scholarly journals Effects of cranioplasty in cerebral blood perfusion using quantification with 99mTc-HMPAO SPECT-CT

2021 ◽  
Author(s):  
Álvaro Galiana ◽  
Igor Paredes ◽  
Sebastián Ruiz ◽  
José Antonio Fernández Alén ◽  
Adolfo Gómez Grande ◽  
...  
Keyword(s):  
Reconstructive Surgery ◽  
Blood Perfusion ◽  
P Value ◽  
Z Score ◽  
Posterior Cingulate ◽  
Cortical Areas ◽  
Hmpao Spect ◽  
Before And After ◽  
The Many ◽  
99Mtc Hmpao

Abstract PURPOSE: SSFS is an underdiagnosed complication of craniectomized patients, which mainly presents with headache, motor weakness, and cognitive impairments. In these patients, cranioplasty improves these symptoms. Furthermore, patients without a classical SSFS have been shown to improve their neurological functions after reconstructive surgery. Amongst the many different pathophysiological theories proposed, the changes of CBP caused by the cranial defect might have a role in the neurological deficiencies. We have studied CBP in twelve cortical areas of both hemispheres, using 99mTc-HMPAO SPECT-CT before and after cranioplasty.METHODS: Twenty-eight craniectomized patients subject to reconstructive surgery were studied with 99mTc- HMPAO in three different times, before cranioplasty, a week after, and three months later. The images were processed with quantification software comparing CBP of 24 cortical areas with a reference area , and with a database of normal individuals. A mixed effects model was used to determine the signification of CBP changes in the cortex regions of both the damaged and undamaged brain hemispheres.RESULTS: CBP increased significantly in both hemispheres after cranioplasty both in ratio (β=0.019 p-value=0,030 first post-surgical SPECT-CT and β=0.021 p-value=0,015 in the second study, vs. pre-surgical) and Z-score (β=0.220 p-value=0,026 and β=0.279 p-value=0,005 respectively). Nine of twelve areas of the damaged side had a significant lower CBP ratio and Z-score than the undamaged. Posterior cingulate showed an increased CBP ratio (p-value=0,034) and Z-score(p-value0,028) in the first post-surgical SPECT-CT.CONCLUSION: CBP changes significantly in specific cortical areas after cranioplasty, which might explain the clinical improvements observed. Posterior cingulate changes might explain some improvements in attention impairments described. 99mTc-HMPAO SPECT-CT might be a valid tool to assess CBP changes in these patients and could have a role in the management of craniectomized individuals.CLINICAL TRIAL REGISTRATIONNot applicable

scholarly journals Efektifitas endorphin massage terhadap fungsi seksual perempuan pada masa menopause

2018 ◽  
Vol 13 (1) ◽  
pp. 88-94
Author(s):  
Sri Wahyuni ◽  
Tutik Rahayu
Keyword(s):  
Data Processing ◽  
Sexual Function ◽  
Wilcoxon Test ◽  
P Value ◽  
Female Sexual Function ◽  
Z Score ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Before And After

Abstract: The purpose of this study is to identify the effectiveness ofendorphine massage on female sexual function during menopause inNgampel District of Kendal Regency. Sampling was done by samplingcriteria acsidental aged less than 60 years old, have a husband, in a healthycondition. Data processing was performed using the Wilcoxon test todetermine differences in sexual function before and after the interventionwhile endorphine effectiveness of massage performed by using MannWhitney.Hasil research: Wilcoxon test showed that there are significantdifferences in sexual function before and after being given endorphineMassage with p value 0.00. While Mann Whitney test showed p value of0.13 and the value of z score of -2.828, which means there is a stronginfluence among endorphine Massage to increased sexual function soendorphine Massage is effective for improving sexual function.

Vergleich von MRT- und SPECT-Befunden bei Patienten mit zerebraler Mikroangiopathie

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  
Keyword(s):  
White Matter Lesions ◽  
Central Nervous System Disease ◽  
Deep White Matter ◽  
Cranial Ct ◽  
System Disease ◽  
Ct Findings ◽  
Hmpao Spect ◽  
Significant Difference ◽  
Cerebral Microangiopathy ◽  
99Mtc Hmpao

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

123J-Iomazenil- und 99mTc-HMPAO in der Diagnostik fokaler Epilepsien: Vergleich von unbehandelten und behandelten Patienten

1994 ◽  
Vol 33 (01) ◽  
pp. 01-07
Author(s):  
M. Cordes ◽  
B. Schmitz ◽  
J. Hierholzer ◽  
R. Siekmann ◽  
U. Keske ◽  
...  
Keyword(s):  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungDie Daten von insgesamt 20 Patienten mit fokalen Epilepsien (beh.: 7; unbeh.: 13) wurden mit dem Ziel ausgewertet, Unterschiede in der Bindung der Radiotracer HMPAO und IM घ zwischen behandelten und unbehandelten Patienten herauszufinden. CT und MIRT zeigten keine pathologischen Befunde. Bei allen Patienten wurden mittels SPECT die Gesamthirnaktivität und durch Anwendung der ROI-Technik regionale Impulsdichten (Rl) bestimmt und der spezifische und unspezifische Anteil der Rl des BZ-Antagonisten für jede Region berechnet. In der Gruppe der beh. Patienten konnte eine signifikant höhere normalisierte Gesamtbindung von IMZ gefunden werden (p <0,001). Die spezifische Bindung von IMZ und die Gesamtbindung von HMPAO zeigten keine Unterschiede zwischen beiden Gruppen. Die IMZ-SPECT hatte in unserem Kollektiv gegenüber der HMPAO-SPECT in bezug auf das EEG eine höhere Sensitivität bei geringerer Spezifität im Nachweis einer Minderanreicherung des Tracers in Arealen mit fokaler hypersynchroner Erregungssteigerung.

Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Kortikale Dysplasie als epileptogener Fokus: Verminderte Bindung von I-Iomazenil bei unauffälliger 99mTc-HMPAO SPECT

1992 ◽  
Vol 31 (04) ◽  
pp. 142-144
Author(s):  
C. Lehmenkühler ◽  
J. Sciuk ◽  
G. Schuierer ◽  
P. Bartenstein
Keyword(s):  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungIn kortikalen Arealen, die einem epileptischen Fokus assoziiert sind, korreliert meist eine verminderte Benzodiazepin-Rezeptorbindung, darstellbar mit 123I- Iomazeml, mit einer Minderung des regionalen zerebralen Blutflusses. Anhand eines Fallbeispiels mit ausgeprägter Minderung der 123l-lomazenilbindung im epileptischen Fokus bei ungestörtem regionalen zerebralen Blutfluß wird illustriert und diskutiert, daß bei einer Minderanreicherung von 123I-Iomazenil im epileptischen Fokus eine Alteration des GABAergen Systems anzunehmen ist.

Diagnostik der SDAT mittels HMPAO-SPECT und Serumvitamin-B12-Spiegel

1995 ◽  
Vol 34 (03) ◽  
pp. 104-109 ◽  
Author(s):  
H. J. Gallowitsch ◽  
I. Gomez ◽  
E. Kresnik ◽  
H. Plöb ◽  
P. Lind ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungDie alleinige klinische Abklärung dementieller Zustandsbilder, so auch der senilen Demenz vom Alzheimertyp (SDAT), ist schwierig. Durch die Kombination von 99mTc-HMPAO-Gehirn-SPECT und Serumvitamin-B12-Bestimmung erwarteten wir eine Beschleunigung und Verbesserung der Diagnostik der SDAT. Von 116 Patienten, die in 4 Gruppen, entsprechend ihrem 99mTc-HMPAO-Verteilungsmuster eingeteilt worden waren, konnten bei 17 klinisch sehr wahrscheinlichen SDAT-Patienten bei 15 Auffälligkeiten mit Hinweis auf SDAT im Gehirn SPECT gefunden werden. Ein Teil der Patienten wies einen niedrig-normalen bzw. pathologisch niedrigen Vitamin-B12-Spiegel auf. Andere Untersuchungen würden durch die Kombination von Gehirn-SPECT und Serumvitamin-B12-Bestimmung nicht überflüssig werden, obwohl beide Untersuchungen Informationen lieferten, die die Zuordnung zur Diagnose SDAT erleichterten. Die zusätzliche Serumvitamin-B12-Bestimmung stellt keinen wesentlichen Mehraufwand dar.

Pengaruh Perawatan Metode Kanguru (PMK) terhadap Pencegahan Hipotermi pada Bayi Baru Lahir

2020 ◽  
Vol 2 (2) ◽  
pp. 66-71
Author(s):  
Parti ◽  
Sumiati Malik ◽  
Nurhayati
Keyword(s):  
Birth Weight ◽  
Infant Mortality ◽  
Low Birth Weight ◽  
Health Workers ◽  
Kangaroo Mother Care ◽  
Infant Mortality Rate ◽  
P Value ◽  
Low Birth Weight Infants ◽  
Low Birth Weight Babies ◽  
Before And After

Most causes of infant death are problems that occur in newborn/neonatal (0-28 days old), Low Birth Weight Babies (LBW) is one of the factors which has a contribution to infant mortality, especially in the neonatal period. Infant Mortality Rate (IMR) is a benchmark in determining the degree of public health, both at the National and Provincial levels. This study aimed to determine the effect of the Kangaroo Mother Care Method (KMC) on the prevention of hypothermia in low birth weight infants at Morowali District Hospital in 2019. The type of research used was a quasi-experiment. The population is all low birth weight babies born from May to July 2019. The sample in this study was all newborns with low birth weight born from May to July 2019, totaling 30 babies. There is a difference (influence) on the baby's body temperature before and after KMC with a p-value=0,000. The kangaroo mother care can continue to be affiliated considering its benefits for both infants and mothers, as well as increasing the ability of health workers in conducting KMC so that they can provide in-house training for mothers to be carried out at home.

Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders

2016 ◽  
Vol 55 (04) ◽  
pp. 158-165 ◽  
Author(s):  
Friedrich Welz ◽  
James Sanders ◽  
Torsten Kuwert ◽  
Juan Maler ◽  
Johannes Kornhuber ◽  
...  
Keyword(s):  
Tissue Concentration ◽  
Tracer Uptake ◽  
Planar Imaging ◽  
Quantitative Spect ◽  
Dementia Patients ◽  
Hmpao Spect ◽  
Patient Groups ◽  
The Absolute ◽  
99Mtc Hmpao

SummaryIt was reported from planar imaging studies that the cerebral uptake of injected 99mTc-HMPAO activity is about 4–7% in humans. Recent work has shown that modern SPECT/ CT devices are able to quantify the tissue concentration of radioactivity in vivo in absolute units (Bq/ml), while avoiding the limitations of planar techniques. The aims of this study were (a) to determine the cerebral uptake of 99mTc-HMPAO in absolute units in SPECT/CT, (b) to investigate potential differences in absolute tracer uptake for patients suspected of dementia. Patients, methods: We performed 99mTc-HMPAO SPECT/CT in 65 patients with suspected dementia. 99mTc-HMPAO uptake was determined using a previously published quantitative SPECT/CT protocol. The absolute HMPAO uptake and the results of a regionalized analysis were compared for MMSE and NINCDS-ADRDA based patient groups. Results: The mean absolute uptake of 99mTc-HMPAO for our patient population was 4.3 ± 0.8% of the injected dose. The uptake, as well as the regionalized analysis yielded significantly different results for low ( 23) and high (>23) MMSE groups and also for some of the NINCDS-ADRDA groups. Conclusion: Our results show that the absolute cerebral uptake of 99mTc-HMPAO is in the range of previously reported results, obtained by planar techniques. Absolute uptake is significantly different between the patient groups.

PENGARUH PIJAT BAYI TERHADAP KUALITAS TIDUR BAYI UMUR 0 – 3 BULAN DI WILAYAH KERJA PUSKESMAS SOSIAL PALEMBANG TAHUN 2016

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Juliana Widyastuti Wahyuningsih Juliana Widyastuti Wahyuningsih
Keyword(s):  
Experimental Design ◽  
Growth And Development ◽  
Sampling Technique ◽  
P Value ◽  
Development Phase ◽  
Quality Of Sleep ◽  
Infant Massage ◽  
Before And After ◽  
The Brain

ABSTRAK Tidur merupakan kebutuhan yang harus terpenuhi terutama pada fase perkembangan karena selama tidur akan terjadi perkembangan otak maupun tubuh, sehingga gangguan tidur merupakan masalah yang akan menimbulkan dampak buruk terhadap pertumbuhan dan perkembangan bayi. Kualitas tidur bayi yang baik dapat diciptakan dengan memberikan pemijatan bayi secara rutin. Penelitian ini bertujuan untuk membuktikan bahwa pemijatan dapat mempengaruhi kualitas tidur bayi umur 0-3 bulan. Penelitian ini menggunakan desain penelitian Quasy Eksperimental dengan metode One Group Pretest-Postest. Sampel 22 bayi yang dipilih dengan tehnik Total Sampling yang di observasi sebelum dan sesudah diberikan pemijatan. Variabel yang diukur dalam penelitian ini adalah kualitas tidur bayi 0-3 bulan. Hasil penelitian menunjukkan bahwa ada pengaruh pijat bayi terhadap kualitas tidur bayi umur 0-3 bulan (p value  0,008 < α = 0,05).Berdasarkan hasil penelitian ini disarankan agar keluarga dan masyarakat memberikan pemijatan secara rutin dan mandiri untuk meningkatkan kebutuhan tidur bayi yang berkualitas.   ABSTRACT Sleep is a human necessity that must be met, especially in the development phase because during sleep will occur the brain and body developments, so that sleep disturbance is a problem that would cause adverse effects on infants’ growth and development. The good quality of sleep can be created by providing the infants massage routinely. This study aimed to prove that the massage could affect the quality of sleep on the 0-3 months old baby. This study used Quasy-experimental design with One Group Pretest-Posttest. The sample 22 infants selected by total sampling technique observed on before and after the massage. The variables measured in this study are the quality of sleep. The results of study indicate that there is an effect of infant massage to the sleep quality on 0-3 months old babies (p value 0,008 < α = 0,05).Based on the results of this study it recommended for the families and communities to provide infant massage regularly and independently to increase the quality of sleep on the baby.  

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