Mediation Effect of C-Reactive Protein in the Relationship between Abdominal Obesity and Intermediate Hyperglycemia

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials & methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

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EVALUATION OF THE RELATIONSHIP OF LEVELS OF C-REACTIVE PROTEIN AND HOMOCYSTEIN IN PATIENTS WITH ABDOMINAL OBESITY AND PATHOLOGICAL CHANGES IN THE LIVER DEFINED BY BIOPROGNOSTIC TEST STEATOSCREEN.

10.26226/morressier.59a6b341d462b80290b53e58 ◽

2017 ◽

Author(s):

Ekaterina Chernetcova

Keyword(s):

Abdominal Obesity ◽

Pathological Changes ◽

C Reactive Protein ◽

Reactive Protein ◽

Relationship Of ◽

The Relationship

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The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women

Korean Journal of Clinical Laboratory Science ◽

10.15324/kjcls.2017.49.2.121 ◽

2017 ◽

Vol 49 (2) ◽

pp. 121-127 ◽

Cited By ~ 2

Author(s):

Kyung-A Shin

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Abdominal Obesity ◽

Elderly Women ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

Communications Biology ◽

10.1038/s42003-021-02036-x ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Longxian Lv ◽

Silan Gu ◽

Huiyong Jiang ◽

Ren Yan ◽

Yanfei Chen ◽

...

Keyword(s):

Clinical Features ◽

Internal Transcribed Spacer ◽

Candida Glabrata ◽

Penicillium Citrinum ◽

Medical Attention ◽

C Reactive Protein ◽

Fungal Burden ◽

Reactive Protein ◽

Bacterial Microbiota ◽

The Relationship

AbstractThe relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the gut mycobiota of 67 COVID-19 patients, 35 H1N1-infected patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing and analysed their associations with clinical features and the bacterial microbiota. Compared to HCs, the fungal burden was higher. Fungal mycobiota dysbiosis in both COVID-19 and H1N1-infected patients was mainly characterized by the depletion of fungi such as Aspergillus and Penicillium, but several fungi, including Candida glabrata, were enriched in H1N1-infected patients. The gut mycobiota profiles in COVID-19 patients with mild and severe symptoms were similar. Hospitalization had no apparent additional effects. In COVID-19 patients, Mucoromycota was positively correlated with Fusicatenibacter, Aspergillus niger was positively correlated with diarrhoea, and Penicillium citrinum was negatively correlated with C-reactive protein (CRP). In H1N1-infected patients, Aspergillus penicilloides was positively correlated with Lachnospiraceae members, Aspergillus was positively correlated with CRP, and Mucoromycota was negatively correlated with procalcitonin. Therefore, gut mycobiota dysbiosis occurs in both COVID-19 patients and H1N1-infected patients and does not improve until the patients are discharged and no longer require medical attention.

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Abstract P150: Association of Non-Framingham Stroke Risk Factors With Incident Stroke Among Individuals With and Without Diabetes

Circulation ◽

10.1161/circ.129.suppl_1.p150 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

John N Booth ◽

Samantha Bromfield ◽

April P Carson ◽

Suzanne E Judd ◽

George Howard ◽

...

Keyword(s):

Risk Factors ◽

Abdominal Obesity ◽

Stroke Risk ◽

Serum Glucose ◽

C Reactive Protein ◽

Fasting Serum ◽

Risk Equation ◽

Stroke Risk Factors ◽

Reactive Protein ◽

Framingham Risk

Diabetes is a pro-inflammatory state characterized by a high burden of non-traditional risk factors not included in the Framingham stroke risk equation. We assessed the association between factors absent from the Framingham stroke risk equation with incident stroke among individuals with and without diabetes, separately, using the US population-based REasons for Geographic and Racial Differences in Stroke study. Diabetes was defined by self-report with concurrent insulin or oral hypoglycemic medication use, fasting serum glucose ≥126 mg/dL or non-fasting serum glucose ≥200 mg/dL. Non-Framingham risk factors included high sensitivity c-reactive protein >3.0 mg/dL, low high-density-lipoprotein (HDL-C; men: <40 mg/dL, women: <50 mg/dL), triglycerides >150 mg/dL, abdominal obesity (waist circumference: men >102 cm, women >88 cm), urinary albumin-to-creatinine-ratio (ACR) >30 mg/dL, and estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 2 . Bi-annual telephone contacts were used to identify incident stroke events that were subsequently adjudicated. During a median follow-up of 5.9 years, there were 329 and 697 incident strokes among individuals with (n = 6,258) and without (n = 22,226) diabetes, respectively. For individuals with and without diabetes, the prevalence of ≥3 non-Framingham risk factors was 50.4% and 23.9%, respectively. C-reactive protein >3.0 mg/dL and eGFR <60 ml/min/1.73 m 2 were associated with stroke among individuals with but not those without diabetes (Figure 1). In addition, ACR >30 mg/dL had a stronger association with stroke among individuals with versus without diabetes [HR (95% CI), 2.08 (1.65[[Unable to Display Character: –]]2.63) versus 1.36 (1.12[[Unable to Display Character: –]]1.66), respectively; p-interaction=0.04]. Low HDL-C, triglycerides >150 mg/dL and abdominal obesity were not associated with stroke among individuals with or without diabetes. In conclusion, non-Framingham stroke risk factors are common and associated with increased stroke risk among individuals with diabetes.

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The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

Korean Circulation Journal ◽

10.4070/kcj.2016.0198 ◽

2017 ◽

Vol 47 (2) ◽

pp. 231 ◽

Cited By ~ 2

Author(s):

Goksel Cagirci ◽

Selcuk Kucukseymen ◽

Isa Oner Yuksel ◽

Nermin Bayar ◽

Erkan Koklu ◽

...

Keyword(s):

Vitamin D ◽

Coronary Artery ◽

Protein Level ◽

Coronary Artery Ectasia ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Annals of the Rheumatic Diseases ◽

10.1136/ard.2009.125260 ◽

2010 ◽

Vol 69 (11) ◽

pp. 1976-1982 ◽

Cited By ~ 46

Author(s):

Hanneke J M Kerkhof ◽

Sita M A Bierma-Zeinstra ◽

Martha C Castano-Betancourt ◽

Moniek P de Maat ◽

Albert Hofman ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

Analysis Of Covariance ◽

C Reactive Protein ◽

Knee Oa ◽

Reactive Protein ◽

Serum Crp ◽

The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

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Correlation of High Sensitive C Reactive Protein Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital

International Journal of Research and Review ◽

10.52403/ijrr.20210703 ◽

2021 ◽

Vol 8 (7) ◽

pp. 14-27

Author(s):

Anwar Sholeh ◽

Alwi Thamrin Nasution ◽

Radar Radius Tarigan

Keyword(s):

General Hospital ◽

Pearson Correlation ◽

Cell Distribution ◽

C Reactive Protein ◽

Distribution Width ◽

Reactive Protein ◽

Pearson Correlation Analysis ◽

The Relationship ◽

Red Blood Cell Distribution ◽

Regular Hemodialysis

Background: Chronic kidney disease (CKD) is characterized by structural and functional disorder of the kidney with irreversible and gradual characteristics with one of the modalities of renal replacement therapy such as hemodialysis (HD). The role of inflammation in HD patients by uremic toxin and dialysis can be assessed by the marker of High Sensitive C Reactive Protein (HsCRP). Several studies have examined the relationship between HsCRP and red cell distribution width (RDW) in regular HD patients which leads to increase patient morbidity and mortality, but until now, there has been no study in Indonesia regarding the correlation between HsCRP and RDW in regular HD patients. This study aims to determine the correlation HsCRP as a marker of inflammation and RDW values in regular HD patients. Methods: This is a cross-sectional study in Regular HD patients at Dialysis Unit-H. Adam Malik General Hospital. A total of 20 subjects were included. Bivariate and multivariate analysis was conducted to analyze the relationship of HsCRP, ureum, creatinin, hemoglobin, and eGFR to RDW. Results: There were 20 Regular HD patients analyzed. The proportion of patients with increased RDW was 80%. In pearson correlation test, there is a strong correlation between HsCRP and RDW (r= 0.667, p<0.001). Discussion: Majority of regular HD patients at H. Adam Malik General Hospital were assessed with increased RDW. Pearson correlation analysis revealed HsCRP was significantly associated with RDW. Conclusion: Increased RDW was found in 80% of regular HD patients at H. Adam malik General Hospital. From pearson correlation analysis, we found HsCRP was significantly associated with RDW. Keywords: inflammation, high sensitive c reactive protein, red blood cell distribution width, regular hemodialysis.

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