scholarly journals Ovarian steroid cell tumors, not otherwise specified: Analysis of nine cases with a literature review

2021 ◽  
Author(s):  
Mengyan Lin ◽  
Lingjia Lu ◽  
Shuhang Xu ◽  
Yun Liang ◽  
Xiaodong Cheng ◽  
...  
Keyword(s):  
Clinical Features ◽  
Histopathological Examination ◽  
Treatment Options ◽  
Age Groups ◽  
Reproductive Function ◽  
Androgen Excess ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Age Range

Abstract Objective Ovarian steroid cell tumors (SCTs), not otherwise specified (NOS), are rare, with few large studies. The purpose of this study was to analyze the clinical features, prognosis, and treatment choices for SCT-NOS patients of different age groups. Methods This was a retrospective study. We identified nine SCT-NOS cases, confirmed by post-operative histopathological examination, and analyzed clinical features, surgical procedures, and follow up outcomes. We also reviewed cases reports of SCT-NOS. Results A total of nine cases were included. The age range was 9–68 years (mean, 41.89 ± 19.72 years). Clinical features included virilization, amenorrhea, abdominal pain, vaginal bleeding, isosexual precocious puberty, Cushing’s syndrome, and abnormal weight gain with elevated testosterone levels. The follow up interval ranged 5–53 months and no recurrence was observed. Conclusion Ovarian SCTs covered all age groups, with manifestations of androgen excess. Younger patients appeared to have a more favorable prognosis, which provided more opportunities for these patients to pursue treatment options that will preserve reproductive function.

scholarly journals Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

2003 ◽  
Vol 10 (8) ◽  
pp. 445-448 ◽  
Author(s):  
Halil Yanardag ◽  
Cüneyt Tetikkurt ◽  
Seza Tetikkurt ◽  
Sabriye Demirci ◽  
Tuncer Karayel
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Therapeutic Response ◽  
Histopathological Examination ◽  
Computed Tomographic ◽  
Before And After ◽  
Endobronchial Tuberculosis ◽  
Age Range

BACKGROUND: The therapeutic response to endobronchial tuberculosis is usually evaluated by bronchoscopy. Currently, there are no published studies investigating the use of computed tomography for the evaluation of therapeutic response in endobronchial tuberculosis.OBJECTIVE: A retrospective study was performed to evaluate the bronchoscopic and computed tomographic features of endobronchial tuberculosis before and after treatment. The aim of this study was to investigate the usefulness of computed tomography for the assessment of treatment.METHODS: The clinical, pathological and bronchoscopic features of endobronchial tuberculosis were evaluated in 55 patients. The age range of the patients was 21 to 52 years. Computed tomography and bronchoscopy were performed before and after treatment.RESULTS: Diagnosis of tuberculosis was confirmed by culture and histopathological examination. Bronchoscopic examination revealed 89 endobronchial lesions of various types in 55 patients. The exudative type was the most common. Follow-up bronchoscopy revealed that exudative-, ulcerative- and granular-type lesions healed completely. Computed tomography performed after treatment correlated well with the follow-up bronchoscopic findings.CONCLUSION: The results suggest that follow-up computed tomography is useful for the evaluation of therapeutic response and complications associated with endobronchial tuberculosis, and may replace bronchoscopy.

Trichomonas Vaginalis (TV) Infection and Its Association With Risk of Cervical Cancer and HPV Status

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S92-S93
Author(s):  
Herleen Rai ◽  
Wissam Dahoud
Keyword(s):  
Trichomonas Vaginalis ◽  
Cervical Screening ◽  
Age Groups ◽  
Developed Countries ◽  
Hpv Infection ◽  
Hpv Status ◽  
Age Range ◽  
The Relationship ◽  
Intraepithelial Lesions

Abstract Background The prevalence of trichomonas vaginalis (TV) infection is low in developed countries and may be due to its incidental diagnosis and treatment during routine screening. Many countries are adopting a new model based on testing for high-risk (HR) human papillomavirus (HPV) instead of cytology. HPV is known to be associated with squamous intraepithelial lesions (SIL). There is limited and conflicting literature on the relationship between TV and SIL. The aim of this study is to determine the prevalence of TV in different age groups and evaluate the association between TV with SIL, BV (bacterial vaginosis), and HPV infection. Design Retrospective study for cytological histologic correlation was performed on 10,546 cases dated between January 2012 and December 2017. HPV results were available in 7,081 cases. Results The age range was 15 to 84 with a mean of 49 years; 249 patients were TV positive (2.3%). The prevalence was highest in 30 to 65 age group (71.5%). HPV was present in 4,386/7,081 cases (61.9%). The associated between TV and HPV infection was not significant (P < .07). There was a significant association between TV and BV infection (P < .001). In total, 4,649/10,546 patients showed squamous abnormalities (44%), of which 52.6% were TV positive and 43.9% were TV negative. CIN2-3/SCC was significantly greater in TV-positive versus TV-negative patients (P < .007). HPV-positive patients that were TV positive showed more squamous abnormalities than those that were TV negative (P < .043). TV-positive patients with ASCH showed higher grade lesions (CIN2-3/SCC) on follow-up than TV-negative patients (P < .003). Conclusion TV is more common among patients with BV and HPV infection and significantly associated with squamous abnormalities. HPV and ASCH patients with TV showed significant squamous abnormalities. Although TV can be detected incidentally through cytology-based cervical screening, a transition to HPV testing is likely to result in increasing TV prevalence over time.

scholarly journals Recurrent vaginal discharge: an unusual presentation of embryonal rhabdomyosarcoma of uterine cervix in an adolescent girl

2019 ◽  
Vol 8 (5) ◽  
pp. 2129
Author(s):  
Divya Sarin ◽  
Urmila Singh ◽  
Seema Mehrotra ◽  
Vandana Solanki
Keyword(s):  
Medical Treatment ◽  
Uterine Cervix ◽  
Adolescent Girl ◽  
Vaginal Discharge ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Reproductive Function ◽  
Embryonal Rhabdomyosarcoma ◽  
Management Challenge

Embryonal rhabdomyosarcoma (ERMS) is a rare tumor of the female genital tract. It tends to occur during childhood in the vagina and rarely it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of 15 year old adolescent girl who presented with recurrent vaginal discharge not responding to medical treatment. Examination under anesthesia showed friable growth arising from the cervix. Histopathological examination revealed embryonal rhabdomyosarcoma (botyroid variant) of the cervix. Patient underwent local excision of growth followed by IRS-4 protocol based chemotherapy and now patient is under follow up at our side and pediatric oncology and doing well. Young girls presenting with recurrent vaginal discharge not responding to medical treatment must undergo proper clinical examination and EUA and any suspicious lesions should be examined so as to avoid missing rare but aggressive etiology like rhabdomyosarcoma. Due to the young age of affected patients, embryonal rhabdomyosarcoma (sarcoma botyroides) poses a management challenge as the preservation of hormonal, sexual and reproductive function is essential. Awareness of such as uncommon lesion and its clinical implications is important for the counseling and management of the patient.

scholarly journals Idiopathic macrocheilia

2018 ◽  
pp. bcr-2018-225682
Author(s):  
Haren Pandya ◽  
Hiren Dharmendrabhai Patel ◽  
Jigar Mayankbhai Purani ◽  
VIvek Ramesh Rayththa
Keyword(s):  
Triamcinolone Acetonide ◽  
Clinical Features ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Exclusion Criteria ◽  
Gingival Enlargement

A 13-year-boy presented with painless swelling of upper and lower lips accompanied with gingival enlargement. The aetiology for these symptoms included vast pathological varieties but none of them could fit in. Clinical features were similar to orofacial graulomatosis but histopathological examination revealed chronic non-specific infection. Therefore, the final diagnosis was made as idiopathic macrocheilia through exclusion criteria. Management with intralesional triamcinolone acetonide 40 mg, twice a week for 3 weeks, resulted in significant remission in lip swelling without recurrence after a 6-month follow-up.

scholarly journals Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified

2020 ◽  
Vol 8 ◽  
pp. 232470962093341
Author(s):  
Evana Valenzuela Scheker ◽  
Amita Kathuria ◽  
Ashwini Esnakula ◽  
Hironobu Sasano ◽  
Yuto Yamazaki ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Steroidogenic Enzymes ◽  
Androgen Excess ◽  
Ovarian Steroid ◽  
Variable Expression ◽  
Not Otherwise Specified ◽  
Chain Cleavage ◽  
Cleavage Enzyme

To characterize the expression of steroidogenic enzymes implicated in the development of ovarian steroid cell tumors, not otherwise specified (SCT-NOS). We present 4 ovarian SCT-NOS evaluated by immunohistochemical staining of steroidogenic enzymes as an approach to define this entity pathologically. All 4 ovarian SCT-NOS showed increased expression for cholesterol side-chain cleavage enzyme (CYP11A1), 17α-hydroxylase (CYP17A1), 17β-hydroxysteroid dehydrogenase 1 (HSD17B1), aldo-ketoreductase type 1 C3 (AKR1C3), 3β-hydroxysteroid dehydrogenase 2 (HSD3B2), 5α-reductase type 2 (SRD5A2), steroid sulfatase (SULT2A1), estrogen sulfotransferase (EST), and aromatase (CYP19A1). Expression was negative for 21-hydroxylase (CYP21A2) and 17β-hydroxysteroid dehydrogenase 2 (HSD17B2). 17β-hydroxysteroid dehydrogenase 3 (HSD17B3) and 5α-reductase type 1 (SRD5A1) showed variable expression. Our analysis reveals a novel finding of increased expression of AKR1C3, HSD17B1, SRD5A2, SULT2A1, and EST in ovarian SCT-NOS, which is clinically associated with androgen excess and virilization. Further studies are needed to validate these enzymes as new markers in the evaluation of hyperandrogenic ovarian conditions.

scholarly journals EVALUATION OF OVARIAN TERATOMAS IN YOUNG FEMALES :A CLINICAL AND HISTOPATHOLOGICAL ANALYSIS:ONE YEAR RETROSPECTIVE STUDY AT RIMS.

2020 ◽  
pp. 1-2
Author(s):  
Anshu Jamaiyar ◽  
Silky Satya
Keyword(s):  
Retrospective Study ◽  
Clinical Features ◽  
Histopathological Examination ◽  
Age Groups ◽  
Cystic Teratoma ◽  
Abdominal Ultrasound ◽  
Young Females ◽  
Risks And Benefits ◽  
Abdominal Masses ◽  
Ovarian Teratomas

It is challenging for the clinicians to make a pre-operative diagnosis of Teratomas, especially, if it is a case of immature cystic teratoma. We diagnosed women of age groups 0-20 yrs, 20-40 yrs, 40-60 yrs, >60 yrs,who presented with abdominal masses, which were diagnosed by abdominal Ultrasound as Teratomas, the types of which were best described after a proper Histopathological examination in the Department of Pathology at RIMS. The aims of the current study were to analyse the clinical features of Ovarian teratomas and to discuss it’s management. Women requiring surgery for Ovarian Teratomas should be appropriately counselled about the risks and benefits of laparoscopic and open approaches.

scholarly journals Clinical Features and Long-Term Follow-Up of Patients with Retinoblastoma in Turkish Children Older Than 5 Years of Age

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Zafer Cebeci ◽  
Samuray Tuncer ◽  
Rejin Kebudi
Keyword(s):  
Clinical Features ◽  
Treatment Options ◽  
Older Children ◽  
Long Term Outcomes ◽  
Turkish Children ◽  
Turkish Patient ◽  
Long Term Follow Up ◽  
Salvage Rate

Purpose. The diagnosis and management of retinoblastoma can be difficult in older children. This study reports the clinical features and long-term outcomes of such patients in a Turkish patient population. Methods. Medical records of 18 patients, between January 1992 and December 2017, were reviewed retrospectively. Results. Of 298 consecutive patients with retinoblastoma, 18 (6%) were at the age of 5 years and older. The median age at diagnosis was 9 years (range, 5–18 years). Misdiagnosis was noted in 8 patients (44.4%). Treatment options included enucleation in 16 patients (88.8%), adjuvant systemic chemotherapy in 3 (16.6%), intra-arterial chemotherapy in one (5.5%), and additional orbital irradiation in one (5.5%). After a median follow-up of 97 months (range, 6–252 months), all patients survived without any recurrence. Conclusions. Our series showed that 6% of patients with retinoblastoma were 5 years of age and older. Over a 15-year period, ocular salvage rate of 11.2% and survival rate of 100% were attained.

scholarly journals Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis

2020 ◽  
Vol 12 ◽  
pp. 251584142097911
Author(s):  
Dheepak Sundar M ◽  
Rohan Chawla ◽  
Akshaya Balaji ◽  
Itika Garg ◽  
Reshmi Kalathil ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Clinical Features ◽  
Treatment Options ◽  
Vitreous Hemorrhage ◽  
Oral Steroid ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Oral Doxycycline ◽  
Oral Steroids

Objectives: To study the clinical features, optical coherence tomography (OCT) findings, treatment options and follow-up outcomes of post-fever retinitis (PFR). Subjects: A total of 19 eyes of 13 patients, diagnosed with PFR (retinitis following febrile episode) over 2 years were retrospectively studied. Methods: Documented history, baseline clinical features and systemic investigations performed for PFR were reviewed. Fundus findings, foveal architecture on swept-source OCT, the treatment options and the follow-up outcomes including best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were reviewed and analyzed. Results: Common fundus findings included whitish retinitis lesions (100%), macular star (95%, 18eyes), retinal flame-shaped hemorrhages (63%, 12 eyes), inflammatory retinal vessels (30%, 6 eyes), vitreous hemorrhage (one eye) and OCT findings included neuro-sensory detachment (79%, 15 eyes), intraretinal white dots (89.5%,17 eyes). The baseline median log MAR BCVA and CFT were 1.30 (interquartile range (IQR):0.8–1.8) and 423 microns (IQR:182–555). Overall, nine patients (12 eyes) received a combination of oral doxycycline and oral steroids and four patients (7 eyes) received a combination of oral doxycycline, oral steroid and intravitreal anti-vascular endothelial growth factor (IVA). Significant improvement was evident at 8 weeks in median BCVA (0.50, IQR: 0.3–0.8, p < 0.05) and median CFT (223 micron, IQR: 170–256, p < 0.05) though only 26% (5 eyes) attained BCVA > = 6/12. Conclusion: Our study puts forth certain characteristic fundus and OCT features of PFR. A combination of oral doxycycline and oral steroids as a treatment option showed improvement in BCVA and CFT. Additional IVA helps in faster visual recovery in patients presenting with severe macular edema at onset.

scholarly journals A Rare Case of Steroid Cell Tumor, Not Otherwise Specified (NOS), of the Ovary in a Young Woman

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Eek Chaw Tan ◽  
Chit Chong Khong ◽  
Kazila Bhutia
Keyword(s):  
Adnexal Mass ◽  
Histopathological Examination ◽  
Treatment Options ◽  
Elevated Serum ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Cell Tumour ◽  
Not Otherwise Specified ◽  
Clinical Presentations ◽  
Leydig Cell Tumour

Steroid cell tumour is a rare sex cord-stromal tumor of the ovary. It may produce steroids and is associated with testosterone secretion which causes symptoms like hair loss, hirsutism, and oligomenorrhea/amenorrhea due to hormonal activity and virilizing properties of tumor. In this article, we reported a 27-year-old woman who presented with hirsutism, hoarseness of voice, scalp hair fall, and amenorrhea for 8 years. Clinical and diagnostic evaluation revealed a left adnexal mass and elevated serum levels of testosterone and she was diagnosed as having a Sertoli Leydig cell tumour of ovary. She underwent left salpingooophorectomy and both histopathological examination and immunohistochemistry confirmed the diagnosis. Her serum testosterone levels normalized 3 days after the surgery and her menses resumed spontaneously a few months after the operation. In addition, we reviewed the literature on the epidemiology, clinical presentations, imaging and histological findings, and the treatment options on this disease.

scholarly journals Androgen Secreting Steroid Cell Tumor of the Ovary Represented with Postmenopasal Bleeding and Extensive Hirsutism

2013 ◽  
Vol 1 (1) ◽  
pp. 93-98
Author(s):  
Jadranka Georgievska ◽  
Vesna Antovska ◽  
Neli Basheska ◽  
Natasha Aleksioska
Keyword(s):  
Elevated Serum ◽  
Serum Testosterone ◽  
Cell Tumor ◽  
Postmenopausal Bleeding ◽  
Normal Range ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
History Of

Introduction: Steroid cell tumors of the ovary present less than 0.1% of all ovarian tumors and belong in the group of sex cord-stromal tumors.Case description: We present a case of 69-year-old woman investigated because of postmenopausal bleeding, a 5-year history of excessive hirsutism, baldness and acne. The evaluation revealed elevated serum testosterone, but ultrasound detected a 2 cm-mass of the left ovary. The patient underwent hysterectomy and bilateral adnexectomy. The histopathology diagnosis was steroid cell tumor, not otherwise specified. Postoperative chemotherapy was administered at the discretion of the radio-oncologist. At the last follow-up 48 months after surgery, the hirsutism was completely resolved, the serum testosterone was within the normal range and there was no evidence of recurrence.Conclusion: In adult patients with hirsutism and elevated serum testosterone a possibility of a presence of an ovarian steroid cell tumor should be considered. Surgery is the main treatment of such patients.

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