scholarly journals Mothers cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rats offspring

2021 ◽  
Author(s):  
Julia Matuszewska ◽  
Tomasz Zalewski ◽  
Adam Klimaszyk ◽  
Kamil Ziarniak ◽  
Stefan Jurga ◽  
...  
Keyword(s):  
Diabetes Type 2 ◽  
Interleukin 10 ◽  
Female Offspring ◽  
Fat Content ◽  
Metabolic Profiles ◽  
Obesity And Diabetes ◽  
Tnf Α ◽  
Pregnancy And Lactation ◽  
High Concentrations

Abstract “Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributing to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet, in animals cafeteria (CAF) diet is used. We hypothesis that CAF diet given to rats before, during pregnancy and lactation differently influence fat content, metabolic and inflammation profiles in offspring. Female were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25) body composition, fat contents were measured, blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet leaded to sex-specific alterations in offspring. At PND25, CAF offspring had: 1) higher percentage of fat content and were lighter; 2) sex-specific differences in levels of glucose; 3) higher levels of interleukins 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); 4) sex-specific differences in concentration of IL-6 and TNF-α, with increase in CAF females; 5) higher level of IL-10 in both sex, with bigger increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

scholarly journals Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julia Matuszewska ◽  
Tomasz Zalewski ◽  
Adam Klimaszyk ◽  
Kamil Ziarniak ◽  
Stefan Jurga ◽  
...  
Keyword(s):  
Diabetes Type 2 ◽  
Interleukin 10 ◽  
Female Offspring ◽  
Fat Content ◽  
Metabolic Profiles ◽  
Pronounced Increase ◽  
Obesity And Diabetes ◽  
Tnf Α ◽  
Pregnancy And Lactation ◽  
High Concentrations

Abstract“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Females were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25), body composition, fat contents were measured, and blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet lead to sex-specific alterations in offspring. At PND25, CAF offspring had: (1) higher percentage of fat content, and were lighter; (2) sex-specific differences in levels of glucose; (3) higher levels of interleukin 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); (4) sex-specific differences in concentration of IL-6 and TNF-α, with an increase in CAF females; (5) higher level of IL-10 in both sexes, with a more pronounced increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

scholarly journals Vitamin D deficiency is a risk factor for obesity and diabetes type 2 in women at late reproductive age

Aging ◽  
2013 ◽  
Vol 5 (7) ◽  
pp. 575-581 ◽  
Author(s):  
Grineva EN ◽  
Karonova T ◽  
Micheeva E ◽  
Belyaeva O ◽  
Belyaeva IL
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Reproductive Age ◽  
Obesity And Diabetes

scholarly journals Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Anna Weiser ◽  
Pieter Giesbertz ◽  
Hannelore Daniel ◽  
Britta Spanier
Keyword(s):  
Amino Acid ◽  
Principal Component ◽  
The Metabolic Syndrome ◽  
Branched Chain Amino Acid ◽  
Nzo Mice ◽  
Obesity And Diabetes ◽  
Human Diabetes ◽  
High Concentrations ◽  
Branched Chain

The New Zealand obese (NZO) mouse is a polygenic model for obesity and diabetes with obese females and obese, diabetes-prone males, used to study traits of the metabolic syndrome like type 2 diabetes mellitus (T2DM), obesity, and dyslipidaemia. By using LC-MS/MS, we here examine the suitability of this model to mirror tissue-specific changes in acylcarnitine (AC) and amino acid (AA) species preceding T2DM which may reflect patterns investigated in human metabolism. We observed high concentrations of fatty acid-derived ACs in 11 female mice, high abundance of branched-chain amino acid- (BCAA-) derived ACs in 6 male mice, and slight increases in BCAA-derived ACs in the remaining 6 males. Principal component analysis (PCA) including all ACs and AAs confirmed our hypothesis especially in plasma samples by clustering females, males with high BCAA-derived ACs, and males with slight increases in BCAA-derived ACs. Concentrations of insulin, blood glucose, NEFAs, and triacylglycerols (TAGs) further supported the hypothesis of high BCAA-derived ACs being able to mirror the onset of diabetic traits in male individuals. In conclusion, alterations in AC and AA profiles overlap with observations from human studies indicating the suitability of NZO mice to study metabolic changes preceding human T2DM.

scholarly journals NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice

2019 ◽  
Vol 12 ◽  
Author(s):  
Olga Ratai ◽  
Joanna Hermainski ◽  
Keerthana Ravichandran ◽  
Olaf Pongs
Keyword(s):  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Obesity And Diabetes

scholarly journals Omega-6:Omega-3 Fatty Acid Ratio and Total Fat Content of the Maternal Diet Alter Offspring Growth and Fat Deposition in the Rat

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2505 ◽  
Author(s):  
Sally A. V. Draycott ◽  
Matthew J. Elmes ◽  
Beverly S. Muhlhausler ◽  
Simon Langley-Evans
Keyword(s):  
Maternal Diet ◽  
Female Offspring ◽  
Fat Content ◽  
Fat Deposition ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Adult Rats ◽  
Offspring Growth ◽  
Pregnancy And Lactation ◽  
Total Fat

Omega-3 long-chain polyunsaturated fatty acids (LCPUFA) have been shown to inhibit lipogenesis and adipogenesis in adult rats. Their possible early life effects on offspring fat deposition, however, remain to be established. To investigate this, female Wistar rats (n = 6–9 per group) were fed either a 9:1 ratio of linoleic acid (LA) to alpha-linolenic acid (ALA) or a lower 1:1.5 ratio during pregnancy and lactation. Each ratio was fed at two total fat levels (18% vs. 36% fat w/w) and offspring were weaned onto standard laboratory chow. Offspring exposed to a 36% fat diet, irrespective of maternal dietary LA:ALA ratio, were lighter (male, 27 g lighter; female 19 g lighter; p < 0.0001) than those exposed to an 18% fat diet between 3 and 8 weeks of age. Offspring exposed to a low LA (18% fat) diet had higher proportions of circulating omega-3 LCPUFA and increased gonadal fat mass at 4 weeks of age (p < 0.05). Reduced Srebf1 mRNA expression of hepatic (p < 0.01), gonadal fat (p < 0.05) and retroperitoneal fat (p < 0.05) tissue was observed at 4 weeks of age in male and female offspring exposed to a 36% fat diet, and hepatic Srebf1 mRNA was also reduced in male offspring at 8 weeks of age (p < 0.05). Thus, while offspring fat deposition appeared to be sensitive to both maternal dietary LA:ALA ratio and total fat content, offspring growth and lipogenic capacity of tissues appeared to be more sensitive to maternal dietary fat content.

Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring

2005 ◽  
Vol 288 (2) ◽  
pp. R368-R373 ◽  
Author(s):  
D. S. Fernandez-Twinn ◽  
A. Wayman ◽  
S. Ekizoglou ◽  
M. S. Martin ◽  
C. N. Hales ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Insulin Signaling ◽  
Plasma Insulin ◽  
Female Offspring ◽  
Protein Restriction ◽  
Female Rat ◽  
Pregnancy And Lactation

Human adult diseases such as cardiovascular disease, hypertension, and type 2 diabetes have been epidemiologically linked to poor fetal growth and development. Male offspring of rat dams fed a low-protein (LP) diet during pregnancy and lactation develop diabetes with concomitant alterations in their insulin-signaling mechanisms. Such associations have not been studied in female offspring. The aim of this study was to determine whether female LP offspring develop diabetes in later life. Control and LP female offspring groups were obtained from rat dams fed a control (20% protein) or an isocaloric (8% protein) diet, respectively, throughout pregnancy and lactation. Both groups were weaned and maintained on 20% normal laboratory chow until 21 mo of age when they underwent intravenous glucose tolerance testing (IVGTT). Fasting glucose was comparable between the two groups; however, LP fasting insulin was approximately twofold that of controls ( P < 0.02). Glucose tolerance during IVGTT was comparable between the two groups; however, LP peak plasma insulin at 4 min was approximately threefold higher than in controls ( P < 0.001). LP plasma insulin area under the curve was 1.9-fold higher than controls ( P < 0.02). In Western blots, both muscle protein kinase C-ζ expression and p110β-associated p85α in abdominal fat were reduced ( P < 0.05) in LPs. Hyperinsulinemia in response to glucose challenge coupled with attenuation of certain insulin-signaling molecules imply the development of insulin resistance in LP muscle and fat. These observations suggest that intrauterine protein restriction leads to insulin resistance in females in old age and, hence, an increased risk of type 2 diabetes.

scholarly journals Role of Curcuma Longa in Type 2 Diabetes and its Associated Complications

2021 ◽  
pp. 369-376
Author(s):  
Waseem Abbas ◽  
Rafeeq Alam Khan ◽  
Mirza Tasawer Baig ◽  
Safdar Ali Shaikh ◽  
Andeep Kumar
Keyword(s):  
Umbilical Vein ◽  
Curcuma Longa ◽  
Diabetes Type 2 ◽  
Nutritional Supplement ◽  
Diabetic Rats ◽  
Diabetes Diagnosis ◽  
Obesity And Diabetes ◽  
Umbilical Vein Endothelial Cells

Background: Occurrence of Diabetes and its related complications increased all over the world due to recent lifestyle trends.  A higher proportion of ultra-processed foods in the diet have been associated with a higher risk of T2D. A lack of fiber and a surplus of refined simple carbohydrate are contributing to obesity and diabetes diagnosis. Hence there is need to evaluate different nutraceuticals for the management of Diabetes. Methodology: A Scopus, pub Med/Medline and Google Scholar electronic database search was done by using the key word role of Curcuma Longa in diabetes type 2 and its associated complications to review the related articles. Summary: Curcumin a yellow color powder is one of the most important components of Curcuma Longa L; and commonly utilized as food additive in Asian countries. Pre-treatment of human umbilical vein endothelial cells curcumin leads to decrease in intracellular MGO level induced by exogenous MGO and also modify the carboxymethyl cellulose formation. Curcumin nutritional supplement fully normalized arterial AGEs. Curcumin reduced AGEs increase in the heart of diabetic rats. Curcumin reduces the development of diabetes in pre-diabetic population. Conclusion: The literature review shows that the Curcuma Longa L; revealed anti-diabetic and antioxidant effects and prevent the development of diabetes associated complications in different animal model.

scholarly journals Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis

2008 ◽  
Vol 14 (30) ◽  
pp. 4771 ◽  
Author(s):  
Felix I Tellez-Avila ◽  
Francisco Sanchez-Avila ◽  
Mauricio García-Saenz-de-Sicilia ◽  
Norberto C Chavez-Tapia ◽  
Ada M Franco-Guzman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Cryptogenic Cirrhosis ◽  
Obesity And Diabetes
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