Systolic Dyssynchrony Index as a Diagnostic Tool for Subclinical Cardiac Involvement of Sarcoidosis: A cross-sectional single center study.
Abstract Purpose: Sarcoidosis with cardiac involvement has a relatively high morbidity and mortality, and early diagnose of cardiac sarcoidosis is a critical issue. Systolic dyssynchrony index (SDI) measured by three-dimensinonal echocardiography was used in our study for detection of subclinical left ventricular (LV) systolic dysfunction in patients with sarcoidosis and normal LV function on two-dimensional echocardiography.Methods: Forty-four patients diagnosed with sarcoidosis (without clinically apparent cardiac involvement) and 44 healthy control subjects were included in this study. Conventional 2D echocardiographic parameters and SDI measured by 3D echocardiography were analyzed in all participants.Results: While two-dimensional echocardiographic results of study groups were similar; SDI_16 (SDI for 16 segments of LV) results were significantly higher in sarcoidosis group compared to healthy controls (6.99 + 5.02 vs 2.89 + 1.32, p<0.0001), and 47.7% of patients with sarcoidosis had SDI_16 value of >6%.Conclusion: SDI_16 was higher in patients with sarcoidosis and this parameter could be used as a marker to identify patients with cardiac involvement of sarcoidosis in the early phase.