Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Abstract Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

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Helicobacter Pylori Infection Is Associated with Neurodegeneration in Cognitively Normal Men

Journal of Alzheimer s Disease ◽

10.3233/jad-210119 ◽

2021 ◽

pp. 1-9

Author(s):

Jaehong Park ◽

Tae Jun Kim ◽

Joo Hye Song ◽

Hyemin Jang ◽

Ji Sun Kim ◽

...

Keyword(s):

Helicobacter Pylori ◽

Cortical Thickness ◽

Smoking Status ◽

Inflammatory Marker ◽

Cross Sectional Study ◽

Intracranial Volume ◽

Cross Sectional ◽

Cortical Thinning ◽

H Pylori ◽

Normal Men

Background: An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies; however, the evidence is inconsistent. Objective: In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods: A cross-sectional study of 822 men who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging, was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analyses were conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results: Men with H. pylori infection exhibited overall brain cortical thinning (p = 0.022), especially in the parietal (p = 0.008) and occipital lobes (p = 0.050) compared with non-infected men after adjusting for age, educational level, alcohol intake, smoking status, and intracranial volume. 3-dimentional topographical analysis showed that H. pylori infected men had cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected men with the same adjustments (false discovery rate corrected, Q < 0.050). The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). Conclusion: Our results indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal men. H. pylori infection may play a pathophysiologic role in the neurodegeneration and further studies are needed to validate this association.

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Abstract T P337: Asymmetric Dimethylarginine Is Related to the Predicted Stroke Risk in Middle-aged Japanese Men

Stroke ◽

10.1161/str.45.suppl_1.tp337 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

yasuhiro nishiyama ◽

Masayuki Ueda ◽

Yasuo Katayama ◽

Toshiaki Otsuka

Keyword(s):

Asymmetric Dimethylarginine ◽

Stroke Risk ◽

Smoking Status ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Cerebrovascular Diseases ◽

Adma Level ◽

Middle Aged ◽

Cross Sectional ◽

Japanese Men

Background: Asymmetric dimethylarginine (ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it remains unclear whether ADMA levels are related to the risk of stroke in the general Japanese population. Methods and Results: In this cross-sectional study, we examined 769 Japanese men (mean, 47 ± 5 years) who underwent health examinations. Each patient’s ADMA level and various vascular risk factors were assessed, and the predicted 10-year risk of stroke was calculated using the point-based prediction model for incident total stroke for Japanese from the Japan Public Health Center Study. In a multiple linear regression analysis, age, body mass index, estimated glomerular filtration rate, and current smoking status were significant independent determinants of the ADMA level. A significant odds ratio (OR) for high predicted stroke risk (10-year risk ≥ 5%) was noted in the highest quartile of ADMA level (OR, 2.47; 95% CI, 1.00-6.07) as compared to the lowest quartile, even after adjusting for potential confounding factors. A significant OR for high predicted stroke risk was also found for each standard-deviation increment in ADMA level (adjusted OR, 1.46; 95% CI, 1.10-1.92). Conclusions: An elevated ADMA level was significantly associated with an increase in predicted stroke risk, suggesting that the measurement of ADMA level may be useful for identifying middle-aged Japanese men at high risk for stroke.

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The Effect of Age and Occupation on the Seroprevalence of Helicobacter pylori Infection

Canadian Journal of Infectious Diseases ◽

10.1155/1992/831523 ◽

1992 ◽

Vol 3 (3) ◽

pp. 134-138 ◽

Cited By ~ 1

Author(s):

GI Perez-Perez ◽

T Marrie ◽

H Inouye ◽

T Shimoyama ◽

G Marshall ◽

...

Keyword(s):

Helicobacter Pylori ◽

Young Adults ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Seroprevalence Rate ◽

Elderly Persons ◽

Blue Collar Workers ◽

Canadian Population ◽

Serological Studies ◽

H Pylori

Serological studies in developed and developing countries using enzyme-linked immunosorbent assays have validated this technique as a rapid, noninvasive method for the diagnosis of Helicobacter pylori infections. The prevalence of serum antibodies to H pylori was studied in 473 Canadian blood donors from Manitoba, 212 healthy Japanese. and 226 healthy Americans. As expected, the seroprevalence rose progressively with age in the three populations and reached its peak (greater than 55%) in subjects 60 years of age and older. The seroprevalence did not decrease in elderly persons (60 to 99 years), indicating a persistent immune response. More detailed analysis was perfom1ed on the Canadian population. Age-adjusted prevalence rates in men and women were similar. Among young adults (15 to 29 years). farmers had a significantly higher seroprevalence rate than white-collar or blue-collar workers. but in older persons occupational rates were similar. A multiple linear regression analysis of the data confirmed that age and occupation in young adults were both significantly associated with seroprevalence of H pylori infections.

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Health and nutrition literacy in adults: Links with lifestyle factors and obesity

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-200471 ◽

2020 ◽

Vol 13 (4) ◽

pp. 361-370

Author(s):

Maria Michou ◽

Demosthenes B. Panagiotakos ◽

Christos Lionis ◽

Vassiliki Costarelli

Keyword(s):

Physical Activity ◽

Alcohol Consumption ◽

Linear Regression ◽

Smoking Status ◽

Linear Regression Analysis ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

Linear Regression Models ◽

Chi Square ◽

Cross Sectional

BACKGROUND: Low Health Literacy (HL) and Nutrition Literacy (NL) are associated with serious negative health outcomes. OBJECTIVES: The aim of this study was to investigate certain lifestyle factors and obesity, in relation to HL and NL. METHODS: This cross-sectional study was conducted in the urban area of the Attica region, in Greece. The sample consisted of 1281 individuals, aged ≥18 years. HL, NL sociodemographic characteristics and lifestyle factors (physical activity, smoking status, alcohol consumption,) were assessed. Mann-Whitney U, the Kruskall Wallis, Pearson chi-square tests and multiple linear regression models were used. RESULTS: Linear regression analysis has shown that smoking, alcohol consumption and physical activity, were associated with HL levels (–1.573 points for ex-smokers in comparison to smokers, p = 0.035, –1.349 points for alcohol consumers in comparison to non-consumers, p = 0.006 and 1.544 points for physically active individuals to non-active, p = 0.001). With respect to NL levels, it was also not associated with any of these factors. Obesity was not associated with HL and NL levels. CONCLUSIONS: Certain lifestyle factors, including physical activity, are predicting factors of HL levels, in Greek adults. The results contribute to the understanding of the relationship between lifestyle factors and HL and should be taken into account when HL policies are designed.

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Association Between Lower Trapezius Isometric Strength and Y-Balance Test Upper Quarter Performance in College Volleyball Players

Journal of Sport Rehabilitation ◽

10.1123/jsr.2021-0048 ◽

2021 ◽

pp. 1-6

Author(s):

Guillermo Mendez-Rebolledo ◽

Ann M. Cools ◽

Rodrigo Ramirez-Campillo ◽

Elias Quiroz-Aldea ◽

Fernanda A.P. Habechian

Keyword(s):

Upper Limb ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Isometric Strength ◽

Serratus Anterior ◽

Balance Test ◽

Cross Sectional ◽

Convenience Sample ◽

Volleyball Players ◽

Lower Trapezius

Context: Knowing the possible association between the isometric strength of the shoulder rotators, scapular muscles, and the Y-balance test upper quarter (YBT-UQ) performance could help identify which indicators of shoulder stability should be considered in this field test. This study aimed to determine whether the isometric strength of the shoulder rotators and scapular muscles is associated with the YBT-UQ performance of the dominant upper limb in amateur volleyball players. Design: Cross-sectional study. Methods: A convenience sample of 22 male and 18 female volleyball players (≥12 h of training/week) between 18 and 26 years of age. The isometric strength of the middle trapezius, lower trapezius, serratus anterior, internal, and external rotator muscles was assessed with a handheld dynamometer. Participants performed the YBT-UQ in the superolateral, medial, and inferolateral directions. The absolute isometric peak force (in Newtons) was normalized to body weight (in Newtons per kilogram) for each muscle test. For each YBT-UQ direction, the distance (in centimeters) was normalized for upper limb length (in percentage). A backward multiple linear regression analysis was used to determine the associations between variables. Results: The analysis revealed that the isometric strength of the lower trapezius (β = 26.82; 95% confidence interval, 21.24–32.40) is associated with inferolateral YBT-UQ performance (adjusted R2 = .706; P < .001). This factor explains 70% of the variability of the YBT-UQ in the inferolateral direction. Conclusions: Lower trapezius isometric strength is associated with inferolateral YBT-UQ performance of the dominant upper limb in amateur volleyball players. These findings could help in the development of more specific training programs and rehabilitation goals according to the performance of the athletes in the test.

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The Clinical Investigation of Disparity of Utility Values Associated with Gallstone Disease: A Pilot Study

Gastroenterology Research and Practice ◽

10.1155/2013/216957 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Chung-Te Hsu ◽

Yi Liao ◽

Jorn-Hon Liu ◽

Tao-Hsin Tung

Keyword(s):

Clinical Investigation ◽

Gallstone Disease ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Older Age ◽

Outpatient Clinics ◽

Cross Sectional ◽

Utility Values ◽

Utility Evaluation

Purpose. The utility evaluation was an effective method to incorporate all of the contributing variables for multiple diseases into one outcome measure. A cross-sectional study was conducted to assess the utility values associated with varying states of gallstone disease among outpatient clinics participants at a teaching hospital in Taipei, Taiwan.Methods. The utility values were measured by using time trade-off method. A total of 120 outpatient clinics participants (30 subjects with no gallstone disease, 30 subjects with single stone, 30 subjects with multiple stones, and 30 subjects with cholecystectomy) evaluated utility values from January 1, 2006 to December 31, 2006. The diagnosis of gallstone disease was performed by a panel of specialists using ultrasound sonography.Results. The overall mean utility value was0.89±0.13(95% CI: 0.87–0.91) indicating that study participants were willing to trade about 11% (95% CI: 9–13%) of their remaining life in return for being free of gallstone disease perpetually. The significant associated factors of utility values based on the multiple linear regression analysis were older age and different degrees of gallstone disease.Conclusion. Our results found that in addition to older age, multiple stones and cholecystectomy could influence utility values from the patient’s preference-based viewpoint.

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Role of Crush Cytology for the Detection of Helicobacter Pylori in Gastroduodenal Diseases

Journal of Dhaka Medical College ◽

10.3329/jdmc.v17i2.6589 ◽

1970 ◽

Vol 17 (2) ◽

pp. 88-93

Author(s):

K Ahsan ◽

MZ Hossain ◽

MR Uddin

Keyword(s):

Helicobacter Pylori ◽

Histopathological Examination ◽

Cross Sectional Study ◽

Biopsy Material ◽

Cross Sectional ◽

Gastroduodenal Disease ◽

Duodenal Lesions ◽

Bismuth Salts ◽

H Pylori ◽

Low Sensitivity

Context: A cross-sectional study was carried out at the Department of Pathology, Dhaka Medical Collage, Dhaka and Immunology Laboratory, Laboratory Sciences Division of ICDDR,B, Dhaka during a period of 1 year from July, 2007 to June, 2008 to determine the efficacy of endoscopic crush cytology in the detection of Helicobacter pylori infection in gastroduodenal diseases. Clinically suspected cases of gastro-duodenal lesions and who had not taken antibiotics, omeprazole or bismuth salts for at least three weeks prior to endoscopy were selected. Patients who were clinically and endoscopically suspected of having malignancy were excluded from the study. A total of 110 such subjects were consecutively included in the study. The statistics used to analyze the data were descriptive statistics and components of accuracy test.Results: The sensitivity of crush cytology in correctly diagnosing H. pylori of those who had the disease was 89.3%, while the specificity of the test in correctly differentiating those who did not have H. pylori was 92.6% when compared against histopathological examination using Giemsa stain. However, a slightly low sensitivity (86.2%) without compromising with specificity (92.3%) was obtained when the crush cytology diagnosis was compared against histopathological examination using haematoxylin-eosin (H & E) stain.Conclusion: The study concludes that the diagnostic accuracy of crush smear cytology (sensitivity and specificity) for detection of Helicobacter pylori in gastric biopsy material is comparable to histopathology. Moreover, the technique is very simple, less expensive and less time consuming which gives clinicians added advantage in making a quicker decision.Key words: Cytology; Helicobacter pylori; Gastroduodenal disease. DOI: 10.3329/jdmc.v17i2.6589J Dhaka Med Coll. 2008; 17(2) : 88-93

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Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running

Journal of Applied Physiology ◽

10.1152/jappl.2001.90.4.1334 ◽

2001 ◽

Vol 90 (4) ◽

pp. 1334-1341 ◽

Cited By ~ 11

Author(s):

R. C. Hickner ◽

P. M. Mehta ◽

D. Dyck ◽

P. Devita ◽

J. A. Houmard ◽

...

Keyword(s):

Body Mass ◽

Muscle Glycogen ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Fat Free Mass ◽

Mass Ratio ◽

Low Fat ◽

Cross Sectional ◽

Leg Strength ◽

Downhill Running

The purpose of this study was to determine whether greater body fat mass (FM) relative to lean mass would result in more severe muscle damage and greater decrements in leg strength after downhill running. The relationship between the FM-to-fat-free mass ratio (FM/FFM) and the strength decline resulting from downhill running (−11% grade) was investigated in 24 male runners [age 23.4 ± 0.7 (SE) yr]. The runners were divided into two groups on the basis of FM/FFM: low fat (FM/FFM = 0.100 ± 0.008, body mass = 68.4 ± 1.3 kg) and normal fat (FM/FFM = 0.233 ± 0.020, body mass = 76.5 ± 3.3 kg, P < 0.05). Leg strength was reduced less in the low-fat (−0.7 ± 1.3%) than in the normal-fat individuals (−10.3 ± 1.5%) 48 h after, compared with before, downhill running ( P < 0.01). Multiple linear regression analysis revealed that the decline in strength could be predicted best by FM/FFM ( r2= 0.44, P < 0.05) and FM-to-thigh lean tissue cross-sectional area ratio ( r2= 0.53, P < 0.05), with no additional variables enhancing the prediction equation. There were no differences in muscle glycogen, creatine phosphate, ATP, or total creatine 48 h after, compared with before, downhill running; however, the change in muscle glycogen after downhill running was associated with a higher FM/FFM ( r = −0.56, P < 0.05). These data suggest that FM/FFM is a major determinant of losses in muscle strength after downhill running.

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Characteristics of Brain Structure in HIV Male Patients with Syphilis Co-Infection: A Cross-Sectional Study.

10.21203/rs.3.rs-155540/v1 ◽

2021 ◽

Author(s):

Yu Qi ◽

Yuan-Yuan Wang ◽

Wei Wang ◽

Xu-Ze Liu ◽

Jing Liu ◽

...

Keyword(s):

Corpus Callosum ◽

Diffusion Tensor ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Infected Male ◽

Syphilis Infection ◽

Cross Sectional ◽

Corona Radiata ◽

Male Patients ◽

The Right

Abstract Background To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients through comparing the differences of WM between HIV-infected male patients with and without syphilitic infection using diffusion tensor imaging (DTI).Methods 27 HIV-infected male patients with current syphilis or a history of syphilis (HIV+/syphilis+) and 29 HIV-infected male patients without syphilis co-infection history (HIV+/syphilis-) were enrolled. All patients received DTI and comprehensive neuropsychological assessment. Clinical data were compared between the two groups with T-test, Mann-Whitney U Test and Chi-square Test. Tract-based spatial statistics (TBSS) was adopted to analyze the DTI metrics. Multiple linear regression analysis was conducted to investigate the relationships between DTI metrics and clinical variables and cognitive performance. Results In the HIV+/syphilis+ group, decreased AD was found in the right superior corona radiata (SCR-R) and body of corpus callosum (BCC); increased RD was found in the bilateral posterior corona radiata (PCR), the right posterior thalamic radiation (PTR-R), the left SCR (SCR-L), splenium of corpus callosum (SCC) and BCC; decreased FA was found in multiple regions. AD in BCC was negatively correlated with CD4/CD8 ratios. AD in SCR-R was positively correlated with CD4/CD8 ratios. Patients in HIV+/syphilis+ group had a lower score in complex motor skills (CMS). RD in SCC and SCR-L was negatively correlated with CMS; RD in PTR-R was positively correlated with CMS. AD in SCR-R was positively correlated with CMS. Conclusions Compared with patients simply infected with HIV, the integrity of WM is more seriously impaired in HIV-infected patients with syphilis co-infection, and it may accelerate the impairment of cognitive function.

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Helicobacter pylori infection reduces the risk of gastroesophageal reflux disease

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-193-9-96-101 ◽

2021 ◽

pp. 96-101

Author(s):

R. I. Khlynova ◽

O. M. Khromtsova ◽

R. B. Berdnikov ◽

I. B. Khlynov

Keyword(s):

Helicobacter Pylori ◽

Gastroesophageal Reflux Disease ◽

Gastric Mucosa ◽

Gastroesophageal Reflux ◽

Observational Study ◽

Reflux Disease ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Biopsy Specimens ◽

H Pylori

The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.

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