Hyperuricemia Resistant to a Xanthine Oxidase Inhibitor, Topiroxostat: a Case Report
Keyword(s):
Abstract Hyperuricemia is a common complication of chronic kidney disease. Gout is a clinical symptom of hyperuricemia, and lowering serum uric acid concentration has been recommended to prevent its recurrence. We present a case whose hyperuricemia was resistant to a xanthine oxidase inhibitor, febuxostat, but not another inhibitor, topiroxostat, while both are presumed to inhibit the same enzymatic center of this rate-limiting enzyme for uric acid production. The different efficacy indicates that xanthine oxidase inhibitors are not interchangeable even among those acting on the same site of the enzyme.
2020 ◽
Vol 20
(2)
◽
pp. 253-256
◽
2010 ◽
Vol 77
(4)
◽
pp. 438-444
◽
Keyword(s):
2007 ◽
Vol 23
(4)
◽
pp. 1179-1185
◽
Keyword(s):
Keyword(s):
Keyword(s):