The Clinical Desire for Pressurized Intraperitoneal Aerosol Chemotherapy in South Korea: An Electronic Survey-based Study

Abstract Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is effective for treating peritoneal metastasis. However, it is currently used in the limited areas. Thus, we performed a survey to evaluate the clinical desire for PIPAC in South Korea, one of the many countries where PIPAC has not yet been introduced.Methods: We performed an online survey between November and December 2019. The questionnaire consisted of 20 questions, which were divided into comprehensive, procedure, and cost inquiries including five, 13 and two questions, respectively. Results: A total of 164 respondents who answered the questionnaire. Among respondents, 41.7-50% majoring in ovarian cancer, pseudomyxoma peritonei, and malignant mesothelioma preferred PIPAC for the curative treatment of primary diseases, whereas 32.7-33.3% majoring in colorectal and hepatobiliary cancers chose it for the palliative treatment of recurrent diseases. Moreover, 66.7-95.2% considered PIPAC appropriate for the cancers the specialized in, and 76-78.7% expected a treatment response of more than 50% and considered grade 1 or 2 minor surgical complications acceptable. Finally, most of the respondents answered the reasonable costs to purchase and implement PIPAC once at between 1,000,000-5,000,000 KRW. Conclusions: This surgery may reflect on the availability, scope, and reasonable cost of PIPAC treatment in South Korea for introducing PIPAC.

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The clinical desire for pressurized intraperitoneal aerosol chemotherapy in South Korea: An electronic survey-based study (Preprint)

10.2196/preprints.33477 ◽

2021 ◽

Author(s):

Eun Ji Lee ◽

Soo Jin Park ◽

Jeesun Lee ◽

Jaehee Mun ◽

Haerin Paik ◽

...

Keyword(s):

Ovarian Cancer ◽

South Korea ◽

Pseudomyxoma Peritonei ◽

Peritoneal Metastasis ◽

Palliative Treatment ◽

Online Survey ◽

Standard Treatment ◽

Tumor Response ◽

Electronic Survey ◽

The Many

BACKGROUND Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is effective for treating solid tumors with peritoneal metastasis. However, PIPAC is not a standard treatment globally and is currently only used in the limited areas. OBJECTIVE We performed a survey of surgical oncologists related to PIPAC to evaluate the clinical desire for PIPAC in South Korea, one of the many countries where PIPAC has not yet been introduced. METHODS We performed an online survey between November and December 2019. The questionnaire consisted of 20 questions, which were divided into comprehensive, procedure, and cost inquiries including five, 13 and two questions, respectively. RESULTS A total of 164 respondents who answered the questionnaire. Among respondents, 41.7-50% majoring in ovarian cancer, pseudomyxoma peritonei, and malignant mesothelioma preferred PIPAC for the curative treatment of primary diseases, whereas 32.7-33.3% majoring in colorectal and hepatobiliary cancers chose it for the palliative treatment of recurrent diseases. Moreover, 66.7-95.2% considered PIPAC appropriate for the cancers the specialized in, and 76-78.7% expected a treatment response of more than 50% and considered grade 1 or 2 minor surgical complications acceptable. Finally, most of the respondents answered the reasonable costs to purchase and implement PIPAC once at between 1,000,000-5,000,000 KRW. CONCLUSIONS Although the treatment scope for applying PIPAC was different among Korean surgical oncologists, most of them expected relatively high tumor response rates with minor toxicities through the repeated implementation of PIPAC.

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Expression of CD133 and CD44 in serous ovarian cancer and peritoneal metastasis

10.26226/morressier.596dfd56d462b80292387a1a ◽

2017 ◽

Author(s):

Snjezana Stemberger-Papic

Keyword(s):

Ovarian Cancer ◽

Peritoneal Metastasis ◽

Serous Ovarian Cancer

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IFOSFAMIDUM AS PALLIATIVE TREATMENT FOR ADVANCED OVARIAN CANCER: IGCS-0063 06. Ovarian Cancer

International Journal of Gynecological Cancer ◽

10.1136/00009577-201505001-00046 ◽

2015 ◽

Vol 25 (Supp 1) ◽

pp. 59-59

Author(s):

S. Plate ◽

Z. Zvirbule ◽

S. Kasperova

Keyword(s):

Ovarian Cancer ◽

Palliative Treatment ◽

Advanced Ovarian Cancer

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Precautionary Behavior Practices and Psychological Characteristics of COVID-19 Patients and Quarantined Persons

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116070 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6070

Author(s):

Yubin Lee ◽

Byung-Woo Kim ◽

Shin-Woo Kim ◽

Hyunjin Son ◽

Boyoung Park ◽

...

Keyword(s):

Public Health ◽

South Korea ◽

Emergency Preparedness ◽

Online Survey ◽

Early Stage ◽

Psychological Characteristics ◽

Social Solidarity ◽

Psychological States ◽

Precautionary Behavior ◽

Public Health Emergency Preparedness

Background: since the coronavirus disease (COVID-19) was first reported in 2019, South Korea has enforced isolation of patients with confirmed cases of COVID-19, as well as quarantine for close contacts of individuals diagnosed with COVID-19 and persons traveling from abroad, in order to contain its spread. Precautionary behavior practices and psychological characteristics of confirmed and quarantined persons were investigated for planning pandemic recovery and preparedness. Methods: this study was conducted with 1716 confirmed patients and quarantined persons in Daegu and Busan, regions where a high number of cases were confirmed during the early stage of the COVID-19 outbreak in South Korea. We collected online survey data from 23 April to 20 May 2020, in Daegu, and 28 April to 27 May 2020, in Busan, in cooperation with Daegu and Busan Infectious Disease Control Centers and public health centers in the regions. COVID-19 symptoms, pre-cautionary behavior practices, psychological states, and the need for improvement in isolation/quarantine environments were examined using an online survey. Results: compared to patients infected with coronavirus, quarantined persons engaged in more hygiene-related behaviors (e.g., hand washing, cough etiquette, and proper mask-wearing) and social distancing. COVID-19 patients had a strong fear of stigma, while quarantined persons had a strong fear of contracting COVID-19. Study participants responded that it was necessary to provide financial support and adequate information during isolation/quarantine. Conclusions: the study highlights the importance of precautionary behavior to prevent COVID-19 infection and the need to provide support (both psychological and financial) to patients and quarantined persons, to reinforce effective communication, social solidarity, and public health emergency preparedness (PHEP) in a pandemic situation.

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Avoidance of Healthcare Utilization in South Korea during the Coronavirus Disease 2019 (COVID-19) Pandemic

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18084363 ◽

2021 ◽

Vol 18 (8) ◽

pp. 4363

Author(s):

Minjung Lee ◽

Myoungsoon You

Keyword(s):

General Population ◽

South Korea ◽

Healthcare Utilization ◽

Online Survey ◽

Negative Impact ◽

Sociodemographic Characteristics ◽

Related Factors ◽

First Case ◽

Significant Difference ◽

Health Related

Avoidance of healthcare utilization among the general population during pandemic outbreaks has been observed and it can lead to a negative impact on population health. The object of this study is to examine the influence of socio-demographic and health-related factors on the avoidance of healthcare utilization during the global outbreak of a novel coronavirus (COVID-19) in 2020. Data were collected through an online survey four weeks after the Korea Centers for Disease Control and Prevention (KCDC) confirmed the first case in South Korea; 1000 subjects were included in the analysis. The logit model for regression was used to analyze the associations between sociodemographic and health-related factors regarding the avoidance of healthcare utilization. Among the participants, 73.2% avoided healthcare utilization, and there was no significant difference in the prevalence of healthcare avoidance between groups with (72.0%) and without (74.9%) an underlying disease. Sociodemographic characteristics (e.g., gender, age, income level, and residential area) were related to healthcare avoidance. Among the investigated influencing factors, residential areas highly affected by COVID-19 (i.e., Daegu/Gyeoungbuk region) had the most significant effect on healthcare avoidance. This study found a high prevalence of healthcare avoidance among the general population who under-utilized healthcare resources during the COVID-19 outbreak. However, the results reveal that not all societal groups share the burden of healthcare avoidance equally, with it disproportionately affecting those with certain sociodemographic characteristics. This study can inform healthcare under-utilization patterns during emerging infectious disease outbreaks and provide information to public health emergency management for implementing strategies necessary to improve the preparedness of the healthcare system.

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LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1

Journal of Experimental & Clinical Cancer Research ◽

10.1186/s13046-021-01899-6 ◽

2021 ◽

Vol 40 (1) ◽

Author(s):

Conghui Wang ◽

Jiaying Wang ◽

Xiameng Shen ◽

Mingyue Li ◽

Yongfang Yue ◽

...

Keyword(s):

Ovarian Cancer ◽

Extracellular Vesicles ◽

Peritoneal Metastasis ◽

Cancer Metastasis ◽

Cancer Therapeutics ◽

Mesothelial Cells ◽

Ovarian Cancer Cells ◽

Adhesion Assay ◽

Mesenchymal Transition

Abstract Background Metastasis is the key cause of death in ovarian cancer patients. To figure out the biological nature of cancer metastasis is essential for developing effective targeted therapy. Here we investigate how long non-coding RNA (lncRNA) SPOCD1-AS from ovarian cancer extracellular vesicles (EVs) remodel mesothelial cells through a mesothelial-to-mesenchymal transition (MMT) manner and facilitate peritoneal metastasis. Methods EVs purified from ovarian cancer cells and ascites of patients were applied to mesothelial cells. The MMT process of mesothelial cells was assessed by morphology observation, western blot analysis, migration assay and adhesion assay. Altered lncRNAs of EV-treated mesothelial cells were screened by RNA sequencing and identified by qRT-PCR. SPOCD1-AS was overexpressed or silenced by overexpression lentivirus or shRNA, respectively. RNA pull-down and RNA immunoprecipitation assays were conducted to reveal the mechanism by which SPOCD1-AS remodeled mesothelial cells. Interfering peptides were synthesized and applied. Ovarian cancer orthotopic implantation mouse model was established in vivo. Results We found that ovarian cancer-secreted EVs could be taken into recipient mesothelial cells, induce the MMT phenotype and enhance cancer cell adhesion to mesothelial cells. Furthermore, SPOCD1-AS embedded in ovarian cancer-secreted EVs was transmitted to mesothelial cells to induce the MMT process and facilitate peritoneal colonization in vitro and in vivo. SPOCD1-AS induced the MMT process of mesothelial cells via interacting with G3BP1 protein. Additionally, G3BP1 interfering peptide based on the F380/F382 residues was able to block SPOCD1-AS/G3BP1 interaction, inhibit the MMT phenotype of mesothelial cells, and diminish peritoneal metastasis in vivo. Conclusions Our findings elucidate the mechanism associated with EVs and their cargos in ovarian cancer peritoneal metastasis and may provide a potential approach for metastatic ovarian cancer therapeutics.

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E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer

British Journal of Cancer ◽

10.1038/bjc.2015.436 ◽

2016 ◽

Vol 114 (2) ◽

pp. 213-220 ◽

Cited By ~ 17

Author(s):

Fabian Trillsch ◽

Sascha Kuerti ◽

Christine Eulenburg ◽

Eike Burandt ◽

Linn Woelber ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Peritoneal Metastasis ◽

Advanced Epithelial Ovarian Cancer ◽

E Cadherin

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Capturing the many faces of an exploded star: communicating complex and evolving astronomical data

Journal of Science Communication ◽

10.22323/2.16050202 ◽

2017 ◽

Vol 16 (05) ◽

pp. A02

Author(s):

Lisa Smith ◽

Kimberly Arcand ◽

Randall Smith ◽

Jay Bookbinder ◽

Jeffrey Smith

Keyword(s):

Science Communication ◽

Online Survey ◽

Object A ◽

Cassiopeia A ◽

The Public ◽

Use Of Technology ◽

The Face ◽

Final Item ◽

The Aesthetic ◽

The Many

This study explored how different presentations of an object in deep space affect understanding, engagement, and aesthetic appreciation. A total of n = 2,502 respondents to an online survey were randomly assigned to one of 11 versions of Cassiopeia A, comprising 6 images and 5 videos ranging from 3s to approximately 1min. Participants responded to intial items regarding what the image looked like, the aesthetic appeal of the image, perceptions of understanding, and how much the participant wanted to learn more. After the image was identified, participants indicated the extent to which the label increased understanding and how well the image represented the object. A final item asked for questions about the image for an atronomer. Results suggest that alternative types of images can and should be used, provided they are accompanied by explanations. Qualitative data indicated that explanations should include information about colors used, size, scale, and location of the object. The results are discussed in terms of science communication to the public in the face of increasing use of technology.

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