scholarly journals INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS

2020 ◽  
pp. 21-23
Author(s):  
Liliya Babinets ◽  
Iryna Halabitska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Functional Capacity ◽  
Glycosylated Hemoglobin ◽  
Pancreatic Insufficiency ◽  
Control Group ◽  
Primary Osteoarthritis

The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome. The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis. Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA. Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.

scholarly journals Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

2020 ◽  
Author(s):  
Xiaomeng Sun ◽  
Jia Liu ◽  
Guang Wang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Fenofibrate Treatment

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment. Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment. Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

scholarly journals POLYMORPHISMS OF INSULIN RECEPTOR SUBSTRATE 1 AS A RISK FACTOR FOR TYPE 2 DIABETES MELLITUS, OBESITY AND CHRONIC PANCREATITIS AMONG POPULATION OF TERNOPIL REGION

2021 ◽  
Vol 6 (2) ◽  
pp. 30-36
Author(s):  
U. P. Hevko ◽  
M. I. Marushchak
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Gene Polymorphism ◽  
University Hospital ◽  
Gene Localization ◽  
Control Group ◽  
Hardy Weinberg Equilibrium

Background. The course of type 2 diabetes mellitus (T2DM), obesity and chronic pancreatitis (CP) in most cases is not isolated, so it requires broadening the knowledge about the pathogenetic links at their combined course. Despite significant advances in genome research, most of the genetic factors that cause development of T2DM are still unclear. Objective. The aim of the study was to establish the prevalence of IRS1 gene polymorphism in the patients with T2DM as well as obesity and CP. Methods. The study involved 34 patients with T2DM who were hospitalized in the endocrinology department of Ternopil University Hospital in 2019-2020 and 10 apparently healthy patients. Analysis of IRS1 gene polymorphism (SNP in the promoter region - rs2943640; gene localization 2q36.3) was performed on the basis of polymerase chain reaction data using specific primers. Results. It was found that the frequencies of the genotype responsible for C/A polymorphism of IRS1 gene in T2DM, T2DM with obesity and in the combined course of T2DM with obesity and CP did not deviate significantly from the Hardy-Weinberg equilibrium (p>0.05). The patients with combined course of T2DM, obesity and chronic pancreatitis experienced a probable influence of genotypes C/C and C/A of IRS1 gene on the development of the studied comorbidity (p<0.05), which is confirmed by a probable difference in the dominant model of IRS1 gene inheritance only when T2DM was combined with obesity and CP compared to the control group (p<0.001). Conclusions. The presence of the C allele in both homozygous and heterozygous states may increase the risk of T2DM comorbidity, obesity and CP in the population of Ternopil region.

scholarly journals Glucose-6-Phosphate Dehydrogenase (G6PD) status in Female Type 2 Diabetes Mellitus and its Relationship with HbA1C

1970 ◽  
Vol 5 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Nadira Akter ◽  
Noorzahan Begum ◽  
Sultana Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
G6pd Deficiency ◽  
Glycosylated Hemoglobin ◽  
Health Science ◽  
Control Group ◽  
Glucose 6 Phosphate Dehydrogenase

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency may be one of the risk factor for type 2 diabetes mellitus. Objective: To observe erythrocyte G6PD status in type 2 female diabetic patients and also to find out its relationship with glycosylated hemoglobin. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka from January to December 2009. For this, 60 female patients with type 2 diabetes mellitus, age ranged from 40 to 60 years were included in the study group (group B). On the basis of glycosylated hemoglobin level (HbA1C) they were further subdivided into group B1, consisting of 30 controlled diabetics (HbA1C 4.8-6%) and group B2, consisting of 30 uncontrolled diabetic (HbA1C>6%) patients. They were selected from Out Patient Department of Bangladesh Institute of Health Science Hospital. For comparison, age & sex matched 30 apparently healthy non diabetic females (group A) were also studied. Erythrocyte G6PD level was measured by Spectrophotometer, HbA1C level by Flex reagent cartridge and serum bilirubin, Hb%, total count of RBC and reticulocyte% were measured by standard laboratory techniques. For statistical analysis ANOVA, independent sample t test, χ2 test and Pearson's correlation coefficient test were performed as applicable. Results: In this study, erythrocyte G6PD level was significantly lower in both the diabetic groups (p <0.001) than those of control group but their difference when compared between B1 and B2 was not statistically significant. In controlled diabetics 20% and in uncontrolled diabetics 6.7% patients were found G6PD deficients. No G6PD deficient subjects were found in control group. HbA1C showed negative correlation with Erythrocyte G6PD which was only significant for uncontrolled diabetes (p < 0.05) Conclusion: This study concludes that G6PD deficiency may be one of the risk factor for type 2 diabetes mellitus irrespective of blood glucose control status.Key words: Glucose-6-PD; Diabetes; Female.DOI: 10.3329/jbsp.v5i2.6778J Bangladesh Soc Physiol. 2010 December; 5(2): 60-65

scholarly journals DEPENDENCE OF PANCREAS FUNCTIONAL CAPACITY AT CHRONIC PANCREATITIS ON ENDOTOXICOSIS AND OTHER METABOLIC FACTORS

2021 ◽  
Vol 74 (4) ◽  
pp. 869-873
Author(s):  
Liliya S. Babinets ◽  
Olexandr S. Zemlyak ◽  
Iryna M. Halabitska ◽  
Halyna M. Sasyk ◽  
Zoreslava Ya. Onufryk
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Pancreatitis ◽  
Functional Capacity ◽  
Immune Complexes ◽  
Thiobarbituric Acid ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
The Status

The aim: Was to investigate the status of endotoxicosis parameters in patients with chronic pancreatitis depending on the presence of a combination with type 2 diabetes mellitus, as well as their impact on the functional capacity of the pancreas. Materials and methods: 87 outpatients with CP with concomitant type 2 diabetes and without it were examined. The main group consisted of 62 patients with CP in the phase of therapeutic exacerbation in combination with diabetes mellitus in a state of sub- or full compensation, the comparison group – 25 patients with isolated CP, the control group consisted of 30 healthy individuals. The content of malonic aldehyde in the blood was determined by reaction with thiobarbituric acid, the levels of medium-molecular peptides MMP1 and MMP2 – by the method of Gabrielyan, circulating immune complexes – by precipitation in 3.75% ethylene glycol with followed photometry. Results: The presence of active endotoxicosis and lipid peroxidation in CP was established, which was significantly more significant in the comorbidity of CP with type 2 diabetes: erythrocyte intoxication index was higher by 19.2%, the content of medium molecules MMP1 – by 29.5%, MMP2 – by 35.4%, malonic aldehyde – 10.9%, circulating immune complexes – 23.9%, ceruloplasmin – by 11.9% (p <0.05) Conclusions: A deeper level of excretory and incretory insufficiency of the pancreas in concomitant diabetes mellitus 2, which deepened with increasing endotoxicosis by the level of erythrocyte intoxication index based on an increase in the strength of significant moderate and moderate inverse correlations between it and fecal α-elastase such in isolated CP (respectively r=-0.517 and r=-0.471, p<0.05) and significant direct moderate and medium strength correlations between levels of HbA1c and erythrocyte intoxication index – respectively r=0.552 and r=0.337, p<0.05.

scholarly journals Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

2020 ◽  
Author(s):  
Xiaomeng Sun ◽  
Jia Liu ◽  
Guang Wang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia.Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment.Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment.Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

High HBA1C Level Is Associated With Low Heamoglobin Level

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Mafooza Rashid ◽  
B. K. Gupta, Vinay Bharat ◽  
Abhishek Gupta ◽  
Zubair Rashid
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Good Control ◽  
Diabetic Control ◽  
Medical College ◽  
High Hba1c ◽  
Normal Controls

Background: The aim of the study was to compare the hemoglobin levels among normal controls (patients) and patients of TypeII diabetes with HbA1c levels below 7 % & above 7 %.and secondly to identify the undetected cases of anemia in TypeII diabetes. Materials & Methods - 50 patients of type 2 diabetes mellitus with their glycosylated hemoglobin levels less than 7 %, 50 patients of type 2 diabetes mellitus with their glycosylated hemoglobin levels more than 7 % attending the Medicine outpatient department of Subharti Medical College and Hospital will be the subjects for the study.50 age and sex matched controls will be selected randomly from Subharti Medical College and Hospital. Informed written consent will be taken from all the subjects. The study will be conducted from January 2016 to January. Result - We studied 50 cases with HbA1C>7(poor control),50 cases with HbA1C 5.6 to7 (good control) and 50 controls with HbA1C ≤5.6, we observed in cases with HbA1C>7 (poorly control) ,the mean HbA1C is 9.9±2 and mean Hb is 9.8±1.3 as compared to cases with HbA1C 5.6 to 7(good control) where mean HbA1C is 6±0.4 and Hb is 13±0.5,this clearly indicates that in cases HbA1C is more Hb levels are low and when HbA1C is less Hb levels are higher. Conclusion - In the present study we found negative correlation between HbA1c & Hb levels. As the value of HbA1c increases, as in cases of HbA1c >7(poor diabetic control), we found low Hb levels as compared to the cases with HbA1c <7(5.6-7) (good control).

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