A Cross-Sectional Study of the Histopathological correlation with serum Level of Carbohydrate Antigen-125 in Different Forms of Ovarian Cancer

Introduction: Involving approximately 4% of malignancies in women, ovarian cancer remains one of the most fatal cancers. However, it is important to consider conditions which are not primary ovarian diseases, but mimic their behaviors. In the present study, the epidemiological characteristics of extra-ovarian conditions mimicking ovarian masses are evaluated. Methods: This cross-sectional study was conducted on patients with a primary diagnosis of ovarian mass who underwent surgery by gynecologists between January 2012 and March 2016. The surgeon’s primary diagnosis and the final histopathology assessment report were evaluated for each patient. In cases where the final histopathology report was not in the spectrum of gynecologic pathology, possible reasons for incompatibility were investigated. Results: Ultimately, 1876 patients with a mean age of 48.26±15.4 years underwent analysis. Among these patients, 27 (1.4%) had masses of a non-gynecologic origin. The final diagnoses were divided into four main categories: masses with a gastrointestinal origin (55.5%), infectious (18.5%), those with a retroperitoneal origin (18.5%), and embryologic-origin masses (7.4%). Conclusion: The results suggest that extra-ovarian diseases should be considered in differential diagnoses of patients with a primary diagnosis of ovarian cancer. Furthermore, it was found that metastases from gastrointestinal tract tumors and infectious diseases are the most common pathologies among extra-ovarian conditions.

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AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Cellular Physiology and Biochemistry ◽

10.1159/000373961 ◽

2015 ◽

Vol 35 (4) ◽

pp. 1401-1412 ◽

Cited By ~ 17

Author(s):

Carla Peluso ◽

Fernando L.A. Fonseca ◽

Guilherme G. Gastaldo ◽

Denise M. Christofolini ◽

Emerson Barchi Cordts ◽

...

Keyword(s):

Serum Level ◽

Assisted Reproduction ◽

Controlled Ovarian Hyperstimulation ◽

Cross Sectional Study ◽

Human Reproduction ◽

Ovarian Hyperstimulation ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Assisted Reproductive Treatment

Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility. We aimed to evaluate AMH and AMHR2 polymorphisms in infertile women, and correlate those findings with AMH, FSH and estradiol serum level response to controlled ovarian hyperstimulation (COH), as well as assisted reproduction outcomes. Methods: A cross-sectional study comprising 186 infertile women that underwent one cycle of high complexity assisted reproductive treatment. Blood samples were collected and a TaqMan assay was used for AMH G146T/rs10407022 and AMHR2 A-482G/rs2002555, A10G/rs11170555, C1749G/rs2071558 and G4952A/rs3741664 genotyping, and FSH, estradiol and AMH levels were measured. The findings were correlated to human reproduction outcomes. Results: AMH rs10407022 and AMHR2 rs2002555 polymorphisms were not associated with hormonal measurements, whereas AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. The genotype distribution of AMH and AMHR2 genes according to Controlled Ovarian Hyperstimulation did not show a positive association. However, an association with AFC, degree of oocyte maturation (allele G of AMHR2 rs2071558) the number of embryos produced (alleles T and G of AMH rs10407022 and AMHR2 rs2002555, respectively) and frozen embryo (allele G of AMHR2 rs11170555) were found to be statistically associated. Considering COH, serum AMH and AFC were a positive predictor to OHSS. Regarding serum AMH and assisted reproduction outcomes, a positive correlation with all variables studied was found. Comparing AFC and AMH as predictors of human reproduction outcomes, the AFC was less effective than serum AMH. Considering pregnancy rates, no marker was positively associated. Conclusion: AMHR2 polymorphisms were associated with estradiol, AMH and FSH measurements, as well as number and quality of embryos, while AMH polymorphisms was associated with number of embryos produced. Serum AMH was correlated with nearly all variables analyzed in assisted reproductive treatment, demonstrating that it represents a better biomarker of OHSS and human reproduction outcomes compared to AMH and AMHR2 polymorphisms.

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Predictors of female health care providers' knowledge on symptoms and risk factors of ovarian cancer: A tertiary health care institutional based cross-sectional study

Nigerian Journal of Medicine ◽

10.4103/njm.njm_147_20 ◽

2020 ◽

Vol 29 (4) ◽

pp. 582

Author(s):

EmmanuelObiora Izuka ◽

ObinnaChinedu Nwafor ◽

JosephTochukwu Enebe ◽

IfeanyichukwuJude Ofor ◽

ChineloElizabeth Obiora-Izuka ◽

...

Keyword(s):

Risk Factors ◽

Ovarian Cancer ◽

Health Care ◽

Health Care Providers ◽

Cross Sectional Study ◽

Care Providers ◽

Sectional Study ◽

Cross Sectional

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The Level of 8-OHdG Serum was Higher in Women with Blighted Ovum

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v2i1.374 ◽

2014 ◽

pp. 18-21

Author(s):

I Made Mahadinata Putra ◽

I Gede P Surya

Keyword(s):

Serum Level ◽

Venous Blood ◽

Normal Pregnancy ◽

Cross Sectional Study ◽

Sectional Study ◽

Hospital Data ◽

Cross Sectional ◽

Independent Test ◽

The Difference ◽

Blighted Ovum

Objective: To determine the difference of 8-hydroxy-2-deoxyguanocyne (8-OHdG) serum level in women experiencing blighted ovum and women with normal pregnancy. Method: This was a cross sectional study with 82 samples, divided into two groups. Thirty two cases of blighted ovum and 51 cases of normal pregnancies, with 7-12 weeks gestational age. The examination of 8-OHdG serum level, was performed with the venous blood taken from the cubiti veins, and its 8-OHdG serum quantities were than examined at the Pathology Lab. at Sanglah General Hospital. Data was analyzed with the Shapiro Wilk Test and the t independent test with alpha 0.05. Result: The average 8-OHdG serum level in women with blighted ovum and normal pregnancies were 0.177 (SD 0.06) ng/ml and 0.111 (SD 0.01)ng/ml, and significantly different (p<0.05). The cut off value of 8-OHdG serum level was 0.138 ng/ml with sensitivity of 96.1% and specificity of 80.6%. Conclusion: The level of 8-OHdG serum was higher in women with blighted ovum than in women with normal pregnancies. Keywords: 8-OHdG serum level, blighted ovum, and normal pregnancy.

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Vitamin D Supplementation in Tuberculosis Patients: A Cross Sectional Study

Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI) ◽

10.32734/jetromi.v1i1.1265 ◽

2019 ◽

Vol 1 (1) ◽

Author(s):

Dina Keumala Sari ◽

Nurfida Khairina Arrasyid ◽

Y. S. Harahap

Keyword(s):

Vitamin D ◽

Serum Level ◽

Serum Levels ◽

Cross Sectional Study ◽

Vitamin D Supplementation ◽

Sectional Study ◽

Cross Sectional ◽

Tuberculosis Patients ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Previous studies have not been able to show with certainty the effect of vitamin D supplementation in tuberculosis patients. The objective of this study is to determine whether vitamin D supplementation to patients with tuberculosis could influence 25-hydroxyvitamin D (25(OH)D) and calcium serum levels. The results, after 28 days, the vitamin D supplementation showed significant increase of 25(OH)D serum level at the end point (p=0.001), but not for the calcium serum level (p=0.3). The Conclusions is supplementation with 1,000 IU vitamin D per day increased the 25(OH)D serum level but there was no association with the calcium serum level.

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Anxiety and Depression Symptoms Among Ovarian Cancer Patients in Western China: A Cross-Sectional Study

Biomedical Journal of Scientific & Technical Research ◽

10.26717/bjstr.2020.26.004404 ◽

2020 ◽

Vol 26 (5) ◽

Author(s):

Jing Chen

Keyword(s):

Ovarian Cancer ◽

Cancer Patients ◽

Cross Sectional Study ◽

Western China ◽

Anxiety And Depression ◽

Depression Symptoms ◽

Sectional Study ◽

Cross Sectional

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25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia

Majalah Obstetri & Ginekologi ◽

10.20473/mog.v23i2.2088 ◽

2015 ◽

Vol 23 (2) ◽

pp. 42

Author(s):

Hanifa Erlin Damayanti ◽

Aditiawarman Aditiawarman

Keyword(s):

Vitamin D ◽

Serum Level ◽

Vitamin D Deficiency ◽

Sandwich Elisa ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Chemiluminescent Immunoassay ◽

Risk Of Preeclampsia

Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia.Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients.Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629).Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.

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FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis

Dermatology Practical & Conceptual ◽

10.5826/dpc.1103a57 ◽

2021 ◽

pp. 2021057

Author(s):

Mahajabeen S Madarkar ◽

Varsha R. Koti

Keyword(s):

Cross Sectional Study ◽

Accurate Diagnosis ◽

Pivotal Role ◽

Papillary Dermis ◽

Histopathological Diagnosis ◽

Sectional Study ◽

Cross Sectional ◽

Histopathological Correlation ◽

Macular Amyloidosis ◽

Atypical Presentations

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to conﬁrm amyloid deposition in the upper papillary dermis. Objectives: This study used FotoFinder dermoscopy to characterize lichen and macular amyloidosis and correlated the dermoscopic features with histopathological findings. Methods: This cross-sectional study enrolled patients with a clinical and histopathological diagnosis of PLCA. Dermoscopic examination was performed using the FotoFinder dermoscope, which provides a range of magnification from 20´ to 140´. Results: A total of 30 patients were included in the study. Common dermoscopic patterns of MA were white or brown central hubs, and common patterns of LA were white structureless, scar-like areas and central hubs. New dermoscopic findings were a day lily appearance in MA and white rosettes in LA. Conclusions: Dermoscopy plays a pivotal role in demonstrating characteristic findings of PLCA. These findings were well corelated with histopathology, thus avoiding unnecessary biopsy for arriving at an accurate diagnosis of PLCA.

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