scholarly journals Effects of Food-Specific IgG on Health Outcomes of Asymptomatic Physical Examination Population

2021 ◽  
Author(s):  
Mingxia Wu ◽  
Xiaofang Wang ◽  
Li Sun ◽  
Zongtao Chen
Keyword(s):  
Blood Glucose ◽  
Physical Examination ◽  
Health Outcomes ◽  
Clinical Symptoms ◽  
Fasting Blood Glucose ◽  
Physiological Mechanism ◽  
Negative Group ◽  
Distribution Profile ◽  
Positive Group ◽  
Specific Igg

Abstract Background: Although food-specific IgG is associated with the development and progression of some diseases as shown by many studies, it is also present in the population without clinical symptoms. However, the damage of the immune response it evokes to the health of such population has not been studied yet.Methods: The asymptomatic physical examination population (APEP) was selected according to the inclusion and exclusion criteria, and the physical examination data were collected. The subjects were divided into IgG-positive group (IgG-po group) and IgG-negative group (IgG-neg group). The hematologic and imaging examination results were compared between the two groups, and their odds ratios (OR) and 95% confidence interval (95%CI) were calculated using binary logistic regression to determine the relationship between food-specific IgG and different health outcomes. Results: The data of 28,292 subjects were included in the analysis of the study. The overall IgG positive rate was up to 52.3%, with mild to moderate IgG positive predominantly. Compared with IgG negative group, IgG positive group was associated with a decrease in the risks of hypertriglyceridemia, abnormal fasting blood glucose and overweight(OR=0.87,95%:CI:0.83-0.92; OR=0.93,95%CI:0.87-0.99; OR=0.92,95%CI:0.87-0.96) and with an increase in the incidence rate of thyroid nodule (OR=1.09,95%CI:1.04-1.15).Conclusion: Food-specific IgG is generally present in APEP and has an unique distribution profile, which plays a positive role in maintaining normal body weight and metabolic indicators(triglyceride(TG) and fasting blood glucose(FBG)), without influencing the nutritional status. The physiological mechanism is worth further study.

scholarly journals Significance of nucleic acid positive anal swab in COVID-19 patients

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 332-337
Author(s):  
Xiaoli Li ◽  
Lei Rong ◽  
Peiyan Zhang ◽  
Jian Xu ◽  
Yan Rong
Keyword(s):  
Platelet Count ◽  
Clinical Symptoms ◽  
Influence Factors ◽  
Recovery Phase ◽  
Negative Group ◽  
Pharyngeal Swab ◽  
Positive Group ◽  
Oral Transmission ◽  
Significant Difference ◽  
Anal Swab

Abstract Aim We compared the clinical characteristics of patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive and negative anal swabs during coronavirus disease 2019 (COVID-19) recovery and investigated the clinical significance and influence factors of anal swab detection. Methods This study retrospectively analyzed 23 moderate COVID-19 patients in the recovery phase. They were divided into anal swab positive group (n = 13) (negative for pharyngeal swabs but positive for anal swabs) and anal swab negative group (n = 10) (negative for pharyngeal and anal swabs). The epidemiology, clinical symptoms, time of pharyngeal swabs turning negative, and laboratory results were compared. Results The time of pharyngeal swabs turning negative in the anal swab positive group was 6 (5–8.5) days, significantly longer than that in the anal swab negative group (1 (1–4.25) days), P = 0.0002). The platelet count of the anal swab positive group was significantly lower than that of the anal swab negative group (198 (135–235) × 109/L vs 240.5 (227–264.75) × 109/L, P = 0.0248). No significant difference was observed between the two groups in other variables. Conclusions The time of pharyngeal swab turning negative in anal swab positive patients is longer than that in anal swab negative patients. The platelet count can be used as an indicator for viral infection evaluation. For patients with a longer time of pharyngeal swabs turning negative, the combined testing of the anal swab and platelet counts may help to avoid pharyngeal swab false negatives, premature discharge, and the possibility of fecal-oral transmission.

scholarly journals CLINICAL, BIOCHEMICALAND HORMONE PROFILE IN HIRSUTE VS NONHIRSUTE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

2020 ◽  
pp. 28-30
Author(s):  
Amaladasu Prasanthi
Keyword(s):  
Blood Glucose ◽  
Polycystic Ovary Syndrome ◽  
Clinical Symptoms ◽  
Polycystic Ovary ◽  
Fasting Blood Glucose ◽  
Clinical History ◽  
Positive Trend ◽  
Ovary Syndrome ◽  
Hormone Profile ◽  
The Mean

Background: Polycystic ovary syndrome (PCOS), a common endocrinopathy present with variety of phenotypes with broad spectrum of clinical symptoms. Hyperandrogenism characterized with the presence of hirsutism remains an important feature of PCOS. Aim: The present study was conducted to assess difference in the clinical, biochemical and hormone profile in hirsute and non-hirsute females with PCOS. Methods: Detailed physical and clinical history was taken in all subjects. Hormonal and biochemical assays were performed by ECLIA. Results: 105 normoglycemic cases were enrolled for this study. The mean age of patients was 22.19 ±4.4 years and the mean age of menarche was 13.3±1.4 years. Acne was present in more than 50% of our cases. 81% cases were hirsute and only 19% were non- hirsute. Mean fasting blood glucose and triglycerides were found to be statistically significant between the two groups. A positive trend of hirsutism was found to be associated with irregular cycles and family history of type-2 diabetes mellitus (T2DM). Conclusion: The mean blood glucose and triglycerides was elevated in hirsute PCOS, while as BMI, weight and waist circumference was slightly elevated in non-hirsute PCOS females.

scholarly journals Focal Maculopathy in the Senile Cataract Population

2020 ◽  
Author(s):  
Mei Zhang ◽  
Kun Yuan ◽  
Jingwen Liu ◽  
Haoran Zheng
Keyword(s):  
Blood Glucose ◽  
Physical Examination ◽  
Total Cholesterol ◽  
Univariate Analysis ◽  
Fasting Blood Glucose ◽  
Multivariate Logistic Regression Analysis ◽  
The Elderly ◽  
Senile Cataract ◽  
Routine Physical Examination ◽  
And Gender

Abstract Objective: Optical Coherence tomography (OCT) was employed to screen for maculopathy in the senile cataract population, investigate its incidence, and establish a healthy mode of management for maculopathy.Methods: A visual examination, slit-lamp microscope examination, direct ophthalmoscopic fundus examination, and a macular OCT examination were performed on 102 people with senile cataracts who were over 60 years in our hospital from January 1, 2019, to July 31, 2019. The demographic characteristics such as sex, age, physical examination mode: organization/individual, and routine physical examination items: presence or absence of hypertension, body mass index (BMI), blood biochemistry, total cholesterol, triglyceride (TG), fasting blood glucose and others.Results: Of the 102 subjects in the study, 28 were positive for maculopathy according to the OCT examination. Univariate analysis found that there were statistical differences between sexes and the presence of maculopathy (p<0.05). There were no significant differences in age, visual acuity, hypertension, BMI, fasting blood glucose, TG, total cholesterol, and cataract type (P>0.05). Multivariate logistic regression analysis, including all factors that might affect maculopathy, indicated that positivity for maculopathy and age (OR =2.549, 95%CI: 1.129–5.756, p<0.05) and gender (OR=3.907, 95%CI: 1.241–12.302, p<0.05) were related.Conclusion: The incidence of maculopathy in the senile cataract population was higher than that in the elderly population without cataract disease, and the proportion is 27.45%. Screening for maculopathy in the senile cataract population, especially among the elderly and females, should be improved.

Evaluation of CBC Parameters in Relation to PCR Test Results in Diagnosing Pediatric COVID-19 Disease

2021 ◽  
Author(s):  
Zafer Bagci ◽  
Ayşe Ruveyda Uğur ◽  
Cüneyt Uğur
Keyword(s):  
Complete Blood Count ◽  
Clinical Symptoms ◽  
Age Factors ◽  
Negative Group ◽  
Operating Characteristics ◽  
Cross Sectional ◽  
Distribution Width ◽  
Positive Polymerase Chain Reaction ◽  
Positive Group ◽  
Pcr Test

Abstract Objective This study aimed to investigate whether complete blood count parameters have predictive properties in diagnosing coronavirus disease 2019 (COVID-19) in regard to positive polymerase chain reaction (PCR) test in children with a prediagnosis of COVID-19, and whether these parameters are related to the severity of clinical findings in children with COVID-19. Methods This retrospective cross-sectional study included children who were hospitalized with a possible diagnosis of COVID-19 and had undergone PCR testing in the COVID-19 children's clinic. Probable case definition was made according to the COVID-19 diagnostic and therapeutic guidelines of the Ministry of Health of the Republic of Turkey. Results A total of 133 patients were included in the study, of which 46 (34.6%) were negative for the PCR test and 87 (65.4%) were positive for the PCR test. white blood cell (WBC), neutrophil, lymphocyte, and platelet levels were significantly lower in the PCR positive group than in the PCR negative group. The platelet to mean platelet volume ratio (PLT/MPV) was significantly lower in the PCR positive group than the PCR negative group, whereas the platelet distribution width (PDW) of the PCR positive patient group was significantly higher than the PCR negative group. For the multivariable model with PDW and neutrophil to lymphocyte ratio/age factors included, F1 score was 0.864, area under the receiver operating characteristics was 0.804, and area under the precision-recall curve was 0.873. The decision tree had a 72.9% cross-validation accuracy value. Conclusion WBC, neutrophils, lymphocytes, platelets, PLT/MPV, and PDW parameters could be used in conjunction with clinical symptoms and findings to predict the PCR test result.

scholarly journals The Clinical and Radiological Manifestations in Coronavirus Disease 2019 With Negative Nucleic Acid Results

2020 ◽  
Vol 7 (7) ◽  
Author(s):  
Guanjing Lang ◽  
Junwei Su ◽  
Wenrui Wu ◽  
Hong Zhao ◽  
Shihong Ying ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Chest Ct ◽  
Common Symptom ◽  
Negative Group ◽  
Rt Pcr ◽  
Positive Group ◽  
Epidemiological Features ◽  
Polymerase Chain ◽  
And Gender ◽  
Positive Results

Abstract Background Coronavirus disease 2019 (COVID-19) was a new emerging disease with high infectiousness. Its diagnosis primarily depended on real-time polymerase chain reaction (RT-PCR) results. This study investigated epidemiological, clinical, and radiological characteristics of COVID-19 with negative RT-PCR results before confirmation. Methods Patients with COVID-19 were enrolled and divided into 2 groups: a negative group with negative RT-PCR results before confirmation and a positive group with positive results at the first detection. Epidemiological and clinical features were compared. Dynamic chest computerized tomography (CT) images of the negative group were evaluated. Results Ninety-nine laboratory-confirmed patients with COVID-19 including 8 patients (8%) with negative RT-PCR results were included. Patients from the negative group had similar epidemiological features: the average age (50.25 ± 13.27 years in the negative group and 53.70 ± 16.64 years in the positive group) and gender distribution (males made up 50% of the negative group and 62.6% of the positive group) were comparable. No significant differences were observed in clinical symptoms between the 2 groups. We found that fever was the most common symptom for both groups, followed by cough, expectoration, chest distress, fatigue, and gastroenterological symptoms. Moreover, ground-glass opacities and consolidations were the main manifestation in chest CT of patients with COVID-19 with or without confirmed RT-PCR results. Conclusions Regardless of initial RT-PCR results, patients with COVID-19 had similar epidemiological, clinical, and chest CT features. Our study suggests value from early chest CT scans in COVID-19 screening and dynamic significance of radiology in disease monitoring should guide clinical decisions.

scholarly journals The association between Helicobacter pylori infection and food intolerance in western China

2020 ◽  
Author(s):  
Ying Liu ◽  
Dongyu Li ◽  
Ning Xiao ◽  
Yuping Liu ◽  
Ping Shuai
Keyword(s):  
Helicobacter Pylori ◽  
Infection Rate ◽  
Multivariate Logistic Regression Analysis ◽  
Food Intolerance ◽  
Western China ◽  
Negative Group ◽  
Positive Group ◽  
Total Food ◽  
Specific Igg ◽  
H Pylori

Abstract IntroductionHelicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases while the studies on its association with food intolerance are rare. In our study, we tried to explore the relationship between H. pylori infection and food intolerance.MethodsWe retrospectively analyzed the physical examination data of 21,822 subjects from February 2014 to December 2018 in this study. H. pylori infection was determined by 13C urea breath test. The food specific IgG in serum were detected to assess the food tolerance status of egg, milk and wheat.ResultsThe total infection rate of H. pylori was 39.3% and the total food intolerance rates of egg, milk and wheat were 25.2%, 9.0% and 4.7%, respectively. The infection rate of H. pylori was higher in males than that in females, while the intolerance rates were lower in males than that in females. The infection rates of H. pylori increased with age except for people over sixty, while the intolerance rates decreased. In H. pylori positive group, the intolerance rates were lower than that in the H. pylori negative group. At the same level of food intolerance, the intolerance rates in H. pylori positive group were lower than that in H. pylori negative group. Multivariate Logistic regression analysis showed that H. pylori infection was negatively correlated with intolerance of egg, milk and wheat (OR value of egg 0.844–0.873, milk 0.741–0.751, wheat 0.762–0.801).ConclusionsH. pylori infection was negatively correlated with intolerance of egg, milk and wheat in Sichuan, western China.

scholarly journals Focal Maculopathy in the Senile Cataract Population

2020 ◽  
Author(s):  
mei zhang ◽  
Kun Yuan ◽  
Jingwen Liu ◽  
Haoran Zheng
Keyword(s):  
Blood Glucose ◽  
Physical Examination ◽  
Total Cholesterol ◽  
Univariate Analysis ◽  
Fasting Blood Glucose ◽  
Multivariate Logistic Regression Analysis ◽  
The Elderly ◽  
Senile Cataract ◽  
Routine Physical Examination ◽  
And Gender

Abstract Objective Optical Coherence tomography (OCT) was employed to screen for maculopathy in the senile cataract population, investigate its incidence, and establish a healthy mode of management for maculopathy. Methods A visual examination, slit-lamp microscope examination, direct ophthalmoscopic fundus examination, and a macular OCT examination were performed on 102 people with senile cataracts who were over 60 years in our hospital from January 1, 2019, to July 31, 2019. The demographic characteristics such as sex, age, physical examination mode: organization/individual, and routine physical examination items: presence or absence of hypertension, body mass index (BMI), blood biochemistry, total cholesterol, triglyceride (TG), fasting blood glucose and others. Results Of the 102 subjects in the study, 28 were positive for maculopathy according to the OCT examination. Univariate analysis found that there were statistical differences between sexes and the presence of maculopathy (p<0.05). There were no significant differences in age, visual acuity, hypertension, BMI, fasting blood glucose, TG, total cholesterol, and cataract type ( P >0.05). Multivariate logistic regression analysis, including all factors that might affect maculopathy, indicated that positivity for maculopathy and age (OR =2.549, 95%CI: 1.129–5.756, p<0.05) and gender (OR=3.907, 95%CI: 1.241–12.302, p<0.05) were related. Conclusion The incidence of maculopathy in the senile cataract population was higher than that in the elderly population without cataract disease, and the proportion is 27.45%. Screening for maculopathy in the senile cataract population, especially among the elderly and females, should be improved.

Abstract P151: Comparison of Standard Definitions and Sagittal Abdominal Diameter as a Measure of Excess Adiposity When Defining Metabolic Syndrome in Adolescents

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Symielle A Gaston ◽  
Nicolle S Tulve ◽  
Tekeda F Ferguson
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Clinical Symptoms ◽  
Fasting Blood Glucose ◽  
Blood Lipid ◽  
Sagittal Abdominal Diameter ◽  
High Waist Circumference ◽  
Effective Interventions ◽  
Definition Of ◽  
Lipid Abnormalities

Introduction: Metabolic syndrome (MetS) is the cluster of several clinical symptoms that together represent the strongest risk factor for cardiovascular disease. The prevalence of MetS in adolescents is difficult to estimate given that there are several, but no agreed upon definition of MetS for this age group. It is important to estimate MetS and identify at-risk adolescents early in order to provide effective interventions prior to the development of diabetes and coronary heart disease. Objective: Study objectives are to: (1) estimate the prevalence of MetS in U.S. adolescents using three widely adopted definitions and (2) compare changes in prevalence of MetS when utilizing sagittal abdominal diameter (SAD) as a component of MetS. Methods: Data from U.S. adolescents ages 12-19 years (N=970) in the NHANES (2011-2014) were analyzed. MetS standard definitions developed by Cook et al. (2003), deFerranti et al. (2007), and the International Disease Federation (IDF, 2007) were applied to estimate the sex-stratified, weighted prevalence of MetS and its individual components (i.e., high waist circumference (WC), hypertension, blood lipid abnormalities, and high fasting blood glucose (FBG)). The definitions were modified by substituting SAD for WC, and weighted MetS prevalence was re-estimated. Results: Regardless of gender and definition, abnormal blood lipids and high WC were the most prevalent MetS components. For both sexes, estimated prevalence of components varied greatly by definition (e.g., boys’ prevalence of high fasting blood glucose: IDF-27.2% vs. Cook and deFerranti-both 2.7%). MetS prevalence in boys using standard and SAD-modified definitions were 4.5% and 5.0%; 10.6% and 9.4%; and 4.6% and 3.3% for the Cook, deFerranti, and IDF definitions, respectively. Among girls, the standard-defined and SAD-modified MetS prevalence were 2.4% and 2.4%; 8.5% and 8.2%; and 4.3% and 2.8% for the Cook, deFerranti, and IDF definitions, respectively. Conclusions: Though the most prevalent MetS components were similar, the estimated prevalence values of individual components varied greatly across MetS definitions. With the risk of false positives, the deFerranti definition of MetS may identify the greatest number of adolescents at potential risk for MetS. Cook and deFerranti definitions may miss the identification of adolescents who could benefit from additional health promotion programs. Compared to WC, use of SAD resulted in similar yet slightly attenuated estimated MetS prevalence.

Diabetes mellitus in phaeochromocytoma Fasting blood glucose levels before and after surgery in 60 patients with phaeochromocytoma

1984 ◽  
Vol 106 (4) ◽  
pp. 511-515 ◽  
Author(s):  
Gunnar Stenström ◽  
Lars Sjöström ◽  
Ulf Smith
Keyword(s):  
Blood Glucose ◽  
Clinical Symptoms ◽  
Fasting Blood Glucose ◽  
Malignant Tumour ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sustained Hypertension ◽  
Before And After ◽  
Vanilmandelic Acid

Abstract. Sixty patients undergoing operation for phaeochromocytoma were investigated in the pre- and postoperative states with respect to fasting blood glucose levels. When 6 previously known or suspected diabetics were excluded, preoperative diabetes (fasting blood glucose levels ≥ 7.0 mmol/l) were found in 3 of 13 (23%) with sustained hypertension, in 6 of 12 (50%) with sustained hypertension associated with paroxysms and in 4 of 24 (17%) with paroxysmal hypertension. None of the 5 patients with atypical clinical symptoms had glucose levels ≥ 7.0 mmol/l. In the groups of patients with particularly high urinary excretion of catecholamines and vanilmandelic acid higher blood glucose levels were also found. The postoperative blood glucose levels in the follow-up study were normal and < 5.8 mmol/l in all cases except in 3 of the 4 still living patients with a previously known diabetes and in 1 patient with a malignant tumour. Thus, manifest diabetes, defined as fasting glucose levels ≥ 7.0 mmol/l, is frequently present in patients with phaeochromocytoma (24% in the present study) and the diabetes is reversed by removal of the tumour.

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

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