scholarly journals Associated factors for celiac disease, and utility of tissue transglutaminase antibody tests for diagnosis: a matched case-control study

2021 ◽  
Author(s):  
Eman Jafar Al Alawi ◽  
Nagarajkumar Yenugadhati ◽  
Sundas Javad ◽  
Hamdan Al Jahdli ◽  
Motasim Badri
Keyword(s):  
Celiac Disease ◽  
Case Control Study ◽  
Tissue Transglutaminase ◽  
Public Awareness ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Screening Tests ◽  
Intestinal Biopsy ◽  
Awareness Campaigns ◽  
Control Study

Abstract Background Prevalence of Celiac disease (CD) increased worldwide in recent decades. Approximately 53% of the 33.4 million Saudi population are genetically susceptible and 1.5% develop CD. This underscores the importance of identification of factors associated with CD and the diagnostic accuracy of CD screening tests. Methods In this case-control study records of patients managed between January 2016 and July 2019 at Gastroenterology Department, King Abdul-Aziz Medical City, Riyadh, Saudi Arabia were reviewed. CD cases with confirmed intestinal biopsy were matched (1:1) by age with biopsy negative controls free of CD. Area under the curve (AUC) for anti-tissue transglutaminase IgA (TTG-IgA) and IgG (TTG-IgG) CD diagnostic tests were calculated and compared. Results The study included 270 cases and 270 controls. Sex distribution was similar in both groups. In a stepwise conditional logistic regression analysis, factors significantly associated with CD were family history (odds ratio (OR)=7.76, 95% confidence interval (CI): 2.26-26.63, P=0.001), Helicobacter pylori infection (OR=1.72, 95% CI: 1.10-2.71, P=0.018), diabetes mellitus (OR=3.37, 95% CI: 1.68-6.74, P=0.001), hypothyroidism (OR=2.46, 95% CI: 1.15-5.28, P=0.02) and respiratory infections (OR=4.89,95% CI 2.26-10.56, P<0.001). AUC for TTG-IgA test was 0.934 and for TTG-IgG was 0.787, P<0.001. The optimal cut-off for TTG-IgA was >=12.7 U/ml, with 89% sensitivity and 86% specificity, and for TTG-IgG was >=3.5 U/ml, with 70% sensitivity and 77% specificity.Conclusion The findings of this study can inform strategies for CD screening and prevention. Public awareness campaigns for CD are urgently needed, particularly, for high-risk groups.

scholarly journals 25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children: A Case–Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Carin Andrén Aronsson ◽  
Xiang Liu ◽  
Jill M. Norris ◽  
Ulla Uusitalo ◽  
Martha D. Butterworth ◽  
...  
Keyword(s):  
At Risk ◽  
Vitamin D ◽  
Celiac Disease ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Early Infancy ◽  
At Risk Children ◽  
Increased Risk ◽  
Control Study

Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children.Study Design: Children prospectively followed in the multinational The Environmental Determinants of Diabetes in the Young study, conducted at six centers in Europe and the US, were selected for a 1-to-3 nested case–control study. In total, 281 case–control sets were identified. CDA was defined as positivity for tissue transglutaminase autoantibodies (tTGA) on two or more consecutive visits. Vitamin D was measured as 25-hydroxyvitamin D [25(OH)D] concentrations in all plasma samples prior to, and including, the first tTGA positive visit. Conditional logistic regression was used to examine the association between 25(OH)D and risk of CDA.Results: No significant association was seen between 25(OH)D concentrations (per 5 nmol/L increase) and risk for CDA development during early infancy (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.95–1.04) or childhood (OR 1.02, 95% CI 0.97–1.07). When categorizing 25(OH)D concentrations, there was an increased risk of CDA with 25(OH)D concentrations &lt;30 nmol/L (OR 2.23, 95% CI 1.29, 3.84) and &gt;75 nmol/L (OR 2.10, 95% CI 1.28–3.44) in early infancy, as compared with 50–75 nmol/L.Conclusion: This study indicates that 25(OH)D concentrations &lt;30 nmol/L and &gt;75 nmol/L during early infancy were associated with an increased risk of developing CDA in genetically at-risk children. The non-linear relationship raises the need for more studies on the possible role of 25(OH)D in the relation to celiac disease onset.

scholarly journals Predictive Value of NKILA and lnc13 lnc RNAs for Distinguishing of Celiac Disease and IBD: A Case-Control Study

2021 ◽  
Vol 12 (4) ◽  
pp. 5089-5099
Keyword(s):  
Celiac Disease ◽  
Noncoding Rna ◽  
Case Control Study ◽  
Mrna Level ◽  
Case Control ◽  
Intestinal Biopsy ◽  
Qrt Pcr ◽  
Inflammatory Bowel ◽  
Pcr Method ◽  
Control Study

Long-noncoding RNA 13 (lnc13) and NF-κB-interacting lncRNA (NKILA) are long noncoding RNAs (lncRNAs) that play a role in inflammatory disorders pathogenesis. This study aimed at investigating the expression of these lncRNAs in inflammatory bowel disease (IBD) and celiac disease (CeD) patients compared to controls. We evaluated mRNA expression of lnc13 and NKILA in peripheral blood and intestinal biopsy samples of 50 CeD, 46 IBD patients, and 20 controls using qRT- PCR method. Compared to the controls, CeD and IBD patients had a significantly higher PBMC mRNA level of Lnc13 (p < 0.0001 for both of them) and NKILA (p < 0.0001 and p=0.0174, respectively). NKILA mRNA level was significantly higher in CeD than in IBD patients (p < 0.0001). IBD subjects had significantly increased colonic NKILA expression (p=0.004). In UC, NKILA, and CD, lnc13 colonic expression was significantly increased compared to others (p=0.002 and p=0.0111 respectively for UC, p = 0.0075 and p = 0.002, respectively for CD). Collectively, increased peripheral expression of lnc13 and NKILA along with their decreased duodenal expression demonstrates CeD. Moreover, suppose the increased peripheral expression of lnc13 and NKILA is associated with increased lnc13 colonic expression. In that case, it indicates CD, and if it is associated with increased NKILA colonic expression, it indicates UC.

Mo1999 – Prevalence of Celiac Disease (CD) in Subjects with Dyspeptic Symptoms. A Case-Control Study

2019 ◽  
Vol 156 (6) ◽  
pp. S-918
Author(s):  
Jahaziel Lara-Carmona ◽  
Mercedes Amieva-Balmori ◽  
Arturo Martínez-Conejo ◽  
Francisco Javier Cabrera Jorge ◽  
Karla Rocío García-Zermeño ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Case Control Study ◽  
Case Control ◽  
Dyspeptic Symptoms ◽  
Control Study

scholarly journals Diabetes mellitus, anti-secretory drugs and other risk factors for campylobacter gastro-enteritis in adults: a case-control study

1997 ◽  
Vol 119 (3) ◽  
pp. 307-311 ◽  
Author(s):  
K. R. NEAL ◽  
R. C. B. SLACK
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Postal Questionnaire ◽  
Foreign Travel ◽  
Drinking Milk ◽  
Campylobacter Infection ◽  
Control Study

The epidemiology of notified cases of campylobacter gastroenteritis in adults in Nottingham Health District was investigated using a case-control study with a postal questionnaire to ascertain data on risk factors. Over a 14-month period 531 cases (a 73% response rate of all laboratory confirmed cases) and 512 controls replied.Conditional logistic regression analysis was used to determine independent associations with infection. These included foreign travel (odds ratio (OR) 3·4; 95% confidence intervals (CI) 2·0–5·7), diabetes mellitus (OR 4·1, CI 1·1–17), medication with omeprazole (OR 3·5, CI 1·1–12) and H2 and H2 antagonists (OR 3·7, CI 1·3–15), contact with puppies (OR11·3, CI1·2–105), eating chicken (OR 1·4, CI 1·1–1·8) and drinking milk from bottles with tops damaged by a bird (OR 3·3, CI 1·0–11). Preparing main meals (OR 0·9, CI 0·8–1·0) and drinking delivered milk (OR 0·6, CI 0·4–0·9) were associated with a reduced risk of campylobacter infection.Foreign travel was reported in 25% of cases and another 15% had significant associations with other risk factors. The majority of cases, 60%, remained unexplained, indicating the need for further evolution of sporadic cases.

scholarly journals 717. Antibiotic treatment of Shiga toxin-producing Escherichia coli related gastroenteritis and the risk of hemolytic uremic syndrome: a population based matched case-control study in Japan

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S409-S410
Author(s):  
Shota Myojin ◽  
Kyongsun Pak ◽  
Mayumi Sako ◽  
Tohru Kobayashi ◽  
Takuri Takahashi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Case Control ◽  
Age Group ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial. Methods We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infections and HUS development. We identified all STEC HUS patients as cases and matched five non-HUS patients as controls using the data from the National Epidemiological Surveillance of Infectious Diseases (NESID) between January 1, 2017, and December 31, 2018. Further medical information was obtained by standardized questionnaires answered by physicians who registered each patient. We used multivariate conditional logistic regression model to evaluate the association between exposures (use of antibiotics, use of antidiarrheal agents, days between disease onset and fosfomycin administration [within two or three days]) and the development of HUS, by matched odds ratios (OR) and 95% confidence intervals (CI). Covariates we used were sex, age group, area code, presence of diarrhea and other factors. We also performed subgroup analyses using age (adults and children) as a stratification factor. Results 7,760 STEC related patients were registered in the NESID. We selected patients who had a record of HUS diagnosis (n=182) and matched controls without HUS (n=910). After collecting standardized paper-based questionnaires, we enrolled 90 HUS patients and 371 non-HUS patients for analysis. In the main analysis, matched OR of fosfomycin was 0.75(0.47-1.20) in all ages, 1.41(0.51-3.88) in adults and 0.58(0.34-1.01) in children. Matched OR of antidiarrheal agents was 2.07(1.07-4.03) in all ages, 1.84(0.32-10.53) in adults, 2.65(1.21-5.82) in children. Matched OR of probiotics was 0.86(0.46-1.61) in all ages, 0.76(0.21-2.71) in adults, 1.00(0.48-2.09) in children. There was no significant association between the timing of fosfomycin use in the first two or five days of illness and HUS development in any age group. Conclusion Our results suggest that fosfomycin might decrease the risk of HUS in children younger than 15 years of age with STEC confirmed bacterial gastroenteritis. Disclosures All Authors: No reported disclosures

scholarly journals Potential risk factors for multiple sclerosis in Rio de Janeiro: a case-control study

2009 ◽  
Vol 67 (2a) ◽  
pp. 229-234 ◽  
Author(s):  
Kátia Regina Penha da Silva ◽  
Regina Maria Papais Alvarenga ◽  
Oscar Fernandez y Fernandez ◽  
Hélcio Alvarenga ◽  
Luiz Claudio Santos Thuler
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Potential Risk ◽  
Rio De Janeiro ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Potential Risk Factors ◽  
Epidemiological Characteristics ◽  
Control Study

PURPOSE: To evaluate potential risk factors for the development of multiple sclerosis in Brazilian patients. METHOD: A case control study was carried out in 81 patients enrolled at the Department of Neurology of the Hospital da Lagoa in Rio de Janeiro, and 81 paired controls. A standardized questionnaire on demographic, social and cultural variables, and medical and family history was used. Statistical analysis was performed using descriptive statistics and conditional logistic regression models with the SPSS for Windows software program. RESULTS: Having standard vaccinations (vaccinations specified by the Brazilian government) (OR=16.2; 95% CI=2.3-115.2), smoking (OR=7.6; 95% CI=2.1-28.2), being single (OR=4.7; 95% CI=1.4-15.6) and eating animal brain (OR=3.4; 95% CI=1.2-9.8) increased the risk of developing MS. CONCLUSIONS: RESULTS of this study may contribute towards better awareness of the epidemiological characteristics of Brazilian patients with multiple sclerosis.

scholarly journals Peran program kelas ibu hamil terhadap pelaksanaan ASI eksklusif di Gunung Kidul

2017 ◽  
Vol 33 (7) ◽  
pp. 317
Author(s):  
Dwi Andayani ◽  
Ova Emilia ◽  
Djauhar Ismail
Keyword(s):  
Exclusive Breastfeeding ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Control Sample ◽  
Case Control ◽  
Bivariate Analysis ◽  
Significance Level ◽  
Breastfeeding Rate ◽  
Regression Tests ◽  
Control Study

Purpose This study aimed to determine the effect of the implementation of the antenatal class toward exclusive breastfeeding.Methods The research was a case-control study with a quantitative approach. This research was also supported by a qualitative approach which aimed to complement and reinforce the results obtained from the quantitative data. Sample cases were 135 exclusive breastfeeding infants aged 6-12 months, and the control sample were 135 not exclusive breastfeeding infants aged 6-12 month. Data analysis used the McNemar and conditional logistic regression tests with significance level of p = <0.05 and 95% confidence interval.Results Bivariate analysis showed that antenatal class affected exclusive breastfeeding p = 0.026 and OR = 1.80 (95% CI: 1.03 to 3.24). In the results of multivariate analysis after controlling by including support of her husband and the ANC p = 0.03 and OR = 1.86 (95% CI: 1.05 to 3.30). Mothers who attended antenatal class have exclusive breastfeeding rate 1.86 times higher compared to mothers who did not attend the antenatal class.Conclusion The antenatal class can directly affect exclusive breastfeeding, in spite of controlling the support of her husband and the ANC.

scholarly journals Effectiveness of CoronaVac, ChAdOx1, BNT162b2 and Ad26.COV2.S among individuals with prior SARS-CoV-2 infection in Brazil

2021 ◽  
Author(s):  
Thiago Cerqueira-Silva ◽  
Jason R Andrews ◽  
Viviane S Boaventura ◽  
Otavio T Ranzani ◽  
Vinicius de Araujo Oliveira ◽  
...  
Keyword(s):  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Rt Pcr ◽  
Symptomatic Infection ◽  
Series Completion ◽  
Negative Controls ◽  
Prior Infection ◽  
Control Study ◽  
Dose Vaccine

Background. COVID-19 vaccines have proven highly effective among SARS-CoV-2 naive individuals, but their effectiveness in preventing symptomatic infection and severe outcomes among individuals with prior infection is less clear. Methods. Utilizing national COVID-19 notification, hospitalization, and vaccination datasets from Brazil, we performed a case-control study using a test-negative design to assess the effectiveness of four vaccines (CoronaVac, ChAdOx1, Ad26.COV2.S and BNT162b2) among individuals with laboratory-confirmed prior SARS-CoV-2 infection. We matched RT-PCR positive, symptomatic COVID-19 cases with RT-PCR-negative controls presenting with symptomatic illnesses, restricting both groups to tests performed at least 90 days after an initial infection. We used multivariable conditional logistic regression to compare the odds of test positivity, and the odds of hospitalization or death due to COVID-19, according to vaccination status and time since first or second dose of vaccines. Findings. Among individuals with prior SARS-CoV-2 infection, vaccine effectiveness against symptomatic infection ≥ 14 days from vaccine series completion was 39.4% (95% CI 36.1-42.6) for CoronaVac, 56.0% (95% CI 51.4-60.2) for ChAdOx1, 44.0% (95% CI 31.5-54.2) for Ad26.COV2.S, and 64.8% (95% CI 54.9-72.4) for BNT162b2. For the two-dose vaccine series (CoronaVac, ChAdOx1, and BNT162b2), effectiveness against symptomatic infection was significantly greater after the second dose compared with the first dose. Effectiveness against hospitalization or death ≥ 14 days from vaccine series completion was 81.3% (95% CI 75.3-85.8) for CoronaVac, 89.9% (95% CI 83.5-93.8) for ChAdOx1, 57.7% (95% CI -2.6-82.5) for Ad26.COV2.S, and 89.7% (95% CI 54.3-97.7) for BNT162b2.

Sign in / Sign up

Export Citation Format

Share Document