Role of Jasmonic and Salicylic Acid on Enzymatic Changes in the Root of Two Alyssum Inflatum Náyr. Populations Exposed to Nickel Toxicity

2021 ◽  
Author(s):  
Shiva - Najafi Kakavand ◽  
Naser - Karimi ◽  
Hamid-Reza - Ghasempour ◽  
Ali - Raza ◽  
Mehrdad - Chaichi ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Interactive Effect ◽  
Plant Tolerance ◽  
Nickel Toxicity ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Enzymatic Changes ◽  
Two Populations ◽  
Ni Accumulation

Abstract Salicylic acid (SA) and jasmonic acid (JA) as plant growth regulators (PGRs) have the potential to ameliorate plant development and tolerance to deleterious effects of toxic metals like nickel (Ni). Therefore, the current study was carried out to evaluate SA and JA's interactive effect on the root antioxidative response of two Alyssum inflatum Nyár. populations against Ni-toxicity. Two A. inflatum species under Ni-stress conditions (0, 100, 200, and 400 µM) were exposed to alone or combined levels of SA (0, 50, and 200 µM) and JA (0, 5, and 10 µM) treatments. Results showed that high Ni doses reduced the roots fresh weight (FW) in two populations than control; however, the use of external PGRs had ameliorated roots biomass by mitigated Ni-toxicity. Under Ni toxicity, SA and JA, especially their combination, induced high Ni accumulation in plants' roots. Moreover, the application of SA and JA alone, as well as combined SA + JA, was found to be effective in the scavenging of hydrogen peroxide (H2O2) by improving the activity of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX) in both populations under Ni-toxicity. Overall, our results manifest that SA and JA's external use, especially combined SA + JA treatments, ameliorate root biomass and plant tolerance by restricting translocation Ni to the shoot, accumulating in roots, and also enhancing antioxidant defense systems.

scholarly journals Role of Jasmonic and Salicylic Acid on Enzymatic Changes in The Root of Two Alyssum Inflatum Náyr. Populations Exposed to Nickel Toxicity

2021 ◽  
Author(s):  
Shiva Najafi Kakavand ◽  
Naser Karimi ◽  
Hamid-Reza Ghasempour ◽  
Ali Raza ◽  
Mehrdad Chaichi ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Interactive Effect ◽  
Plant Tolerance ◽  
Nickel Toxicity ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Enzymatic Changes ◽  
Two Populations ◽  
Ni Accumulation

Abstract Salicylic acid (SA) and jasmonic acid (JA) as plant growth regulators (PGRs) have the potential to ameliorate plant development and tolerance to deleterious effects of toxic metals like nickel (Ni). Therefore, the current study was carried out to evaluate SA and JA's interactive effect on the root antioxidative response of two Alyssum inflatum Nyár. populations against Ni-toxicity. Two A. inflatum species under Ni-stress conditions (0, 100, 200, and 400 µM) were exposed to alone or combined levels of SA (0, 50, and 200 µM) and JA (0, 5, and 10 µM) treatments. Results showed that high Ni doses reduced the roots fresh weight (FW) in two populations than control; however, the use of external PGRs had ameliorated roots biomass by mitigated Ni-toxicity. Under Ni toxicity, SA and JA, especially their combination, induced high Ni accumulation in plants' roots. Moreover, the application of SA and JA alone, as well as combined SA + JA, was found to be effective in the scavenging of hydrogen peroxide (H2O2) by improving the activity of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX) in both populations under Ni-toxicity. Overall, our results manifest that SA and JA's external use, especially combined SA + JA treatments, ameliorate root biomass and plant tolerance by restricting translocation Ni to the shoot, accumulating in roots, and also enhancing antioxidant defense systems.

scholarly journals The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor

2020 ◽  
Vol 2020 ◽  
pp. 1-29 ◽  
Author(s):  
Rossella D’Oria ◽  
Rossella Schipani ◽  
Anna Leonardini ◽  
Annalisa Natalicchio ◽  
Sebastio Perrini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Injury ◽  
Antioxidant Defense ◽  
Experimental Studies ◽  
Chemical Species ◽  
Oxygen Species ◽  
Molecular Abnormalities ◽  
Defense Systems ◽  
Antioxidant Defense Systems

Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen, controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart, ROS play an important role in cell homeostasis, by modulating cell proliferation, differentiation, and excitation-contraction coupling. Oxidative stress occurs when ROS production exceeds the buffering capacity of the antioxidant defense systems, leading to cellular and molecular abnormalities, ultimately resulting in cardiac dysfunction. In this review, we will discuss the physiological sources of ROS in the heart, the mechanisms of oxidative stress-related myocardial injury, and the implications of experimental studies and clinical trials with antioxidant therapies in cardiovascular diseases.

scholarly journals Role of germanium L-cysteine α-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats

2007 ◽  
Vol 57 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Mamdouh Ali ◽  
Eman Noaman ◽  
Sherien Kamal ◽  
Saaed Soliman ◽  
Dina Ismail
Keyword(s):  
Total Protein ◽  
Antioxidant Defense ◽  
Whole Body ◽  
Albino Rats ◽  
Protective Agent ◽  
Γ Irradiation ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Gamma Irradiated

Role of germanium L-cysteine α-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats This study was conducted to evaluate the potency of the newly prepared germanium L-cysteine α-tocopherol complex [germanium dichloro tetrakis (L-cysteinyl-α-tocopherol amide) dichloride] as a protective agent against γ-irradiation-induced free radicals production and liver toxicity. Male Swiss albino rats were injected intraperitoneally with the germanium complex in a concentration of 75 mg kg-1 body mass per dose, for 6 successive doses, last dose administered twenty minutes pre-exposure to a single dose of whole body γ-irradiation of 6.5 Gy. Lipid peroxidation (LPx), nitric oxide (NO), glutathione (GSH) levels, and activity of the antioxidant enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were estimated in blood and liver. Blood total protein, cholesterol, triglyceride and α-tocopherol content were estimated as well. The results revealed that administration of germanium complex pre-irradiation resulted in significant (p < 0.001) improvement compared to the irradiated group in the level of hepatic and blood LPx. Hepatic GSH revealed a significant increase (p < 0.001), while its level showed no significant variation in blood. Also, the level of NO in blood and liver increased significantly (p < 0.001). On the other hand, pretreatment with the germanium complex normalized the activities of SOD, GPx and CAT in blood and liver when compared to the irradiated group. The study also documents a marked decrease in a blood triglyceride and cholesterol (p < 0.001) and a significant increase (p < 0.001) of α-tocopherol and total protein contents in blood. These biochemical changes were associated with marked improvement of histological status. Therefore, the germanium L-cysteine α-tocopherol complex may be a good candidate for ameliorating the changes induced by irradiation, which indicates the beneficial radio-protective role of this antioxidant agent.

scholarly journals Salicylic Acid Pretreatment Modulates Wheat Responses to Glyphosate

Crops ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 88-96
Author(s):  
Elena Shopova ◽  
Liliana Brankova ◽  
Zornitsa Katerova ◽  
Ljudmila Dimitrova ◽  
Dessislava Todorova ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Antioxidant Defense ◽  
Triticum Aestivum L ◽  
Plant Responses ◽  
Plant Tolerance ◽  
Glutathione S Transferase ◽  
Acid Pretreatment ◽  
Stress Markers ◽  
Oxidative Damages ◽  
Antioxidant Defense Systems

Glyphosate is an extensively used herbicide because of its non-selective action for weed control. Salicylic acid (SA) is a phenolic compound that has the potential to increase plant tolerance to diverse stresses. To test SA ability to modulate plant responses to glyphosate we used young wheat (Triticum aestivum L.) seedlings grown as a water culture. Plants were sprayed with 1 mM SA, and 24 h later with 0.5 mM glyphosate. All measurements were performed 14 days after herbicide treatment. Wheat growth was reduced by glyphosate. Stress markers (proline and malondialdehyde) were significantly increased by glyphosate showing oxidative damages. Incapacity of wheat to cope with the oxidative stress was evidenced by reduction in thiols and phenolics content, accompanied by slight induction of superoxide dismutase and catalase activities. Enhanced activities of peroxidase, glutathione reductase and glutathione-S-transferase were expected to participate in glyphosate detoxification. SA applied alone had no important effects on measured parameters. SA pretreatment decreased stress markers and caused additional amplification of antioxidant defense systems in glyphosate-treated plants. Growth was partially restored in combine-treated plants due to SA application. SA probably triggered antioxidant defense to cope with the herbicide stress.

scholarly journals An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle-Induced Toxicities

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Vladimir Mihailovic ◽  
Jelena S. Katanic Stankovic ◽  
Dragica Selakovic ◽  
Gvozden Rosic
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Therapeutic Agents ◽  
Protective Mechanisms ◽  
Defense Systems ◽  
Naturally Occurring ◽  
New Findings ◽  
Antioxidant Defense Systems ◽  
Harmful Effects

Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

scholarly journals The Protective Role of Toll-like Receptors Agonist Monophosphoryl Lipid A against Vaccinated Murine Schistosomiasis

2019 ◽  
Author(s):  
Ibrahim Aly ◽  
Essam H. Ibrahim ◽  
Rabab S. Hamad ◽  
Hoda EL Sayed ◽  
Sama M.N. Attiyah ◽  
...  
Keyword(s):  
Lipid A ◽  
Significant Degree ◽  
Protective Role ◽  
Oxidative Stress Marker ◽  
Defense Systems ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Antioxidant Defense Systems ◽  
Egg Antigen

Schistosomiasis, a crippling ailment that afflicts over 220 million people worldwide. Yet or up till now, there is no vaccine for schistosomiasis, and chemotherapy relies heavily on a single drug, the praziquantel. The present study was undertaken to investigate the therapeutic effect of Monophosphoryl Lipid A (MPLA) as an adjuvant in soluble egg antigen (SEA) vaccinated mice against the deleterious pathological impacts induced in hepatic tissues of mice by Schistosoma mansoni infection. In addition, to study the associated parasitological, immunological and biochemical parameters. Parasitological parameters showed that intraperitoneal injection of MPLA into SEA-vaccinated and S. mansoni-infected mice was effective to a significant degree in reducing the worm and egg burden, granuloma count and diameter as well as the total area of infection in their livers versus SEA-untreated but infected ones. In addition, MPLA showed ameliorative action on the elevated liver oxidative stress marker, including malondialdehyde (MDA) and decrease in the level of the antioxidant enzymes, reduced glutathione (GSH) and catalase (CAT) which may have a role in the liver damage and fibrosis due to S. mansoni infection. In conclusion, treatment with MPLA has multi-functions in attenuating the deleterious impacts of S. mansoni infection in mice livers. Its effects are mediated through a reduction of ova count, worm burden, granuloma diameter and amelioration of antioxidant defense systems, and liver function biomarkers.

Role of rat adrenal antioxidant defense systems in the aldosterone turn-off phenomenon

2000 ◽  
Vol 73 (1-2) ◽  
pp. 71-78 ◽  
Author(s):  
Tetsuya Suwa ◽  
Tomoatsu Mune ◽  
Hiroyuki Morita ◽  
Hisashi Daido ◽  
Masanao Saio ◽  
...  
Keyword(s):  
Antioxidant Defense ◽  
Defense Systems ◽  
Antioxidant Defense Systems
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