RT-PCR Positive 40 Days after Onset in Ambulatory Patients, Case Report

2020 ◽  
Author(s):  
Loïc Drouet ◽  
Christophe Chapuis ◽  
Guillaume Teissier ◽  
Christian Poirel ◽  
Pierre Tur
Keyword(s):  
Case Report ◽  
Rt Pcr ◽  
Ambulatory Patients

scholarly journals Transient benign hyperphosphatasemia due to COVID-19: the first case report

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tugba Erat ◽  
Müge Atar ◽  
Tugba Kontbay
Keyword(s):  
Polymerase Chain Reaction ◽  
Alkaline Phosphatase ◽  
Case Report ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Benign Condition ◽  
Case Presentation ◽  
Normal Ranges ◽  
First Case ◽  
Polymerase Chain

AbstractObjectivesCoronavirus disease (COVID-19) rapidly spread worldwide in a few months and was declared as a worldwide pandemic by WHO in March 2020. Transient benign hyperphosphatasemia (THI) is a benign condition associated with marked elevation of alkaline phosphatase (ALP) without any other kidney, bone, and liver pathologies.Case presentationHerein, we report a previously healthy 16-month-old female patient who developed a secondary transient benign hyperphosphatasemia associated with SARS-CoV-2. Patient whole family’s SARS-CoV-2 real-time reverse transcription-polymerase chain reaction (RT-PCR) results were positive. Since THI is a diagnosis of exclusion, other reasons that may cause ALP elevation should be ruled out. ALP activity decreased and turned to normal ranges within the following month. THI has been reported to be in association with various conditions. Its relationship with many viruses has been reported previously.ConclusionsIf ALP elevation is detected in patients with COVID 19 due to the increasing number of infections, THI should be considered if there is no other accompanying pathology.

scholarly journals SARS-CoV-2 as a Trigger in the Development of Tourette’s-Like Symptoms: A Case Report

2021 ◽  
Author(s):  
Sabine Hazan ◽  
Sheldon Jordan
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Gut Microbiota ◽  
Dramatic Improvement ◽  
Next Generation ◽  
Rt Pcr ◽  
Gastrointestinal Microbiota ◽  
Next Generation Sequencing Ngs ◽  
The Impact ◽  
Generation Sequencing

Abstract Background: Reports have been surfacing surrounding CNS-associated symptoms in individuals affected by coronavirus disease 19 (COVID-19). Tourette syndrome is a neuropsychiatric disorder with usual onset in childhood. Gut microbiota can affect central physiology and function via the microbiota-gut-brain axis. The authors of this case report describe Tourette’s-like symptoms in a patient resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupting gut microbiota. Case Presentation: This case involves a 16-year-old female that developed acute onset Tourette’s-like symptoms along with neuropsychiatric symptoms after exposure to and infection from SARS-CoV-2. The patient had negative nasopharyngeal (NP) real-time reverse transcription-PCR (RT-PCR) tests for SARS-CoV-2 on five occasions from August of 2020 through June of 2021. The patient’s symptoms continued to worsen over the next six months until next-generation sequencing (NGS) revealed SARS-CoV-2 in her stool. Her treatment was adjusted as NGS revealed SARS-CoV-2 in her stool. Repair of the gastrointestinal microbiota, treatment with nutraceutical and pharmaceutical agents, as well as alterations in her surroundings resulted in dramatic improvement in the microbiome and a significant reduction of symptoms.Discussion: The use of (RT-PCR) testing to determine the presence or absence of SARS-CoV-2 may be inadequate and inaccurate for individuals that have been exposed to the virus. In addition, the impact of SARS-CoV-2 infection of the GI tract may cause significant havoc in the gut microbiota. Additional testing, eradication of infectious agents, as well as restoration of the gut microbiome are needed to effectively manage and treat this condition. The patient’s symptoms worsened over the next six months until next-generation sequencing (NGS) revealed SARS-CoV-2 in her stool and her treatment was adjusted. Treatment with nutraceuticals and alterations in her surroundings was followed by a more normal microbiome and a dramatic reduction in symptoms.

scholarly journals Invasive mucormycosis in post COVID-19 infection: Case report with review

2021 ◽  
Vol 6 (2) ◽  
pp. 135-139
Author(s):  
Sunil V Jagtap ◽  
Swati S Jagtap ◽  
Vaidehi Nagar ◽  
Kaushiki Varshney
Keyword(s):  
Case Report ◽  
Facial Pain ◽  
Rare Case ◽  
Steroid Treatment ◽  
Rt Pcr ◽  
Histopathological Findings ◽  
Face Region ◽  
Radio Imaging ◽  
In The Beginning ◽  
Pcr Test

COVID-19 is an infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Now there are increased cases with super infections by mucormycosis, which were rarely reported in the beginning of the current pandemic of COVID 19. Herewith a case of 47 year-old male patient of post COVID-19 infection having severe hypoxia and was on ventilator, received steroid treatment and also known case of HIV/AIDS. Now admitted to our hospital having fever, facial pain, and swelling mid-face region. His RT-PCR test was positive. On clinical, radio imaging and on histopathological findings diagnosed as maxillary mucormycosis. We are presenting this rare case for its clinical, radio imaging, and on histopathological findings.

scholarly journals TRANSMISI VIRUS COVID-19 DARI IBU HAMIL KE JANIN : SYSTEMATIC LITERATURE REVIEW

2021 ◽  
Vol 8 (2) ◽  
pp. 85-93
Author(s):  
Claudia Leniensi ◽  
Catur Wulandari ◽  
Eka Vicky Yulivantina ◽  
Galuh Tunggal Prastiti
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Google Scholar ◽  
Rt Pcr

Jumlah pasien dengan Covid-19 terus meningkat, sehingga kesehatan maternal dan neonatal mendapatkan dampak. Pemerintah menerapkan kebijakan dan surat edaran tentang upaya pencegahan dan penanganan virus Covid-19, termasuk masalah maternal dan neonatal dengan Covid-19. Masyarakat juga telah menerapkan peraturan pemerintah. Metode dalam penelitian ini literature review jurnal dengan jenis systematic literature review dari database PubMed, Google Scholar, dan Cochrane. Sampel penelitian ini merupakan jurnal yang sudah dilakukan critical apprasial yang memenuhi kriteria inklusi dan kriteria eksklusi. Hasil literature review menunjukkan jurnal tahun 2020 dipublikasi secara internasional dan desain penelitian case report. Ibu hamil melahirkan sectio caesaria pada usia kehamilan ≥ 37 minggu. Ibu melakukan pemeriksaan swab (RT-PCR) untuk menegakakn diagnosa. Sebagian besar bayi lahir laki-laki dengan berat badan lahir lahir ≥ 2500 gram. Semua bayi melakukan isolasi mandiri dalam keadaan baik dengan apgar skor ≥ 7 pada menitpertama dan kelima. Komplikasi yang terjadi prematuredan dilakukan pemeriksaan swab (RT-PCR) pada nasofaring. Hasil labolatorium transmisi virus Covid-19 dari ibu hamil ke janin negatif. Hasil labolatorium tidak terdapat asam nukleat virus Covid-19 pada sampel plasenta, darah tapi pusat, cairan ketuban, tenggorokan dan feses. Hasil pemeriksaan labolatorium transmisi vertikal virus Covid-19 dari ibu hamil ke janin negatif.

scholarly journals Case Report: Acute Intracardiac Thrombosis in Children With Coronavirus Disease 2019 (COVID-19)

2021 ◽  
Vol 9 ◽  
Author(s):  
Hamid Bigdelian ◽  
Mohsen Sedighi ◽  
Mohammad Reza Sabri ◽  
Bahar Dehghan ◽  
Chehreh Mahdavi ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Cardiac Surgery ◽  
Case Report ◽  
Case Series ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Inflammatory State ◽  
Polymerase Chain ◽  
Underlying Mechanisms ◽  
Intracardiac Thrombosis

We herein describe a case series of children with SARS-CoV-2 infection (COVID-19) complicated with acute intracardiac thrombosis. The diagnosis of COVID-19 was confirmed through the reverse transcription-polymerase chain reaction (RT-PCR). Transthoracic echocardiography of patients revealed large intracardiac mobile masses resected successfully via cardiac surgery. The underlying mechanisms of this thrombus in the COVID-19 infection may be attributed to the hypercoagulation and inflammatory state of the disease incurred by the SARS-CoV-2 virus.

scholarly journals COVID-19 and Dengue Co-infection in a Young Girl: A Case Report

2021 ◽  
Vol 33 (1) ◽  
pp. 104-108
Author(s):  
Homayra Tahseen Hossain ◽  
Refaya Tasnim ◽  
Halima Khatun ◽  
Nawsabah Noor ◽  
Mahbub Mayukh Rishad ◽  
...  
Keyword(s):  
Case Report ◽  
Oxygen Therapy ◽  
Private Hospital ◽  
Monsoon Season ◽  
Rt Pcr ◽  
Happy Face ◽  
Healthcare Resources ◽  
Great Satisfaction ◽  
Course Of Illness ◽  
Plasma Leakage

During COVID-19 pandemic, the increasing incidence of dengue in Monsoon season has become a further threat especially in the dengue endemic countries of Southeast Asia like Bangladesh. Co-infection of dengue with COVID-19 has created a number of practical challenges to combat the diseases simultaneously, especially at a time when healthcare resources are already exhausted tackling the COVID pandemic. We are presenting the case report of a 14 year old girl who suffered from both RT-PCR positive COVID -19 infection & NS1 positive Dengue. She was managed in a Private Hospital of Dhaka as Dengue fever Group C (due to severe plasma leakage) with severe COVID-19 infection (as required oxygen therapy). She had a critical course of illness, having continued fever, cough, breathlessness, desaturation along with thrombocytopenia & plasma leakage. However, to our great satisfaction, the patient was ultimately improved & could be discharged in a happy face. Bangladesh J Medicine July 2022; 33(1) : 104-108

scholarly journals A promising therapy of tocilizumab and helmet CPAP to prevent intubation for COVID-19 induced severe ARDS: a case report

2020 ◽  
Vol 24 (6) ◽  
Author(s):  
Septian Adi Permana ◽  
Adhrie Sugiarto ◽  
Muhammad Husni Thamrin ◽  
Arifin . ◽  
Harsini .
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Laboratory Tests ◽  
Leukocyte Count ◽  
Cytokine Storm ◽  
Rt Pcr ◽  
Life Threatening ◽  
Cost Efficient ◽  
The Cost ◽  
Easy Operation

A 59 yrs old male with severe ARDS due to COVID-19 infection was in life threatening ‘cytokine storm’. He had also co-morbids including diabetes mellitus and hypertension. He had come from Grobogan, a red area for COVID-19. Clinical finding indicted systemic inflammatory response syndrome (SIRS) with dyspnea, tachycardia, and high fever. Laboratory tests showed raised leukocyte count, CRP, SGOT/SGPT, blood sugar, PCT, low PaO2/FiO2 ratio. RT PCR showed he was infected by COVID-19. Sputum culture showed Klebsiella infection and CXR showed bilateral pneumonia. Patient was treated with standard therapy and a combination of tocilizumab for cytokine-storm and helmet CPAP for severe ARDS. Helmet CPAP has become the first modality for COVID-19 ARDS in some countries but not in Indonesia. We chose helmet CPAP because of the cost efficient, comfortable, and easy operation compared to other modality. We chose tocilizumab because it uses a single dose. Although it is expensive, only one dose is enough and it is effective in blocking the cytokine storm. We found that helmet CPAP and tocilizumab combination in COVID-19 lead severe ARDS could be promising to prevent intubation for patients. Key words: Helmet CPAP; ARDS; COVID-19; Tocilizumab; Cytokine storm Citation: Permana SA, Sugiarto A, Thamrin MH, Arifin, Harsini. A promising therapy of tocilizumab and helmet CPAP to prevent intubation for COVID-19 induced severe ARDS: a case report. Anaesth. pain intensive care 2020;24(6):659-663; DOI: 10.35975/apic.v24i6.1409 Received - 17 September 2020, Reviewed – 01 October 2020, Accepted – 6 November 2020

scholarly journals The COVID-19 with Gastrointestinal Symptoms: A Case Report

2020 ◽  
Vol 21 (2) ◽  
pp. 158-161
Author(s):  
Eka Surya Nugraha ◽  
Davin Takaryanto ◽  
Susantina Prodjosoewojo ◽  
Nenny Agustanti
Keyword(s):  
Case Report ◽  
Serum Level ◽  
Fluid Therapy ◽  
Nasal Swab ◽  
Severe Disease ◽  
Gastrointestinal Symptoms ◽  
Supportive Treatment ◽  
Shortness Of Breath ◽  
Rt Pcr ◽  
Mild Fever

The COVID-19 mostly manifested as fever and pulmonary symptoms, but recent evidence demonstrated the frequent gastrointestinal symptoms in particular moderate to severe disease. Here, we present a case of a 51-years old man with confirmed COVID-19 diagnosis who was admitted with profuse acute diarrhea and nausea. He previously had a mild fever, cough, and shortness of breath. Administration of oseltamivir, levofloxacin, and chloroquine sulfate exaggerated vomiting, nausea, and increased serum level transaminase. After withdrawal, the gastrointestinal symptoms were relieved gradually. Adequate supportive treatment and fluid therapy ceased diarrhea and led to the negative result of the nasal swab RT-PCR COVID-19 after seven days.

Identification of SARS-CoV-2 RNA in the conjunctival swab of an Italian pediatric patient affected with COVID-19: A case report

2020 ◽  
pp. 112067212097782
Author(s):  
Luciano Quaranta ◽  
Francesca Rovida ◽  
Ivano Riva ◽  
Carlo Bruttini ◽  
Ilaria Brambilla ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Pediatric Patient ◽  
Ocular Involvement ◽  
Case Description ◽  
Rt Pcr ◽  
Reverse Transcription Pcr ◽  
Ocular Symptoms ◽  
Pediatric Clinic ◽  
Conjunctival Swab

Introduction: To report a case of identification of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in ocular specimen in a pediatric patient affected with Coronavirus disease 2019 (COVID-19) with no signs of ocular involvement. Case description: A 11-year old male patient with confirmed COVID-19 infection was hospitalized at the Pediatric Clinic Clinic of the IRCCS Foundation and Hospital San Matteo, Pavia, Italy. Three days after hospital admission, because of the patient complaining very mild ocular symptoms, an ophthalmological evaluation was performed. No signs related to conjunctivitis or keratitis were found but a conjunctival swab was collected as well, based on patient’s medical history. The specific SARS-CoV-2 reverse transcription PCR (RT-PCR) was performed, unearthing the presence of viral RNA from the swab. On day 25 from hospitalization, the conjunctival swab was repeated, giving negative result. Conclusions: This is the first report of the identification of SARS-CoV-2 RNA in ocular specimen in a pediatric patient without signs of ocular involvement. However, despite the transmission through tears is theoretically possible, it is still unclear whether this could be considered as an important route for the spread of SARS-CoV-2.

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