scholarly journals BRAF p.V600E Mutation as Acquired Resistance Mechanism of Lorlatinib in a ROS1 Rearrangement Lung Adenocarcinoma Patient with Primary Ceritinib Resistance

2021 ◽  
Author(s):  
Zhulin Liu ◽  
Zhaojie Han ◽  
Naifu Nie ◽  
Mingxia Feng ◽  
Li Li ◽  
...  
Keyword(s):  
High Frequency ◽  
Acquired Resistance ◽  
Resistance Mechanism ◽  
First Line ◽  
Very High Frequency ◽  
First Case ◽  
Lung Adenocarcinoma Patient ◽  
Ros1 Rearrangement ◽  
First Time ◽  
Very High

Abstract Both crizotinib and ceritinib are recommended as first-line theray for NSCLC with ROS1 rearrangements, with the latter having stronger infiltration ability across blood-brain barrier. Here we report for the first time that a brain metastatic adenocarcinoma patient with CD74-ROS1 rearrangement was sensitive to crizotinib but resistant to ceritinib. Intracranial progression happened after 7 months of crizotinib, and sencond-line lorlatinib resulted in partial response and a PFS of 8 months. Upon lorlatinib resistance, repeated NGS detection of ctDNA from peripheral blood showed BRAF p.V600E, CD74-ROS1 and ROS1 pG2032R. Then, Trametinib, dabrafenib, and cabozantinib was administered to the patient. However, disease progressed very quickly and the patient passed away only one month later, with a overall survival of months. The last ctDNA test, one week before death of the patient, found that BRAF p.V600E disappeared, leaving only CD74-ROS1and ROS1 pG2032R,with a very high frequency. To our knowledge, this is the first case report of a ROS-1 rearrangement lung cancer patient that is sensitive to crizotinib but resistant to ceritinib, and BRAF p.V600E as resistant mechanism for lorlatinib.

scholarly journals Spectropolarimetric observations of the CIZA J2242.8+5301 northern radio relic: no evidence of high-frequency steepening

2020 ◽  
Vol 498 (2) ◽  
pp. 1628-1637 ◽  
Author(s):  
F Loi ◽  
M Murgia ◽  
V Vacca ◽  
F Govoni ◽  
A Melis ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Power Law ◽  
High Frequency ◽  
Galaxy Cluster ◽  
Very High Frequency ◽  
Best Fitting ◽  
First Time ◽  
Polarization Fraction ◽  
Very High ◽  
Fitting Model

ABSTRACT Observations of radio relics at very high frequency (>10 GHz) can help to understand how particles age and are (re-)accelerated in galaxy cluster outskirts and how magnetic fields are amplified in these environments. In this work, we present new single-dish 18.6 GHz Sardinia Radio Telescope and 14.25 GHz Effelsberg observations of the well-known northern radio relic of CIZA J2242.8+5301. We detected the relic which shows a length of ∼1.8 Mpc and a flux density equal to $S_{14.25\, \mathrm{ GHz}}=(9.5\pm 3.9)\, \mathrm{ mJy}$ and $S_{18.6\, \mathrm{ GHz}}=(7.67\pm 0.90)\, \mathrm{ mJy}$ at 14.25 and 18.6 GHz, respectively. The resulting best-fitting model of the relic spectrum from 145 MHz to 18.6 GHz is a power-law spectrum with spectral index α = 1.12 ± 0.03: no evidence of steepening has been found in the new data presented in this work. For the first time, polarization properties have been derived at 18.6 GHz, revealing an averaged polarization fraction of $\sim\! 40{{\ \rm per\ cent}}$ and a magnetic field aligned with the ’filaments’ or ’sheets’ of the relic.

Experimental Investigation of very High Frequency Slot Antenna on M-60A-1 Tank

1977 ◽  
Author(s):  
D. V. Campbell ◽  
William Kennebeck ◽  
A. Zanella ◽  
Paul Sexton
Keyword(s):  
Experimental Investigation ◽  
High Frequency ◽  
Slot Antenna ◽  
Very High Frequency ◽  
Very High

A collision feedback based multiple access control protocol for very high frequency data exchange system in E-navigation

2021 ◽  
pp. 1-16
Author(s):  
Xu Hu ◽  
Bin Lin ◽  
Ping Wang ◽  
Hongguang Lyu ◽  
Tie-Shan Li
Keyword(s):  
Access Control ◽  
High Frequency ◽  
Multiple Access ◽  
Data Exchange ◽  
High Frequency Data ◽  
Frequency Data ◽  
Exchange System ◽  
Very High Frequency ◽  
Time Division ◽  
Very High

Abstract The very high frequency data exchange system (VDES) is promising in promoting electronic navigation (E-navigation) and improving navigation safety. The multiple access control (MAC) protocol is crucial to the transmission performance of VDES. The self-organising time division multiple access (SOTDMA) protocol, as the only access mode given by current recommendations, leads to a high rate of transmission collisions in the traditional automatic identification system (AIS), especially with heavy traffic loads. This paper proposes a novel feedback based time division multiple access (FBTDMA) protocol to address the problems caused by SOTDMA, such that collision of transmissions can be avoided in information transmission among vessels. Simulation results demonstrate that the proposed FBTDMA outperforms the traditional SOTDMA in terms of channel utilisation and throughput, and significantly reduces the transmission collision rate. The study is expected to provide insights into VDES standardisation and E-navigation modernisation.

scholarly journals Measurement of Electrical Properties of Superconducting YBCO Thin Films in the VHF Range

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3360
Author(s):  
Yakir Dahan ◽  
Eldad Holdengreber ◽  
Elichai Glassner ◽  
Oz Sorkin ◽  
Shmuel E. Schacham ◽  
...  
Keyword(s):  
Thin Films ◽  
Theoretical Model ◽  
Quality Factor ◽  
High Frequency ◽  
Unit Length ◽  
Superconducting Thin Films ◽  
Electrical Parameters ◽  
Very High Frequency ◽  
Production Constraints ◽  
Very High

A new measurement technique of electrical parameters of superconducting thin films at the Very High Frequency (VHF) range is described, based on resonators with microstrip (MS) structures. The design of an optimal resonator was achieved, based on a thorough theoretical analysis, which is required for derivation of the exact configuration of the MS. A theoretical model is presented, from which an expression for the attenuation of a MS line can be derived. Accordingly, simulations were performed, and an optimal resonator for the VHF range was designed and implemented. Production constraints of YBa2Cu3O7 (YBCO) limited the diameter of the sapphire substrate to 3″. Therefore, a meander configuration was formed to fit the long λ/4 MS line on the wafer. By measuring the complex input reflection coefficients of a λ/4 resonator, we extracted the quality factor, which is mainly affected by the dielectric and conductor attenuations. The experimental results are well fitted by the theoretical model. The dielectric attenuation was calculated using the quasi-static analysis of the MS line. An identical copper resonator was produced and measured to compare the properties of the YBCO resonator in reference to the copper one. A quality factor of ~6·105 was calculated for the YBCO resonator, three orders of magnitude larger than that of the copper resonator. The attenuation per unit length of the YBCO layer was smaller by more than five orders of magnitude than that of the copper.

Da eine oder mehrere betroffen …

2020 ◽  
Vol 48 (1) ◽  
pp. 47-100
Author(s):  
Melitta Gillmann
Keyword(s):  
High Frequency ◽  
Formal Language ◽  
Subordinate Clause ◽  
Matrix Clause ◽  
Very High Frequency ◽  
Corpus Study ◽  
Causal Relations ◽  
Legal Texts ◽  
The Matrix ◽  
Very High

AbstractBased on a corpus study conducted using the GerManC corpus (1650–1800), the paper sketches the functional and sociosymbolic development of subordinate clause constructions introduced by the subjunctor da ‘since’ in different text genres. In the second half of the 17th and the first half of the 18th century, the da clauses were characterized by semantic vagueness: Besides temporal, spatial and causal relations, the subjunctor established conditional, concessive, and adversative links between clauses. The corpus study reveals that different genres are crucial to the readings of da clauses. Spatial and temporal usages, for example, occur more often in sermons than in other genres. The conditional reading, in contrast, strongly tends to occur in legal texts, where it displays very high frequency. This could be the reason why da clauses carry indexical meaning in contemporary German and are associated with formal language. Over the course of the 18th century, the causal usages increase in all genres. Surprisingly, these causal da clauses tend to be placed in front of the matrix clause despite the overall tendency of causal clauses to follow the matrix clause.

scholarly journals Sintering, Microstructure, and Dielectric Properties of Copper Borates for High Frequency LTCC Applications

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 4017
Author(s):  
Dorota Szwagierczak ◽  
Beata Synkiewicz-Musialska ◽  
Jan Kulawik ◽  
Norbert Pałka
Keyword(s):  
Dielectric Properties ◽  
Dielectric Permittivity ◽  
High Frequency ◽  
Ceramic Materials ◽  
Sintering Behavior ◽  
Terahertz Time Domain Spectroscopy ◽  
Very High Frequency ◽  
X Ray ◽  
Low Dielectric ◽  
Very High

New ceramic materials based on two copper borates, CuB2O4 and Cu3B2O6, were prepared via solid state synthesis and sintering, and characterized as promising candidates for low dielectric permittivity substrates for very high frequency circuits. The sintering behavior, composition, microstructure, and dielectric properties of the ceramics were investigated using a heating microscope, X-ray diffractometry, scanning electron microscopy, energy dispersive spectroscopy, and terahertz time domain spectroscopy. The studies revealed a low dielectric permittivity of 5.1–6.7 and low dielectric loss in the frequency range 0.14–0.7 THz. The copper borate-based materials, owing to a low sintering temperature of 900–960 °C, are suitable for LTCC (low temperature cofired ceramics) applications.

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