The Effect of Age and Occupation on the Seroprevalence of Helicobacter pylori Infection

Serological studies in developed and developing countries using enzyme-linked immunosorbent assays have validated this technique as a rapid, noninvasive method for the diagnosis of Helicobacter pylori infections. The prevalence of serum antibodies to H pylori was studied in 473 Canadian blood donors from Manitoba, 212 healthy Japanese. and 226 healthy Americans. As expected, the seroprevalence rose progressively with age in the three populations and reached its peak (greater than 55%) in subjects 60 years of age and older. The seroprevalence did not decrease in elderly persons (60 to 99 years), indicating a persistent immune response. More detailed analysis was perfom1ed on the Canadian population. Age-adjusted prevalence rates in men and women were similar. Among young adults (15 to 29 years). farmers had a significantly higher seroprevalence rate than white-collar or blue-collar workers. but in older persons occupational rates were similar. A multiple linear regression analysis of the data confirmed that age and occupation in young adults were both significantly associated with seroprevalence of H pylori infections.

Download Full-text

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

10.21203/rs.3.rs-47476/v1 ◽

2020 ◽

Author(s):

Jaehong Park ◽

Tae Jun Kim ◽

Joo Hye Song ◽

Hyemin Jang ◽

Ji Sun Kim ◽

...

Keyword(s):

Helicobacter Pylori ◽

Cortical Thickness ◽

Smoking Status ◽

Inflammatory Marker ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Intracranial Volume ◽

Cross Sectional ◽

Normal Males ◽

H Pylori

Abstract Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

Download Full-text

Immunoglobulin G Antibody against Helicobacter pylori: Clinical Implications of Levels Found in Serum

Clinical and Vaccine Immunology ◽

10.1128/cdli.9.5.1044-1048.2002 ◽

2002 ◽

Vol 9 (5) ◽

pp. 1044-1048 ◽

Cited By ~ 2

Author(s):

Tseng-Shing Chen ◽

Fen-Yau Li ◽

Full-Young Chang ◽

Shou-Dong Lee

Keyword(s):

Helicobacter Pylori ◽

Chronic Gastritis ◽

Predictive Value ◽

Linear Regression Analysis ◽

Serum Antibody ◽

Quantitative Detection ◽

Enzyme Linked Immunosorbent Assay ◽

Multivariate Linear Regression Analysis ◽

H Pylori ◽

Antibody Levels

ABSTRACT The clinical significance of high levels of antibody against Helicobacter pylori is still unclear. We sought to evaluate whether the serum antibody levels could predict the presence of macroscopic gastroduodenal disease, to identify factors that correlate with antibody levels in a multivariate context, and to determine the predictive value of antibody levels for diagnosing H. pylori infection. The grades of gastritis and density of H. pylori colonization were scored separately using the updated Sydney system for antral and body mucosa. An enzyme-linked immunosorbent assay (ELISA) for the quantitative detection in serum of IgG antibodies to H. pylori was performed. Of the 170 dyspeptic patients, 105 (62%) had H. pylori infection. There was no difference in antibody levels among endoscopic findings of normal mucosa, chronic gastritis, and duodenal ulcer. On multivariate linear regression analysis, the status of H. pylori infection, mononuclear cell infiltration of body mucosa, and age correlated with antibody levels. The negative predictive value for antibody levels of <30 U/ml is 94%, and the positive predictive value of antibody levels of >70 U/ml is 98%. We conclude that serum antibody levels do not predict the severity of gastroduodenal diseases or the density of H. pylori colonization in H. pylori-infected dyspeptic patients. Higher levels are associated with the presence of H. pylori infection, the chronic gastritis score of the corpus, and older age. Setting a gray zone is necessary for ELISA, since the accuracy in this zone does not allow a precise determination of H. pylori status.

Download Full-text

Gratitude and Forgiveness as Predictors of Subjective Well-Being Among Young Adults in Pakistan

Pakistan Journal of Psychological Research ◽

10.33824/pjpr.2020.35.4.39 ◽

2020 ◽

Vol 35 (4) ◽

pp. 725-738

Author(s):

Hudaa Hermaen ◽

Zainab Hussain Bhutto

Keyword(s):

Young Adults ◽

Regression Analysis ◽

Linear Regression Analysis ◽

Explanatory Power ◽

Well Being ◽

Multiple Linear Regression Analysis ◽

Extensive Study ◽

Subjective Well Being ◽

Positive Relation ◽

The Impact

The present study was aimed to explore the impact of gratitude and forgiveness in predicting subjective well-being in young adults. The sample for the study included 300 participants between the ages of 18 and 24 years who were conveniently selected from a university in Karachi city. Gratitude Questionnaire (McCullough et al., 2002), Heartland Forgiveness Scale (Thompson et al., 2005) and Flourishing Scale (Diener et al., 2010) were used as the measures to collect data. Multiple linear regression analysis revealed gratitude to be nonsignificant predictor of subjective well-being, whereas, forgiveness was found to be a significant predictor of subjective well-being . Further, weak positive relation of gratitude with subjective well-being (r = .14), and forgiveness with subjective well-being (r = .34) has been found. However, the explanatory power of this model was revealed to be significant (R2 = .12), suggesting that the variables share an important association which needs further extensive study. This study implies that forgiveness and gratitude may be effectively used in psychotherapy and substantially integrated in general counselling for young adult clients.

Download Full-text

A Comparative Study of the Peak Expiratory Flow Rate of Indian and Nepalese Young Adults in a Teaching Institute

Journal of Nepal Medical Association ◽

10.31729/jnma.207 ◽

2009 ◽

Vol 47 (169) ◽

Author(s):

Parthasarathi Debray ◽

B M Shreevatsa ◽

R B MG ◽

T K Sen ◽

S Roy ◽

...

Keyword(s):

Young Adults ◽

Linear Regression ◽

Multiple Linear Regression ◽

Adult Population ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Prediction Equation ◽

Regression Equation ◽

Stepwise Multiple Linear Regression ◽

The Mean

Peak expiratory fl ow rate (PEFR) measurement is the easiest and cheapest method to evaluaterespiratory functions. So, the study was carried out to evaluate PEFR of healthy Nepalese adults andcompare their values with healthy Indian counterparts to know whether Indian prediction equationsfor PEFR can be used for Nepalese adult population or not.One hundred twenty-three healthy, young, non smoker adult Indian (64: 28 Males, 36 Females) andNepalese (59: 32 Males, 27 Females) medical students of 18 to 20 years of age participated in the study.The mean PEFR of Indian (male: 490.4 liter/min, female: 386.0 liter/min) and Nepalese (male: 485.9liter/min, Female: 365.2 liter/min) young adults were found to have no signifi cant differences.As there is no signifi cant difference in the mean PEFR of Indian and Nepalese young adults, predictionequations made for Indian adults can be used to predict PEFR of Nepalese subjects. Therefore, anattempt has been made to formulate a regression equation from the combined Indian and Nepalesesubjects. A stepwise, multiple, linear, regression analysis was performed for this purpose. The analysisshowed that height is the best predictor for PEFR in the present study. The regression equation basedon height for the combined Indian and Nepalese young adults is calculated as: PEFR = 5.687 × Height(cm) – 495.787. However, a stepwise, multiple, linear, regression equation with residual analysisfor the best fi t model was performed to formulate prediction equation for PEFR and this showed achange of the earlier regression equation to PEFR = 5.930 × Height (cm) – 536.131.Keywords: Peak expiratory fl ow rate, peak fl ow meter, prediction equation, spirometry, youngadults

Download Full-text

Connection between basic values and emigration attitudes of Russian youth

Izvestiya of Saratov University New Series Series Educational Acmeology Developmental Psychology ◽

10.18500/2304-9790-2021-10-4-323-333 ◽

2021 ◽

Vol 10 (4) ◽

pp. 323-333

Author(s):

Zhanagul Zh. Romasheva ◽

◽

Olga V. Kalinichenko ◽

Ivan V. Malyshev ◽

◽

...

Keyword(s):

Young Adults ◽

Linear Regression Analysis ◽

Well Being ◽

Multiple Linear Regression Analysis ◽

International Mobility ◽

Individual Values ◽

Positive Correlation ◽

Openness To Change ◽

Personal Attitudes ◽

Youth Attitudes

The ambiguity and inconsistency of the data on the connection between emigration attitudes and metavalues spurs the research on the relation between emigration attitudes and basic values. Hence, the problem of studying the deterministic character of youth attitudes to emigration is seen as of relevance. The purpose of this research is to determine the nature of the connection between basic values and emigration attitudes. Hypotheses: 1. The basic values that make up metavalues act as the predictors of emigration attitudes. 2. The basic values constituting the contrastive metavalues of Preservation and Openness to Change are simultaneously connected with emigration attitudes, and the nature of their connections is different. 3. The basic values constituting the metavalue of Self-Affirmation have a positive correlation with emigration attitudes. The study is carried out on a sample of respondents (N = 646) aged 17 to 35, including 78% (504) of women. The research applies the “Scales of Migration Attitudes” (S. A. Kuznetsova, I. Yu. Kuznetsov, A. V. Feshchenko) modified to study emigration attitudes. The study also uses PVQ-21–ESS7 versions of the questionnaire measuring individual values (Sh. Schwartz) which enables to document the degree of expression of values. Finally, the research makes use of the method of multiple linear regression analysis. The results show that the attitude of the subject is the most pronounced one among all other components of emigration attitudes (the attitude of the loved ones, the expectations of the loved ones). Basic values have a major impact on the revealed connections between emigration attitudes and metavalues. For example, the values of tradition and security have a negative correlation with the metavalue of Preservation. The values of stimulation have a positive correlation with the metavalue of Openness to Change. The values of power have a positive correlation with the metavalue of Self-Affirmation. Evidently, young adults are more likely to plan to emigrate due to their personal attitudes and motives rather than to those of their close environment. Attitudes towards emigration are expressed by those young adults who: 1) are less focused on traditions and customs but appreciate security; 2) strive to enrich their lives with new sensations and emotions; 3) appreciate material well-being. The results of the study reveal the factors contributing to the emergence of attitudes to emigration in young adults. The results of the study can be used to predict international mobility of young adults. Additionally, they are of importance for the psychological work with potential emigrants.

Download Full-text

Significant Association between Serum Interleukin-6 andHelicobacter pyloriAntibody Levels amongH. pylori-Positive Japanese Adults

Mediators of Inflammation ◽

10.1155/2013/142358 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 15

Author(s):

Hiroko Nakagawa ◽

Takashi Tamura ◽

Yoko Mitsuda ◽

Yasuyuki Goto ◽

Yoshikazu Kamiya ◽

...

Keyword(s):

Interleukin 6 ◽

Breath Test ◽

Geometric Mean ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Urea Breath Test ◽

Japanese Adults ◽

H Pylori ◽

Igg Level ◽

Multifunctional Cytokine

Background. Interleukin-6 (IL-6) is a multifunctional cytokine produced by many types of cells. Inflammation plays a key role in the pathogenesis of atherosclerosis that is an underlying cause of coronary heart disease (CHD). Since the 1990s, some studies have shown an association betweenH. pyloriinfection and CHD, which may be mediated by inflammation. Therefore, this study aimed to evaluate the association between serum anti-H. pyloriIgG levels and serum IL-6 levels inH. pylori-infected adults.Methods.We enrolled 158 subjects who visited a clinic located in an urban area to be tested forH. pyloriinfection, using the13C-urea breath test, and who were found to be infected and subsequently received eradication.Results.The geometric mean serum IL-6 level was 1.78 pg/mL for men, 1.57 pg/mL for women, and 1.64 pg/mL overall. Logarithms of serum IL-6 levels were positively correlated with logarithms of serumH. pyloriIgG levels(r=0.24, P=0.002). In multiple linear regression analysis adjusting for sex and age, the serum IL-6 level was still significantly associated with the IgG level in all subjects(β=0.18, P=0.012).Conclusion.HigherH. pyloriIgG levels were significantly associated with higher serum IL-6 levels amongH. pylori-infected individuals.

Download Full-text

Contact disturbance and self-esteem as the predictors of the abuse perceived in romantic relationshipRomantik ilişkilerde algılanan istismarın yordayıcıları olarak temas engelleri ve benlik saygısı

Journal of Human Sciences ◽

10.14687/jhs.v15i2.4996 ◽

2018 ◽

Vol 15 (2) ◽

pp. 707 ◽

Cited By ~ 2

Author(s):

Özlem Tagay ◽

Fatma Çalışandemir ◽

Perihan Ünüvar

Keyword(s):

Young Adults ◽

Romantic Relationships ◽

Romantic Relationship ◽

Work Group ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Self Esteem ◽

English Summary ◽

Correlation Technique ◽

Full Contact

Abuse in romantic relationships, in a general sense, includes provision of power and control by means of physical, psychological and sexual senses by couples who are in an emotional relationship. The aim of this study is to examine the relationship between young adults’ perceived abuse in romantic relationships and their self-esteem and contact disturbances. Work group of the study consisted of a total of 255 young adults including 182 women (71.4%) and 73 men (28.6%) whose age ranged between 21 and 35. Considering relationship status in the work group, it was specified that 91 of young adults did not have any relationships, 67 of them had a relationship, 23 of them were engaged, 72 of them were married and 2 of them were divorced. Research data was collected through Romantic Relationships Assessment Scale, Contact Disturbances Scale and Rosenberg Self-Esteem Scale. For the analysis of data obtained, Pearson Moment Correlation technique and multiple linear regression analysis were used. When research results were examined, it was found that full contact disturbances predicted perceived abuse in romantic relationships significantly in positively and self-esteem predicted perceived abuse significantly negatively.Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetRomantik ilişkilerde yaşanan istismar en genel anlamda duygusal beraberliği olan çiftlerin birbirlerine karşı fiziksel, psikolojik ve cinsel anlamda baskı yoluyla güç ve kontrol sağlamasıdır. Bu çalışmanın amacı genç yetişkinlerin romantik ilişkilerinde algıladıkları istismar ile temas engelleri ve benlik saygısı arasındaki ilişkiyi incelemektedir. Araştırmanın çalışma grubunu Burdur ilinde yaşayan lisans mezunu ve lisan son sınıfa devam eden yaşları 21 ile 35 arasında değişen 182 kadın (%71,4) ve 73 erkek (%28,6) olmak üzere toplam 255 genç yetişkin oluşturmaktadır. Çalışma grubunun ilişki durumuna bakılacak olursa genç yetişkinlerin 91’i ilişkisinin olmadığını, 67’si flört yaşadığını, 23’ü nişanlı olduğunu, 72’si evli olduğunu, 2’si boşanmış olduğunu belirtmiştir. Araştırmanın verileri Romantik İlişkileri Değerlendirme Ölçeği, Temas Engelleri Ölçeği ve Rosenberg Benlik Saygısı Ölçeği ile elde edilmiştir. Elde edilen verilerin analizi için Pearson Momentler Çarpımı Korelasyon tekniği ve çoklu doğrusal regresyon analizi kullanılmıştır. Araştırma sonuçları incelendiğinde tam temas engelinin romantik ilişkilerde algılanan istismarı pozitif yönde anlamlı düzeyde yordadığı ve benlik saygısının ise romantik ilişkilerde algılanan istismarı negatif yönde anlamlı düzeyde yordadığı bulunmuştur.

Download Full-text

Is the Utilization of Helicobacter pylori Stool Antigen Tests Appropriate in an Urban Canadian Population?

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz210 ◽

2020 ◽

Vol 153 (5) ◽

pp. 686-694

Author(s):

Irene Ma ◽

Maggie Guo ◽

Dylan R Pillai ◽

Deirdre L Church ◽

Christopher Naugler

Keyword(s):

Helicobacter Pylori ◽

Census Data ◽

Laboratory Data ◽

Stool Antigen Test ◽

Testing Rate ◽

Canadian Population ◽

Risk Patients ◽

Stool Antigen ◽

Antigen Tests ◽

H Pylori

Abstract Objectives Helicobacter pylori stool antigen test (HpSAT) appropriateness was investigated by assessing its testing and positivity rates in Calgary, Canada. Methods The laboratory information system was accessed for all patients who received an HpSAT in 2018. Testing volume, test results, age, and sex of patients were collected. Sociodemographic risk factors and geospatial analysis were performed by matching laboratory data to the 2016 census data. Testing appropriateness was defined as a concordance between testing and positivity rates for each sociodemographic variable. Results In 2018, 25,518 H pylori stool antigen tests were performed in Calgary, with an overall positivity rate of 14.7%. Geospatial mapping demonstrated significant distribution variations of testing and positivity rates of HpSAT in the city. Certain sociodemographic groups studied (eg, recent immigrants) appeared to be appropriately tested (testing rate relative risk [RR] = 2.26, positivity rate RR = 4.32; P < .0001), while other groups (eg, male) may have been undertested (testing rate RR = 0.85, positivity rate RR = 1.14; P < .0001). Conclusions Determining concordance of testing and positivity rate of a laboratory test can be used for assessing testing appropriateness for other diseases in other jurisdictions. This study demonstrated some at-risk patients may be missed for H pylori testing.

Download Full-text

The rod-to-coccoid body transformation in cultures of Helicobacter pylori

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160686 ◽

1990 ◽

Vol 48 (3) ◽

pp. 626-627

Author(s):

A. R. Crooker ◽

W. G. Kraft ◽

T. L. Beard ◽

M. C. Myers

Keyword(s):

Helicobacter Pylori ◽

Growth Cycle ◽

Negative Bacterium ◽

Body Formation ◽

Coccoid Form ◽

Spiral Form ◽

Prolonged Culture ◽

H Pylori ◽

Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

Download Full-text