scholarly journals Diffuse hair loss in women: causes and therapeutic approach

2020 ◽  
pp. 60-63
Author(s):  
O. O. Melnichenko ◽  
A. L. Piruzyan ◽  
I. M. Korsunskaya
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Clinical Effectiveness ◽  
Growth Cycle ◽  
Trigger Factor ◽  
Results Of Treatment ◽  
Trigger Event ◽  
Specialized Care ◽  
Post Menopause

Throughout human history, women have paid great attention to the beauty of their hair, and modern women are no exception. About 63% of young American women use different nutritional supplements to prevent hair loss. Diffuse hair loss is quite common in women and can occur against the background of various events: pregnancy, pre- and post-menopause, chronic diseases, etc. The most common is telogen effluvium (TE), which begins 2-3 months after the trigger event. Usually, TE process stops on its own, but can also become chronic. For many women, pregnancy and associated psycho-emotional stress become the triggering event, and in 75% of cases hair loss can become chronic.In fact, TE is a violation of the hair growth cycle. First of all, it is necessary to exclude the trigger factor from the patient's life and only then to start normalizing the hair growth cycle and improve the quality of hair follicle nutrition. The most effective topical remedy for the treatment of diffuse hair loss is minoxidil. The reasons for its clinical effectiveness have not been fully studied, but it is known that it prolongs the hair growth phase. Unfortunately, after cancellation of the drug, hair loss is often renewed. Avoiding these effects is possible with a comprehensive approach to therapy. Inclusion of additional components in the therapy scheme, such as vitamin and mineral complexes, growth stimulants, specialized care products, allows to maintain and improve the results of treatment with minoxidil. 

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

scholarly journals Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

2020 ◽  
Vol 21 (14) ◽  
pp. 4915 ◽  
Author(s):  
Bu Young Choi
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
In Vivo Studies ◽  
Intracellular Targets ◽  
Remarkable Progress ◽  
Made In

Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

THE EFFECT OF ADRENALECTOMY AND ADRENOCORTICAL HORMONES ON THE HAIR GROWTH CYCLE IN THE RABBIT AND RAT

1958 ◽  
Vol 17 (2) ◽  
pp. 167-NP ◽  
Author(s):  
H. J. WHITELEY
Keyword(s):  
Body Weight ◽  
Mitotic Activity ◽  
Hair Growth ◽  
Inhibitory Action ◽  
Growth Cycle ◽  
Bilateral Adrenalectomy ◽  
Hair Regrowth ◽  
Cycle Growth ◽  
The Difference

SUMMARY The effect of cortisone and adrenalectomy on the hair regrowth cycle of the rat and rabbit was investigated. It was found that bilateral adrenalectomy had no effect on the rate of regrowth of hair or on the quality of the coat in the rabbit, but there was decreased mitotic activity of the follicles on the 2nd and 7th day of the regrowth cycle and increased mitotic activity of the epidermis on the 7th day of this cycle. In the rat bilateral adrenalectomy, apart from causing a generalized wave of hair growth, which was not observed in the rabbit, had no effect on the hair regrowth cycle. The local application of hydrocortisone had a slight inhibitory action in the early stages of the cycle, but i.m. injection of cortisone produced profound inhibition. In the rabbit doses of 12·5 mg/kg body weight caused suppression of the usual regrowth cycle, but in some animals the outercoat hairs were unaffected. There was depression of the mitotic activity of the epidermis on the 7th and 10th days of the cycle. If cortisone was given during different stages of the regrowth cycle growth of undercoat hair was much more inhibited than that of the outercoat hair. Similar results were observed in the rat. These results are discussed and it is postulated that the difference in response between the two types of hair might be related to differences in blood supply of the outercoat and undercoat hairs.

scholarly journals Alopecia by COVID-19: About a Case

2021 ◽  
pp. 1-2
Author(s):  
Juan Tafur Delgado ◽  
Michael Muñoz Ortiz ◽  
Víctor Otero Marrugo ◽  
Juan Farak Gómez
Keyword(s):  
Emergency Department ◽  
Positive Result ◽  
Female Patient ◽  
Hair Loss ◽  
Clinical Picture ◽  
Medical Management ◽  
Hair Growth ◽  
Growth Cycle ◽  
Antigen Test ◽  
Limited Period

Some research that has been carried out in patients who have already undergone COVID-19, indicate that between 20%-30% of these will suffer intense hair loss, multiplied by 4 or 5 after 2 to 4 months later of the illness. This exaggerated hair loss is known as telogenic effluvium. In telogenic effluvium, it is produced by an alteration in the hair growth cycle that generates an alarming loss for a limited period of time. As in any infection or period of stress, the root of the hair weakens and months after having overcome it, the hair falls in an abnormal and exaggerated way. The objective of presenting this case is to describe one of the most important and rare dermatological manifestations, which has been derived from SARS-CoV-2 infection. We present the case of a 41-year-old female patient, who was admitted to the emergency department after presenting a clinical picture of 8 days of evolution consisting of dry cough, tachycardia and diaphoresis, for which the antigen test for SARS-CoV-2, revealing a positive result, so it was decided to enter for medical management.

scholarly journals ADMINISTRATION OF PHLEBOTROPIC DRUGS DURING COMPLEX TREATMENT OF ACUTE HEMORRHOIDS

2018 ◽  
pp. 48-53 ◽  
Author(s):  
B. M. Belik ◽  
A. N. Kovalev ◽  
A. L. Khatlamadzhiyan
Keyword(s):  
Pain Syndrome ◽  
Clinical Effectiveness ◽  
Complex Treatment ◽  
Standard Drug ◽  
Inflammatory Phase ◽  
Results Of Treatment ◽  
Clinical Observations ◽  
Group I ◽  
Sf 36

OBJECTIVES OF RESEARCH. To assess the clinical effectiveness of phlebotrophic drug Detralex (Micronized purifiedflavonoid fraction (MPFF)) during complex treatment of patients with acute hemorrhoids. MATERIALS AND METHODS. A comparative analysis of treatment outcomes of 293 patients with acute hemorrhoids was conducted. All patients were divided into two groups for further clinical observations. Standard drug therapy was performedfor 145 patients (group I). For 148 patients (group II), in addition to the standard treatment, phlebotrophic drug Detralex was additionally initiated. Research program included detection of content of acute inflammatory phase reactants and pro-inflammatory cytokines in blood plasma, evaluation of pain syndrome severity (VRS) and quality of life parameters (SF-36 questionnaire). RESULTS. Initiation of MPFF with complex treatment of patients with acute hemorrhoids was found to be contributed to faster elimination of edema and inflammation, a decrease in severity of hemorrhoids thrombosis, relief of pain syndrome and improvement in patients'quality of life, along withwell-marked regression of laboratory markers of inflammatory reaction This allows to increase the number of good outcomes of acute hemorrhoids treatment from 66,2% to 89,9%, that is by 23,7% and to reduce the number of unsatisfactory outcomes from 4,2% to 1,3%, that is by 2,9%. CONCLUSION. Inclusion of Detralex into program of acute hemorrhoids treatment contributes to a faster elimination of clinical and laboratory manifestations of the disease and allows improving the results of treatment for this category of patients.

scholarly journals COVID-19 Can Exacerbate Pattern Hair Loss and Trigger Telogen Effluvium – The Role of Proteoglycan Replacement Therapy with Nourkrin® in Clinical Treatment of COVID-19 Associated Hair Loss

2020 ◽  
Author(s):  
Aida Gadzhigoroeva ◽  
Daniela Guzman-Sanchez ◽  
Alireza Firooz ◽  
Hamideh Moravvej ◽  
Nelly Espinoza ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Proinflammatory Cytokines ◽  
Hair Loss ◽  
Hair Growth ◽  
Clinical Investigation ◽  
Stress Hormones ◽  
Growth Cycle ◽  
Normal Metabolism ◽  
Dermatological Disorders

The unfolding coronavirus disease 2019 (COVID-19) has increased the incidence of several dermatological disorders, including diffuse hair loss. Observational studies revealed an escalated incidence of pattern hair loss (PHL) and telogen effluvium (TE) in COVID-19 patients. Psychological stress, systemic inflammation and oxidative stress are potential culprits. Reduced anagenic expression of proteoglycans is a potential mediating mechanism that connects hair loss to critical health conditions such as COVID-19. Proinflammatory cytokines and stress hormones negatively affect the normal metabolism of proteoglycans, which are known regulators of the hair growth cycle. Anagen shortening and hair miniaturisation are thus conceivable consequences of a resultant hypofunctional follicular matrix. In this review, we discuss the association between COVID-19 and diffuse hair loss and elucidate the position of proteoglycan replacement therapy (PRT) using Nourkrin® with Marilex® in addressing the dysmetabolism of proteoglycans in COVID-19. PRT with Nourkrin® is a hair loss treatment with ‘anti-inflammatory’ and ‘hair growth cycle normalising’ effects. This treatment is shown to improve the histological severity of inflammation, suppress several proinflammatory cytokines and expand regulatory T-cell lineages in-vivo. Accordingly, Nourkrin® has potential in treating new-onset or aggravated PHL in COVID-19 survivors. In addition, bioactive proteoglycans in Marilex®, e.g., decorin and versican, exhibit anagen inducing and catagen suppressing properties, which help to reverse anagen shortening in stress-induced TE. Further clinical investigation of PRT in COVID-19 survivors through controlled trials and real-world studies is warranted. In conclusion, Nourkrin® can be considered as a safe treatment to prevent and treat COVID-19 related PHL and TE.

scholarly journals Role of proteoglycans in the treatment of alopecia of various genesis

2021 ◽  
pp. 347-351
Author(s):  
L. R. Sakaniya ◽  
O. O. Melnichenko ◽  
A. L. Piruzyan ◽  
I. M. Korsunskaya
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Growth Cycle ◽  
Strong Impact ◽  
Natural Hair ◽  
Number Of Patients ◽  
Anagen Phase ◽  
Life Threatening ◽  
Specific Proteins

Hair loss has always been and remains an urgent challenge in the world today. Although this condition is not life-threatening, it still has a strong impact on the patients’ quality of life. Hairlines are affected by multiple factors including age, family history, smoking, nutrition, etc. Alopecia can take many forms, and the specialist’s objective is to determine the correct cause of the disorder of hair growth cycle by taking a medical history from a patient.The key role in the pathogenesis of androgenetic alopecia is assigned to changes in hormonal status. Telogen effluvium can be triggered by stress, medication, pregnancy, or other medical conditions. For instance, the high number of patients who have had COVID-19 are now faced with hair loss a few months after recovery.Despite the variety of underlining causes of hair loss, the principle of therapy is the same – the elimination of the trigger and the selection of drugs to normalize the natural hair growth cycle. In this case, the use of drugs containing proteoglycans that are specific proteins involved in the regulation of the hair growth cycle looks promising. Numerous studies demonstrate the efficacy of such proteoglycans as versican, decorin, and syndecan. They activate hair growth and help prolong the anagen phase. This effect of proteoglycans affords to speak about their good therapeutic and even prophylactic properties applied to the problem of hair loss. 

scholarly journals The potential of androgenic alopecia management from plant derivatives

Food Research ◽  
2020 ◽  
Vol 4 (S2) ◽  
pp. 1-13
Author(s):  
N.M. Noor ◽  
N.Z. Nazri ◽  
N.A. Mohamad-Salam ◽  
Z.I. Abdul-Rasid ◽  
R. Hasham ◽  
...  
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Self Esteem ◽  
Androgenetic Alopecia ◽  
Depression And Anxiety ◽  
Androgenic Alopecia ◽  
Growth Cycles ◽  
Male Pattern Baldness ◽  
Male Pattern

Hair loss or alopecia is a common dermatological issue that can affect millions of human population of all ages and both gender, male and female. Frequently, alopecia has been found to be associated with significant adverse effects or reduction of psychological and self-esteem. Consequently, this may lead to psychological problems such as depression and anxiety, thus it may negatively impact the quality of life as well. There are several types of hair loss including androgenetic alopecia (AGA), alopecia areata (AA), alopecia totalis (AT), Alopecia Universalis (AU), cicatricial alopecia (CA), senescent alopecia (SA), traction alopecia (TA) and telogen effluvium. However, this review will focus on the androgenic alopecia only. Androgenic alopecia (AGA) also known as male pattern baldness is referred to as hair loss that often occurs in men after puberty caused by the androgen. In addition, this review will discuss on the hair growth cycles and their mechanism on the androgenic alopecia and lastly the management of androgenic alopecia using plant derivatives and methods used in order to prolong the efficacy of androgenetic alopecia treatment.

scholarly journals Ginseng in Hair Growth and Viability

2021 ◽  
Author(s):  
Mirecki-Garrido Mercedes ◽  
Santana-Farré Ruymán ◽  
Guedes-Hernandez Noelia ◽  
Jimenez-Acosta Francisco ◽  
Lorenzo-Villegas Dionisio L.
Keyword(s):  
Nutritional Status ◽  
Hair Follicle ◽  
Hair Loss ◽  
Growth Pattern ◽  
Hair Growth ◽  
Social Impact ◽  
Well Being ◽  
Growth Cycle ◽  
Hair Root ◽  
Body Side

The hair follicle is the unique organ that has the capacity of undergoing cyclic transformations following periods of growth (anagen), regression (catagen), and rest (telogen) regenerating itself to restart the cycle. The dynamic capacity of hair to growth and rest enables mammals to control hair growth and length in different body side and to change their coats. Unlike what is observed in many animals in which the pelage synchronously passes from one phase of the cycle to other all stages of growth cycle are simultaneously found in the human pelage, the growth pattern is a mosaic where the hair cycling staging of one hair root is completely independent of it nearest hair follicle, meaning that each follicular unit (FU) can contain follicles in different stages at any given time. A variety of factors, such as nutritional status, hormones, exposure to radiations, chemotherapy or radiotherapy, environmental pollution or drugs may affect hair growth, and affects the number of hairs, this progressive hair loss has a cosmetic and social impact that often significantly affects social and psychological well-being of the patient that suffers from this hair loss. Although a number of therapies, such as finasteride and minoxidil, are approved medications, a wide variety of classes of phytochemicals and natural products, including those present in ginseng are being testing. The purpose of this chapter is to focus on study the potential of ginseng and its metabolites in hair loss.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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