Idiopathic hemosiderosis of the lung tissue

Idiopathic hemosiderosis of lung tissue is a rare disease with lung damage caused by massive hemorrhage into the lung tissue, with iron-containing hemosiderin deposition. Mainly it occurs in childhood. The article describes the clinical case of idiopathic hemosiderosis of lung tissue in a 3 years 11 months old child. The girl was observed for anemia of unclear etiology, she was repeatedly treated at a hospital and received erythrocyte transfusions. In the future, respiratory syndrome joined the anemic syndrome. It should be noted that a correctly collected anamnesis, timely diagnosis of the disease and the appointment of immunosuppressive therapy make it possible to prevent the rapid progression of the process and the development of complications, including pneumosclerosis.

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Clinical case of lung lesions in patient with newly diagnosed systemic lupus erythematosus

Medical alphabet ◽

10.33667/2078-5631-2019-1-9(384)-53-56 ◽

2019 ◽

Vol 1 (9) ◽

pp. 53-57

Author(s):

T. N. Gavva ◽

L. V. Kuzmenkova ◽

Yu. N. Fedulaev ◽

T. V. Pinchuk ◽

D. D. Kaminer ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Clinical Case ◽

Clinical Manifestations ◽

Lung Damage ◽

Newly Diagnosed ◽

Systemic Lupus ◽

Lung Lesions ◽

Laboratory Parameters ◽

Clinical Interest

A case of lung damage in systemic lupus erythematosus (SLE) in a 33-year-old woman is described. This case is of clinical interest due to the complexity of diagnosis due to the fact that SLE is a disease with diverse clinical manifestations involving many organs and systems, which often makes it difficult to timely recognize the onset of the disease. SLE still remains a challenge and requires special attention to the patient s history, clinical and laboratory parameters of the patient, as well as specific immunological examinations.

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Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-020-03081-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Weigang Jia ◽

Wei Wang ◽

Rui Li ◽

Quanyu Zhou ◽

Ying Qu ◽

...

Keyword(s):

Substance P ◽

Inflammatory Cytokines ◽

Lung Tissue ◽

Inflammatory Cell ◽

Neutral Endopeptidase ◽

Inflammatory Cell Infiltration ◽

Lung Damage ◽

Cell Infiltration ◽

Cough Frequency ◽

Post Infectious

Abstract Background In recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum. However, the therapeutic potentials of QQCP on post-infectious cough (PIC) rat models has not been elucidated. So the current study was aimed to scientifically validate the efficacy of QQCP in post infectious cough. Methods All rats were exposed to sawdust and cigarette smokes for 10 days, and intratracheal lipopolysaccharide (LPS) and capsaicin aerosols. Rats were treated with QQCP at dose of 80, 160, 320 mg/kg. Cough frequency was monitored twice a day for 10 days after drug administration. Inflammatory cell infiltration was determined by ELISA. Meanwhile, the histopathology of lung tissue and bronchus in rats were evaluated by hematoxylin-eosin staining (H&E). Neurogenetic inflammation were measured by ELISA and qRT-PCR. Results QQCP dose-dependently decreased the cough frequency and the release of pro-inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8, but exerted the opposite effects on the secretion of anti-inflammatory cytokines IL-10 and IL-13 in BALF and serum of PIC rats. The oxidative burden was effectively ameliorated in QQCP-treated PIC rats as there were declines in Malondialdehyde (MDA) content and increases in Superoxide dismutase (SOD) activity in the serum and lung tissue. In addition, QQCP blocked inflammatory cell infiltration into the lung as evidenced by the reduced number of total leukocytes and the portion of neutrophils in the broncho - alveolar lavage fluid (BALF) as well as the alleviated lung damage. Furthermore, QQCP considerable reversed the neurogenetic inflammation caused by PIC through elevating neutral endopeptidase (NEP) activity and reducing Substance P (SP) and Calcitonin gene related peptide (CGRP) expression in BALF, serum and lung tissue. Conclusions Our study indicated that QQCP demonstrated a protective role of PIC and may be a potential therapeutic target of PIC.

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Protective Effects of Flavonoid and Polyphenol from Lotus Leaf on Lung Damage Induced by Inhalation of N2O4 in mice

E3S Web of Conferences ◽

10.1051/e3sconf/202123302013 ◽

2021 ◽

Vol 233 ◽

pp. 02013

Author(s):

Wenjun Li ◽

Ning Xu ◽

Yong Hu ◽

Zhijie Liu ◽

Wei Li ◽

...

Keyword(s):

Lung Tissue ◽

Damage Model ◽

Physiological Saline ◽

Normal Group ◽

Lung Damage ◽

Protective Effects ◽

Male Mice ◽

Lotus Leaf ◽

Animal Damage ◽

Mda Content

To study the protective effects of flavonoid and polyphenol (FP) from lotus leaf on the damage induced by N2O4 in mice. Constructing an animal damage model through exposing mice to 45μl N2O4 in a 120 L sealed cabinet for 30 minutes. ICR male mice were randomly divided into normal group, physiological saline+N2O4 group,1.25g/kgFP +N2O4 group, 2.50g/kgFP + N2O4 group, 3.75g/kg FP +N2O4 group. 1.25, 2.50, 3.75 g/kg FP were orally administered to mice respectively for 5 days, equal volume physiological saline for normal group and physiological saline+N2O4 group. Then, the three FP groups and the physiological saline+N2O4 group were exposed to N2O4 in the cabinet on 5th day. In an hour after N2O4 exposure, killing the mice by dislocation to measure the SOD, GSH-Px activity and MDA content in lung tissue, checking pathology change in lung tissue slice. Results were shown: the 1.25, 2.50g/kg FP increased SOD (U/mg pro) by 30.3% and 24.4%, GSH-Px (U/mg pro) by 77.4% and 60.9%, respectively. Pathological observation of lung tissue showed that three FP groups had lighter damage than the physiological saline+N2O4 group. So, FP has significant protective effects on damage caused by N2O4 in mice.

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Intestinal epithelial dysplasia

Pacific Medical Journal ◽

10.34215/1609-1175-2020-1-91-94 ◽

2020 ◽

pp. 91-94

Author(s):

T. E. Taranushenko ◽

E. M. Vasilyeva ◽

E. V. Antsiferova ◽

L. N. Karpova ◽

Y. S. Shamova

Keyword(s):

Small Intestine ◽

Rare Disease ◽

Histological Examination ◽

Mucous Membrane ◽

Clinical Case ◽

Clinical Presentation ◽

Epithelial Dysplasia ◽

Intestinal Epithelial ◽

Electronic Microscopy

The article presents a clinical case of intestinal epithelial dysplasia (tufting enteropathy), a rare disease which relates to congenital diarrheas, has a particular clinical presentation and is life-threating. The diagnosis was confirmed by histological examination and electronic microscopy of mucous membrane of small intestine. Additional evidence is substantiated for the existence of prenatal markers of intestinal epithelial dysplasia represented as polyhydramnios and intrauterine dilatation of fetal intestinal loops. These symptoms are considered to be a clinical hallmark of sodium and chloride diarrheas and are described in single cases in enteropathy called a microvillus inclusion disease.

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Leiomyoma of the Deferens: A Curious and Extremely Rare Disease

Urologia Journal ◽

10.5301/uj.5000252 ◽

2017 ◽

Vol 84 (3) ◽

pp. 206-207

Author(s):

Aldo F. De Rose ◽

Guglielmo Mantica ◽

Nataniele Piol ◽

Carlo Toncini ◽

Bruno Spina ◽

...

Keyword(s):

Urinary Tract ◽

Rare Disease ◽

Clinical Case ◽

Vas Deferens ◽

Benign Tumors ◽

Case Description ◽

Unique Case ◽

Unusual Event ◽

Fourth Case ◽

The Right

Introduction Leiomyomas are rare benign tumors that can occur in the male urinary tract. We present a unique case of leiomyoma of the vas deferens. Case Description We present the clinical case of a 69-year-old patient with a suspected bulk close to the right epididymis, which turned out to be a leiomyoma of the vas deferens. To our knowledge, it is the fourth case in literature. Conclusions A proper identification and the knowledge of this pathology, even if it is a very unusual event, is necessary to avoid a surgical over treatment and preserve the testicle, by removing only the tumor.

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The effect of benzo[α]pyrene on expression and signaling cross talk of aryl hydrocarbon receptor and NFATc1 in mouse lung tissue

Toxicology and Industrial Health ◽

10.1177/0748233714555153 ◽

2014 ◽

Vol 32 (7) ◽

pp. 1246-1253 ◽

Cited By ~ 4

Author(s):

Maliheh Parsa ◽

Seyed Nasser Ostad ◽

Seyed Mohammad Hossein Noori Moogahi ◽

Mohammad Bayat ◽

Mohammad Hossein Ghahremani

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Lung Tissue ◽

Cross Talk ◽

Environmental Pollutants ◽

Lung Damage ◽

Mouse Lung ◽

Aryl Hydrocarbon ◽

Embedded Blocks ◽

Mouse Lung Tissue ◽

Imagej Software

Objective: Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T cell (NFAT) pathway is unclear. AhR and NFAT signaling pathways have common roles in pathological functions in immunotoxicity and lung cancer. In this study, the effect of AhR activation on expression and signaling cross talk of AhR and NFATc1 pathways in mouse lung tissue has been investigated. Methods: Swiss albino mice were randomly allocated to five groups and administered with cyclosporin A (CsA) and B[α]P for seven constitutive days. Animals were then killed, and lung tissues were obtained after washing the whole blood. Paraffin-embedded blocks were prepared, and 5 µm sections were cut for histopathological and immunohistochemical assessments. The results were scored by observer and digitally analyzed using ImageJ software. Results: Our data showed that CsA administration resulted in a significant reduction of AhR expression. This effect was partly blocked in mice coadministrated with B[α]P and CsA. NFATc1 expression was also reduced in CsA-treated animals. Furthermore, CsA inhibited the pathological effects of B[α]P in mouse lung tissue. Conclusion: AhR expression is dependent on NFATc1 activation, and NFATc1 inhibition remarkably decreases AhR expression. However, it seems that total expression of NFATc1 is not dependent on AhR expression or activation. Moreover, CsA can prevent B[α]P-induced lung tissue damage, and it remarkably decreases NFATc1 expression. The results from this study point toward the molecular interactions of AhR and NFATc1 activation in lung tissue and the benefit of CsA treatment in B[α]P-induced lung damage.

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Klajoklio nervo krūtininės dalies neurilemoma: klinikinis atvejis

Lietuvos chirurgija ◽

10.15388/lietchirur.2014.3892 ◽

2014 ◽

Vol 13 (3) ◽

pp. 200-203

Author(s):

Renatas Aškinis ◽

Arnoldas Krasauskas ◽

Sigitas Zaremba ◽

Saulius Cicėnas

Keyword(s):

Rare Disease ◽

Clinical Case ◽

Clinical Symptoms ◽

Chest Ct ◽

Vagal Nerve ◽

Surgical Removal ◽

Radiological Findings ◽

X Ray ◽

Chest X Ray

Neurilemoma – periferinių nervų dangalų auglys. Jis auga lėtai ir pradžia dažniausiai būna besimptomė. Pasiekęs kritinį dydį auglys, priklausomai nuo atsiradimo vietos, pasireiškia spaudimo į aplinkinius organus klinika. Neurilemomos dažniausiai atsiranda galūnėse 30–50 gyvenimo metais nepriklausomai nuo lyties. Klajoklio nervo neurilemoma yra nedažna patologija, o krūtininės klajoklio nervo dalies neurilemoma pasitaiko itin retai. Diagnozuojant svarbiausi yra radiologiniai tyrimo metodai. Gydymas – chirurginis auglio pašalinimas. Pateikiame krūtininės klajoklio nervo dalies neurilemomos, nustatytos 39 metų moteriai, klinikinį atvejį. Auglys aptiktas radiologiniais tyrimais (krūtinės rentgeno, kompiuterinės tomografijos ir tarpuplaučio magnetinio branduolių rezonanso), pašalintas naudojant vaizdo torakoskopinę (VATS) metodiką. Diagnozė galutinai patvirtinta histologiniu tyrimu. Aštuntą parą po operacijos ligonė išrašyta į namus.Reikšminiai žodžiai: neurilemoma, klajoklis nervas, operacija Neurilemoma of intrathoracal vagal nerve: clinical caseRenatas Aškinis, Arnoldas Krasauskas, Sigitas Zaremba, Saulius Cicėnas Neurilemoma is a tumour of peripleurical nervous tissues. It grows slowly and has an asymptomatic manifestation. During tumour enlargement, depending on localisation, clinical symptoms appear because of the tumour pressure to the surrounding tissues. Mostly neurilemomas appear in extremities of patients aged 30–50 years. N. vagus neurilemoma is a very rare disease. The diagnosis is made using radiology. The treatment is surgical removal. We present a clinical case of intrathoracal n. vagus neurilemoma in a 39-year-old woman. The diagnosis was made using radiological findings (chest X-ray, chest CT, and the MRI of the mediastinum). The removal of the tumour was made by VATS. The diagnosis was proved morphologically. After 8 days, the patient was discharged from the hospital.Key words: neurilemoma, vagal nerve, operation

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Branchio-oto-renal syndrome: a clinical case

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2018033 ◽

2019 ◽

Vol 25 (1) ◽

pp. 5

Author(s):

Xavier Lagarde ◽

Mathilde Fenelon ◽

Jean Christophe Fricain

Keyword(s):

Medical History ◽

Rare Disease ◽

Genetic Study ◽

Clinical Case ◽

Autosomal Dominant ◽

Clinical Criteria ◽

Dermatology Clinic ◽

Family Medical History ◽

The Family ◽

Renal Abnormalities

Observation: A 19-week-old patient seen in an oral dermatology clinic had small labial commissures pits associated with auricular abnormalities. Similar clinical elements were found in the family medical history. A diagnosis of branchio-oto-renal syndrome (BOR) was quickly evoked. Commentary: BOR syndrome is a rare disease. This autosomal dominant pathology is characterized by facial lesions and renal abnormalities. Diagnosis is based on many clinical criteria. An optional genetic study can sometimes assist in diagnosis.

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ANTISYNTHETASE SYNDROME AND THE POSITION OF CLINICAL IMMUNOLOGIST

Immunology and Allergy: Science and Practice ◽

10.37321/immunology.2020.02-07 ◽

2020 ◽

pp. 66-71

Author(s):

Валентина Чоп’як ◽

Христина Ліщук-Якимович ◽

Роман Пукаляк ◽

Омелян Синенький

Keyword(s):

Clinical Case ◽

Inflammatory Myopathy ◽

Idiopathic Inflammatory Myopathy ◽

Pulse Therapy ◽

Lung Damage ◽

Aged Patient ◽

Antisynthetase Syndrome ◽

Erythematous Rash ◽

Fibrosing Alveolitis ◽

High Doses

Antisynthetase syndrome is a clinical and laboratory syndrome that develops in patients with idiopathic inflammatory myopathy and is characterized by the development of interstitial lung disease, namely fibrosing alveolitis syndrome, resistance to traditional corticoid therapy and the presence of myositis-specific antibodies.We present a clinical case of an antisynthetase syndrome in a middle-aged patient who has presented severe myalgic syndrome, photodermatosis, Raynaud’s phenomenon. The disease debuted with cutaneous (heliotropic erythema, erythematous rash on the skin of the upper torso) and myalgic symptoms, fever with next adding of the joint syndrome, as well as lung damage (pulmonitis and infiltrates). Immunological testing revealed anti-Jo-1, anti-PL-12-, anti-PL-7 antibodies («Polycheck», BIOCHECK, Germany). Since years, the patient has got the diagnosis of antisynthetase syndrome. The use of combined pulse therapy with cyclophosphamide and methylprednisolone, as well as the addition of high doses of vitamin D3 has contributed to the regression oflung damage and reduction of dermatomyositis activity.

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