scholarly journals Topical glucocorticosteroids in the treatment of patients with allergic rhinitis

2019 ◽  
pp. 94-97
Author(s):  
A. Yu. Ovchinnikov ◽  
N. A. Miroshnichenko ◽  
I. V. Smirnov
Keyword(s):  
Allergic Rhinitis ◽  
Mucous Membrane ◽  
Inflammatory Cells ◽  
Developed Countries ◽  
The Body ◽  
Common Disease ◽  
Upper Respiratory Tract ◽  
Inflammatory Infiltration ◽  
Nasal Mucous Membrane ◽  
The Impact

Allergic rhinitis (AR) is a common disease that affects people regardless of age, place of residence or social status. As a rule, the allergen enters the body through the upper respiratory tract, the entrance gate is mainly the nasal mucous membrane. According to statistics, in recent years the frequency of perennial AR (PAR) in economically developed countries has been approaching 40-50%. In AR, inflammatory infiltration of the nasal mucous membrane by various cells is observed. Nowadays, AR is characterized by early onset, often with continuous relapsing course and resistance to antiallergic therapy. The study of the mechanisms of disease development creates the basis for rational therapy, which involves the impact on a complex inflammatory response, not only on the symptoms of allergy. Therefore, timely conservative therapy with intranasal topical glucocorticosteroid is advisable. The article shows the importance of the effectiveness of Flixonase intranasal spray in the treatment of AR. This drug may be recommended for the treatment of PAR. Studies of the use of the drug have shown a multi-purpose mechanism of its action. Flixonase significantly reduces the number of inflammatory cells in the nasal mucous membrane and inhibits the action of local inflammatory mediators in both seasonal ARs and PARs. To achieve the best results, the drug should be used at the first signs of nascent AR.

Quality of life in allergic rhinitis

2011 ◽  
Vol 6 (1) ◽  
pp. 25-39 ◽  
Author(s):  
Tunis Ozdoganoglu ◽  
Murat Songu ◽  
Hasan Mete Inancli
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
School Performance ◽  
Work Performance ◽  
Upper Respiratory Tract ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Allergic rhinitis is a global health problem that causes major illness and disability worldwide. Although nasal and nonnasal symptoms are directly attributable to inflammation in the upper respiratory tract, individuals also experience generalized symptoms that include fatigue, mood changes, depression, anxiety and impairments of work and school performance, and cognitive function. Health-related quality of life focuses on patients’ perceptions of their disease and measures impairments that have a significant impact on the patient. The burden of disease, as the patient perceives it, forms the basic motivation to seek medical aid or to undergo therapy. Adherence to therapy requires changes in health, perceived by patients as relevant and outweighing eventual disadvantages of intervention. Because so many factors are involved in health-related quality of life, there are multiple ways in which it can be measured. A variety of validated and standardized questionnaires have been developed including assessments of school performance, work performance, productivity, and other parameters that quantify the impact of allergic rhinitis and its treatment on quality of life. The aim of this review is to highlight the impact of allergic rhinitis on the quality of life and to analyze the most commonly used health-related quality of life instruments.

scholarly journals A modern approach to the combination treatment of allergic rhinitis

2018 ◽  
pp. 92-95
Author(s):  
S. A. Karpischenko ◽  
G. V. Lavrenova ◽  
E. I. Muratova
Keyword(s):  
Allergic Rhinitis ◽  
Disease Incidence ◽  
The Body ◽  
Bronchial Obstruction ◽  
Common Disease ◽  
Nasal Breathing ◽  
Modern Approach ◽  
Life Threatening ◽  
Adults And Children ◽  
Consistent Increase

Allergic rhinitis is a common disease that significantly worsens the patient’s quality of life. In some cases, the disease can be life threatening. Severe attacks of bronchial obstruction may occur in patients with allergic rhinitis. The widespread prevalence of allergic rhinitis in adults and children, consistent increase in disease incidence constitutes a great medical and social issue. Treatment for allergic rhinitis should be aimed at reaching increased remission duration, preventing the exacerbation of the disease and educating patients to maintain control over the symptoms of the disease. A challenge that otolaryngologists and allergists face is to restore nasal breathing in patients with allergic rhinitis. The updated approach to the challenge is to suggest treatment that takes into account the pathophysiological mechanisms that occur not only in the mucous membrane of the nasal cavity, but throughout the body, in particular, in the intestine.

NEW CORONOVIRUS INFECTION: CLINICAL AND PATHOGENETIC ASPECTS OF COVID-19 IN PREGNANT WOMEN

2021 ◽  
pp. 57-62
Author(s):  
Allakhyarov D.Z. ◽  
Petrov Yu.A. ◽  
Chernavsky V.V.
Keyword(s):  
Pregnant Women ◽  
The Body ◽  
World Health ◽  
Upper Respiratory Tract ◽  
Global Pandemic ◽  
High Prevalence ◽  
Coronavirus Infection ◽  
The Moment ◽  
Health Organization ◽  
The Impact

This article presents reviews of literature sources on the clinical and pathogenetic aspects of the course of a new coronovirus infection in pregnant women, in order to analyze the features of the course of COVID-19 in pregnant women and to assess the impact of infection on the body of a woman and a fetus. Pregnancy is a special physiological condition, during which a number of changes occur in the body, not only in the hormonal status, but also in the immune system. The urgency of this problem is due to the high prevalence of new coronavirus infection among the population. On March 12, 2020, the World Health Organization (WHO), as a result of the dynamic development of the epidemic in many countries and continents, declared a global pandemic of the contagious disease COVID-19 caused by the SARS-CoV-2 virus. According to available studies, pregnant women are more susceptible to a more severe course of infectious diseases affecting the upper respiratory tract. According to various studies, a new coronavirus infection can lead to premature birth, miscarriage, and preeclampsia. Separate studies show increased mortality in pregnant women diagnosed with COVID-19. The SARS-CoV-2 virus does not have a direct teratogenic effect on the fetus, but it can indirectly lead to harmful effects on the developing organism. Special attention should be paid to the issue of vaccination of pregnant women against a new coronavirus infection, at the moment there is no accurate data on the effect of the vaccine on the body of the pregnant woman and the fetus. In this regard, the question of the impact of a new coronavirus infection on the course of pregnancy has become relevant.

Systematized literature review on financial inclusion and exclusion in developed countries

2019 ◽  
Vol 38 (3) ◽  
pp. 600-626 ◽  
Author(s):  
Beatriz Fernández-Olit ◽  
José María Martín Martín ◽  
Eva Porras González
Keyword(s):  
Literature Review ◽  
Financial Services ◽  
Meta Analysis ◽  
Developed Countries ◽  
The Body ◽  
Financial Inclusion ◽  
Vulnerable Groups ◽  
Theoretical Frameworks ◽  
Content Type ◽  
The Impact

Purpose The purpose of this paper is to provide a systematic literature review of the research published on financial inclusion (FI) and financial exclusion (FE) in developed countries using key terms and strict inclusion and exclusion criteria. Design/methodology/approach In total, 52 papers were deemed to be relevant to the analysis. These works were critiqued using a framework that addressed geographical contexts, topics, methodologies and theoretical frameworks. Findings This review highlights the uneven level of development of the academic debate between North America, the UK and continental Europe, and identifies the different theoretical frameworks that construe the body of literature in each region. In addition, the findings show the scant offer of work on the impact that the digital economy has on FE, as well as the reduced number of studies which have focused on certain vulnerable groups and the access to some financial services. Social implications The studies reviewed have not analyzed the specific needs of vulnerable groups while considering the different contexts and pathways to exclusion. The evaluation of solutions and strategies to achieve inclusion is one of the least addressed aspects in the literature. Originality/value The paper synthesizes the main contributions of the top literature on the redefinition of FI/FE in developed countries, the role of fringe services and new determinants of exclusion. The proliferation of studies regarding FI in low- and middle-income countries has generated a great amount of meta-analysis and systematized reviews of asymmetric results. However, no systematized literature review on the broad scope of FI/FE in developed countries has been published in the last decade. This work sheds light over poorly analyzed areas of research that refer to notable social problems.

scholarly journals Impact of Acupuncture on Antihistamine Use in Patients Suffering Seasonal Allergic Rhinitis: Secondary Analysis of Results from a Randomised Controlled Trial

2018 ◽  
Vol 36 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Daniela Adam ◽  
Linus Grabenhenrich ◽  
Miriam Ortiz ◽  
Sylvia Binting ◽  
Thomas Reinhold ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Secondary Analysis ◽  
Sham Acupuncture ◽  
Mean Difference ◽  
Acupuncture Group ◽  
The Other ◽  
Common Disease ◽  
The Impact ◽  
Non Parametric

Background Seasonal allergic rhinitis (SAR) is a common disease that has detrimental effects on the quality of life (QoL) of affected individuals. Approximately 18% of patients try to alleviate their symptoms through acupuncture. The ACUSAR (ACUpuncture in Seasonal Allergic Rhinitis) study (ClinicalTrials.gov registration no. NCT00610584) assessed the impact of acupuncture on SAR, showing significant improvements in rhinitis-specific QoL (RQoL) and in rescue medication (RM) use. Objective A secondary analysis of SAR patients’ use of antihistamine. Methods Patients were randomised into three study groups: acupuncture plus RM, sham acupuncture plus RM, and RM alone. The patients documented their medication use before and during the intervention period (8 weeks). The main outcome was the number of days with antihistamine use. Statistical analyses were conducted using parametric and non-parametric tests. The robustness of the results was tested by sensitivity analyses using non-parametric bootstrapping. Results The data from 414 patients were analysed. The acupuncture group used antihistamines significantly less often compared with the other groups (acupuncture vs sham acupuncture: mean difference −4.49 days, p=0.01; acupuncture vs RM: mean difference −9.15 days, p<0.001). Approximately 38% of the acupuncture group did not use any antihistamine in contrast to only 16% in the RM group. The pre-post comparison suggested that the acupuncture patients did not need to increase the days of antihistamine use to alleviate their symptoms, unlike the other groups. Conclusions Acupuncture appeared to significantly reduce the number of days of antihistamine use while improving RQoL and SAR symptoms; it can therefore be considered a valuable, additional treatment option for patients with SAR. Trial Registration Number NCT00610584; Post-results.

scholarly journals The impact of allergic rhinitis on symptoms, and quality of life using the new criterion of ARIA severity classification

2012 ◽  
Vol 50 (1) ◽  
pp. 33-36
Author(s):  
Antonio Valero ◽  
Rosa Munoz-Cano ◽  
Joaquin Sastre ◽  
Ana M. Navarro ◽  
Enrique Marti-Guadano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Common Disease ◽  
Life Questionnaire ◽  
Nasal Symptoms ◽  
Severity Classification ◽  
New Criterion ◽  
The Impact ◽  
Severity Criterion

Introduction: Allergic rhinitis (AR) is a common disease with major socieconomic burden and a significant impact on quality of life. Objective: The objective of the study was to assess the impact of AR severity, using the modified ARIA (m-ARIA) severity criterion in order to discriminate among moderate and severe AR, in symptoms and quality of life assessed with the questionnaire ESPRINT-15. Methods: The specific quality of life questionnaire (ESPRINT-15) was applied in over thousand untreated RA patients. Severity was evaluated by the m-ARIA classification, which categorizes AR as mild, moderate, and severe. Nasal symptoms were evaluated by using categorized (none, low, middle, and high) Total Four Symptom Score (T4SS). Results: Using the m-ARIA severity classification, significant differences in quality of life, both global score and specific domains, and categorized T4SS were found among the AR severity groups. Conclusion: Modified ARIA severity classification in mild, moderate, and severe allergic rhinitis clearly discriminates the impact of AR in all domains of quality of life and categorized symptom`s score.

scholarly journals The impact of allergic rhinitis on symptoms, and quality of life using the new criterion of ARIA severity classification

2012 ◽  
Vol 50 (1) ◽  
pp. 33-36
Author(s):  
Antonio Valero ◽  
Rosa Munoz-Cano ◽  
Joaquin Sastre ◽  
Ana M. Navarro ◽  
Enrique Marti-Guadano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Common Disease ◽  
Life Questionnaire ◽  
Nasal Symptoms ◽  
Severity Classification ◽  
New Criterion ◽  
The Impact ◽  
Severity Criterion

Introduction: Allergic rhinitis (AR) is a common disease with major socieconomic burden and a significant impact on quality of life. Objective: The objective of the study was to assess the impact of AR severity, using the modified ARIA (m-ARIA) severity criterion in order to discriminate among moderate and severe AR, in symptoms and quality of life assessed with the questionnaire ESPRINT-15. Methods: The specific quality of life questionnaire (ESPRINT-15) was applied in over thousand untreated RA patients. Severity was evaluated by the m-ARIA classification, which categorizes AR as mild, moderate, and severe. Nasal symptoms were evaluated by using categorized (none, low, middle, and high) Total Four Symptom Score (T4SS). Results: Using the m-ARIA severity classification, significant differences in quality of life, both global score and specific domains, and categorized T4SS were found among the AR severity groups. Conclusion: Modified ARIA severity classification in mild, moderate, and severe allergic rhinitis clearly discriminates the impact of AR in all domains of quality of life and categorized symptom`s score.

scholarly journals Dysfunction of the mucous membrane in the pathogenesis of chronic diseases of the nasal cavity

2021 ◽  
pp. 94-99
Author(s):  
G. N. Nikiforova ◽  
P. S. Artamonova ◽  
E. A. Shevchik
Keyword(s):  
Nasal Cavity ◽  
Mucous Membrane ◽  
The Body ◽  
Atrophic Rhinitis ◽  
Protective Mechanism ◽  
Mucociliary Transport ◽  
Upper Respiratory Tract ◽  
Physiological Functions ◽  
Upper Respiratory ◽  
All Diseases

Performing not only respiratory, but also protective, olfactory, aesthetic and a number of other functions, the nose is an important part of the upper respiratory tract. The mucous membrane of the nasal cavity is the first protective barrier of the body that protects against the effects of adverse environmental factors, carrying out warming, purification and neutralization of the inhaled air. This mission is provided by the activity of the multilayered columnar ciliated epithelium, consisting of three main types of cells: ciliate, goblet and basal. The main protective mechanism in the nasal cavity is mucociliary clearance, carried out by means of nasal mucus and beating of cilia unidirectional towards the nasopharynx with a frequency of up to 1000 per minute. Violation of the integrity and disruption of the physiological functions of the mucous membrane of the nasal cavity leads to the development of pathological processes, which in turn can lead to a failure in the work of other organs and systems of the body. To date, about 16-18% of all diseases of the ENT organs are chronic forms of rhinitis. According to the ICAR classification, which is based on the pathophysiological mechanisms of the development of rhinitis, allergic and non-allergic forms are distinguished. Common to various forms is the effect of certain factors on the mucous membrane of the nasal cavity and, as a consequence, a violation of the mechanisms of its work.One of the forms of chronic rhinitis, caused by thinning of the mucous membrane and severe disorders of mucociliary transport, is atrophic rhinitis. The main symptoms of the disease are dryness, the formation of crusts in the nasal cavity, periodic bleeding. The approach to the treatment of acute and chronic processes against the background of atrophic changes in the nasal cavity should be comprehensive and aimed at restoring the physiological functions of the mucous membrane and the mechanisms of mucociliary transport.

Lymphocyte infiltration and thickness of the nasal mucous membrane in perennial and seasonal allergic rhinitis

1994 ◽  
Vol 93 (3) ◽  
pp. 635-643 ◽  
Author(s):  
Moisés A. Calderón ◽  
Stefan Lozewicz ◽  
Andrew Prior ◽  
Susan Jordan ◽  
Cecilia J. Trigg ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mucous Membrane ◽  
Seasonal Allergic Rhinitis ◽  
Lymphocyte Infiltration ◽  
Nasal Mucous Membrane

scholarly journals Prevalence of thinness and its effect on height velocity in schoolchildren

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hassib Narchi ◽  
Afaf Alblooshi ◽  
Maisoon Altunaiji ◽  
Nawal Alali ◽  
Latifa Alshehhi ◽  
...  
Keyword(s):  
United Arab Emirates ◽  
Task Force ◽  
Health Assessment ◽  
Developed Countries ◽  
Peak Height ◽  
The Body ◽  
World Health ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
The Impact

AbstractObjectiveIn contrast to childhood obesity, studies involving thin children are much fewer, especially in developed countries. Furthermore, most reports do not address the impact of childhood thinness on height velocity. This study investigated the prevalence of thinness and its effect on height velocity in schoolchildren in the United Arab Emirates (UAE). Weight and height were measured in 29,410 schoolchildren (50.5% females), as part of the health assessment (academic year 2014–2015). The body mass index (BMI) was classified as normal, thinness, overweight, or obese using cutoffs established by the International Obesity Task Force (IOTF), World Health Organization, and Centers for Disease Control.ResultsThe median age was 10.2 years (range, 3–19). Using the IOTF scale, one-quarter of the children aged 4–6 years and one-third of the children aged 7–9 years were thin (BMI ≤ 18.5 kg/m2). Thinness was less prevalent (8–10%) in adolescents. Group peak height velocity was delayed 1–3 years in thin children and was higher in children with excess body fat. In conclusion thinness was the highest (25–33%) in children aged 4–9 years of age and their peak height velocity was delayed 1–3 years when compared to the other children.

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