scholarly journals 034 Prospective study of 24-hour levodopa-carbidopa intestinal gel therapy for unresponsive freezing of gait

2019 ◽  
Vol 90 (e7) ◽  
pp. A12.1-A12
Author(s):  
Sai Nagaratnam ◽  
Florence Ching-Fen Chang ◽  
David S Tsui ◽  
Neil Mahant ◽  
Nigel Wolfe ◽  
...  
Keyword(s):  
Infusion Rate ◽  
Freezing Of Gait ◽  
Rank Test ◽  
Open Label ◽  
Night Time ◽  
Open Label Study ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean

IntroductionWe report a prospective, open-label study of 24-hour levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa ‘unresponsive’ freezing of gait (FOG) associated with Parkinson’s disease.Method14 patients with disabling FOG, documented as being levodopa ‘unresponsive’ following dose cycle assessment, were commenced on continuous 24-hour infusion LCIG therapy with the night-time rate at 50–80% of the daytime infusion rate. Patients underwent baseline and 6 months gait assessments, documentation of their falls frequency and completed FOG questionnaires. The statistical analysis was performed with SPSS 25 software (IBM), using Wilcoxon Signed Rank test and p < 0.05 was set as statistically significant.ResultThe fall frequency score reduced from 3 to 1 at 6 months (p=0.011), The FOG questionnaire was 19.3±1.5 at baseline and reduced to 16.0±1.7, at 6 months, respectively (p=0.039). The mean 360 degree turn time was not significantly changed (p=0.77). The daytime LCIG infusion rate was not significantly different before and after 24-hour LCIG therapy (p=0.315). 7 subjects developed visual hallucinations, one required temporary withdrawal from 24-hour LCIG, but as FOG worsened on 16-hour LCIG, he elected to recommence 24-hour LCIG infusion with improvement in FOG with a reduction in falls. 1 subject had postural hypotension which was ameliorated after adjustment of LCIG infusion rate.ConclusionWe provide further evidence that 24-hour LCIG therapy can reduce levodopa ‘unresponsive’ FOG and associated falls.

The Dizziness Handicap Inventory questionnaire scores before-and-after vestibular rehabilitation therapy of presbyastasis patients

2020 ◽  
Vol 50 (1) ◽  
pp. 21
Author(s):  
Etty Sekardewi ◽  
Achmad Chusnu Romdhoni ◽  
Haris Mayagung Ekorini
Keyword(s):  
The Elderly ◽  
Vestibular Rehabilitation ◽  
Rank Test ◽  
Dizziness Handicap Inventory ◽  
Rehabilitation Therapy ◽  
Consecutive Sampling ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean

Background: Presbyastasis is multifactorial balance dysfunction that occurs in the elderly person. Presbyastasis can increase the risk of fall, anxiety, and decrease the quality of life. Vestibular rehabilitation therapy (VRT) has been proven effective to overcome balance disorders, and it is safe for the elderly. Several studies had reported the success of VRT for balance disorders. All this time, the accomplishment of VRT was assessed by using balance test, which had a risk of falling in elderly patients. Objective: To find out the outcome of Dizziness Handicap Inventory (DHI) questionnaire score in presbyastasis patients after VRT. Method: Ten presbyastasis patients in age range 60-75 years old who met the study criteria were taken by consecutive sampling. A longitudinal observational (pre and posttest) study by analyzing the DHI questionnaire scores. Assessment was performed twice, before and after VRT. The data was analyzed using paired T test and Wilcoxon signed rank test with outcome p<0.05. Result: The measurement of the emotional subscale DHI (DHI.E) showed the mean score before VRT was 4.00 (1.63), after therapy was 0.00 (0.63), p=0.004. The functional subscale (DHI.F) measurement showed the mean score before VRT was 10.40 (3.98), after therapy was 2.40 (2.07), p 0.00. The mean score of physical subscales (DHI.P) measurement before VRT was 9.00 (4.40), after therapy was 2.00 (1.58), p=0.008. The total DHI score (DHI.T) before VRT was 22.6 (7.67), after VRT was 4.20 (2.2) with p=0.000. Conclusion: There was an improvement in DHI questionnaire score before and after 6 weeks VRT.Keywords: Vestibular rehabilitation therapy (VRT), Dizziness Handicap Inventory (DHI), presbyastasis ABSTRAK Latar belakang: Presbiastasis dapat meningkatkan angka jatuh, kecemasan dan menurunkan kemandirian sehingga menurunkan kualitas hidup pada usia lanjut. Terapi rehabilitasi vestibuler (TRV) merupakan modal terapi yang terbukti dapat mengatasi gangguan keseimbangan, dan aman untuk usia lanjut. Beberapa penelitian melaporkan adanya keberhasilan TRV pada penderita gangguan keseimbangan. Keberhasilan dari TRV selama ini dinilai dengan menggunakan pemeriksaan keseimbangan yang memiliki risiko jatuh pada penderita usia lanjut. Tujuan: Membuktikan adanya perubahan skor kuesioner Dizziness Handicap Inventory (DHI) pada penderita presbiastasis sesudah TRV. Metode: Sepuluh penderita presbiastasis usia 60-75 tahun yang memenuhi kriteria penelitian diambil secara consecutive sampling. Studi observasi longitudinal (pre dan posttest) dengan menghitung dan menganalisis skor kuesioner DHI. Pengukuran dilakukan 2 kali yaitu sebelum TRV dan sesudah TRV. Analisis data dilakukan dengan paired T test dan Wilcoxon signed rank test, dengan hasil p<0,05. Hasil: Pengukuran skor kuesioner DHI subskala Emotional (DHI.E) sebelum TRV mempunyai mean 4,00 (1,63), 6 minggu sesudah TRV didapatkan mean 0,00 (0,63), p=0,004. Hasil subskala Functional (DHI.F) sebelum TRV didapatkan mean 10,40 (3,98), 6 minggu sesudah TRV, mean 2,40 (2,07), p=0,00. Pada subskala Physical (DHI.P) didapatkan mean 9,00 (4,40), dan 6 minggu sesudah TRV didapatkan mean 22,6 (7,67), sesudah TRV didapatkan mean 4,20 (2,2) dengan p=0,000. Kesimpulan: Terdapat perbaikan skor kuesioner DHI sesudah 6 minggu terapi rehabilitasi vestibuler (TRV).

scholarly journals The Impact of a Dedicated Research Education Month for Anesthesiology Residents

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Robert E. Freundlich ◽  
Jessica W. Newman ◽  
Kevin K. Tremper ◽  
Jill M. Mhyre ◽  
Sachin Kheterpal ◽  
...  
Keyword(s):  
Effective Means ◽  
Posttest Score ◽  
Interquartile Range ◽  
Rank Test ◽  
Research Education ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Mean ◽  
The Impact

An educational intervention was implemented at the University of Michigan starting in 2008, in which anesthesiology interns complete a dedicated month-long didactic rotation in evidence-based medicine (EBM) and research methodology. We sought to assess its utility. Scores on a validated EBM test before and after the rotation were compared and assessed for significance of improvement. A survey was also given to gauge satisfaction with the quality of the rotation and self-reported improvement in understanding of EBM topics. Fourteen consecutive interns completed the research rotation during the study period. One hundred percent completed both the pre- and postrotation test. The mean pretest score was 7.78 ± 2.46 (median = 7.5, 0–15 scale, and interquartile range 7.0–10.0) and the mean posttest score was 10.00 ± 2.35 (median = 9.5, interquartile range 8.0–12.3), which represented a statistically significant increase (P=0.011, Wilcoxon signed-rank test). All fourteen of the residents “agreed” or “strongly agreed” that they would recommend the course to future interns and that the course increased their ability to critically review the literature. Our findings demonstrate that this can be an effective means of improving understanding of EBM topics and anesthesiology research.

The Degree of Subjective Complaints of Students Practice in Mechanical Technology Laboratories

2018 ◽  
Vol 4 (1) ◽  
pp. 22
Author(s):  
I Ketut Widana
Keyword(s):  
Engineering Students ◽  
Standing Position ◽  
Statistical Test ◽  
Rank Test ◽  
Cross Sectional ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
The Difference ◽  
Paired T Test

The working practice of the engineering students is part of the learning process that is irreducible and indispensable. The composition of  lecturing between theoretical and practical one is 40% to 60%. With this condition, the students spend more time at the laboratory. Generally, the students perform in the laboratory work by standing position. The design of research is observational cross-sectional. The method applied is observation, interview and measuring. The subjects of research are practicing students amounting to 21 students. Referring to the analysis of statistical test or Wilcoxon signed ranks test, the difference of effect of work position is significant, namely p < 0.05 towards musculoskeletal disorders (MSDs) before and after working. The quantity of the average complaint after working is score 44.62 ± 9.47. The result of Wilcoxon signed rank test shows that there is significant different effects of standing work position, namely p < 0.05 towards fatigue generally before and after working. The degree of the working pulse is on the average of 110.78  ± 17.80 bpm (beats per minutes) which can be categorized into the medium workload. Using paired t-test, the result is p < 0.05.

PERBANDINGAN KADAR ENZIM KREATININ FOSFOKINASE DAN NYERI OTOT SEBELUM DAN SESUDAH LATIHAN BERENANG SELAMA EMPAT MINGGU PADA PERENANG UNIT KEGIATAN MAHASISWA KLUB RENANG

2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Nur Akmal Binti A'ffan ◽  
Reni Farenia ◽  
Delita Prihatni
Keyword(s):  
Muscle Soreness ◽  
Creatine Phosphokinase ◽  
Rank Test ◽  
Healthy Male ◽  
Blood Draw ◽  
Normality Test ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Enzyme Elevation

A research has been done to compare the differences on the enzyme creatine phosphokinase (CPK) level and muscle soreness before and after 4-weeks swim practices on swimmers of College swimming club. Eighteen healthy male swimmers (mean ± SD; age: 19,94 ± 1,86 years; weight: 65,28 ± 6,14 kg; height: 1,72 ± 0,43 m) participated in this study. All subjects performed their 4-weeks swim practices which consist of 2x120 hours per week with 500 meters average daily swim distance and weight training. Blood was collected before and after the practices and CPK were analyzed. Questionnaires concerning muscle soreness were filled put before each blood draw. Results were analyzed using normality test and Wilcoxon signed rank test (p<0.05). There was significant increase in CPK level during 4-weeks swim practices by 59.41% (p=0.044). Whereas for muscle soreness (overall and specifically in arms and thighs), there was no significant differences between before and after the 4-weeks swim practices. As a conclusion, participation in 4-weeks swim practices resulted in significant serum CPK enzyme elevation, but there was lack of significance in muscle soreness differences on swimmers of College swimming club.

Frenotomy in Infants with Tongue-Tie and Breastfeeding Problems

2018 ◽  
Vol 35 (4) ◽  
pp. 706-712 ◽  
Author(s):  
Anjana Srinivasan ◽  
Alex Al Khoury ◽  
Svetlana Puzhko ◽  
Carole Dobrich ◽  
Meira Stern ◽  
...  
Keyword(s):  
Medical Community ◽  
Rank Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Breastfeeding Counseling ◽  
The Right ◽  
Breastfeeding Problems ◽  
Numeric Rating

Background: Infant tongue-tie can cause breastfeeding problems, which may be improved by frenotomy. However, controversy exists among the medical community. Research aim: To examine the influence of frenotomy on infants with posterior ankyloglossia, by quantifying the changes in breastfeeding and maternal nipple pain using standardized tools. Methods: Newborns ( N = 30) below 12 weeks of age were recruited from the Herzl–Goldfarb Breastfeeding Clinic between April 2014 and April 2015. Diagnosis of posterior ankyloglossia was made clinically. Frenotomy was performed. Mothers received breastfeeding counseling before and after the procedure. Pain and breastfeeding were assessed before the procedure, immediately after the procedure, and after 2 days, 7 days and 14 days. Breastfeeding was assessed using the LATCH Tool and by subjective questioning. Maternal nipple pain was assessed using the Numeric Rating System. Results: No complications were reported with frenotomy. There was a significant improvement in LATCH score immediately post-frenotomy, with an increase in median scores from 7.5 to 8.5 ( p < .0001, Wilcoxon signed rank test). There was a significant decrease in median pain score immediately post-frenotomy, from 3.0 on the left nipple and 3.25 on the right nipple, to 0 bilaterally ( p < .0001, Wilcoxon signed rank test). Subjective improvement in breastfeeding was reported by 90% of mothers immediately after frenotomy and 83% of mothers at Day 14. Conclusion: Frenotomy for posterior ankyloglossia may improve breastfeeding and nipple pain.

scholarly journals Improving indicators of tuberculosis program cascades by leveraging HIV program strategies

2019 ◽  
Vol 9 (4) ◽  
pp. 191-195
Author(s):  
S. C. Meribe ◽  
E. Harausz ◽  
I. Lawal ◽  
A. Ogundeji ◽  
C. Mbanefo ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Rank Test ◽  
Military Hospitals ◽  
Us Army ◽  
Signed Rank ◽  
Before And After ◽  
Army Medical Research ◽  
Signed Rank Test ◽  
The Impact ◽  
Number Of Individuals

Background: To improve rates of human immunodeficiency virus (HIV) case detection and treatment, the Nigerian Ministry of Defense Health Implementation Program and the US Army Medical Research Directorate-Africa/Nigeria introduced a HIV standard of care (SOC) package. Given the integration of tuberculosis (TB) and HIV programs and evolving policies, we evaluated the impact of this strategy on TB program indicators.Methods: Routine, de-identified program data from 27 Nigerian military hospitals were analyzed. Using Wilcoxon signed-rank test, bivariate analyses were performed to compare data from 12 months before and after implementation of the SOC package.Results: Our data showed improvements post-implementation as follows: the number of individuals receiving antiretroviral therapy (ART) screened for TB increased from 14 530 to 29 467 (P < 0.001); the number of individuals with presumptive TB identified increased from 803 to 1800 (P < 0.001); the number of ART clients bacteriologically tested for TB increased from 746 to 1717 (P < 0.001); and the number of ART clients treated for TB increased from 152 to 282 (P < 0.001). Newly registered or relapsed TB cases increased from 436 to 906 (P < 0.001), the number of TB cases with known HIV status increased from 437 to 837 (P < 0.001), the number of TB-HIV co-infected cases increased from 182 to 301 (P = 0.006), and the number of TB-HIV co-infected clients who started ART increased from 101 to 176 (P = 0.003).Conclusion: The implementation of the updated HIV SOC package led to the improvement in key TB diagnosis and treatment indicators. When emulated, this could help improve the performance of other TB programs in countries other than Nigeria.

scholarly journals MARKET REACTION ON THE ANNOUNCEMENT OF SRI KEHATI INDEX IN INDONESIAN STOCK EXCHANGE

2019 ◽  
Author(s):  
Anggita Langgeng Wijaya ◽  
Mia Noviyanti ◽  
Probo Mahayu
Keyword(s):  
Trading Volume ◽  
Market Reaction ◽  
Stock Exchange ◽  
Abnormal Returns ◽  
Rank Test ◽  
Stock Trading ◽  
Population Sampling ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test

The purpose of this study was to test the market reaction to the announcement of the Sri Kehati Index on the Indonesia Stock Exchange. The population in this study is all companies included in the Sri Kehati Index from 2013 to 2016. The selection of samples was taken by the population sampling method. Hypothesis testing is done by paired t test and Wilcoxon Signed Rank Test. The findings of this research are: 1) there is no difference in abnormal returns before and after the announcement of the Sri Kehati Index on the Indonesia Stock Exchange. 2) There is a difference in the activity of stock trading volume before and after the announcement of the Sri Kehati index in the 5th and 6th periods, but there is no difference in the activity of stock trading volume in other periods. The Indonesia Stock Exchange did not react consistently to the announcement of the Sri Kehati Index.

scholarly journals Effectiveness of Picture Story Books Reading to Increase Kindness in Children Aged 5-6 Years

2018 ◽  
Vol 12 (1) ◽  
pp. 89 ◽  
Author(s):  
Giyati Retnowati ◽  
Rose Mini Agoes Salim ◽  
Airin Y Saleh
Keyword(s):  
Test Score ◽  
Measurement Instrument ◽  
Rank Test ◽  
Average Score ◽  
Storybook Reading ◽  
Signed Rank ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Signed Rank Test

This research aimed to determine the effectiveness of picture in storybook reading to increase kindness in children. This research involved 31 children aged 5-6 years; they were taken from the kindergarten in Bandung as the participants. The intervention was done by reading eight picture books in eight days. The kindness was measured using a measurement instrument created by the researcher, in the form of nine coloured cards that described the behaviour of kindness. The measurement was also done by seeing through the kindness tree and observation sheets that filled out by the teacher. The data analysis using the Wilcoxon Signed-rank test shows a significant difference in the average score of kindness (p<0,05) before and after picture storybook reading. Two weeks after the intervention, the improvement on all kindness behaviours with the post-test score is greater than pre-test score that still can be found. Observation through kindness tree and observational sheets shows the same result.

scholarly journals Analisis Kinerja Keuangan Bank Umum Syariah Sebelum dan Sesudah Pengalihan Dana Haji pada Bank Syariah

2021 ◽  
Vol 1 (2) ◽  
pp. 309-331
Author(s):  
Lisa Erliana Marwan ◽  
Iwan Setiawan ◽  
Ine Mayasari
Keyword(s):  
Financial Performance ◽  
Rank Test ◽  
Positive Contribution ◽  
Islamic Banks ◽  
Fund Management ◽  
Financial Report ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Conventional Banks

Government policy through UU No 34 Thn 2014 about Hajj Fund Management said that the Hajj Fund Management should with the principle of sharia. Then in 2014, there was a transfer Hajj Fund from Conventional banks to Islamic banks. Hajj Fund that transferred to Islamic banks have a large value so it can give positive contribution to the  financial performance such as DPK.The aim of this study was to find out the financial performance of 6 BPS BPIH before and after the transfer of Hajj Fund from conventional banks to Islamic banks. Taking case studies at PT. Bank Syariah Mandiri, PT. Bank BRI Syariah, PT. Bank BNI Syariah, PT. Bank Mega Syariah, PT. Bank Panin Dubai Syariah, and PT. Bank Muamalat.  The Data that used in this study is Return On Assets (ROA) and Financing to Deposit Ratio (FDR) in Quarterly Financial Report of 6 BPS BPIH,4 years before the transfer of hajj fund that started 2010 until 2013, and 4 years after the transfer of hajj fund that started from 2015 until 2018. The method of data analysis in this study uses a different samples in non parametrik, which is Wilcoxon Signed Rank Test. The result of this  study  shows us that there was a difference in ROA and FDR of BPS BPIH before and after the transfer of  hajj  fund  from  conventional  banks  to Islamic banks.

scholarly journals Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals

2005 ◽  
Vol 49 (8) ◽  
pp. 3373-3381 ◽  
Author(s):  
Gene D. Morse ◽  
Susan Rosenkranz ◽  
Michael F. Para ◽  
Yoninah Segal ◽  
Robin DiFrancesco ◽  
...  
Keyword(s):  
Confidence Intervals ◽  
Geometric Mean ◽  
Rank Test ◽  
Control Group ◽  
Median Percentage ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Aids Clinical Trials

ABSTRACT Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). Subjects (n = 56) received 600 mg of EFV every 24 h (q24h) for 10 days and restarted APV with EFV for days 11 to 13 with a PK study on day 14. A second protease inhibitor (PI) (NFV, 1,250 mg, q12h; IDV, 1,200 mg, q12h; RTV, 100 mg, q12h; or SQV, 1,600 mg, q12h) was added to APV and EFV on day 15, and a PK study was conducted on day 21. Controls continued APV and EFV without a second PI. Among subjects, the APV areas under the curve (AUCs) on days 0, 14, and 21 were compared using the Wilcoxon signed-rank test. Ninety-percent confidence intervals around the geometric mean ratios (GMR) were calculated. APV AUCs were 46% to 61% lower (median percentage of AUC) with EFV (day 14 versus day 0; P values of <0.05). In the NFV, IDV, and RTV groups, day 21 APV AUCs with EFV were higher than AUCs for EFV alone. Ninety-percent confidence intervals around the GMR were 3.5 to 5.3 for NFV (P < 0.001), 2.8 to 4.5 for IDV (P < 0.001), and 7.8 to 11.5 for RTV (P = 0.004). Saquinavir modestly increased the APV AUCs (GMR, 1.0 to 1.4; P = 0.106). Control group AUCs were lower on day 21 compared to those on day 14 (GMR, 0.7 to 1.0; P = 0.042). African-American non-Hispanics had higher day 14 efavirenz AUCs than white non-Hispanics. We conclude that EFV lowered APV AUCs, but nelfinavir, indinavir, or ritonavir compensated for EFV induction.

Sign in / Sign up

Export Citation Format

Share Document