scholarly journals The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women

2017 ◽  
Vol 49 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Kyung-A Shin
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Elderly Women ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

Abstract P150: Association of Non-Framingham Stroke Risk Factors With Incident Stroke Among Individuals With and Without Diabetes

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
John N Booth ◽  
Samantha Bromfield ◽  
April P Carson ◽  
Suzanne E Judd ◽  
George Howard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Obesity ◽  
Stroke Risk ◽  
Serum Glucose ◽  
C Reactive Protein ◽  
Fasting Serum ◽  
Risk Equation ◽  
Stroke Risk Factors ◽  
Reactive Protein ◽  
Framingham Risk

Diabetes is a pro-inflammatory state characterized by a high burden of non-traditional risk factors not included in the Framingham stroke risk equation. We assessed the association between factors absent from the Framingham stroke risk equation with incident stroke among individuals with and without diabetes, separately, using the US population-based REasons for Geographic and Racial Differences in Stroke study. Diabetes was defined by self-report with concurrent insulin or oral hypoglycemic medication use, fasting serum glucose ≥126 mg/dL or non-fasting serum glucose ≥200 mg/dL. Non-Framingham risk factors included high sensitivity c-reactive protein >3.0 mg/dL, low high-density-lipoprotein (HDL-C; men: <40 mg/dL, women: <50 mg/dL), triglycerides >150 mg/dL, abdominal obesity (waist circumference: men >102 cm, women >88 cm), urinary albumin-to-creatinine-ratio (ACR) >30 mg/dL, and estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 2 . Bi-annual telephone contacts were used to identify incident stroke events that were subsequently adjudicated. During a median follow-up of 5.9 years, there were 329 and 697 incident strokes among individuals with (n = 6,258) and without (n = 22,226) diabetes, respectively. For individuals with and without diabetes, the prevalence of ≥3 non-Framingham risk factors was 50.4% and 23.9%, respectively. C-reactive protein >3.0 mg/dL and eGFR <60 ml/min/1.73 m 2 were associated with stroke among individuals with but not those without diabetes (Figure 1). In addition, ACR >30 mg/dL had a stronger association with stroke among individuals with versus without diabetes [HR (95% CI), 2.08 (1.65[[Unable to Display Character: &#8211;]]2.63) versus 1.36 (1.12[[Unable to Display Character: &#8211;]]1.66), respectively; p-interaction=0.04]. Low HDL-C, triglycerides >150 mg/dL and abdominal obesity were not associated with stroke among individuals with or without diabetes. In conclusion, non-Framingham stroke risk factors are common and associated with increased stroke risk among individuals with diabetes.

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

2020 ◽  
Vol 14 (15) ◽  
pp. 1427-1437
Author(s):  
Hend Alqaderi ◽  
Ebaa Al-Ozairi ◽  
Saadoun Bin-Hasan ◽  
Mary Tavares ◽  
Jo M Goodson ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Multilevel Regression ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials & methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

scholarly journals Association of Testosterone, Insulin-Like Growth Factor-I, and C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes

2005 ◽  
Vol 90 (12) ◽  
pp. 6418-6423 ◽  
Author(s):  
Peter C. Y. Tong ◽  
Chung-Shun Ho ◽  
Vincent T. F. Yeung ◽  
Maggie C. Y. Ng ◽  
Wing-Yee So ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Family History ◽  
Total Testosterone ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Igf I ◽  
History Of ◽  
Hs Crp

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

scholarly journals Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19

2021 ◽  
Vol 8 ◽  
Author(s):  
Ricardo Wesley Alberca ◽  
Paula Ordonhez Rigato ◽  
Yasmim Álefe Leuzzi Ramos ◽  
Franciane Mouradian Emidio Teixeira ◽  
Anna Cláudia Calvielli Branco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Immune Responses ◽  
Social Practice ◽  
Death Rate ◽  
Clinical Characteristics ◽  
Systemic Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Excessive Consumption

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease–2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19.

scholarly journals Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Lara Gomes Suhett ◽  
Helen Hermana Miranda Hermsdorff ◽  
Naruna Pereira Rocha ◽  
Mariane Alves Silva ◽  
Mariana De Santis Filgueiras ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Disease Risk ◽  
Elevated Serum ◽  
Cardiometabolic Risk Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Brazilian Children

C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

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