scholarly journals FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis

2021 ◽  
pp. 2021057
Author(s):  
Mahajabeen S Madarkar ◽  
Varsha R. Koti
Keyword(s):  
Cross Sectional Study ◽  
Accurate Diagnosis ◽  
Pivotal Role ◽  
Papillary Dermis ◽  
Histopathological Diagnosis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Macular Amyloidosis ◽  
Atypical Presentations

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Objectives: This study used FotoFinder dermoscopy to characterize lichen and macular amyloidosis and correlated the dermoscopic features with histopathological findings. Methods: This cross-sectional study enrolled patients with a clinical and histopathological diagnosis of PLCA. Dermoscopic examination was performed using the FotoFinder dermoscope, which provides a range of magnification from 20´ to 140´. Results: A total of 30 patients were included in the study. Common dermoscopic patterns of MA were white or brown central hubs, and common patterns of LA were white structureless, scar-like areas and central hubs. New dermoscopic findings were a day lily appearance in MA and white rosettes in LA. Conclusions: Dermoscopy plays a pivotal role in demonstrating characteristic findings of PLCA. These findings were well corelated with histopathology, thus avoiding unnecessary biopsy for arriving at an accurate diagnosis of PLCA.

scholarly journals Ultrasonographic Evaluation of Solitary Thyroid Nodule with Histopathological Comparison

2020 ◽  
Vol 25 (2) ◽  
pp. 76-84
Author(s):  
Samia Quadir ◽  
Sabiha Quadir ◽  
Md Momin Uddin ◽  
Kazi Shameemus Salam ◽  
Mohammad Sazzad Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Follicular Adenoma ◽  
Nodular Goiter ◽  
Cross Sectional Study ◽  
The Body ◽  
Histopathological Diagnosis ◽  
Sectional Study ◽  
Diagnostic Modality ◽  
Cross Sectional ◽  
Solitary Thyroid Nodule

Background: Thyroid gland is the largest gland of the body which secretes thyroid hormones named T3 & T4. Incidence of solitary thyroid nodule is common in Bangladesh. Objectives: To validate the ultrasonography evaluation of solitary thyroid nodule comparing with histopathological diagnosis. Methodology: This cross sectional study enrolled 75 patients of age range between 14 to 72 years during July 2016 to June 2018 and the study was carried out in the department of Radiology & Imaging of Ultrasonography evaluation was finally compared with histopathological diagnosis which was considered as gold standard. Results: Among 75 patients are included in this study the age ranged between 14 to 72 years. Majority of the patients 37 (49.3%) were found between 31 to 40 years. 65 (86.3%) were female & 10 (13.3%) were male. All patients were presents with thyroid swelling. In USG findings Microcalcifications were present 9 (12%) in benign & 5(6.7%) in malignant cases. Presence of Halo were in all benign cases 14 (18.7%). Comet tail sign were in 5 (6.7%) in benign & 3 (4%) in malignant cases. Histological nodular goiter were 57 (76%), Follicular adenoma 8 (10.7%), Thyroditis 5 (6.7%) and Papillary carcinoma 4 (5.3%), Follicular Carcinoma 1 (1.3%). Conclusion: This cross sectional study was carried out with an aim to determine the usefulness of ultrasonogram diagnosis of solitary thyroid nodule compared with histopathology findings. As the validity test results are higher, it can be concluded that the ultrasonogram is a useful diagnostic modality in the evaluation of solitary thyroid nodule. Bangladesh J Otorhinolaryngol; October 2019; 25(2): 76-84

scholarly journals Diagnostic efficacy of Fenyo-Lindberg scoring system in patients of acute appendicitis a one-year cross sectional study

2020 ◽  
Vol 7 (12) ◽  
pp. 3998
Author(s):  
Kartik Sahu ◽  
Anil P. Bellad
Keyword(s):  
Acute Appendicitis ◽  
Sample Size ◽  
Scoring System ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Sectional Study ◽  
Diagnostic Efficacy ◽  
Cross Sectional ◽  
Group I ◽  
One Year

Background: Diagnostic scores have been found to be very efficient. The present study was taken up to calculate diagnostic efficacy of Fenyo-Lindberg (FL) scoring system in patients of acute appendicitis.Methods: A one-year cross sectional study was done on 100 patients in patients with right lower quadrant pain. Group I had patients with score of -2 and above and group II with score below -2. The groups were compared with histopathological diagnosis. Then, the sensitivity, specificity, positive predictable value (PPV) and negative predictable value (NPV) were calculated.Results: In this study, the males were 52 and females were 48.15 patients, Total leucocyte count (TLC) had more than 14,000 whereas 16 patients had onset of pain in less than 24 hours. 47 patients had vomiting. Tenderness was present in all cases, while rebound tenderness was present in 54% of cases. 98% of patients had progression of pain, whereas migration was seen in 76%. 56% patients had increased pain on coughing. 54 patients had acute appendicitis on histopathology. The study shows that this scoring system has sensitivity of 72% and specificity of 71% in diagnosing acute appendicitis. The PPV was 75% and NPV was 68%.Conclusions: The FL score is an inexpensive clinical tool that may help the diagnosis of acute appendicitis. The results are comparable to previous studies but as the sample size is small, study has to be done in higher sample size to get the data necessary to generalize the findings and the fact that this study was first on this scoring system in India should also be considered.

scholarly journals Prevalence and risk factors of Appendicitis at Surgery Department of a Tertiary Care Hospital in Pakistan

2021 ◽  
Vol 15 (8) ◽  
pp. 2497-2499
Author(s):  
Laraib Zafar ◽  
Kiran Maqbool ◽  
Maj Uzma Javed Gul ◽  
Ishfaq Ahmad Khan ◽  
Arshid Mahmood
Keyword(s):  
Risk Factors ◽  
Acute Appendicitis ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Surgical Department

Background: Appendicitis needs immediate surgical intervention based on indication in the pediatric age group. Among high-risk young children, the prevalence of pre-existing perforation ranges from 30% to 75%. Aim: To investigate the prevalence and risk factors for appendicitis in the inpatient surgical department. Place and Duration: Study was conducted at surgical department of Combined Military Hospital, Rawalakot for the period of six months from October 2020 to March 2021. Materials and Methods: A single-center cross-sectional study was conducted on 102 patients with acute appendicitis diagnosed and confirmed by Ultrasonography among the patients admitted to the surgical department during October 2020 to March 2021. Pretested questionnaire were used to collect and record the necessary information. Results: The sample size of 102 patients had 61 (60%) males and 41 (40%) were females. Appendicitis patients were divided into four age groups: 10-19 years 16 (15.7%), 20-29 years 19 (32.35%), 30-39 years 15 (14.7%), 40-49 years 14 (13.7%), and 50-59 years 7 (.6.8 %). The male-to-female ratio was 3:2. (60 %, 40 %). The most common complaints are abdominal pain (100%), vomiting (55.12%), and fever (87.21%). Based on histopathological diagnosis, the categorical distributions of appendicitis were Acute Appendicitis (48.10%), Lymphoid Hyperplasia (25.50%), and Resolving Appendicitis (47.05%). Conclusion: The prevalence of acute appendicitis is more common in males especially in the age group of 20-29 years based on histological diagnosis. Keywords: Appendicitis, Cross-sectional Study

scholarly journals Spectrum of Malignant Skin Lesion in Patients attending Nepalgunj Medical College and Teaching Hospital

2017 ◽  
Vol 2 (2) ◽  
pp. 156-161
Author(s):  
Reena Rana ◽  
G P Ghimire ◽  
S Gupta ◽  
M Singh ◽  
KK Jha ◽  
...  
Keyword(s):  
Skin Lesion ◽  
Clinical Diagnosis ◽  
Teaching Hospital ◽  
Malignant Tumor ◽  
Histopathological Examination ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Cross Sectional ◽  
Medical College ◽  
Histopathological Correlation

IntroductionClinical diagnosis of dermatological manifestation of neoplastic skin lesion can pose a diagnostic difficulty at times. Histopathological diagnosis is mandatory for accurate characterization of disease entity for proper and timely management of cases.ObjectiveThe aim of this study was to analyze malignant tumor of skin with respect to age, sex, clinical features and histopathological features and to evaluate the accuracy of clinical diagnosis with histopathological correlation.MethodologyThis is hospital based cross-sectional study conducted at Nepalgunj Medical College and Teaching Hospital, Kohalpur from February 2010 to January 2011. A total of 70 histopathological specimens of skin biopsies were studied and correlated with the clinical diagnosis. The data was entered into Microsoft  office excel and analyzed using statistical package for social sciences (SPSS 17.0).ResultsMalignant tumor of skin constituted 21.4% of total cases. In malignant tumor, most common sites were head and neck regions followed by lower limb with keratinocytic tumors being in the majority. Most of the specimens (65.7%) were obtained as excisional biopsies.  Seven cases diagnosed as benign lesions clinically, turned out to be malignant on histopathological examination. Out of 13 cases in which clinical diagnosis was of malignancy, only 8 turned out to be malignant, thus for malignant lesions, the clinical diagnosis had a sensitivity of 53.3%, specificity of 90.9% and a positive predictive value of 61.5%.ConclusionsSquamous cell carcinoma was the most common malignant tumor in this study and histopathological correlation significantly modifies the overall management in dermatological disorders where clinical diagnoses are equivocal.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, Page: 156-161

scholarly journals Performance of Plasma B-Type Natriuretic Peptide as a Diagnostic Biomarker in Heart Failure

1970 ◽  
Vol 3 (2) ◽  
pp. 126-130
Author(s):  
MM Hoque ◽  
S Shafiullah ◽  
P Sultana ◽  
N Sultana
Keyword(s):  
Heart Failure ◽  
Natriuretic Peptide ◽  
Cross Sectional Study ◽  
Accurate Diagnosis ◽  
Clinical Parameters ◽  
Diagnostic Biomarker ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cardiac Ventricles ◽  
Sensitivity Specificity

Background: Accurate diagnosis of heart failure (HF) is essential for its proper management and logical drug therapy to reduce morbidity and mortality. On this perspective researcher are in search of a good biomarker as complementary to the clinical parameters to improve the performance of HF diagnosis. B-type natriuretic peptide (BNP) secreted by cardiac ventricles in HF has emerged as a new promising biomarker in this regard. Objective: To evaluate the performance of plasma BNP as a diagnostic biomarker in HF. Methods: In a cross sectional study 180 clinically suspected HF patients were selected. Their plasma BNP were measured and then subjected to echocardiogram. Patients were categorized as HF and without HF on the basis of echocardiogram and against this information the performance of plasma BNP of study subjects were evaluated as a diagnostic biomarker of HF considering 100 pg/ ml as its cut off point. Results: Sensitivity, specificity, accuracy, PPV, NPV, PLR and NLR of plasma BNP for diagnosis of HF found to be 88 %, 63.8 %, 77.2 %, 75.2 %, 81.0 %, 2.4 and 0.2 respectively. Conclusion: Plasma BNP concentration increases in HF. Based on 100 pg/ml as cut off point, plasma BNP shows good performance in diagnosis of HF Keywords: BNP; Heart failure DOI: http://dx.doi.org/10.3329/cardio.v3i2.9180 Cardiovasc. J. 2011; 3(2): 126-130

scholarly journals Isolated Gall Bladder Perforation in A Tertiary Care Hospital in Eastern Nepal: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (232) ◽  
Author(s):  
Brikh Raj Joshi ◽  
Swotantra Gautam ◽  
Saroj Adhikari Yadav ◽  
Sushil Dhakal ◽  
Rasmita Thapaliya ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Acute Cholecystitis ◽  
Cross Sectional Study ◽  
Bladder Perforation ◽  
Histopathological Diagnosis ◽  
Type I ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Co Morbidity

Introduction: Cholelithiasisis is a common surgical problem worldwide. Gall bladder perforation is a rare life-threatening complication with considerable mortality. This study aims to find the etiology, demography, type of perforation, and outcome of gall bladder perforation. Methods: This descriptive cross-sectional study was done on patients above 18 years of age visiting the department of surgery of B. P. Koirala Institute of Health Sciences (BPKIHS) who were diagnosed with isolated gall bladder perforation. The study was done from 1st January 2006 till 30 December 2016. Ethical approval was obtained from the Institutional Research Committee (reference number. 34/074/075). The convenient sampling method was used. Data were entered in excel sheets and analyzed. Results: Out of 49 patients included in the study, 28 (57.14%) were females and the commonest age group was 36 to 50 years 22 (44.9%) followed by 51 to 65 years 16 (32.6%). Most of the patients presented in emergency with pain in their abdomen. Diabetes mellitus was the commonest co-morbidity present in 10 (20.41%) patients. Operative management was done in 45 (91.84%) of the patient and conservative management in 4 (8.16%). After surgery of 45 patients, 43 (95.56%) improved and 2 (4.44%) expired. The most common type of perforation was Niemeier Type I in 21 (46.67%) followed by Type III 14 (31.11%). The most common histopathological diagnosis was acute cholecystitis 20 (44.44%). Conclusions: Isolated gall bladder perforation is not an uncommon complication. The most common etiological factor was acute cholecystitis with a slight female predominance. Most of the patients needed surgical intervention and they had good outcomes when diagnosed and managed on time.

scholarly journals Histopathological features of thrombotic microangiopathies in renal biopsies

2019 ◽  
Vol 8 (3) ◽  
pp. 27-27
Author(s):  
Miguel Ernandes Neto ◽  
Lucas de Moraes Soler ◽  
Halita Vieira Gallindo Vasconcelos ◽  
Daniela Cristina dos Santos ◽  
Rosa Marlene Viero ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Shiga Toxin ◽  
Membranoproliferative Glomerulonephritis ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Thrombotic Microangiopathies ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Uremic Syndrome

Background: Thrombotic microangiopathy (TMA) is a morphologic lesion characterized by thrombi occluding microvasculature related to endothelial injury. Objectives: This study aimed to assess the association between histopathological findings and etiology of TMA. Patients and Methods: This cross-sectional study comprised a sample of 34 patients who underwent renal biopsy and received an initial TMA diagnoses resulting in 29 definitive TMA cases. We evaluated the TMA features and clinical histopathological correlation. Results: The most frequent etiologies were atypical hemolytic uremic syndrome (aHUS) (n= 10; 34.5%), hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STECHUS) (n=6; 24.1%) and secondary causes of TMA (n= 12; 41.4%). We found the following histological features; patients with aHUS had thrombi in 60% of biopsies, membranoproliferative glomerulonephritis (MPGN)-like pattern in 20% and ischemia in 20%; patients with STEC-HUS had thrombi (14.3%), MPGN-like pattern (14.3%), endothelial swelling (14.3%) and ischemia (57.1%); patients with secondary etiologies had thrombi (58.3%), endothelial swelling (16.7%), ischemia (16.7%) and MPGN-like pattern (8.3%). Conclusions: The distribution of classic TMA findings was not related to etiology in spite of microthrombi having been found mostly in aHUS and secondary etiologies, whereas ischemia was found mainly in STEC-HUS. We did not find a histopathological pattern to each etiology of TMA.

scholarly journals THE ESSENTIAL ROLE OF SOCIAL WORK IN THE TREATMENT OF TUBERCULOSIS

2020 ◽  
pp. 1-3
Author(s):  
Sandesh K S ◽  
Sriharshavardha na S V ◽  
Suresh Baliga, K ◽  
Ranjan O R
Keyword(s):  
Social Work ◽  
Cross Sectional Study ◽  
Accurate Diagnosis ◽  
Ecological Perspective ◽  
Future Research ◽  
Sectional Study ◽  
Cross Sectional ◽  
The World ◽  
Effective Medication

Tuberculosis has been a world epidemic which has claimed thousands of lives in the world with India taking the lead. The disease is curable and only when compliance with effective medication and follow-ups are ensured. However, it has been challenging to control the spread and commitment to medication for those who are affected and infected. A cross sectional study that involved 160 patients at Dakshina Kannada District of Karnataka found out that patient compliance is negatively affected by factors such as alcohol and substance abuse, the fear of losing a job, and patient illiteracy. Accurate diagnosis and management of chest TB is also important. The hospitals need to deploy changes which include having a social work department. The department should use the ecological perspective to work with victims with cases of non-compliance, alcoholism, homelessness, loneliness, and joblessness. The content of interviews with patients revealed and identified problems for future research.

scholarly journals Clinicopathological Study of Parapharyngeal Space Tumor

2020 ◽  
Vol 23 (1) ◽  
pp. 41-46
Author(s):  
Muhammad Nazrul Islam ◽  
Belayat Hossain Siddiquee ◽  
Mosleh Uddin ◽  
Kanu Lal Saha ◽  
Md Delwar Hossain
Keyword(s):  
Parapharyngeal Space ◽  
Cross Sectional Study ◽  
Accurate Diagnosis ◽  
Neck Swelling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diagnosis And Management ◽  
Parapharyngeal Space Tumor ◽  
Medical University ◽  
Good Number

Objective: To see the mode of presentation, diagnosis and management of parapharyngeal space tumours. Study design: Cross sectional study. Setting: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Methods: The condition being relatively rare, it was difficult to find good number of fresh cases. We have studied all cases of parapharyngeal space tumour attending in the Bangabandhu Sheikh Mujib Medical University from January 2010 to March 2011. Result: Parapharyngeal space tumours are rare head and neck neoplasms.The third decade of life showed greatest incidence. The main presenting complaint’s were painless neck swelling (73%). The highest number of pathology were attached to the deep lobe of parotid gland (pleomorphic adenoma-27%) and then neurofibroma (20%). Of all cases 77% were benign. Their accurate diagnosis and management is challenging. Bangladesh J Otorhinolaryngol; April 2017; 23(1): 41-46

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