scholarly journals Analysis of clinical characteristics, nucleic acid detection and prognosis of 72 cases of common type Corona Virus Disease 2019(COVID-19) pneumonia in Hubei Province,China

2020 ◽  
Author(s):  
Jiangrong Liao ◽  
Yueyan Lou ◽  
Shuoyan Lu ◽  
Xueyun Xian ◽  
Xiulin Wu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Neutrophil Count ◽  
Clinical Characteristics ◽  
Treatment Time ◽  
Leukocyte Count ◽  
Virus Disease ◽  
Common Type ◽  
Nucleic Acid Test ◽  
Corona Virus ◽  
Acid Test

Abstract Background: To describe the clinical characteristics and the time of nucleic acid turning negative in patients with common type Corona Virus Disease 2019(COVID-19) pneumonia and analyze the treatment time and prognostic factors.Methods: It’s a retrospective analysis of 72 cases of common type COVID-19 pneumonia diagnosed by nucleic acid test and Computed tomography (CT).Results: The average time of nucleic acid test turning negative is 17.37±9.29 days, and the average treatment time was 23.74±8.06 days. There was no influence of Blood leukocyte count, Neutrophil count, lymphocyte count, C-reactive protein (CRP), glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), creatinine, D-dimer on the prognosis of the patients, whether univariate or multivariate logistic regression analysis. By χ2 test of the drugs and prognosis, we found that oseltamivir may have an impact on the prognosis of patients (P<0.05), while other drugs have no significant impact on the prognosis of patients. Through the correlation analysis, we found that age, the admission temperature, leukocyte count, neutrophil count, CRP were positively correlated with the treatment time of the patients (both P<0.05). Leukocyte count and neutrophil count were positively correlated with the time of nucleic acid test turning negative (both P<0.05).Conclusions: Age, the admission temperature, leukocyte count, neutrophil count, CRP were positively correlated with the treatment time of the patients. Leukocyte count and neutrophil count were positively correlated with the time of nucleic acid test turning negative. Oseltamivir may have an impact on the prognosis of patients, but the detailed role needs further study.

scholarly journals Changes in the clinical characteristics of severe Corona Virus Disease 2019 in Jiangxi Province

2020 ◽  
Author(s):  
Jingjing Yu ◽  
Tianxin Xiang ◽  
Xinping Xu ◽  
Wei Zuo ◽  
Congyang Zhou ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Respiratory Rate ◽  
Neutrophil Count ◽  
Virus Disease ◽  
Type A ◽  
Duration Of Symptoms ◽  
Nucleic Acid Test ◽  
Corona Virus ◽  
Acid Test ◽  
Lung Lobes

Abstract Backgrounds: To determine the differences in clinical manifestations and biomarker levels of Corona Virus Disease 2019 (COVID-19) patients, including common patients and severe (serious and critical) patients.Methods: A total of 89 COVID-19 patients were diagnosed and treated at the First Affiliated Hospital of Nanchang University. We clinically classified the patients and collected data. Findings: There was a higher proportion of confirmed cases in patients with type A blood (44.8%). There were no obvious differences in number of lung lobes involved in the lesion between the patients with or without a positive nucleic acid test (p>0.05).There were obvious differences in contact history (p<0.001), duration of symptoms (p=0.004), and respiratory rate (p=0.029) between the patients with or without a positive nucleic acid test. According to the results of the nucleic acid diagnosis test, there were no obvious differences in the number of lung lobes involved in the lesion and all items of routine blood, liver, and kidney function tests between the patients with or without positive nucleic acid tests (all p>0.05). Between the common patients and severe patients, there were obvious differences in age (p=0.006), duration of symptoms (p=0.001), diastolic blood pressure (p=0.046), lymphocyte count (p＜0.0001), neutrophil count (p=0.019), albumin (p=0.002), lactate dehydrogenase (p=0.007), calcium (p＜0.0001), C-reactive protein (CRP) (p=0.004), erythrocyte sedimentation rate (p=0.021), international standard ratio (p=0.020), and CD3 (p=0.001), CD3+CD4 (p=0.006), and CD3+CD8 (p=0.001) levels. In patients infected with SARS-COV-2, the number of lung lobes involved in the lesion were positively correlated with lymphocytes (R=0.261, p=0.044); the body mass index (BMI) values were positively correlated with the number of lung lobes involved in the lesion (R=0.320, P=0.034); the age (R=0.391, p<0.001) and respiratory rate (R=0.352, p=0.001) were positively correlated with neutrophil count; and the age (R=0.349, p=0.001) and the number of lung lobes involved in the lesion (R=0.422, p=0.001) were positively correlated with CRP.Conclusion: Patients with blood type A may be more susceptible to SARS-COV-2. The decrease in lymphocytes may indicate the aggravation of COVID-19, whereas the number of lung lobes involved in the lesion may not be a valid criterion for COVID-19 diagnosis.

scholarly journals Analysis of clinical characteristics of SARS-CoV-2 infected cases: a retrospective study of medical records

2020 ◽  
Author(s):  
Han Zhang ◽  
Lian Lu ◽  
Wei Hu ◽  
Jian Zhang ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Virus Disease ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Lower Serum ◽  
Nucleic Acid Test ◽  
Treatment And Prevention ◽  
Acid Test

Abstract In order to identify the clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) and find out the characteristic effects of 2019 New Coronavirus (SARS-CoV-2) infection on changes in clinical and laboratory data, we analyzed the medical records of 80 suspected cases who admitted in the national designated hospital due to the relevant clinical manifestations of SARS-CoV-2 infection from January 22 to February 13, 2020. 62 (77.5%) confirmed cases and 18 (22.5%) negative cases were confirmed by SARS-CoV-2 nucleic acid test. Epidemiological investigation and statistical analysis were carried out on the clinical and laboratory data of all suspected cases of COVID-19, the specific indicators were found, and the clinical characteristics of COVID-19 were described. Compared with the patients with negative nucleic acid test, the patients with positive nucleic acid test showed shorter time of onset of symptoms, higher plasma CO2 level, lower eosinophil ratio, lower platelet count and hematocrit, lower serum sodium level, higher serum creatinine, higher blood urea and plasma albumin levels (all P<0.05). Our results might provide some suggestions in diagnosis, clinical treatment and prevention for COVID-19.

scholarly journals Analysis of clinical characteristics of SARS-CoV-2 infected cases: a retrospective study of medical records

2020 ◽  
Author(s):  
Han Zhang ◽  
Lian Lu ◽  
Wei Hu ◽  
Jian Zhang ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Clinical Characteristics ◽  
Virus Disease ◽  
Laboratory Data ◽  
Organ Damage ◽  
Multiple Organ ◽  
P Value ◽  
Data Types ◽  
Nucleic Acid Test ◽  
Acid Test

Abstract Objectives In order to identify the clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) and find out the characteristic effects of 2019 New Coronavirus (SARS-CoV-2) infection on changes in clinical and laboratory data. Patients and methods From January 22 to February 13, 2020, we enrolled consecutive patients with acute respiratory tract symptoms admitted to a hospital (Ezhou, Hubei, China). For different data types t-test, the variables associated with the diagnosis of COVID-19 were compared by chi-square test and u-test, the statistically significant variables (P-value<0.05) were selected into the final logistic regression model. Results 62 (77.5%) confirmed cases and 18 (22.5%) negative cases were confirmed by SARS-CoV-2 nucleic acid test. Epidemiological investigation and statistical analysis were carried out on the clinical and laboratory data of all suspected cases of COVID-19, the specific indicators were found, and the clinical characteristics of COVID-19 were described. Compared with the patients with negative nucleic acid test, the patients with positive nucleic acid test showed shorter time of onset of symptoms, higher plasma CO2 level, lower eosinophil ratio, lower platelet count and hematocrit, lower serum sodium level, higher serum creatinine, higher blood urea and plasma albumin levels (all P<0.05). Conclusions we argue that the SARS-CoV-2 infection can cause multiple organ damage to the heart, liver, kidney and bone marrow other than lung injury.

scholarly journals Management strategy of Corona Virus Disease-2019 in quarantine zones outside hospitals: Analysis of 1232 cases from a district in Wuhan

2020 ◽  
Author(s):  
Xiaojian Zhu ◽  
Jue Wang ◽  
Hao Wang ◽  
Yutong Tang ◽  
Shu Zhou ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Management Strategy ◽  
Virus Disease ◽  
Cardinal Number ◽  
Nucleic Acid Test ◽  
Corona Virus ◽  
Global Pandemic ◽  
Positive Rate ◽  
Discharged Patients ◽  
Acid Test

Abstract The Corona Virus Disease 2019 (COVID-19) has evolved into a global pandemic in the early 2020. Management strategy outside hospitals of the suspected cases, close contacts and discharged patients might be as important as treatment in hospital. We analyzed information from 1232 cases at 14 hotels (requisitioned as quarantine zones) in Qiaokou district, Wuhan during Feb 8th to Mar 4th 2020. Abide by the unquarantine and hospitalization standard, 603 (48.94%) cases were released from quarantine zones; 540 (43.83%) cases were sent to hospital for further medical care. 89 (7.22%) cases remained on quarantine up to the end of the analysis. The reasons for cases sent to the hospital for treatment were either positive for COVID-19 nucleic acid test, progression in pulmonary CT scan, or aggravation of symptoms. 11/59 patients switched from negative to positive for nucleic acid test during stayed in quarantine zones after being discharged from the hospitals. In total, hospitalization and positive rate for COVID-19 nucleic acid test both decreased over time. The quarantine measures were important and played a pivotal role in identification of cardinal number, cutting off the transmission, reducing the scope of prevention and rehabilitation therapy. This protocol adopted in Wuhan provided countries worldwide with valuable experience.

scholarly journals COVID-19 versus non-COVID-19 pneumonia: A retrospective cohort study in Chengdu, China

2020 ◽  
Author(s):  
Xiao-Jin Li ◽  
Bing-Xing Shuai ◽  
Zhong-Wei Zhang ◽  
Yan Kang
Keyword(s):  
Nucleic Acid ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Epidemiological Data ◽  
Group Differences ◽  
Test Results ◽  
Imaging Findings ◽  
Viral Nucleic Acid ◽  
Nucleic Acid Test ◽  
Acid Test

Background and ObjectiveSince the outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, Hubei Province, China, it has spread throughout the world and become a global public health emergency. It is important to distinguish COVID-19 from other viral pneumonias to properly screen and diagnose patients, reduce nosocomial infections, and complement the inadequacy of nucleic acid testing. In this study, we retrospectively analysed the clinical data of COVID-19 versus non-COVID-19 patients treated at our hospital between January 17 and February 27, 2020 to summarize our clinical experience in the differential diagnosis of COVID-19.MethodsIn this retrospective cohort study, 23 confirmed COVID-19 patients were consecutively enrolled from January 17 to February 27, 2020, and 29 confirmed non-COVID-19 patients were enrolled in the West China Hospital of Sichuan University. We collected baseline data, epidemiological data, clinical characteristics, imaging findings, viral nucleic acid test results, and survival data. SPSS v22.0 was used for the statistical analysis. Outcomes were followed-up until March 25.ResultsA total of 52 patients were included in this study, including 23 COVID-19 patients and 29 non-COVID-19 patients. No significant between-group differences were observed for age, sex, primary signs or symptoms, cellular immunity, or platelet count. Significant between-group differences were observed in clinical characteristics such as dry cough, contact with individuals from Wuhan, some underlying diseases, nucleated cell count, chest imaging findings, viral nucleic acid test results, 28-day mortality, and 28-day survival.ConclusionEpidemiological data, clinical symptoms, nucleic acid test results for COVID-19 and chest CT manifestation may help distinguish COVID-19 from non-COVID-19 cases, prevent imported cases and nosocomial infections.

Clinical Characteristics of the Discharged COVID-19 Patients with Re-Positive Nucleic Acid Test

2020 ◽  
Author(s):  
Yun Yu ◽  
Di Zhang ◽  
Guoxi Chen ◽  
Xing Lan ◽  
Min Hou ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Clinical Characteristics ◽  
Nucleic Acid Test ◽  
Acid Test

scholarly journals Clinical Characteristics of Imported Cases of Coronavirus Disease 2019 (COVID-19) in Jiangsu Province: A Multicenter Descriptive Study

2020 ◽  
Vol 71 (15) ◽  
pp. 706-712 ◽  
Author(s):  
Jian Wu ◽  
Jun Liu ◽  
Xinguo Zhao ◽  
Chengyuan Liu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Liver Dysfunction ◽  
Clinical Characteristics ◽  
Average Length ◽  
Clinical Manifestations ◽  
Jiangsu Province ◽  
World Health ◽  
Nucleic Acid Test ◽  
Imported Cases ◽  
Acid Test

Abstract Background We aimed to report the clinical characteristics of imported cases of coronavirus disease 2019 (COVID-19) in Jiangsu Province. Methods We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with World Health Organization interim guidance in 3 grade IIIA hospitals of Jiangsu from 22 January to 14 February 2020. Real-time RT-PCR was used to detect the new coronavirus in respiratory samples. Results Of the 80 patients infected with COVID-19, 41 were female, with a median age of 46.1 years. Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. Nine patients were unconfirmed until a third nucleic acid test; 38 cases had a history of chronic diseases. The main clinical manifestations of the patients were fever and cough, which accounted for 63 (78.75%) and 51 (63.75%) cases, respectively. Only 3 patients (3.75%) showed liver dysfunction. Imaging examination showed that 55 patients (68.75%) showed abnormal density shadow and 25 cases (31.25%) had no abnormal density shadow in the parenchyma of both lungs. Currently, 21 cases have been discharged from the hospital, and no patient died. The average length of stay for discharged patients was 8 days. Conclusions Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptibility. The proportion of patients having liver dysfunction and abnormal CT imaging was relatively lower than that in Wuhan. Notably, infected patients may be falsely excluded based on 2 consecutively negative respiratory pathogenic nucleic acid test results.

scholarly journals Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers

2020 ◽  
Vol 221 (12) ◽  
pp. 1940-1947 ◽  
Author(s):  
Yanfeng Pan ◽  
Xue Yu ◽  
Xinwei Du ◽  
Qingqing Li ◽  
Xianyang Li ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
False Negative ◽  
Test Results ◽  
Nucleic Acid Test ◽  
Ct Findings ◽  
Asymptomatic Patients ◽  
Median Period ◽  
Acid Test

Abstract Background We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. Methods Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained. Results Twenty-two patients (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8–24 days) and 21.5 days (10–36 days), respectively. The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n = 16, 61.5%; 7.5 days [2–20 days]) and patients with typical ground-glass or patchy opacities on CT (n = 10, 38.5%; 12.5 days [8–22 days]; P &lt; .01). Seven patients (70.0%) with initial positive nucleic acid test results had a negative result simultaneously with improved CT findings. Obvious improvement in CT findings was observed in 3 patients (30.0%) despite positive nucleic acid test results. Conclusions In asymptomatic patients, changes in biochemical and inflammatory variables are small and changes on chest CT can occur. It is worth noting that the long existence of SARS-CoV-2 in some asymptomatic patients and false-negative results need to be considered in SARS-CoV-2 nucleic acid test.

scholarly journals Clinical characteristics of Covid-19 patients with re-positive test results: an observational study

2020 ◽  
Author(s):  
Ying Su ◽  
Ling-Shuang Zhu ◽  
Yong Gao ◽  
Yuncheng Li ◽  
Zhanlu Xiong ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Nucleic Acid ◽  
Clinical Characteristics ◽  
Test Results ◽  
Nucleic Acid Test ◽  
Artery Disease ◽  
Acid Test ◽  
Positive Results

AbstractBackgroundWith coronavirus disease 2019 (Covid-19) ravaging the global, concern has been aroused whether discharged Covid-19 patients with reappeared positive nucleic acid test results are infected again.ObjectiveTo analyze the clinical characteristics of discharged Covid-19 patients with reappeared positive nucleic acid test results and to track clinical outcomes of them.MethodsWe extracted clinical data on 938 Covid-19 patients from Wuhan Union Hospital (West Branch), and we obtained information about residual symptoms and nucleic acid tests after discharge through follow-up study. We evaluated the relationship of clinical characteristics and reappeared positive results. Each patient had at least 44 days of follow-up.ResultsOf 938 discharged patients, a total of 58 (6.2%) had reappeared positive nucleic acid test results and 880 remain negative. Among patients over the age of 50, the factors we found to be associated with re-positive results were coronary artery disease (14.1%, vs. 5.5% among those without coronary artery disease; odds ratio, 2.81; 95% confidence interval [CI], 1.28 to 6.15), and hypertension (9.5%, vs. 4.9% among those without hypertension; odds ratio, 2.05; 95% CI, 1.10 to 3.82). As of May 11, 2020, 54 (93.1%) re-positive patients turned negative again while two patients remained positive, and two patients was lost to the second follow-up.ConclusionCoexisting diseases including coronary artery disease and hypertension were substantial risk factors for re-positive outcomes among patients over 50. And most re-positive patients tended to return negative eventually.

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