scholarly journals Oral iodine supplementation in very low birth weight infants. Thyroid function and Neurodevelopmental follow up at 24 months. A Randomized Clinical Trial

2021 ◽  
Author(s):  
Susana Ares ◽  
BELEN SAENZ-RICO ◽  
JUAN ARNAEZ ◽  
Jesus Diez-Sebastian ◽  
Felix Omeñaca ◽  
...  
Keyword(s):  
Breast Milk ◽  
Thyroid Hormones ◽  
Preterm Infants ◽  
Thyroid Function ◽  
Iodine Deficiency ◽  
Iodine Content ◽  
Iodine Intake ◽  
Control Group ◽  
Premature Babies ◽  
Iodine Supplementation

Abstract The trace element iodine (I) is essential for the synthesis of thyroid hormones. Premature babies need >30 µg I / kg /day (ICCIDD recommendations). Neonates and especially preterm infants are a population at risk of suffering the consequences of iodine deficiency, because of the impact of neonatal hypothyroxinemia on brain development. The main aim of this project is to prevent the mental retardation and increased risk of cerebral palsy of premature infants, which is partially caused by neonatal hypothyroxinemia. We gave Oral iodine supplementation in very premature babies during the neonatal period. Population: we included 94 infants born <1500g. Intervention group: we administered 30 µg I / kg /day of iodine in oral drops to 47 infants from first day of life until hospital discharge. Control group: 47 infants without supplements. The study was approved by the Ethics Committee. Samples of different formulas, maternal milk was kept for the determination of the iodine content. Interventions: Blood, food and urine samples (collected at 1, 7, 15, 21, 30 days after birth and at discharge). Measurements: milk and urine for iodine determination (Benotti method). Blood samples: for thyroid hormones (T4, free T4, T3 and TSH) and tyroglobulin. Their neurological development was assessed at 2 years of age (Bayley Test).Iodine content of mothers´ breast milk: 15 (5.0) µg I /dL (range 1-60); Infants in the supplemented group reached the recommendations from the first days of life. Infants in the control group did not reach the recommended intake of iodine to 60 days of life. We found a positive relation between iodine intake and the concentrations of thyroid hormones until 60 days of life. Conclusions: Thyroid function is related to iodine intake in preterm infants. Breast milk appears to be the best source of iodine for the premature infant. Preterm babies on formula preparations and with exclusive parenteral nutrition are at high risk of iodine deficiency. Therefore, supplements should be added if iodine intake is found to be inadequate.

scholarly journals Oral Iodine Supplementation in Very Low Birth Weigh Infants. Thyroid Function and Neurodevelopmental Follow Up at 24 Months. A Randomized Clinical Trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ares S ◽  
◽  
Arnaez J ◽  
Saenz Rico B ◽  
Diez J ◽  
...  
Keyword(s):  
Breast Milk ◽  
Thyroid Hormones ◽  
Preterm Infants ◽  
Thyroid Function ◽  
Iodine Deficiency ◽  
Iodine Content ◽  
Iodine Intake ◽  
Control Group ◽  
Premature Babies ◽  
Iodine Supplementation

Background: The trace element Iodine (I) is essential for the synthesis of thyroid hormones. Premature babies need >30μg I/kg/day (ICCIDD recommendations). Neonates and especially preterm infants are a population at risk of suffering the consequences of iodine deficiency, because of the impact of neonatal hypothyroxinemia on brain development. Aims: The main aim of this project is to prevent the mental retardation and increased risk of cerebral palsy of premature infants, which is partially caused by neonatal hypothyroxinemia. We gave Oral iodine supplementation in very premature babies during the neonatal period. Methods: Population: we included 94 infants born <1500g. Intervention group: we administered 30μg I/kg /day of iodine in oral drops to 47 infants from first day of life until hospital discharge. Control group: 47 infants without supplements. The study was approved by the Ethics Committee. Samples of different formulas, maternal milk was kept for the determination of the iodine content. Interventions: Blood, food and urine samples (collected at 1, 7, 15, 21, 30 days after birth and at discharge). Measurements: milk and urine for iodine determination (Benotti method). Blood samples: for thyroid hormones (T4, free T4, T3 and TSH) and tyroglobulin. Their neurological development was assessed at 2 years of age (Bayley Test). Results: Iodine content of mothers´ breast milk: 15 (5.0) μg I/dL (range 1-60); Infants in the supplemented group reached the recommendations from the first days of life. Infants in the control group did not reach the recommended intake of iodine to 60 days of life. We found a positive relation between iodine intake and the concentrations of thyroid hormones until 60 days of life. Conclusion: Thyroid function is related to iodine intake in preterm infants. Breast milk appears to be the best source of iodine for the premature infant. Preterm babies on formula preparations and with exclusive parenteral nutrition are at high risk of iodine deficiency. Therefore, supplements should be added if iodine intake is found to be inadequate. Acknowledgments. We are grateful to the Fondo de Investigaciones Sanitarias (National Grant 06/1310 for financial support).

scholarly journals The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2639 ◽  
Author(s):  
Simona Censi ◽  
Sara Watutantrige-Fernando ◽  
Giulia Groccia ◽  
Jacopo Manso ◽  
Mario Plebani ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Iodine Deficiency ◽  
Harmful Effect ◽  
Urinary Iodine ◽  
Thyroid Volume ◽  
Iodine Intake ◽  
Controlled Clinical Trial ◽  
Iodine Supplementation ◽  
T1 And T2 ◽  
Single Blind

Background: Iodine supplementation during pregnancy in areas with mild-to-moderate iodine deficiency is still debated. Methods: A single-center, randomized, single-blind and placebo-controlled (3:2) trial was conducted. We enrolled 90 women before 12 weeks of gestation. From enrollment up until 8 weeks after delivery, 52 women were given an iodine supplement (225 ug/day, potassium iodide tablets) and 38 were given placebo. At recruitment (T0), in the second (T1) and third trimesters (T2), and 8 weeks after delivery (T3), we measured participants’ urinary iodine-to-creatinine ratio (UI/Creat), thyroid function parameters (thyroglobulin (Tg), TSH, FT3, and FT4), and thyroid volume (TV). The newborns’ urinary iodine concentrations were evaluated in 16 cases. Results: Median UI/Creat at recruitment was 53.3 ug/g. UI/Creat was significantly higher in supplemented women at T1 and T2. Tg levels were lower at T1 and T2 in women with UI/Creat ≥ 150 ug/g, and in the Iodine group at T2 (p = 0.02). There was a negative correlation between Tg and UI/Creat throughout the study (p = 0.03, r = −0.1268). A lower TSH level was found in the Iodine group at T3 (p = 0.001). TV increased by +Δ7.43% in the Iodine group, and by +Δ11.17% in the Placebo group. No differences were found between the newborns’ TSH levels on screening the two groups. Conclusion: Tg proved a good parameter for measuring iodine intake in our placebo-controlled series. Iodine supplementation did not prove harmful to pregnancy in areas of mild-to-moderate iodine deficiency, with no appreciable harmful effect on thyroid function.

scholarly journals Subclinical Hypothyroidism in Korean Preterm Infants Associated with High Levels of Iodine in Breast Milk

2009 ◽  
Vol 94 (11) ◽  
pp. 4444-4447 ◽  
Author(s):  
Hye Rim Chung ◽  
Choong Ho Shin ◽  
Sei Won Yang ◽  
Chang Won Choi ◽  
Beyong Il Kim
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Thyroid Function Tests ◽  
The Third ◽  
Excessive Iodine ◽  
Excessive Iodine Intake

Context: The dietary iodine intake of lactating women has been reported to be high in Korea. Objectives: The aim of this study was to assess iodine balance and to determine its relationship with thyroid function in preterm infants. Design: Thyroid functions of preterm infants born at 34 wk gestation or less were evaluated in the first (n = 31) and third (n = 19) weeks. Mothers’ breast milk (BM) and random urine samples of infants were taken on the same days for thyroid function tests. Results: Iodine concentrations in BM were very high (198–8484 μg/liter), and one third of the infants had an iodine intake of more than 100 μg/kg per day at the third week after birth (excessive iodine intake group). At that time, the levels of TSH were positively correlated with urinary iodine (r = 0.622; P = 0.004). The frequencies of subclinical hypothyroidism were high in the excessive iodine intake group at the third and sixth weeks. The estimated daily iodine intake at the third week (51.2 ± 45.5 vs. 149.0 ± 103.8 μg/kg per day; P = 0.033), urinary iodine at the third week (913.2 ± 1179.7 vs. 1651.3 ± 1135.2 μg/liter; P = 0.051), and estimated daily iodine intake at the sixth week (32.8 ± 35.5 vs. 92.1 ± 51.2 μg/kg per day; P = 0.032) were significantly higher in infants with subclinical hypothyroidism than in controls. Conclusions: Excessive iodine intake from BM contributed to subclinical hypothyroidism in these preterm Korean infants. An excessive amount of iodine in breast milk causes subclinical hypothyroidism in preterm infants.

Olfactory Stimulation of Preterm Infants with Breast Milk

2021 ◽  
pp. 105477382110189
Author(s):  
Woon Ae Lee ◽  
Jin Suk Ra
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Repeated Measures ◽  
Physiological Responses ◽  
Nursing Intervention ◽  
Olfactory Stimulation ◽  
Control Group ◽  
Repeated Measures Analysis ◽  
Equivalent Control ◽  
Experimental Group

Maintaining stable physiological responses may be important for the growth and development of preterm infants. The purpose of our study was to evaluate the effects of olfactory stimulation with maternal breast milk on the occurrence of abnormal physiological responses in preterm infants. With a non-equivalent control group pretest-posttest design, 13 preterm infants in the experimental group and 18 preterm infants in the control group completed the intervention. The intervention was implemented three times a day for 5 days in a row with 2 hours of administration per intervention. The frequency of abnormal physiological responses was assessed over 6 days (one day before intervention administration and 5 days during intervention administration). With repeated-measures analysis of variance, the experimental group showed a significantly lower frequency of apnea than the control group ( p = .021). Olfactory stimulation with maternal breast milk may be an effective nursing intervention for reducing apnea episodes in preterm infants.

The Effect of Individualized Developmental Care Practices in Preterm Infants

2019 ◽  
Vol 27 (2) ◽  
pp. 97-104
Author(s):  
Dilek Küçük Alemdar ◽  
Sevil İnal
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Controlled Trial ◽  
Oral Feeding ◽  
Control Group ◽  
Developmental Care ◽  
Significant Difference ◽  
Care Practices ◽  
Maternal Voice

Background: Preterm infants are vulnerable humans requiring much care and attention. They may be exposed to irregular noise, light, and odor in the neonatal intensive care unit for a period of several weeks or months. This study was carried out to determine the effect of individualized developmental care on physiological parameters, growth, and transition to oral feeding in preterm infants. Methods: The study was a randomized controlled trial. The sample comprised premature infants meeting the inclusion criteria. They were randomly assigned to four groups: the maternal voice group, the breast milk odor (BMO) group, the incubator cover (IC) group, and the control group. Results: No statistically significant difference was found between the groups in terms of weight, height, and head circumference at time of discharge. Mean SO2 values were statistically higher in the IC group than the other groups; however, the heart rate and respiratory rate were not statistically different in a significant sense between the groups. The briefest duration of transition to total oral feeding was seen in the BMO group. Conclusion: Individualized developmental care practices based on the results of these interventions are likely to support the care of preterm infants. Breast milk odor may ease the transition to breastfeeding.

Effects of oral stimulation with breast milk in preterm infants oral feeding: a randomized clinical trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Qiong Le ◽  
Sheng-hua Zheng ◽  
Lan Zhang ◽  
Li-fen Wu ◽  
Feng-juan Zhou ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Breast Milk ◽  
Premature Infant ◽  
Preterm Infants ◽  
Oral Feeding ◽  
Transition Time ◽  
Control Group ◽  
Oral Motor ◽  
Oral Stimulation ◽  
Nutritive Sucking

Abstract Objectives This study was performed to evaluate the effect of oral stimulation with breast milk for preterm infants. Methods A total of 68 subjects form neonatal intensive care unit were randomly assigned into control group (n=20), premature infant oral motor intervention (PIOMI) group (n=25) and premature infant oral motor intervention with breast milk (BM-PIOMI) group (n=23). Results BM-PIOMI group had significant shorter initiation of oral feeding (IOF) time compared to PIOMI group (2.95 days, 95% CI [0.42–5.48]) or control group (9.79 days, 95% CI [7.07–12.51]). BM-PIOMI group had significant sooner transition time from IOF to full oral feeding (FOF) compared to control group (6.68 days, 95% CI [2.2–11.16]), but not to PIOMI group (2.09 days, 95% CI [−2.07 to 6.25]). Length of hospital stay (LOS) did not show statistical different between three groups (control 38.85 ± 14.40 vs. PIOMI 38.48 ± 11.76 vs. BM-PIOMI 38.04 ± 12.2). Growth mixture model identified improvement in non-nutritive sucking (NNS) score in BM-PIOMI group compared to control and PIOMI group (0.8293, p<0.0001, and 0.8296, p<0.0001, respectively). Conclusions Oral stimulation with breast milk can better promotes the oral feeding process of premature infants than the simple oral stimulation, by shorten IOF time and improve early NNS score, but does not shorten transition time from IOF to FOF and LOS. Trial registration The trial identification number is ChiCTR1800019134 (Chinese Clinical Trial Registry http://www.who.int/ictrp/network/chictr2/en/)

scholarly journals Assessment of Dietary Iodine Intake in School Age Children: The Cross-Sectional ANIVA Study

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1884 ◽  
Author(s):  
María Morales-Suárez-Varela ◽  
Isabel Peraita-Costa ◽  
Agustín Llopis-Morales ◽  
Agustín Llopis-Gonzalez
Keyword(s):  
Thyroid Hormones ◽  
Iodine Deficiency ◽  
Dairy Products ◽  
Iodine Intake ◽  
School Age Children ◽  
School Age ◽  
Nutritional Adequacy ◽  
Cross Sectional ◽  
The World ◽  
Important Health

Iodine deficiency is one of the most important health problems in the world. It intervenes in the synthesis of thyroid hormones, which carry out important functions, so that a deficit of this mineral causes alterations of different kinds such as those related to growth. The objective of the present study was to know the prevalence of iodine deficit in the diet of Valencian children from 6 to 8 years old and their relationship with anthropometry. The analysis of the dietary intake was carried out through questionnaires. Thirteen schools participated in the study. The sample studied consists of 661 school children belonging to the Valencian Community, between 6 and 8 years of age: 298 boys and 363 girls. 79.12% of the children did not meet recommended daily iodine intakes. When comparing the groups of girls and boys with an inadequate intake, in general, girls show worse nutritional adequacy. When comparing the groups of girls and boys with sufficient iodine intake, no statistically significant differences were observed. No immediate effects of iodine deficiency on children’s anthropometry were observed. Intake of dairy products, fish and iodized salt is recommended, since they can contribute to the diet the iodine required to avoid a deficiency.

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