning the assistance provided to them.

scholarly journals Effectiveness of Horticultural Therapy in People with Schizophrenia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (3) ◽  
pp. 964
Author(s):  
Shan Lu ◽  
Yajie Zhao ◽  
Jianjiao Liu ◽  
Feng Xu ◽  
Zhiwen Wang
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Social Functioning ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Therapeutic Effects ◽  
Horticultural Therapy ◽  
Rehabilitation Outcomes ◽  
Hospital Environments

Horticultural therapy is increasingly being used in the non-pharmacological treatment of patients with schizophrenia, with previous studies demonstrating its therapeutic effects. The healing outcomes are positively correlated with the settings of the intervention. This review aimed to evaluate the effectiveness of horticultural therapy on the symptoms, rehabilitation outcomes, quality of life, and social functioning in people with schizophrenia, and the different effectiveness in hospital and non-hospital environments. This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines. We researched studies through PubMed, Embase, the Cochrane Library, Science Direct, and the China National Knowledge Infrastructure. We included randomized controlled trials (RCTs) and quasi-experimental studies about horticultural therapy for people with schizophrenia, from January 2000 to December 2020, with a total of 23 studies involving 2024 people with schizophrenia included in this systematic review. This study provided evidence supporting the positive effect of horticultural therapy. This review demonstrated that non-hospital environments have a better therapeutic effect on all indicators than hospital environments. The results also demonstrated the effectiveness of horticultural therapy on symptoms, rehabilitation outcomes, quality of life, and social functioning in patients in hospital and non-hospital environments, providing further evidence-based support for landscape design.

scholarly journals Physical Exercise and Health-Related Quality of Life in Office Workers: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (7) ◽  
pp. 3791
Author(s):  
Thi Mai Nguyen ◽  
Van Huy Nguyen ◽  
Jin Hee Kim
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Physical Exercise ◽  
Meta Analysis ◽  
Office Workers ◽  
Cochrane Library ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Office workers are at high risk for many chronic diseases, lowering their health-related quality of life (HRQOL). This systematic review and meta-analysis aimed to summarize the effects of physical exercise on HRQOL in office workers with and without health problems using data obtained from randomized controlled trials (RCTs), quasi-experimental, and observational studies. We searched PubMed, Web of Science, Scopus, Cochrane Library, and several grey literature databases, and identified 26 relevant studies for the synthesis. Overall, physical exercise significantly improved general (standardized mean difference (SMD) = 1.05; 95% confidence interval (CI): 0.66 to 1.44) and mental (SMD = 0.42; 95% CI: 0.19 to 0.66) HRQOL in office workers. Compared with healthy office workers, unhealthy office workers experienced greater improvements in general (unhealthy, SMD = 2.76; 95% CI: 1.63 to 3.89; healthy, SMD = 0.23; 95% CI: −0.09 to 0.56) and physical (unhealthy, SMD = 0.38; 95% CI: 0.17 to 0.58; healthy, SMD = −0.20; 95% CI: −0.51 to 0.11) HRQOL. Unsupervised physical exercise significantly improved general and mental HRQOL, while directly supervised physical exercise significantly improved only general HRQOL. Although physical exercise, especially unsupervised physical exercise, should be encouraged to improve HRQOL in office workers, detailed recommendations could not be made because of the diverse exercise types with different intensities. Therefore, further studies are needed to determine the optimal exercise for office workers with different health conditions.

scholarly journals Internet Addiction Effect on Quality of Life: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Farzaneh Noroozi ◽  
Soheil Hassanipour ◽  
Fatemeh Eftekharian ◽  
Kumars Eisapareh ◽  
Mohammad Hossein Kaveh
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Internet Addiction ◽  
Negative Impact ◽  
Human Life ◽  
Meta Analysis ◽  
Health Concern ◽  
Cochrane Library ◽  
Study Results

Purpose. Due to the use of different methodologies, tools, and measurements, the positive or negative impact of Internet use on human life quality is accompanied by a series of ambiguities and uncertainties. Therefore, in this study, a systematic review and meta-analysis are conducted regarding the effect of Internet addiction on the quality of life. Methods. A systematic search of resources was conducted to investigate the effect of Internet addiction on the quality of life. The databases of PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Science Direct were searched from January 1980 to July 2020. The articles were screened by two researchers in multiple levels in terms of the title, abstract, and full-text; then, final studies that met the inclusion criteria were retrieved and included in the study. Results. After searching the previously mentioned international databases, 3863 papers were found, 18 of which we included in the final analysis. Surveys indicated that people who had a high Internet addiction received lower scores of quality of life than those who were normal Internet users (OR = 2.45, 95% CI; 2.31–2.61, p < 0.001 ; I2 = 85.23%, p < 0.001 ). Furthermore, There was a negative significant relationship between Internet addiction and quality of life in the psychological (OR = 0.56, 95% CI: 0.32–0.99, p = 0.04 , I2 = 97.47%, p < 0.001 ), physical (OR = 0.58, 95% CI: 0.39–0.86, p = 0.007 , I2 = 95.29%, p = 0.001 ), and overall quality of life score (OR = 0.39, 95% CI: 0.27–0.55, p < 0.001 , I2 = 0.0%, p = 0.746 ). Conclusion. These findings illustrate that Internet addiction should be regarded as a major health concern and incorporated into health education and intervention initiatives.

scholarly journals COVID 19 Vaccine Hesitancy: A Protocol for Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Emmanuel Okechukwu Nna ◽  
Michael Abel Alao ◽  
Babatunde Ogunbosi ◽  
Uchenna Okeke ◽  
Canice Anyachukwu
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Observational Studies ◽  
Meta Analysis ◽  
Herd Immunity ◽  
Risk Of Bias ◽  
Vaccine Uptake ◽  
Vaccine Hesitancy ◽  
Cochrane Library ◽  
Geographical Regions

Abstract Background The unprecedented development of COVID 19 vaccine within a few months and its introduction into the population brought a sigh of relief with the promise of preventing primary infections, halting spread, reducing hospitalization of infected people, and ultimately inducing herd immunity. However, public perception in many communities leaves a lot to worry about as the so much sort-after vaccine has been met with safety concerns, scepticism and hesitancy. We seek to produce a protocol for a reliable and accurate systematic review and meta-analysis on the hesitancy of COVID 19 vaccine uptake in the mist of a global pandemic.MethodsWe developed a search strategy using MeSH terms, text words and entry terms. Nine databases will be searched: PubMed, Embase, CINAHL, AJOL, Google Scholar, Web of Science, Cochrane Library, Research gate and Scopus. Only observational studies retrievable in the English Language will be included. The primary measurable outcome is the prevalence of COVID 19 vaccine hesitancy globally. The secondary outcomes are factors that influence COVID 19 vaccine hesitancy including race, age, gender, occupation, socioeconomic class, level of education, geographic location, misinformation, social media influence and vaccine safety. Identified studies will be screened, deduplicated, selected and data items extracted using DistillerSR software. All studies will be assessed for methodological, clinical and statistical heterogeneity. Assessment of risk of bias in the selected studies will be performed using the NIH Quality assessment tool for observational studies and the Cochrane tool of risk of bias. Publication bias will be assessed using the funnel plot as well as Egger’s regression intercept. The pooled prevalence, standard error and 95% CI will be reported. The strength of evidence from this analysis will be assessed by using NIH Quality Assessment for Systematic Reviews and Meta-analysis.DiscussionThe outcome of this analysis will give insight into the level of COVID 19 vaccine hesitancy and its correlates across geographical regions globally. It will examine if herd immunity via vaccination is attainable at the pooled rate of hesitancy. This will help Governments to redesign their public messages and sensitization. Systematic Review RegistrationThis protocol has been registered with PROSPERO, registration number CRD42021231165.

scholarly journals The Efficacy of the proprioceptive neuromuscular facilitation (PNF) approach in stroke rehabilitation to improve basic activities of daily living and quality of life: a systematic review and meta-analysis protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e016739 ◽  
Author(s):  
Francesc Xavier Guiu-Tula ◽  
Rosa Cabanas-Valdés ◽  
Mercè Sitjà-Rabert ◽  
Gerard Urrútia ◽  
Natàlia Gómara-Toldrà
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Meta Analysis ◽  
Stroke Survivors ◽  
Proprioceptive Neuromuscular Facilitation ◽  
Registration Number ◽  
Randomised Controlled

IntroductionProprioceptive neuromuscular facilitation (PNF) is a widely used rehabilitation concept, although its efficacy has not yet been demonstrated in stroke survivors. The aim of this systematic review is to identify, assess and synthesise the potential benefits of using PNF to improve the activities of daily living (ADL) and quality of life (QoL) of individuals with stroke.Methods and analysisA systematic electronic search will be conducted in MEDLINE, Embase, CENTRAL and PEDro. We will include randomised or quasi-randomised controlled trials of PNF interventions conducted in stroke survivors up to April 2017. Two review authors will independently select relevant studies and will extract data using the Cochrane handbook for systematic reviews of interventions approach and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The methodological quality will be assessed by using the PEDro scale. Finally, with the permitted numeric data, we will carry out a meta-analysis.Ethics and disseminationEthical considerations will not be required. Results will be disseminated in a peer-review journal. This systematic review aims to examine the effects of PNF (neurophysiological approach) in order to clarify its efficacy in improving ADL and QoL in the rehabilitation process of stroke survivors.PROSPERO registration numberCRD42016039135.

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