Derivatives of acridone acetic acid in pediatric practice

The article justifies the use of interferon inducers in a clinical practice of pediatrician. The authors isolated a group of derivatives of acridone acetic acid, which effectiveness is associated with the features of pharmacokinetics and pharmacological activity. They demonstrated preventive and therapeutic efficacy of cycloferon in the complex treatment of children with influenza and other acute respiratory viral infections, herpes virus, arbovirus, rotavirus infections, viral hepatitis and tick-borne encephalitis due to its immunomodulatory potency. The article analyzed the use of cycloferon in frequently sick children, patients with allergic diseases, chronic tonsillitis, etc.; also it showed a decrease in the frequency of relapses of both infectious and allergic diseases, the possibility of combined use with other etiotropic and symptomatic drugs.

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Investigation of markers of allergic sensitization and viral infections in children with allergy and asthma

Acta medica Lituanica ◽

10.6001/actamedica.v24i3.3548 ◽

2017 ◽

Vol 24 (3) ◽

pp. 145-152

Author(s):

Rūta Dubakienė ◽

Vilija Rubinaitė ◽

Malvina Petronytė ◽

Indrė Dalgėdienė ◽

Odilija Rudzevičienė ◽

...

Keyword(s):

Viral Infections ◽

Allergic Sensitization ◽

Allergic Diseases ◽

Developed Countries ◽

Specific Ige ◽

High Rate ◽

Control Group ◽

Igg Antibodies ◽

Airway Infections ◽

Respiratory Viral Infections

Background. Allergic diseases are the most prevalent chronic diseases in the developed countries. It is believed that early allergic sensitization and respiratory viral infections play an important role in the development of allergic diseases and asthma. Methods. The current study investigated the correlation between asthma, allergy, and various markers – allergen-specific IgE, IgG4 and IgA, ECP, IgM, and IgG antibodies against respiratory viruses hRSV and hPIV1-4 – in blood serum samples from 80 children (mean age 5.2 years) recruited from the Lithuanian birth cohort. Children were divided into three groups according to their diagnosis: asthma (n = 25), allergy without asthma (n = 14), and control group (n = 41). Results. Based on retrospective data, airway infections and bronchitis by the age of two years were associated with asthma in later childhood. The presence of IgM and IgG antibodies against hRSV and hPIV1–4 at the age of five years were not associated with asthma and allergy: a high rate of persistent or past respiratory viral infections was revealed in all three groups. Among allergic children, increased levels of allergen-specific IgE and d1-specific IgG4 were determined. Conclusion. The current study provides new insights into the relationships between allergic sensitization and respiratory virus infections in children.

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Arguments in favor of the use of modern blockers of H1-histamine receptors for the treatment of patients with allergic rhinitis occurring against the background of acute respiratory viral infection

Russian otorhinolaryngology ◽

10.18692/1810-4800-2021-6-125-135 ◽

2021 ◽

Vol 20 (6) ◽

pp. 125-135

Author(s):

A. Yu. Ovchinnikov ◽

◽

N. A. Miroshnichenko ◽

Yu. O. Nikolaeva ◽

◽

...

Keyword(s):

Allergic Rhinitis ◽

Viral Infections ◽

Adult Population ◽

Allergic Diseases ◽

Therapeutic Effects ◽

Upper Respiratory Tract ◽

Therapy Regimen ◽

Nasal Symptoms ◽

Respiratory Viral Infections

Allergic rhinitis is characterized by a significant prevalence among the adult population. Patients with allergic diseases have a higher sensitivity to pathogens of acute respiratory infection of the upper respiratory tract (ARVI). Inflammation of the mucous membrane of the nasal cavity and paranasal sinuses in such patients is characterized by more pronounced symptoms and greater resistance to therapy. An observational study was conducted at the Department of Otorhinolaryngology of the Moscow State Medical University named after A. I. Evdokimov, during which the effect of modern antihistamines on the severity of nasal and non-nasal symptoms of inflammation was evaluated in patients who were diagnosed with the development of acute respiratory viral infections against the background of seasonal exacerbation of allergic rhinitis. The data of 50 patients divided into two groups were analyzed. In the first group (n = 25), benzhydrylpiperazinylbutylmethylxanthine succinate (Theoritin) was included in the therapy regimen, in the second – cetirizine preparations (n = 5). During the follow-up, each patient underwent a clinical assessment of the severity of nasal and non-nasal symptoms three times (1st, 7th and 14th days of follow-up), and the severity of nasal obstruction was assessed using anterior active rhinomanometry. According to the data obtained, there was a pronounced positive dynamics in both groups, while the clinical efficacy was confirmed by instrumental evaluation data. However, by the 7th day of treatment, the positive dynamics was more pronounced in the group of patients receiving theoritin as part of therapy. The use of modern antihistamines in patients comorbid for allergic rhinitis and acute respiratory diseases has a significant therapeutic effect. Theoritin provides more pronounced therapeutic effects in the early stages, which makes its further study and use of the drug for the treatment of acute respiratory viral infections against the background of allergic rhinitis promising.

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Management of children with allergic rhinitis in the practice of a local pediatrician

Medical Council ◽

10.21518/2079-701x-2021-17-212-219 ◽

2021 ◽

pp. 212-219

Author(s):

I. V. Koltuntceva ◽

I. M. Gaiduk ◽

L. V. Sakhno ◽

S. V. Bairova

Keyword(s):

Allergic Rhinitis ◽

Viral Infections ◽

Allergic Diseases ◽

Integrated Approach ◽

Point Of View ◽

Diagnosis And Treatment ◽

Upper Respiratory Tract ◽

General Pathology ◽

Respiratory Viral Infections ◽

Acute Rhinitis

Due to the increase in the weight of allergic diseases in the general pathology of childhood, the diagnosis and treatment of allergic rhinitis in children and the management of these patients at the outpatient stage have not lost their relevance. The period of preschool and school age is characterized by a high frequency of acute respiratory diseases of the upper respiratory tract, especially acute rhinitis, rhinopharyngitis, rhinosinusitis. This daily poses to the district pediatrician the tasks of differential diagnosis of allergic rhinitis and acute rhinitis with a prolonged course. Allergic rhinitis most often does not require hospitalization and, with timely diagnosis, does not lead to serious consequences. It is known that children who are prone to allergies suffer from acute respiratory viral infections more often and more severely than their peers. An integrated approach to the diagnosis and treatment of such children with the participation of an allergist, an otorhinolaryngologist, under the constant supervision of a district pediatrician, the rational use of drug therapy can reduce the duration of the disease, improve the quality of life of the patient.The article presents generalized principles of management of patients with allergic rhinitis from the point of view of domestic and international recommendations, describes in detail the rules of life for children with allergic rhinitis, emphasizes the role of the district pediatrician in teaching parents to ensure a hypoallergenic environment of the child. The authors present a clinical example of the effective use of a combined decognensant and an antihistamine for the treatment of acute respiratory viral infections in a child with allergic rhinitis.

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THERAPY OPTIMIZATION OF INFLUENZA AND OTHER ACUTE RESPIRATORY VIRAL INFECTIONS IN PEDIATRIC PRACTICE

Педиатрическая фармакология ◽

10.15690/pf.v9i2.258 ◽

2012 ◽

Vol 9 (2) ◽

pp. 110

Author(s):

G. P. Martynova ◽

Ya. A. Bogvilene ◽

I. A. Soloveva ◽

I. A. Kutischeva ◽

T. A. Kartel ◽

...

Keyword(s):

Viral Infections ◽

Pediatric Practice ◽

Respiratory Viral Infections

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CHLOROPYRAMINE: EFFICACY AND SAFETY, APPROVED IN PRACTICE

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja622 ◽

2014 ◽

Vol 11 (4) ◽

pp. 55-58

Author(s):

S V TSAREV

Keyword(s):

Viral Infections ◽

Allergic Diseases ◽

Efficacy And Safety ◽

Respiratory Viral Infections

This article presents data about the importance of chloropyramine in the treatment of allergic diseases and acute respiratory viral infections.

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Functional state of the liver in different clinical forms of respiratory viral and viral bacterial infections in children of early age

Kazan medical journal ◽

10.17816/kazmj64698 ◽

1993 ◽

Vol 74 (3) ◽

pp. 211-214

Author(s):

H. S. Khaertynov

Keyword(s):

Blood Serum ◽

Functional State ◽

Bacterial Infections ◽

Viral Infections ◽

Clinical Manifestations ◽

Early Age ◽

Acute Period ◽

Clinical Forms ◽

Respiratory Viral Infections ◽

Sick Children

The content of prealbumin, fibroncctine and urokanisasc activity are determined in 232 sick children of early age with different clinical manifestations of acute respiratory viral infections (uncomplicated forms and acute respiratory viral infections ' complicated by pneumonia). It is stated that the acute period of acute respiratory viral infections goes in the presence of a decrease the levels of prealbumin, fibronectine and an increase of urokanisase activity of blood serum. The connection between pronounced changes of the parameters studied and manifestations of the intoxication symptoms is revealed. More pronounced changes are noted in grave forms of the disease (toxicosis development) and in presence of bacterial complications (pneumonia).

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