scholarly journals Chemical basis underline the bioactivity fortification of licorice by honey-frying due to the natural deep eutectic solvent characteristics of honey

2021 ◽  
Author(s):  
Shasha Kong ◽  
Pengyue Li ◽  
Robert Verpoorte ◽  
Jia Wang ◽  
Chao Zhu ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Deep Eutectic Solvent ◽  
Chemical Mechanism ◽  
Immunomodulatory Activity ◽  
Chemical Basis ◽  
Synergistic Mechanism ◽  
Pharmacologically Active ◽  
Natural Deep Eutectic Solvent ◽  
Novel Applications

Abstract Background Honey has been widely used in medicine plants processing since ancient times. Honey-frying of herbal medicine is a well-known treatment in Chinese medicine. It has been reported that honey-frying can improve the immunomodulatory efficacy of licorice. However, it is still unknown why honey-frying improves the immunomodulatory activity of licorice. And our previous research demonstrated that honey has natural deep eutectic solvent (NADES) characteristics. NADES is a kind of solvent with broad polarity range and has attracted extensive attention of scholars in different fields. In the present study, we investigated chemical basis underline the possible potentiation of honey-frying on licorice to elucidate its chemical mechanism. Methods Firstly, immunological experiments were conducted to investigate whether the honey-processing could enhance the immunomodulatory efficacy of licorice. Then, the synergistic mechanism of honey-processed licorice was explored based on cell biological activity test, chemical composition test, bioavailability test, and Fourier transform-infrared (FT-IR) spectra. Results Pharmacological experiment verified that honey-processing enhanced the immunomodulatory efficacy of licorice. Moreover, honey increased the total flavonoid and polysaccharide contents in licorice decoction, improved the thermal stability and oral bioavailability of certain pharmacologically active constituents, and augmented their overall immunostimulatory functions. Similar effects of honey were also observed with NADES. The above effects are due to multiple molecular interactions between active compounds and sugar molecules of NADES. Conclusion These findings indicate that the biological activities of medicinal plants might be fortified by NADES/honey in the processing of the plant material. At the meantime, these findings provide theoretical and empirical basis for potential novel applications of honey or other NADESs at augmenting the health-promoting effects of medicinal plants.

scholarly journals Screening, Optimization, and Bioavailability Research of Natural Deep Eutectic Solvent Extracts from Radix Pueraria

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 729
Author(s):  
Yan Huang ◽  
Jiehong Yang ◽  
Yu Zhao ◽  
Li Yu ◽  
Yu He ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Extraction Efficiency ◽  
Biological Activities ◽  
Deep Eutectic Solvent ◽  
Relative Bioavailability ◽  
Pharmacokinetic Analysis ◽  
Optimal Conditions ◽  
Solubility In Water ◽  
Wide Range ◽  
Natural Deep Eutectic Solvent

Natural deep eutectic solvent (NaDES) is generally considered as a greener alternative to fossil solvent, with great potential in various areas. In the present work, 25 different NaDESs were screened for the extraction of puerarin (PUE) and its two natural derivatives from Radix Pueraria (RP). As the main isoflavone in RP, PUE has a wide range of biological activities. However, its application is restricted due to its poor solubility in water and low oral bioavailability. In this study, the extraction of PUE with NaDESs showed significant advantages compared with traditional solvents. While using L-Pro-Maa (L-proline-malic acid) under optimal conditions, the optimized yields of PUE, 3-MPR and PRX were 98.7 mg/g, 16.3 mg/g and 9.9 mg/g, respectively, which were 2.2-, 2.9- and 3.4-fold higher than that of water. Furthermore, the oral bioavailability of PUE in NaDES extracts was comparatively investigated in rats with HPLC-MS technique. Pharmacokinetic analysis revealed that the relative bioavailability of PUE in L-Pro-Maa extract is 323%. The result indicated that NaDES is not only a sustainable ionic liquid with higher extraction efficiency, but also an enhancer of oral bioavailability of specific natural products.

scholarly journals Acute Toxicity Evaluation of the Malagasy Endemic Aloe helenae and A. analavelonensis in Mice

2020 ◽  
Vol 2 (4) ◽  
pp. 452-457
Author(s):  
Rokiman Letsara ◽  
Rigobert Andrianantenaina ◽  
Colette Masengo Ashande ◽  
Clarisse Falanga Mawi ◽  
M. Yoserizal Saragih ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Acute Toxicity ◽  
Biological Activities ◽  
Toxicity Evaluation ◽  
Isolation And Characterization ◽  
Anticancer Effects ◽  
Herbal Plants ◽  
Intestinal Worms ◽  
Pharmacologically Active

The therapeutic virtues of medicinal plants are known and used in Africa and in Madagascar where natural products form the basis of Traditional Medicine. More than 300 million people worldwide consume dietary supplements and herbal plants. Scientific studies confirm that Aloes contains pharmacologically active ingredients associated with diverse biological activities including fungicidal, antiviral, antibacterial, anti-inflammatory, antimicrobial, laxative, immunomodulating, and anticancer effects. The aim of the present study was to evaluate the effects of orally administered extracts of two Aloe species: A. helenae, A. analavelonensis on mice. Mice were gavaged with crude whole leaves extracts after 24 hours of empty stomach. The extracts administration was found to be not acute toxic at the dose 1200 mg/kg with 100% survival of mice. Since the Aloe helenae is traditionally used against intestinal worms in sheep and goats, it is thus desirable that the plant species could be submitted to phytochemical for the isolation and characterization of new antihelminthic compounds.

A Review on Pharmacological Activities and Active Phytoconstituents of Roadside Trees of Tamil Nadu

2020 ◽  
Vol 18 ◽  
Author(s):  
Arunambiga Subramaniam ◽  
Praveena Alagaraj ◽  
Balakrishnan Arumugam
Keyword(s):  
Medicinal Plants ◽  
Tamil Nadu ◽  
Biological Activities ◽  
Modern Medicine ◽  
Environmental Benefits ◽  
Pharmacological Activities ◽  
Medical Practitioners ◽  
Modern Knowledge ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds

: Roadsides are habitats with very specific environmental conditions, often substantially differing from their natural surroundings. Roadside trees provide home for many floral and faunal species and have many environmental benefits including removing air pollutants, supporting wildlife etc. Many medicinal plants including road side trees have been discovered and traditionally they are being used for treating many kinds of diseases. Phytochemicals are chemical compounds that are usually secreted by the plants for performing functions like defense against insects, fungi, diseases and animals that feed on them. These phytochemicals with potential biological activities have been identified from various plant species, yet many of the medicinal potency of the plants remain unexplored. Modern knowledge on the potential value of the medicinal plants has made it possible for the researchers and medical practitioners to use the plant derived products in modern medicine with diminished adverse effects. Road side plants in Tamilnadu also possess many such pharmacologically active compounds with therapeutical actions.

Recovery of metabolites from natural deep eutectic solvent matrices by countercurrent separation

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
Y Liu ◽  
J Garzon ◽  
JB Friesen ◽  
DC Lankin ◽  
JB McAlpine ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Natural Deep Eutectic Solvent

Biologically Active 2,5-Disubstituted-1,3,4-Oxadiazoles

2009 ◽  
Vol 2 (1) ◽  
pp. 390-406
Author(s):  
Harish Rajak ◽  
Murli Dhar Kharya ◽  
Pradeep Mishra
Keyword(s):  
Heterocyclic Compounds ◽  
Medical Literature ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Synthetic Drugs ◽  
Physiologic Activity ◽  
Pharmacologically Active

There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1,3,4-oxadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Medical Literature is flooded with reports of a variety of biological activities of 2,5-Disubstituted-1,3,4-oxadiazoles. The present work is an attempt to summarize and enlist the various reports published on biologically active 2,5-disubstituted-1,3,4-oxadiazoles.

Medicinal Chemistry of Alternative Therapeutics: Novelty and Hopes with Genus Ammannia

2019 ◽  
Vol 19 (10) ◽  
pp. 784-794 ◽  
Author(s):  
Harish C. Upadhyay
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
World Health ◽  
Biologically Relevant ◽  
Traditional Medicines ◽  
Drug Molecules ◽  
Health Organization ◽  
Tract Infections ◽  
Pharmacologically Active ◽  
Herbal Formulations

The plants have formed the basis of folklore remedy since the beginning of human civilization. The cumulative human endeavor and experience over a period of thousands of years developed into well to organize traditional medicine systems viz. Ayurvedic, Unani, Chinese amongst others. Across the world, traditional medicine is either the mainstay of health care or serves as a complement to modern drugs. In view of worldwide use of traditional medicines, World Health Organization launched ‘WHO-Traditional Medicine Strategy 2014-2023’ for the development of strong policies regarding knowledge-base, safety, quality-control and effectiveness of traditional/alternative therapeutics for national health systems. Besides their use in traditional medicine, plants have always been a good source of modern drug/pharmacologically active molecules. More than half of the modern pharmaceuticals are either plant isolates or their derivatives. The plant-based drugs are not only effective, but have better compatibility with human biological systems because of more biologically relevant chemistry, hence lesser side effects. Some of the species of genus Ammannia (Lythraceae) have been reported for their magical medicinal values. Many herbal formulations containing Ammannia spp. have been patented for treatment of serious diseases/disorders like cancer, spinal disease, human female infertility, chronic tonsillitis, pelvic inflammatory disease, treatment of bladder stones, urinary tract infections, dermatitis etc. The uses of Ammannia spp. in traditional medicine have been further verified by the biological activities of their extracts as well as isolation of bioactive phytomolecules. The current review provides details about Ammannia spp.; its use in folklore remedy, herbal formulations, biological activities of extracts, isolation of bioactive phytomolecules and SAR study of semi-synthetic derivatives to analyze the possibility of new drug molecules of plant origin.

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

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