Comprehensive analysis of the association between human diseases and water pollutants
Abstract Drinking water is an important natural resource. For many people around the world, especially in developing countries, access to safe drinking water is still a distant dream. An increasing number of human activities and industrialization have caused various physical, chemical and biological pollutants to enter water bodies, affecting human health. Efforts to figure out an effective method to predict water pollution poisons and human diseases have increased worldwide. Water pollutants contain a vast number of additives such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metal and pharmacologies. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to the many diseases, including colonic neoplasms, breast neoplasms hepatitis B, bladder cancer and human cytomegalovirus infection. Therefore, conducting an integrative toxicogenomic analysis of water pollutants are more appropriate for evaluating the potential effects of plastics in human health.