scholarly journals FEATURES OF INNATE AND ADAPTIVE IMMUNITY IN PRETERM INFANTS WITH HYPOXIC-ISCHEMIC LESIONS OF THE CENTRAL NERVOUS SYSTEM

2017 ◽  
Vol 62 (3) ◽  
pp. 59-65 ◽  
Author(s):  
L. S. Ust’janceva ◽  
G. N. Chistjakova ◽  
I. I. Remizova ◽  
S. Yu. Zaharova ◽  
K. P. Shamova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adaptive Immunity ◽  
Preterm Infants ◽  
Innate And Adaptive Immunity ◽  
The Central Nervous System

scholarly journals Modulation of the Complement System by Neoplastic Disease of the Central Nervous System

2021 ◽  
Vol 12 ◽  
Author(s):  
Steven K. Yarmoska ◽  
Ali M. Alawieh ◽  
Stephen Tomlinson ◽  
Kimberly B. Hoang
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Adaptive Immunity ◽  
Complement System ◽  
Neoplastic Disease ◽  
Innate And Adaptive Immunity ◽  
Neoplastic Diseases ◽  
The Central Nervous System ◽  
The Complement System

The complement system is a highly conserved component of innate immunity that is involved in recognizing and responding to pathogens. The system serves as a bridge between innate and adaptive immunity, and modulation of the complement system can affect the entire host immune response to a foreign insult. Neoplastic diseases have been shown to engage the complement system in order to evade the immune system, gain a selective growth advantage, and co-opt the surrounding environment for tumor proliferation. Historically, the central nervous system has been considered to be an immune-privileged environment, but it is now clear that there are active roles for both innate and adaptive immunity within the central nervous system. Much of the research on the role of immunological modulation of neoplastic disease within the central nervous system has focused on adaptive immunity, even though innate immunity still plays a critical role in the natural history of central nervous system neoplasms. Here, we review the modulation of the complement system by a variety of neoplastic diseases of the central nervous system. We also discuss gaps in the current body of knowledge and comment on future directions for investigation.

scholarly journals THE LEVEL OF SYSTEMIC INFLAMMATION AND CHANGES IN ADAPTIVE IMMUNITY IN ALCOHOLIC PSYCHOSES

2019 ◽  
Vol 19 (1S) ◽  
pp. 68-70
Author(s):  
N A Didkovsky ◽  
I K Malashenkova ◽  
D P Ogurtsov ◽  
S A Krynskiy ◽  
N A Hailov ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adaptive Immunity ◽  
Systemic Inflammation ◽  
Early Period ◽  
Control Group ◽  
Acute Psychosis ◽  
Th2 Response ◽  
Proinflammatory Mediators ◽  
The Central Nervous System

The aim of the work is to study the level of systemic inflammation and changes in adaptive immunity in the early period after acute psychosis to assess their participation in the pathogenesis of alcoholic mental and cognitive disorders. We examined 28 patients with alcoholic psychosis (AP) and a control group of 17 healthy volunteers. Indicators of systemic inflammation and immunity, including key cytokines and lymphocyte subpopulations, were investigated. After acute psychosis of patients with alcoholism, pronounced activation of humoral immunity with impaired clearance of immune complexes, increased content and activity of Th2 with signs of insufficiency and dysfunction of Th1, reduced content and activity of cytotoxicity system cells and signs of systemic inflammation (increased CRP, cortisol, cytokines). Activation of Th2 response and an excess of proinflammatory mediators in patients with AP through various ways of interaction with the Central nervous system (n. vagus, choroidal plexus of the ventricles, and others) can participate in the disorders of metabolism of neurotransmitters in the Central nervous system involved in the pathogenesis of alcoholism, and in the maintenance of neuroinflammation. A high level of systemic inflammation can be both a trigger of psychosis and a manifestation of violations of neuroimmune interactions, as well as the development of excitotoxicity and damage to neurons in acute psychosis.

scholarly journals The effects of nutritional support for premature babies with ELBW and VLBW with hypoxic damage to the central nervous system

2020 ◽  
Vol 4 (Issue 2) ◽  
pp. 45
Author(s):  
Gulban Abdullayeva ◽  
Shayhslam Batyrhanov ◽  
Stalbek Akhunbaev ◽  
Orozaly Uzakov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Weight Gain ◽  
Preterm Infants ◽  
Head Circumference ◽  
Nutritional Support ◽  
Body Weight Gain ◽  
The Central Nervous System ◽  
Neurological Prognosis

Objective: Effect of nutritional support for preterm infants with very low (VLBW) and extremely low body (ELBW) weight with hypoxic damage of the central nervous system (CNS) of varying severity is not well elucidated.  The aim of this investigation is to study clinical, laboratory, neurosonography and electroencephalography characteristics of preterm infants with VLBW and ELBW with hypoxic of CNS on complex comprehensive nutritional support, diagnostic criteria of which were infants body weight gain,  increase in growth and head circumference Methods: Criteria of including into the study were VLBW and ELBW of an infant at birth and hypoxic damage to the CNS. Overall, 254 preterm infants born at the term of 23-24 weeks of gestation with body weight at birth less than 1500 grams were included into the prospective study.  All patients underwent anthropometric and clinical observation of height, weight, head circumference and body mass index till 50 weeks of postconceptual age with following evaluation by central curves; standard laboratory and biochemical blood analyses, neurosonography and electroencephalography. Data analysis of further growth of observed infants after discharge from hospital was made in 2017-2019 years on the basis of studying of stationary cards. Results: In the ELBW group with severe level of hypoxic damage to the CNS, optimum gain was 20-22 g/kg/daily, which allowed to avoid complications on the alimentary tract; in the VLBW group with severe degree it was 16-18g/kg/daily during the first three months of life. In  the ELBW and VLBW groups of children with moderate degree of hypoxic damage the desired gain did not differ and was at the level of 20-25 g/kg/daily. Physiological body weight gain in infants with VLBW and ELBW according to gestational time is connected with favorable somatic and neurological prognosis in these infants. Calculation of calorie intake, selection of the type of feeding for infants with ELBW and with VLBW according to recommendations made by ESPGHAN (2010) ensures positive anthropometric data dynamics without metabolic disruptions. Conclusion: Physiological body weight gain according to gestation period is connected with favorable somatic and neurological prognosis in these infants.

Is It a New Syndrome or Due to Overstimulation in the ICU?

PEDIATRICS ◽  
1990 ◽  
Vol 86 (2) ◽  
pp. 324-324
Author(s):  
JEAN GARDNER COLE
Keyword(s):  
Intensive Care Unit ◽  
Central Nervous System ◽  
Nervous System ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Recent Article ◽  
Supportive Environment ◽  
The Central Nervous System

To the Editor.— A recent article by Perlman and Volpe in Pediatrics1 described a new syndrome of movement disorder in infants with severe bronchopulmonary dysplasia. I should like to take issue with these findings and feel that what Perlman and Volpe are describing is actually infants responding behaviorally to an overstimulating environment. This "new syndrome" is, I feel, what Als calls "the consequence of a mismatch of extrauterine environment and the capacity of the central nervous system of the fetal neonate which is adapted for an intrauterine existence"2 to deal with the onslaught of stimulation which it encounters in the noisy, chaotic environment of the average Neonatal Intensive Care Unit. The behaviors described in the article are seen routinely in preterm infants responding behaviorally to overstimulation.3 These behaviors become learned maladaptive responses to stress. They can be prevented or ameliorated by the provision of a more supportive environment, one which recognizes early signs of behavioral disorganization and responds by reducing the cause of the overstimulation, be it auditory, visual, tactile, or kinesthetic.4-6

Umbilical Blood Levels of IL-6 and TNF-α as Predictors of the Central Nervous System Damage and Retinopathy in Preterm Infants

2020 ◽  
Author(s):  
Daiva Bartkevičienė ◽  
Ingrida Pilypienė ◽  
Danielius Serapinas ◽  
Brigita Vaigauskaitė ◽  
Rasa Aurelija Vankevičiūtė ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cord Blood ◽  
Preterm Infants ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Central Nervous System Damage ◽  
Umbilical Blood ◽  
Tnf Α ◽  
The Central Nervous System

Abstract Objective The aim was to identify the critical levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A in umbilical cord blood that could be used as markers for predicting the central nervous system (CNS) damage and retinopathy of prematurity (ROP) in preterm infants. Study Design A total of 158 preterm infants, born at 22 to 34 weeks of gestation, were evaluated in the first week after birth and at 36 to 37 weeks of postconceptual age. Results A significant relationship between CNS changes and concentrations of IL-6 (p < 0.001) and TNF-α (p < 0.001) in umbilical cord blood at 22 to 34 weeks of gestation was determined. The concentration of IL-6 >13.0 pg/mL predicts significant CNS damages in 36 to 37-week infants (p = 0.013). ROP was diagnosed in 24.8% infants (n = 149). It was detected that the levels of TNF-α >116.4 pg/mL (p < 0.001) and IL-6 >13.0 pg/mL (p < 0.05) in umbilical cord blood could predict 2 to 3/3 to 4 stages of ROP. Conclusion Critical values of IL-6 and TNF-α in predicting ≥grade III intraventricular hemorrhage in the early adaptation and in predicting marked CNS damages and severe ROP stages in the later adaptation of preterm infants were determined.

Sign in / Sign up

Export Citation Format

Share Document