scholarly journals Efficacy of Steroid Therapy for Fukuyama Congenital Muscular Dystrophy

2021 ◽  
Author(s):  
Terumi Murakami ◽  
Takatoshi Sato ◽  
Michiru Adachi ◽  
Kumiko Ishiguro ◽  
Minobu Shichiji ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Steroid Therapy ◽  
Congenital Muscular Dystrophy ◽  
Rank Test ◽  
Clinical Trial Registration ◽  
Motor Functions ◽  
Significance Level ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean

Abstract Background: Although a fundamental treatment for Fukuyama congenital muscular dystrophy (FCMD) is not developed yet, several reports have suggested that steroid therapy could be effective for FCMD; however, no independent intervention studies have been conducted.Objective: This study aimed to evaluate the efficacy of steroid therapy for restoring motor functions in FCMD patients.Subjects: This study involved 3-to-10-year-old FCMD patients who exhibited a decline in motor functions, requested steroid therapy.Methods: The dose regimen started with oral administration of prednisolone at 0.5 mg/kg every other day and was increased to 1.0 mg/kg if the response was insufficient. The motor functions of the patients were evaluated and compared using the Gross Motor Function Measure (GMFM). Statistical analysis was performed using the Wilcoxon signed-rank test (significance level, P ≤ 0.05)Results: The mean age of FCMD patients at the onset of steroid therapy was 8.10 years (SD, 2.14 years). The mean GMFM difference between before and after the steroid therapy was +1.23 (SD, 1.10), with a P value of 0.015 representing a significant improvement in the GMFM.Conclusions: Our results indicate that steroid therapy may contribute to the maintenance and improvement of the motor functions of advanced-stage FCMD patients.Clinical Trial Registration: Registration Number: UMIN000020715, Registration Date: 01/02/2016.

scholarly journals Efficacy of steroid therapy for Fukuyama congenital muscular dystrophy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Terumi Murakami ◽  
Takatoshi Sato ◽  
Michiru Adachi ◽  
Kumiko Ishiguro ◽  
Minobu Shichiji ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Steroid Therapy ◽  
Congenital Muscular Dystrophy ◽  
Symptomatic Treatment ◽  
Rank Test ◽  
Clinical Trial Registration ◽  
Motor Functions ◽  
Significance Level ◽  
Before And After ◽  
The Mean

AbstractAlthough there is only symptomatic treatment for Fukuyama congenital muscular dystrophy (FCMD), several reports have suggested that steroid therapy could be effective for FCMD; however, no independent intervention studies have been conducted. This study aimed to evaluate the efficacy of steroid therapy for restoring motor functions in FCMD patients. This study involved 3-to-10-year-old FCMD patients who exhibited a decline in motor functions, requested steroid therapy. Patients with consent started oral administration of 0.5-mg/kg prednisolone every alternate day, which was increased to 1.0 mg/kg if the response was inadequate. We used the Gross Motor Function Measure (GMFM) to evaluate and compare the motor functions of all patients. Wilcoxon signed-rank test (significance level, P ≤ 0.05) was used for statistical analysis. At the onset of steroid therapy, 8.10 years (SD, 2.14 years) was the mean age of FCMD patients. The mean GMFM difference between before and after the steroid therapy was + 1.23 (SD, 1.10), and a P value of 0.015 represented significant improvement in GMFM. Our results indicate that steroid therapy may contribute to the maintenance and improvement of the motor functions of advanced-stage FCMD patients.Clinical Trial Registration Registration Number: UMIN000020715, Registration Date: Feb 1st, 2016 (01/02/2016).

scholarly journals Group Education Model Improving The Knowledge of School Age Children in Protecting of Sexual Violence

2019 ◽  
Vol 3 (4) ◽  
pp. 204
Author(s):  
I Ketut Labir ◽  
Ni Luh Kompyang Sulisnadewi ◽  
I Nyoman Ribek
Keyword(s):  
Sexual Violence ◽  
Sampling Technique ◽  
School Age Children ◽  
Rank Test ◽  
Average Score ◽  
P Value ◽  
School Age ◽  
Significance Level ◽  
Before And After ◽  
Signed Rank Test

Cases of sexual violence and abuse in Indonesia are increasingly common. Not only in adults, children are now victims. Some cases of victims or perpetrators involve underage children. Many parents feel taboo to talk about early childhood education with children. This causes children not to get information that is supposed to protect themselves from sexual violence. Need to do various efforts to provide education to children about knowledge to protect themselves from sexual violence. The purpose of this study was to determine the effect of sexual violence education on children on efforts to protect from sexual violence. This study uses pre-experimental design with approach pretest-posttest design. The number of samples is 195 children taken by purposive sampling technique. Analyze data using  different Wilcoxon Signed Rank test with 95% significance level, p ≤ (0.05). The results showed that the average age of the respondents was 10.2 years and most of the men were 52.8%. Before giving education, the average score of respondents' knowledge about efforts to protect themselves from sexual violence was 6.7 and increased to 7.79 after giving education. There is a difference in knowledge about efforts to protect themselves from sexual violence before and after being given education (p value ≤ 0.001; <α = 0.05). It is recommended that the provision of information about sexual violence be given regularly by teachers and parents.Keywords: Education - Elementary School Age Knowledge - Efforts to Protect Themselves from Sexual Violence

The Dizziness Handicap Inventory questionnaire scores before-and-after vestibular rehabilitation therapy of presbyastasis patients

2020 ◽  
Vol 50 (1) ◽  
pp. 21
Author(s):  
Etty Sekardewi ◽  
Achmad Chusnu Romdhoni ◽  
Haris Mayagung Ekorini
Keyword(s):  
The Elderly ◽  
Vestibular Rehabilitation ◽  
Rank Test ◽  
Dizziness Handicap Inventory ◽  
Rehabilitation Therapy ◽  
Consecutive Sampling ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean

Background: Presbyastasis is multifactorial balance dysfunction that occurs in the elderly person. Presbyastasis can increase the risk of fall, anxiety, and decrease the quality of life. Vestibular rehabilitation therapy (VRT) has been proven effective to overcome balance disorders, and it is safe for the elderly. Several studies had reported the success of VRT for balance disorders. All this time, the accomplishment of VRT was assessed by using balance test, which had a risk of falling in elderly patients. Objective: To find out the outcome of Dizziness Handicap Inventory (DHI) questionnaire score in presbyastasis patients after VRT. Method: Ten presbyastasis patients in age range 60-75 years old who met the study criteria were taken by consecutive sampling. A longitudinal observational (pre and posttest) study by analyzing the DHI questionnaire scores. Assessment was performed twice, before and after VRT. The data was analyzed using paired T test and Wilcoxon signed rank test with outcome p<0.05. Result: The measurement of the emotional subscale DHI (DHI.E) showed the mean score before VRT was 4.00 (1.63), after therapy was 0.00 (0.63), p=0.004. The functional subscale (DHI.F) measurement showed the mean score before VRT was 10.40 (3.98), after therapy was 2.40 (2.07), p 0.00. The mean score of physical subscales (DHI.P) measurement before VRT was 9.00 (4.40), after therapy was 2.00 (1.58), p=0.008. The total DHI score (DHI.T) before VRT was 22.6 (7.67), after VRT was 4.20 (2.2) with p=0.000. Conclusion: There was an improvement in DHI questionnaire score before and after 6 weeks VRT.Keywords: Vestibular rehabilitation therapy (VRT), Dizziness Handicap Inventory (DHI), presbyastasis ABSTRAK Latar belakang: Presbiastasis dapat meningkatkan angka jatuh, kecemasan dan menurunkan kemandirian sehingga menurunkan kualitas hidup pada usia lanjut. Terapi rehabilitasi vestibuler (TRV) merupakan modal terapi yang terbukti dapat mengatasi gangguan keseimbangan, dan aman untuk usia lanjut. Beberapa penelitian melaporkan adanya keberhasilan TRV pada penderita gangguan keseimbangan. Keberhasilan dari TRV selama ini dinilai dengan menggunakan pemeriksaan keseimbangan yang memiliki risiko jatuh pada penderita usia lanjut. Tujuan: Membuktikan adanya perubahan skor kuesioner Dizziness Handicap Inventory (DHI) pada penderita presbiastasis sesudah TRV. Metode: Sepuluh penderita presbiastasis usia 60-75 tahun yang memenuhi kriteria penelitian diambil secara consecutive sampling. Studi observasi longitudinal (pre dan posttest) dengan menghitung dan menganalisis skor kuesioner DHI. Pengukuran dilakukan 2 kali yaitu sebelum TRV dan sesudah TRV. Analisis data dilakukan dengan paired T test dan Wilcoxon signed rank test, dengan hasil p<0,05. Hasil: Pengukuran skor kuesioner DHI subskala Emotional (DHI.E) sebelum TRV mempunyai mean 4,00 (1,63), 6 minggu sesudah TRV didapatkan mean 0,00 (0,63), p=0,004. Hasil subskala Functional (DHI.F) sebelum TRV didapatkan mean 10,40 (3,98), 6 minggu sesudah TRV, mean 2,40 (2,07), p=0,00. Pada subskala Physical (DHI.P) didapatkan mean 9,00 (4,40), dan 6 minggu sesudah TRV didapatkan mean 22,6 (7,67), sesudah TRV didapatkan mean 4,20 (2,2) dengan p=0,000. Kesimpulan: Terdapat perbaikan skor kuesioner DHI sesudah 6 minggu terapi rehabilitasi vestibuler (TRV).

scholarly journals The Effectiveness of a Radiation Safety Training Program in Increasing the Radiation Safety Knowledge of Physicians: A Pilot Study

2020 ◽  
Vol 24 (1) ◽  
pp. 32-43
Author(s):  
Azam Janati Esfahani ◽  
◽  
Reihaneh Mehrabi ◽  
Nematollah Gheibi ◽  
Reza Paydar ◽  
...  
Keyword(s):  
Training Program ◽  
Work Experience ◽  
Radiation Safety ◽  
Safety Training ◽  
Rank Test ◽  
Before And After ◽  
Post Test ◽  
Signed Rank Test ◽  
The Mean ◽  
Safety Knowledge

Background: Ionizing and non-ionizing radiation are widely used in the diagnosis and treatment of diseases. Considering the potential risks of radiation, radiation safety training courses are important for medical staff. Objective: The aim of this study was to investigate the effectiveness of one-day radiation safety training program in increasing the radiation safety knowledge of physicians. Methods: In this descriptive-analytical study, subjects were 12 physicians (6 general practitioners and 6 non-radiologist specialists) participated in the training program organized by Qazvin University of Medical Sciences in 2018. A researcher-made questionnaire was used for surveying physicians before and after the training. The mean and standard deviation of the scores were first calculated. Then, the pre- and post-test scores were compared using Wilcoxon signed-rank test, and the correlation of these scores with their age, gender, expertise area, and work experience was examined by Spearmanchr('39')s correlation test. Findings: The mean total scores of the physicians before and after training were 7.00±2.56 (ranged 3-11) and 11.92± 2.31 (ranged 8-15) out of 18, respectively. The radiation safety knowledge of physicians significantly increased after training (P<0.001). No significant relationship was found between their scores and their age, gender, expertise area and work experience. Conclusion: The radiation safety training program was effective in increasing the radiation safety knowledge of physicians and it can be used for a larger community of physicians.

scholarly journals The Return Difference between Before and After Issuance of Sharia Bonds (Sukuk)

2020 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
Sindi Wiranda
Keyword(s):  
Stock Exchange ◽  
Abnormal Returns ◽  
Rank Test ◽  
Study Program ◽  
Significance Level ◽  
Signed Rank ◽  
Significant Difference ◽  
Before And After ◽  
Signed Rank Test ◽  
Return Difference

This study aims to analyze sharia downloading which returns shares on the Indonesian Stock Exchange. This study uses a study program to see the average abnormal returns around the sharia promulgation date (sukuk) and the average difference in abnormal returns before and after sharia withdrawal (sukuk). The population in this study were all sharia negotiations published in the 2014-2019 period. and still published in February 2020. The window period is 60 days (t - 30 and t + 30) with a sample of 15 publication events. The method used in this study was the t test and Wilcoxon signed rank test. The results showed that there was an average significant abnormal return around the date of promulgation of sharia (sukuk), namely on the 29th and 1st days before the promulgation of sharia (sukuk). And the results of the Wilcoxon sign rank test show that the significance level is 0.003, which means that H0 is accepted so that there is a significant difference in average returns between before and after the announcement of the sharia withdrawal (sukuk) announcement.

scholarly journals 034 Prospective study of 24-hour levodopa-carbidopa intestinal gel therapy for unresponsive freezing of gait

2019 ◽  
Vol 90 (e7) ◽  
pp. A12.1-A12
Author(s):  
Sai Nagaratnam ◽  
Florence Ching-Fen Chang ◽  
David S Tsui ◽  
Neil Mahant ◽  
Nigel Wolfe ◽  
...  
Keyword(s):  
Infusion Rate ◽  
Freezing Of Gait ◽  
Rank Test ◽  
Open Label ◽  
Night Time ◽  
Open Label Study ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean

IntroductionWe report a prospective, open-label study of 24-hour levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa ‘unresponsive’ freezing of gait (FOG) associated with Parkinson’s disease.Method14 patients with disabling FOG, documented as being levodopa ‘unresponsive’ following dose cycle assessment, were commenced on continuous 24-hour infusion LCIG therapy with the night-time rate at 50–80% of the daytime infusion rate. Patients underwent baseline and 6 months gait assessments, documentation of their falls frequency and completed FOG questionnaires. The statistical analysis was performed with SPSS 25 software (IBM), using Wilcoxon Signed Rank test and p < 0.05 was set as statistically significant.ResultThe fall frequency score reduced from 3 to 1 at 6 months (p=0.011), The FOG questionnaire was 19.3±1.5 at baseline and reduced to 16.0±1.7, at 6 months, respectively (p=0.039). The mean 360 degree turn time was not significantly changed (p=0.77). The daytime LCIG infusion rate was not significantly different before and after 24-hour LCIG therapy (p=0.315). 7 subjects developed visual hallucinations, one required temporary withdrawal from 24-hour LCIG, but as FOG worsened on 16-hour LCIG, he elected to recommence 24-hour LCIG infusion with improvement in FOG with a reduction in falls. 1 subject had postural hypotension which was ameliorated after adjustment of LCIG infusion rate.ConclusionWe provide further evidence that 24-hour LCIG therapy can reduce levodopa ‘unresponsive’ FOG and associated falls.

scholarly journals The Impact of a Dedicated Research Education Month for Anesthesiology Residents

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Robert E. Freundlich ◽  
Jessica W. Newman ◽  
Kevin K. Tremper ◽  
Jill M. Mhyre ◽  
Sachin Kheterpal ◽  
...  
Keyword(s):  
Effective Means ◽  
Posttest Score ◽  
Interquartile Range ◽  
Rank Test ◽  
Research Education ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean ◽  
The Impact

An educational intervention was implemented at the University of Michigan starting in 2008, in which anesthesiology interns complete a dedicated month-long didactic rotation in evidence-based medicine (EBM) and research methodology. We sought to assess its utility. Scores on a validated EBM test before and after the rotation were compared and assessed for significance of improvement. A survey was also given to gauge satisfaction with the quality of the rotation and self-reported improvement in understanding of EBM topics. Fourteen consecutive interns completed the research rotation during the study period. One hundred percent completed both the pre- and postrotation test. The mean pretest score was 7.78 ± 2.46 (median = 7.5, 0–15 scale, and interquartile range 7.0–10.0) and the mean posttest score was 10.00 ± 2.35 (median = 9.5, interquartile range 8.0–12.3), which represented a statistically significant increase (P=0.011, Wilcoxon signed-rank test). All fourteen of the residents “agreed” or “strongly agreed” that they would recommend the course to future interns and that the course increased their ability to critically review the literature. Our findings demonstrate that this can be an effective means of improving understanding of EBM topics and anesthesiology research.

PERBEDAAN FINANCIAL PERFORMANCE PASCA SECONDARY OFFERINGS

Wahana ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 41-49
Author(s):  
Djaja Perdana ◽  
Herbowo Herbowo
Keyword(s):  
Financial Performance ◽  
Stock Exchange ◽  
Hypothesis Test ◽  
Poor Performance ◽  
Rank Test ◽  
Growth Ratio ◽  
Significant Difference ◽  
Before And After ◽  
Signed Rank Test ◽  
Asset Turnover

This study aims to examine the differences in corporate financial performance before and after secondary offerings. The financial performance is proxied by WCR, DER, Solvency, ROA, ROE, Asset Turnover (ATO) and Growth ratio which representing the value of liquidity, financing, activity, performance and growth of the firm. The study involved 67 samples of the companies listed on the Indonesia Stock Exchange conducting secondary offerings during 2008-2013 period and selected through purposive random sampling method and using Financial Statement data from 2005-2016 period. Hypothesis test is performed using Wilcoxon Signed Rank test. The results of this study indicate that there is no significant difference in the ratio of Solvency, ROA and ROE between before and after secondary offerings, but there are significant differences in the ratio of WCR, DER, Asset Turnover and Growth. WCR ratio after secondary offerings increased, while DER ratio after secondary offerings decreased, the condition of both ratios showed better performance. While the indication of poor performance seen in decreasing asset turnover ratio and growth ratio.Keywords : agency theory, financial performance, secondary offerings

The Degree of Subjective Complaints of Students Practice in Mechanical Technology Laboratories

2018 ◽  
Vol 4 (1) ◽  
pp. 22
Author(s):  
I Ketut Widana
Keyword(s):  
Engineering Students ◽  
Standing Position ◽  
Statistical Test ◽  
Rank Test ◽  
Cross Sectional ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Difference ◽  
Paired T Test

The working practice of the engineering students is part of the learning process that is irreducible and indispensable. The composition of  lecturing between theoretical and practical one is 40% to 60%. With this condition, the students spend more time at the laboratory. Generally, the students perform in the laboratory work by standing position. The design of research is observational cross-sectional. The method applied is observation, interview and measuring. The subjects of research are practicing students amounting to 21 students. Referring to the analysis of statistical test or Wilcoxon signed ranks test, the difference of effect of work position is significant, namely p < 0.05 towards musculoskeletal disorders (MSDs) before and after working. The quantity of the average complaint after working is score 44.62 ± 9.47. The result of Wilcoxon signed rank test shows that there is significant different effects of standing work position, namely p < 0.05 towards fatigue generally before and after working. The degree of the working pulse is on the average of 110.78  ± 17.80 bpm (beats per minutes) which can be categorized into the medium workload. Using paired t-test, the result is p < 0.05.

The potential role of an activity-based guitar program on the anxiety and fulfillment levels of younger relatives of cancer patients: A pilot study

2021 ◽  
pp. 025576142110273
Author(s):  
Erkan Sülün ◽  
Hüseyin Olgaçer ◽  
Hakkı Cengiz Eren
Keyword(s):  
Cancer Patients ◽  
Trait Anxiety ◽  
Potential Role ◽  
Rank Test ◽  
Satisfaction Scale ◽  
Before And After ◽  
Signed Rank Test ◽  
Total State ◽  
Rank Differences

In this study, the authors evaluated the potential role of an activity-based guitar training program on reducing anxiety and providing fulfillment for younger relatives of cancer patients. Ten active members of KHYD (The Society for Relatives of Cancer Patients), between ages 11 and 17 participated in an 8-week guitar education program. The participants filled out two questionnaires before and after their engagement in the 8-week program, one to measure changes in their anxiety levels (State-Trait Anxiety Inventory) and the other to measure changes in their general fulfillment levels (Multidimensional Students’ Life Satisfaction Scale). Wilcoxon signed rank test, as well as descriptive statistics were used in the analysis of data. Mean rank differences were observed to be statistically significant with respect to total state and trait anxiety scores; in both cases, the participants’ scores decreased after their engagement in the program. Statistically significant mean rank differences were also observed in the overall MSLSS scores and its “friends” and “environment” sub-dimensions; with respect to these, participants’ scores increased after their engagement in the program. Recommendations for more comprehensive, larger-scale studies are given at the end.

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