scholarly journals Thyroid and Sex Hormones Ratios in Predicting Breast Cancer Risk

2021 ◽  
Author(s):  
Kasuni Akalanka ◽  
Sagarika Ekanayake ◽  
Kamani Samarasinghe
Keyword(s):  
Breast Cancer ◽  
Sex Hormones ◽  
Significant Risk ◽  
Serum Testosterone ◽  
Subclinical Hyperthyroidism ◽  
Newly Diagnosed ◽  
Healthy Women ◽  
History Of ◽  
Normal Controls ◽  
Tsh Levels

Abstract Purpose: The study intended to analyze the incidence of thyroid related diseases and to assess thyroid to sex hormones ratios of breast cancer (BC) patients Methods: TSH, T3, T4, Estrogen, progesterone and testosterone levels of newly diagnosed BC patients (n=155) aged 30 to 75 years and age-matched normal controls (n=75) were analyzed. Data on history of thyroid related diseases were collected from an interviewer administered questionnaire. Thyroid/sex hormone ratios were analyzed and compared against healthy women. Results: History of thyroid related diseases was significantly higher (p<0.05) in BC patients compared to controls. Patients (10%) with history of thyroid related diseases were excluded from the study. Subclinical hyperthyroidism was identified among 14% of the remaining BC patients and was the only dysfunction (7%) among healthy women. Significantly higher (p<0.05) mean T3 and T4 values, lower TSH levels and non-significant levels of estrogen and progesterone were observed in patients with BC when compared to healthy. Serum Testosterone of BC patients were significantly low (p<0.05). Considering the thyroid to sex hormones ratios among postmenopausal women, T3/testosterone, T4/testosterone, T3/estrogen, T4/ estrogen, ratios were significantly different in the two groups and the highest significance was found with T3/testosterone. Cutoff values studied from receiver operative characteristic curves indicated that a woman having T3/testosterone above 7.47 showed 12.5 times odds (p=0.000) of being diagnosed with BC. Conclusion: Incidence of thyroid related diseases are higher among BC patients and elevation of T3/testosterone ratio indicated a significant risk of BC. However, a study involving a larger number of participants could confirm the above.

scholarly journals Expanding the search for germline pathogenic variants for breast cancer. How far should we go and how high should we jump? The missed opportunity!

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Hikmat Abdel-Razeq
Keyword(s):  
Breast Cancer ◽  
Brca1 And Brca2 ◽  
Healthy Women ◽  
Panel Testing ◽  
Pathogenic Variants ◽  
Gene Panel Testing ◽  
History Of ◽  
Risk Reducing ◽  
Current Guidelines ◽  
Missed Opportunity

Since the identification of BRCA1 and BRCA2 genes 3 decades ago, genetic testing and genetic counseling have become an integral part of routine clinical practice. The risk of breast cancer among carriers of germline pathogenic variants, like BRCA1 and BRCA2, is well established. Risk-reducing interventions, including bilateral mastectomies and salpingo-oophorectomies are both effective and have become more acceptable. Many researchers and professional societies view current guidelines as restrictive and may miss many at-risk women, and are calling to expand testing to include all patients with breast cancer, regardless of their personal or family history of cancer, while others are calling for wider adoption to even include all healthy women at age 30 or older. This review will address expanding testing in two directions; horizontally to include more patients, and even healthy women, and vertically to include more genes using next-generation sequencing-based multi-gene panel testing.

scholarly journals Breast cancer prevention: what women think about the illness, its risks and self-care

Psico ◽  
2018 ◽  
Vol 49 (3) ◽  
pp. 266
Author(s):  
Carolina Ribeiro Seabra ◽  
Maria Júlia Armiliato ◽  
Luisa Vital ◽  
Paola Otaran ◽  
Ana Carolina Peuker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Perception ◽  
Illness Perception ◽  
Self Care ◽  
Personal History ◽  
Cáncer De Mama ◽  
Healthy Women ◽  
History Of ◽  
The Relationship ◽  
Illness Coherence

Background: Early detection of breast cancer (BC) is important to reduce mortality rates. To prevent BC, women should adopt self-care behaviors. This study aimed at examining risk and illness perception and self-care of healthy women regarding breast cancer. Methods: Participants were 211 women (M = 59.11 years, SD = 8.54) and with no personal history of the illness, selected by convenience. Measures were a sociodemographic, clinical and health behavior questionnaire, illness perception and risk perception questionnaires. Nonparametric statistics (Spearman) was employed to analyze the relationship between illness perception, risk perception and sociodemographic variables. The open answers to the causes of the illness were classified according to the content analysis. Results: We found a relationship between risk and illness perception and self-care in healthy women regarding BC. It was identified that women had reasonable illness coherence (M = 3.18) and considered the illness more timeline chronic than timeline acute (M = 3.22), reasonable timeline cyclical (M = 3.56), with severe consequences for health (M = 4.22), and reasonably threatening (M = 3.15). Conclusions: BC and risk perception and self-care are interrelated variables among healthy women. ***Prevenção do cancer de mama: o que as mulheres pensam sobre a doença, seus riscos e autocuidado***Introdução: A detecção precoce do câncer de mama (CM) é importante para reduzir as taxas de mortalidade. Para preveni-lo, a mulher deve adotar comportamentos de autocuidado em saúde. Esse estudo objetiva examinar a percepção de risco, a percepção da doença e o autocuidado de mulheres saudáveis com relação ao CM. Método: Participaram 211 mulheres (M = 59,11 anos; DP = 8,54) sem histórico de CM selecionados por conveniência. Os instrumentos foram questionário de dados sociodemográficos, clínicos e decomportamento em saúde, questionários de percepção da doença e percepção de risco. Estatística não paramétrica (Spearman) foi utilizada para analisar a relação entre percepção da doença, percepção de risco e variáveis sociodemográficas. As respostas abertas sobre as causas da doença foram classificadas segundo análise de conteúdo. Resultados: Observou-se que existe relação entre a percepção de risco e da doença, e autocuidado em mulheres saudáveis. Identificou-se que as mulheres têm razoável percepção de entendimento da doença (M = 3.18), a consideravam mais crônica que aguda (M = 3.22), razoavelmente cíclica (M = 3,56), com consequências graves à saúde (M = 4,22), e relativamente ameaçadora (M = 3,15). Conclusões: A percepção do CM, a percepção de risco e o autocuidado são variáveis inter-relacionadas em mulheres saudáveis.Palavras-chave: Neoplasias; Autorregulação; Câncer de mama; Autocuidado.

A PRELIMINARY STUDY OF RISK FACTORS OF BREAST CANCER AND THE USEFULNESS OF BREAST MRI AS AN ADDITION TO MAMMOGRAPHY IN DETECTING BREAST CANCER IN HIGH RISK WOMEN

2016 ◽  
Vol 78 (11-3) ◽  
Author(s):  
Noor Khairiah A. Karim ◽  
Rohayu Hami ◽  
Nur Hashamimi Hashim ◽  
Nizuwan Azman ◽  
Ibrahim Lutfi Shuaib
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
High Risk ◽  
Cancer Detection ◽  
Significant Risk ◽  
Breast Mri ◽  
Breast Cancer Detection ◽  
P Value ◽  
High Risk Women ◽  
History Of

The risk factors of breast cancer among women, such as genetic, family history and lifestyle factors, can be divided into high-, intermediate- and average-risk. Determining these risk factors may actually help in preventing breast cancer occurrence. Besides that, screening of breast cancer which include mammography, can be done in promoting early breast cancer detection. Breast magnetic resonance imaging (MRI) has been recommended as a supplemental screening tool in high risk women. The aim of this study was to identify the significant risk factor of breast cancer among women and also to determine the usefulness of breast MRI as an addition to mammography in detection of breast cancer in high risk women. This retrospective cohort study design was conducted using patients’ data taken from those who underwent mammography for screening or diagnostic purposes in Advanced Medical and Dental Institute, Universiti Sains Malaysia, from 2007 until 2015. Data from 289 subjects were successfully retrieved and analysed based on their risk factors of breast cancer. Meanwhile, data from 120 subjects who had high risks and underwent both mammography and breast MRI were further analysed. There were two significant risk factors of breast cancer seen among the study population: family history of breast cancer (p-value=0.012) and previous history of breast or ovarian cancer (p-value <0.001). Breast MRI demonstrated high sensitivity (90%) while mammography demonstrated high specificity (80%) in detection of breast cancer in all 120 subjects. The number of cases of breast cancer detection using breast MRI [46 (38.3%)] was higher compared to mammography [24 (20.0%)]. However, breast MRI was found to be non-significant as an adjunct tool to mammography in detecting breast cancer in high risk women (p-value=0.189). A comprehensive screening guideline and surveillance of women at high risk is indeed useful and should be implemented to increase cancer detection rate at early stage

scholarly journals Miscellaneous Exogenous Hormones and Breast Diseases: A Matter of Concern for the Gynecologist

2019 ◽  
pp. 150-155
Author(s):  
Sadaf Alipour ◽  
Amirhossein Eskandari
Keyword(s):  
Breast Cancer ◽  
Sex Hormones ◽  
Hormone Replacement ◽  
Positive Family History ◽  
Hormonal Contraceptives ◽  
Breast Diseases ◽  
History Of ◽  
Comprehensive Search ◽  
Contraceptive Implants ◽  
Benign Disorders

Background: The effect of exogenous sex hormones on the risk of breast cancer has been shown for some compounds but for other compounds it is under detailed investigation. This study, as part of a quadruple of articles reviewing the consequences of using sex hormones in women with various breast conditions, discusses the prescription of non-oral hormonal contraceptives and miscellaneous exogenous steroid hormones. Methods: We browsed international clinical guidelines and carried out a comprehensive search in the literature by relevant keywords in order to extract data about the effects of hormone-releasing intrauterine devices, injectable depot-medroxyprogesterone acetate, contraceptive implants, cyproterone acetate, finasteride, and spironolactone on the breast. Results: Studies are scarce for most of these compounds, and information comes mainly from researches about oral contraceptives and hormone replacement therapy. Although none is recommended for use in patients with breast cancer, administration in benign disorders of the breast, women with positive family history of breast cancer and general women is acceptable with minor risks. Conclusions: Most non-oral hormonal methods of contraception and miscellaneous available hormone compounds prescribed for the treatment of hormonal disorders are safe for temporary use, except for women with breast cancer. For them, analogues of gonadotropin-releasing hormones may be considered a safe hormonal prescription.

Personal history of atypical ductal hyperplasia and risk of multifocal breast cancer among newly diagnosed women: Implications for workup and management.

2014 ◽  
Vol 32 (30_suppl) ◽  
pp. 300-300
Author(s):  
Curtis Lee Petersen ◽  
Tracy Onega
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Atypical Ductal Hyperplasia ◽  
Newly Diagnosed ◽  
Multifocal Breast Cancer ◽  
Ductal Hyperplasia ◽  
Significant Difference ◽  
History Of ◽  
In Situ Breast Cancer

300 Background: Multifocal breast cancer (MFBC) is associated with a higher risk of mortality than unifocal and often changes evaluation and management compared to unifocal breast cancer. Although there are known risk factors for invasive breast cancer, including atypical ductal hyperplasia (ADH), none have been explicitly associated with risk of MFBC. Our objective was to determine if there is an association between ADH and MFBC to help guide clinical decisions in workup and management in women with newly-diagnosed breast cancer. Methods: Using data (1999-2008) from the New Hampshire Mammography Network (NHMN) – a longitudinal breast imaging registry, including pathology data – we identified a cohort of 3,039 women (median age: 59) with a diagnosis of invasive or in situ breast cancer, and ascertained all prior biopsy results if applicable. We performed multivariable logistic regression to test the association of ADH with MFBC v. unifocal, adjusting for other benign breast disease, family history, breast density, age, race, and DCIS/invasive. Results: Of the 3,039 women with breast cancer during the study period, 498 had a diagnosis of ADH (16.4%) and 277 had MFBC (9.1%). Women with a history of ADH had over a two-fold greater likelihood of having MFBC compared to women without an ADH diagnosis (OR: 2.20, 95% CI: 1.61-2.99). No notable difference in this association was noted for DCIS v. invasive, and no other risk factors were found to have a significant difference, except for number of biopsies. Conclusions: We found that ADH diagnosis is positively associated with MFBC among women with a diagnosed invasive or in situ breast cancer. Our results suggest that among women with a newly diagnosed breast cancer, history of an ADH diagnosis increases the pre-test probability of MFBC, which may influence evaluation of extent of disease, such as adding breast MRI, and ultimately in treatment and management.

Gynecological Cancer as a Second Malignancy in Patients With Breast Cancer

2017 ◽  
Vol 27 (6) ◽  
pp. 1298-1304 ◽  
Author(s):  
Budhi Singh Yadav ◽  
Suresh C. Sharma ◽  
Firuza D. Patel ◽  
Bhavana Rai ◽  
Sushmita Ghoshal
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Relative Risk ◽  
Family History ◽  
Hormonal Therapy ◽  
Gynecological Cancer ◽  
Significant Risk ◽  
Second Primary ◽  
Second Malignancy ◽  
History Of

PurposeThe aim of this study was to determine the incidence and risk factors for gynecological cancer as second malignancy (SM) after treatment of breast cancer (BC).Methods and MaterialsBetween January 1985 and December 2007, a total of 2756 patients with BC were analyzed for gynecological cancers as an SM. Analysis was carried out for patient-, disease-, and treatment-related characteristics. The Cox proportional hazards regression model was used to estimate the relative risk of gynecologic malignancies.ResultsThe median age at BC diagnosis was 49 years and median follow-up of 14 years. In total, 25 cases of gynecological cancer were noted with an incidence of 0.9%. We observed 9 ovarian and endometrium (0.3%) as well as 7 uterine cervix (0.25%) cancers. Family history of BC was the most significant risk factor for SM (relative risk, 7.4; 95% confidence interval, 3.03–18.28; P<0.001). Women with a family history of BC had a higher incidence of endometrial (12%) and ovarian (16%) cancer compared with those who have no family history (0.1%, P = 0.003). Statistically significant higher incidence of endometrial cancer was seen in patients undergoing hormonal therapy (0.4%) as compared with those who are not undergoing hormonal therapy (0.1%, P = 0.001). Most of the endometrial (88.9%) and cervical (71%) cancers were detected at an early stage but ovarian cancers (66.6%) in advanced stage. Chemotherapy and radiotherapy did not increase the risk of gynecological SM.ConclusionsWomen with BC are at risk of developing a second primary gynecological malignancy particularly of endometrium and ovary. Family history of BC was a high risk factor for gynecologic SM. These patients should be followed up for its early detection.

scholarly journals PATH-64. PROSPECTIVE, BLINDED PLASMA BASED ANALYSIS FOR DIAGNOSIS OF NEWLY DIAGNOSED GLIOMA

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi157-vi158
Author(s):  
Ian Lee ◽  
Lisa Scarpace ◽  
Rachel Hunt ◽  
Kevin Nelson ◽  
Darshana Patil ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
Molecular Testing ◽  
Low Grade ◽  
Newly Diagnosed ◽  
Dna And Rna ◽  
Blinded Study ◽  
Treatment Naïve ◽  
Droplet Pcr ◽  
History Of ◽  
Normal Controls

Abstract INTRODUCTION In patients with newly diagnosed intracerebral lesions, gliomas are often suspected. However, other conditions such as multiple sclerosis, abscess or lymphoma are possible, as well. Furthermore, biopsy can be challenging due to eloquent and/or deep location within the brain. In this prospective, blinded study, analysis of plasma isolated cell-free DNA and exosome mRNA and miRNA from newly diagnosed glioma patients and from cancer-free volunteers was used to predict disease. METHODS Plasma was drawn from 52 patients with newly diagnosed gliomas (28 high grade glioma (HGG), 10 low grade (LGG)) and 14 patients without documented history of cancer and recent MRI brain which was negative for brain tumor. High quality DNA and RNA was isolated and sequenced using Next Generation Sequencing and Digital Droplet PCR was used for detection and verification of trace molecular artifacts. Multianalyte processing yielded data that was harmonized and interpreted through an Artificial Intelligence based algorithm to assess for possible glioma and to assign grade in a blinded fashion. EGFRvIII, TP53 and IDH1 mutations were also analyzed and compared to molecular testing from tumor specimens. RESULTS 66% (25 of 38) of glioma patients were correctly diagnosed as having a malignancy. 43% of HGG and 60% of LGG patients were correctly graded. Of the 14 normal controls, 6 were concluded to be cancer-free. IDH1, EGFRvIII, and TP53 mutation had concordance of 64% (21/33), 82% (14/17) and 36% (5/14), respectively. CONCLUSIONS Analysis of plasma cell free tumor derived DNA and RNA was relatively sensitive for detecting glioma in treatment naïve patients. In contrast, this analysis was not specific in ruling out malignancy in the normal control patients. Given this profile, in patients with newly diagnosed intracerebral lesions suspicious for glioma, this may be a useful screening test to determine the need for more invasive testing, i.e. biopsy/resection.

Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer

2008 ◽  
Vol 14 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Trevor J Powles ◽  
Anthony Howell ◽  
D Gareth Evans ◽  
Eugene V Mccloskey ◽  
Sue Ashley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adverse Event ◽  
Family History ◽  
Postmenopausal Women ◽  
Breast Density ◽  
Red Clover ◽  
Mineral Density ◽  
Adverse Event Profile ◽  
Healthy Women ◽  
History Of

Objective To assess the safety and tolerability of a standardized 40 mg red clover isoflavone dietary supplement (Promensil®, Novogen) in women with a family history of breast cancer to evaluate the feasibility of using the supplement for prevention of breast cancer in healthy women. Study design Healthy women aged 35–70 years (n = 401) with at least one first-degree relative with breast cancer received red clover isoflavones or placebo for three years in a randomized, double-blind, placebo-controlled pilot trial. Participants were assessed clinically and blood samples taken for biochemical analysis every six months. In addition, study participants underwent mammography, bone density and transvaginal ultrasound (postmenopausal women only) once per year. Results No significant differences in breast density, endometrial thickness, serum cholesterol, follicle stimulating hormone levels and bone mineral density were detected between those taking red clover isoflavones and placebo. In postmenopausal women, some significant differences in bone marker levels were seen between active and placebo groups, at six months and at 12 months. The adverse event profile was similar across all red clover isoflavone and placebo groups. Conclusion This three-year study supports the growing body of evidence that treatment with red clover isoflavones is safe and well tolerated in healthy women. Supplements containing red clover isoflavones did not adversely affect breast density, skeletal strength or cardiovascular status. In postmenopausal women, endometrial status was not adversely affected. The adverse event profile was similar between red clover isoflavones, and placebo and endocrine status did not differ.

scholarly journals Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data

2021 ◽  
Vol 18 (12) ◽  
pp. 6409
Author(s):  
Hyo Geun Choi ◽  
Jung Ho Park ◽  
Yeon Ju Choi ◽  
Yong Joon Suh
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Family History ◽  
Odds Ratio ◽  
Significant Risk ◽  
Premenopausal Women ◽  
Significant Risk Factor ◽  
Large Cohort ◽  
Large Cohort Study ◽  
History Of

Background: Breast cancer is the most common cancer among women. The Korean Genome and Epidemiology Study (KoGES) is a large cohort study that is available to the public. Using this large cohort study, we aimed to unravel the relationship between breast cancer development and a family history of breast cancer in Korea. Methods: This cohort study relied on data from the KoGES from 2001 through 2013. A total of 211,725 participants were screened. Of these, 129,374 women were evaluated. They were divided into two groups, including participants with and without breast cancer. A logistic regression model was used to retrospectively analyze the odds ratio of breast cancer history in families of women with and without breast cancer. Results: Of 129,374 women, 981 had breast cancer. The breast cancer group had more mothers and siblings with histories of breast cancer (p < 0.001). A history of breast cancer in the participant’s mother resulted in an odds ratio of 3.12 (1.75–5.59), and a history of breast cancer in the participant’s sibling resulted in an odds ratio of 2.63 (1.85–3.74). There was no interaction between the history of maternal breast cancer and the history of sibling breast cancer. Based on the subgroup analysis, family history was a stronger factor in premenopausal women than in menopausal and postmenopausal women. Conclusions: A family history of breast cancer is a significant risk factor for breast cancer in Korea. Premenopausal women with a maternal history of breast cancer are of particular concern. Intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.

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