scholarly journals INTERVENTION PROGRAM FOR IMPROVING INSULIN SENSITIVITY AND AMELIORATING ADIPOKINES ALTERED SERUM LEVELS IN OBESE AND TYPE-2 DIABETIC CHILDREN.

2016 ◽  
Vol 4 (10) ◽  
pp. 110-119
Author(s):  
AdelF.Al-Kholy MD ◽  
Keyword(s):  
Insulin Sensitivity ◽  
Intervention Program ◽  
Serum Levels ◽  
Diabetic Children ◽  
Altered Serum ◽  
Type 2 Diabetic

scholarly journals Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children

2020 ◽  
Author(s):  
Khalid Mohammad Mohany ◽  
Osamah Alrugaie ◽  
Osama Alwutayd ◽  
Abdullah Al-Nafeesah ◽  
Tahia H. Saleem
Keyword(s):  
Serum Insulin ◽  
Serum Levels ◽  
Serum Glucose ◽  
Circulating Microrna ◽  
Obese Children ◽  
Circulating Micrornas ◽  
Serum Microrna ◽  
Diabetic Children ◽  
Type 2 Diabetic

Abstract Background: This study tested the association between serum levels of microRNA-486, -146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM). Methods: the study included 120 children; divided into three groups: G1 (50 healthy), G2 (35 obese) and G3 (35 obese with T2DM). The levels of microRNA-486, 146b and 15b and serum betatrophin were measured by their corresponding methods. Results: serum microRNA-486, -146b, -15b and betatrophin levels were significantly high in G3 followed by G2 then G1 (p=0.002, >0.001, >0.001, and >0.001, respectively). Especially in G3, these levels correlated positively with the BMI percentile (r=0.44, 0.58, 0.38, and 0.46, p=0.007, >0.001, 0.021, and 0.005, respectively), serum glucose (r=0.56, 0.49, 0.82, 0.60, and 0.42, p>0.001, 0.003, >0.001, and >0.001, respectively) and HbA1c% (r=0.56, 0.39, 0.66, and 0.42, p>0.001, 0.019, >0.001, and 0.032, respectively) while, showed negative correlations with correlated with serum insulin levels (r=-0.37, -0.42, -0.58, and -0.41, p=0.021, 0.012, >0.001 and 0.013, respectively) and with serum C-peptide levels (r=-0.76, -0.50, -0.35 and -0.42, p>0.001, 0.002, 0.036 and 0.011, respectively). Serum betatrophin levels correlated positively with microRNA-486, -146b and -15b levels in G2 (r=0.35, 0.80, and 0.67, p= 0.036, >0.001, and,>0.001, respectively), and in G3 (r=0.57, 0.36, and 0.38, p >0.001, 0.029 and, 0.023, respectively). Conclusions: Circulating microRNA-486, 146b and 15b increase significantly in obese children with T2DM and these levels correlate positively with serum betatrophin levels. Targeting these microRNAs or betatrophin may help the timely management of obesity and/or T2DM in children.

Changes in insulin sensitivity and DHEAS in type 2 diabetic men treated with liraglutide

2014 ◽  
Author(s):  
Gonzalo Piedrola ◽  
Daniel Cepero ◽  
Concepcion Gil ◽  
Jessica Ramirez ◽  
Ricardo Roa
Keyword(s):  
Insulin Sensitivity ◽  
Type 2 Diabetic

Long-Term Oral L-Arginine Administration Improves Peripheral and Hepatic Insulin Sensitivity in Type 2 Diabetic Patients

Diabetes Care ◽  
2001 ◽  
Vol 24 (5) ◽  
pp. 875-880 ◽  
Author(s):  
P. Piatti ◽  
L. D. Monti ◽  
G. Valsecchi ◽  
F. Magni ◽  
E. Setola ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hepatic Insulin Sensitivity ◽  
Type 2 Diabetic

scholarly journals Consumption of Whole Eggs Promotes Insulin Sensitivity in Db/db Mice (OR34-01-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Peiran Lu ◽  
Lei Wu ◽  
Xin Guo ◽  
Siau Yen Wong ◽  
Stephen Clarke ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Cholesterol Synthesis ◽  
Respiratory Activity ◽  
High Cholesterol ◽  
Egg Consumption ◽  
Type 2 Diabetic ◽  
Mitochondrial Respiratory Activity

Abstract Objectives Chicken eggs have a high nutrient density. Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs due to its high cholesterol content. However, several clinical studies showed that egg intake is associated with a lower risk of type 2 diabetes. In the current study, we sought to explore whether egg consumption improves insulin sensitivity and subsequent blood glucose management in type 2 diabetic db/db mice. Methods Six-week-old male db/db mice were fed a low-fat diet (LFD, 10 kCal % from fat) or LFD supplemented with 1% whole eggs (Egg) for 8 weeks. At the termination of the study, mice were fasted for 3 hrs prior to euthanization. Blood and other tissues were collected for laboratory assessments. Plasma metabolic parameters and pro-inflammatory cytokines were monitored by a clinical analyzer and ELISA, respectively. Hepatic and skeletal muscle mitochondrial respiratory activity was assessed by a Seahorse XFe Analyzer. Hepatic gene expression was analyzed by transcriptomics and confirmed by real-time PCR and/or Western blot. Results Egg consumption significantly increased body weight gain, lowered fasting blood glucose, insulin, and IL-6 levels, and elevated total cholesterol, HDL, LDL, and GLP-1 levels. Only the basal mitochondrial respiratory activity was decreased, and the complex II respiratory activity was increased in gastrocnemius muscles in mice fed Egg. Hepatic mitochondrial activity was not altered by diet. Mechanistically, transcriptomics results revealed that hepatic genes involved in enhanced insulin sensitivity were highly expressed, but genes in endogenous cholesterol synthesis were significantly suppressed after egg consumption. Conclusions The results suggest that egg consumption is beneficial to blood glucose control in type 2 diabetic mice. Type 2 diabetic animal could manage the cholesterol level through suppression of de novo cholesterol synthesis when consuming a high cholesterol diet, e.g., egg diet. Funding Sources National egg nutrition center grant USDA NIFA grant

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