scholarly journals Prospects for the drug use based on common ivy for bronchopulmonary pathology in childhood

2021 ◽  
pp. 122-127
Author(s):  
Yu. L. Mizernitskiy ◽  
N. L. Dorovskaya ◽  
I. M. Melnikova
Keyword(s):  
Respiratory Infections ◽  
Inflammatory Diseases ◽  
Physical Exertion ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Hedera Helix ◽  
Runny Nose ◽  
Complex Therapy ◽  
Acute Respiratory Viral Infection ◽  
Phenolcarboxylic Acids

Respiratory diseases persistently lead in the structure of general morbidity in both children and adolescents. Acute respiratory infections are the most common among them. Interest of pediatricians to phytotherapy is not accidental and is due to the fact that it has a mild therapeutic effect, enhances the effectiveness of complex therapy, has few side effects. Of particular interest are herbal remedies containing ivy extract (Hedera helix), the active ingredients are mainly found in ivy leaves, they are biologically active substances: Triterpene saponins, glycosides, also contain carbohydrates, essential oils, steroids, phenolcarboxylic acids, coumarins, flavonoids, carotenoids, tocopherols (vitamin E), B and C vitamins, tannins, phytoncides. Ivy preparations are prescribed as an expectorant in the treatment of infectious and inflammatory diseases of the upper and lower respiratory tract due to their proven multidirectional effects: secretolytic, mucolytic, bronchospasmolytic. They also have anti-inflammatory, reparative, antioxidant effects.This article presents a clinical example of an officinal ivy-based preparation used in the treatment of a 3.5 year old patient diagnosed with acute respiratory viral infection. Temperature increased to 38 °C, runny nose; on the second day of illness the temperature remained subfebrile and a dry cough appeared. Nasal vasoconstrictor drops and oral acetylcysteine were prescribed, but there was no relief. On the third day of the illness, against the background of subfebrile temperature, the cough persisted, single dry rales were heard in the lungs, wheezing appeared during physical exertion. Acetylcysteine was withdrawn and replaced by ivy-based drops (16 drops 3 times a day orally after meals in a small amount of water). After 2 days the cough was moist, the sputum was easily expectorated, the wheezing in the lungs was almost gone, there was no more wheezing and the temperature was normal. By the sixth day of treatment the cough was gone and the girl had almost recovered. Nevertheless, Gedelix was continued for another 4 days. Prospective results and detailed study of the effects of herbal preparations on the basis of ivy extracts served as the basis for their recommendation as a complex therapy of cough in children.

Peculiarities of the clinical course and complex therapy of peritonitis after cesarean section

1986 ◽  
Vol 67 (6) ◽  
pp. 450-451
Author(s):  
A. I. Nagovitsina ◽  
Z. S. Kornyaeva ◽  
Z. Ya. Soboleva ◽  
F. N. Ivshin ◽  
V. N. Borozdina
Keyword(s):  
Cesarean Section ◽  
Pregnant Women ◽  
Clinical Course ◽  
Respiratory Infections ◽  
Inflammatory Diseases ◽  
Mitral Valve Insufficiency ◽  
Chronic Pyelonephritis ◽  
Spontaneous Abortions ◽  
Complex Therapy ◽  
Valve Insufficiency

We observed 23 women who developed peritonitis after cesarean section. The average age of the patients was 28.9 years. There were 7 first-pregnant women and 16 second-pregnant women. The anamnesis revealed the presence of endogenous foci of infection in all the patients. Thus, flu, sore throat, acute respiratory infections were diagnosed in 20 women, pneumonia in 3; chronic pyelonephritis in 5, inflammatory uterine appendages in 6, rheumatism with mitral valve insufficiency in 1, Botkin disease in 1. Genuine pregnancy was preceded by abortions in 19 women, of whom 11 had formal abortions, 3 had criminal abortions, and 5 had spontaneous abortions at 10 to 25 weeks' gestation against a background of chronic pyelonephritis and inflammatory diseases of the uterine appendages.

scholarly journals Possibilities of phyto preparations in treatment of patients with acute cough

2021 ◽  
pp. 56-61
Author(s):  
V. M. Svistushkin ◽  
G. N. Nikiforova ◽  
A. V. Zolotova ◽  
E. S. Novtseva
Keyword(s):  
Respiratory Tract ◽  
Respiratory Infections ◽  
Inflammatory Diseases ◽  
Infectious Agent ◽  
Pharmacological Action ◽  
Severe Allergic Reaction ◽  
Upper Respiratory Tract ◽  
Acute Cough ◽  
Hedera Helix ◽  
Respiratory Pathology

Patients with complaints of coughing make up a significant percentage of doctors in various specialties. Cough is not an independent disease, in most clinical cases it is a symptom of a respiratory disease. In acute respiratory pathology, the cough is usually short-lived and stops after the eradication of the infectious agent and the relief of inflammatory changes. It is important therapeutically to provide a reduction in the duration and relief of cough, as well as the prevention of complications. An effective symptomatic agent in the treatment of coughs of various origins, including inflammatory diseases of the respiratory tract, are herbal preparations. The fairly widespread use of phytopreparations in clinical practice is due to their high safety, physiological action, availability and effectiveness. The pharmacological action of these drugs in respiratory infections is manifested by antiinflammatory, cytoprotective, antiviral and antioxidant effects, multifactorial improvement of mucociliary cleansing processes. One of these phytopreparations is a monocomponent syrup with expectorant, mucolytic and antispasmodic. The therapeutic effect of drug is explained by the presence in the composition of triterpene glycosides (saponins) from the leaves of Hedera helix . The effectiveness and safety of drug is proved by a sufficient volume of clinical studies and observations. Literature data show that Hedera helix leaf preparations significantly reduce the severity of acute respiratory infections of the upper respiratory tract.Virtually none of the patients had severe side effects. Allergic reactions were recorded in less than 0.5% of cases, with no mention of a severe allergic reaction of the anaphylaxis type. Thus, the drug of plant origin in the form of drops can be successfully used in patients with symptoms of acute respiratory diseases.

Clinical and immunological efficacy of the drug Nobazit® (enisamium iodide) in the complex therapy of acute respiratory viral infections

2020 ◽  
pp. 23-34
Author(s):  
O. A. Gizinger
Keyword(s):  
Viral Infections ◽  
Respiratory Infections ◽  
Clinical Manifestations ◽  
Peripheral Blood Lymphocytes ◽  
Upper Respiratory Tract ◽  
Innate And Adaptive Immunity ◽  
Complex Therapy ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection ◽  
Etiological Agents

The term «acute respiratory viral infections» refers to a group of diseases whose etiological agents are respiratory viruses, mainly affecting the epithelium of the upper respiratory tract. The article presents the results of studying the effectiveness of the drug Nobazit® in 32 patients with body temperature > 37.5 °C having at least one catarrhal symptom (cough, rhinitis, or sore throat) and one symptom of intoxication (chills, sweating, malaise, weakness, or headache) who consulted a doctor within the first 48 hours from the onset of symptoms of an acute respiratory viral infection. The use of the drug Nobazit® (enisamium iodide) allowed to reduce the severity of clinical manifestations, eliminate lymphopenia, normalize factors of innate and adaptive immunity, and restore the receptor landscape of peripheral blood lymphocytes. The registered clinical and immunological efficacy of the drug Nobazit® allows recommending its inclusion in the complex therapy of acute respiratory infections.

scholarly journals Efficacy of Miramistin in the correction of the oropharynx microbiocenosis in sickly children

2019 ◽  
Vol 19 (1) ◽  
pp. 9-14
Author(s):  
Irina V. Nikolaeva ◽  
E. S. Gerasimova ◽  
T. Yu. Pavlova
Keyword(s):  
Pathogenic Bacteria ◽  
High Efficiency ◽  
Respiratory Infections ◽  
Inflammatory Diseases ◽  
Upper Respiratory Tract ◽  
Bacteriological Study ◽  
Opportunistic Bacteria ◽  
Complex Therapy ◽  
Upper Respiratory ◽  
Isolated Species

There are presented data of the analysis of the composition of the oropharynx microbiota and antimicrobial resistance of opportunistic bacteria isolated in sickly children to determine the effectiveness of the preparation Miramistin. There was executed a bacteriological study of the microflora of the oropharynx in 71 children with respiratory recurrent infections (RIRs). There was determined the resistance of isolated species ofpathogens of respiratory infections to antibiotics of different classes. Children suffering from RIRs were found to have species and and quantitative disorders of the pattern ofpharynx microflora in 90,2% of cases. In cultures from oropharyngeal mucosa there were isolated 15 types of potentially pathogenic bacteria, among them there were dominated: S. aureus (31%), Haemophilus influenzae (11,3%),) Strept. pyogenes (11,3%) and Strept. pneumoniae (8,4%). All of the isolated in sickly children strains of S. aureus and Strept. pyogenes (including strains resistant to antibiotics and bacteriophages) were susceptible to Miramistin. There was proved high efficiency and safety of Miramistin in the complex therapy of various forms of inflammatory diseases oa upper respiratory tract: angina, chronic tonsillitis, pharyngitis and nasopharyngitis in children. It is recommended to always include Miramistin in the complex treatment of infectious and inflammatory diseases of the oropharynx.

scholarly journals The Use of Plant Origin Remedies in Children with ARVI

2018 ◽  
Vol 17 (4) ◽  
pp. 43-45
Author(s):  
O. V. Shamsheva
Keyword(s):  
Respiratory Diseases ◽  
Scientific Literature ◽  
Respiratory Infections ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Symptomatic Therapy ◽  
Plant Origin ◽  
Clinical Safety ◽  
Safety And Efficacy ◽  
Proven Efficacy

The analysis of the scientific literature and the results of clinical studies on the safety and efficacy of using for respiratory infections components of plant origin and bee products included in the composition of biologically active food supplements — «Propolis with Herbs» marmalade, throat lollipop with honey and Althaea night syrup with honey-line INVAR KIDS. It has been shown that the use of herbal remedies that contain components with established clinical safety and proven efficacy as a symptomatic therapy is reasonable for alleviating the main symptoms of respiratory diseases in children.

Complex therapy of acute respiratory infections in children

2016 ◽  
Vol 77 (5) ◽  
pp. 34-39
Author(s):  
G.V. Beketova ◽  
◽  
O.V. Soldatova ◽  
R.Z. Gan ◽  
◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Complex Therapy

Antistaphylococcal activity of carbonic acid extract of hops

2018 ◽  
Vol 22 (2) ◽  
pp. 297-300
Author(s):  
V.V. Nevmerzhitsky ◽  
V.Yu. Ivannik ◽  
V.V. Kazmirchuk ◽  
T.N. Moiseenko ◽  
T.A. Volkov ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Antimicrobial Agents ◽  
Carbonic Acid ◽  
Inflammatory Diseases ◽  
Acquired Resistance ◽  
Biologically Active ◽  
Antibacterial Drugs ◽  
Antistaphylococcal Activity ◽  
Prevention And Treatment ◽  
Main Disadvantage

The fight against staphylococcal infection, increasing the effectiveness of methods of prevention and treatment of diseases of staphylococcal etiology is of interest to scientists and practitioners, both in Ukraine and around the world. The urgency of this problem is growing rapidly, as there is a tendency to increase the resistance of not only staphylococci, but also other gram-positive bacteria. The spread of methicillin-resistant staphylococci restricts the choice of antibiotics for the treatment of diseases of staphylococcal etiology. Staphylococcus aureus is the most common and dangerous type, which is one of the main factors of purulent-inflammatory lesions of the skin and mucous membranes. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. One of the unique and promising medicinal plants, which contains a rich complex of biologically active substances (BAS), is common hops (Humulus lupulus L.). The complex of BAS (flavonoids, hormones, vitamins, bitter, phenolic compounds, essential oils) causes anti-inflammatory, bactericidal, hyposensitizing and analgesic action of hops. The purpose of this work is to determine the antistaphylococcal activity of the carbon dioxide extract of hops and to justify the development on its basis of new antimicrobial agents for the prevention and treatment of infectious and purulent-inflammatory diseases. The following methods were used: microbiological (method of diffusion into agar (well method)) and mathematical and statistical. The high antimicrobial activity of the carbon dioxide extract of hops has been established for museum test strains of the genus Staphylococcus. The results of the studies testify to the prospects of further study of the bactericidal properties of the extract of hops carbon dioxide with the aim of creating effective antimicrobial agents on its basis for the prevention and treatment of infectious and purulent-inflammatory diseases of staphylococcal etiology.

scholarly journals Clinical Pharmacology of Antibody-Drug Conjugates

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 20
Author(s):  
Iftekhar Mahmood
Keyword(s):  
Clinical Pharmacology ◽  
Patient Population ◽  
Inflammatory Diseases ◽  
Biologically Active ◽  
Myelogenous Leukemia ◽  
Optimum Dose ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Selection Of ◽  
Antibody Drug

Antibody-drug conjugates (ADCs) are biopharmaceutical products where a monoclonal antibody is linked to a biologically active drug (a small molecule) forming a conjugate. Since the approval of first ADC (Gemtuzumab ozogamicin (trade name: Mylotarg)) for the treatment of CD33-positive acute myelogenous leukemia, several ADCs have been developed for the treatment of cancer. The goal of an ADC as a cancer agent is to release the cytotoxic drug to kill the tumor cells without harming the normal or healthy cells. With time, it is being realized that ADCS can also be used to manage or cure other diseases such as inflammatory diseases, atherosclerosis, and bacteremia and some research in this direction is ongoing. The focus of this review is on the clinical pharmacology aspects of ADC development. From the selection of an appropriate antibody to the finished product, the entire process of the development of an ADC is a difficult and challenging task. Clinical pharmacology is one of the most important tools of drug development since this tool helps in finding the optimum dose of a product, thus preserving the safety and efficacy of the product in a patient population. Unlike other small or large molecules where only one moiety and/or metabolite(s) is generally measured for the pharmacokinetic profiling, there are several moieties that need to be measured for characterizing the PK profiles of an ADC. Therefore, knowledge and understanding of clinical pharmacology of ADCs is vital for the selection of a safe and efficacious dose in a patient population.

Physiological and Biochemical Evaluation of the Effectiveness of a New Food Ingredient, a Source of Phytoecdysteroids and Flavonoids from Quinoa Grain

2021 ◽  
Vol 37 (5) ◽  
pp. 88-95
Author(s):  
N.A. Petrov ◽  
S.N. Zorin ◽  
N.A. Biryulina ◽  
V.K. Mazo
Keyword(s):  
Wistar Rats ◽  
Immobilization Stress ◽  
Field Tests ◽  
Physical Exertion ◽  
Biologically Active ◽  
Food Sources ◽  
Food Ingredient ◽  
In Vivo Evaluation ◽  
Russian Scientific

Abstract- One of the promising food sources of biologically active substances is quinoa grain, which is valued for its high content of protein, sulfur-containing amino acids, lysine, fiber, and minerals. In addition, quinoa grain can be a valuable food source of polyphenolic compounds and phytoecdysteroids. The method for production of a concentrate of flavonoids and 20-hydroxyecdysone from quinoa grains sorbed on coagulated egg protein has been developed. The in vivo evaluation of efficacy of the developed food ingredient was conducted using male Wistar rats under immobilization stress and after exhausting physical exertion. The consumption of the food ingredient prevented an increase in the level of the main stress markers, catecholamines, in animals subjected to immobilization stress. The opposite effect was observed in animals that received the food ingredient after exhausting physical exertion: their levels of catecholamines were significantly higher than in the rest comparison groups. Using the Elevated Plus Maze and Open Field tests, it was shown that the consumption of the developed concentrate neutralized the negative effect of immobilization stress and treadmill exercise on anxiety in Wistar rats. The results obtained require additional study under conditions of preventive introduction of the food ingredient into the diet of intact animals, as well as a toxicological safety assessment. Key words: quinoa, 20-hydroxyecdysone, flavonoids, stress, immobilization, exhaustive physical exercise, catecholamines, corticosterone This work was supported by the Russian Scientific Foundation, grant no. 19-16-00107.

scholarly journals Study on domestic market of medicinal products of plant origin

2018 ◽  
pp. 30-36
Author(s):  
V. M. Minarchenko ◽  
A. Yu. Butko
Keyword(s):  
Medicinal Plants ◽  
Raw Materials ◽  
Domestic Market ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Plant Origin ◽  
Resource Base ◽  
Natural Resource Base ◽  
Active Substances

The popularity of herbal remedies and medicines, with the participation of biologically active substances from plants is traditionally high. The annual increase of the domestic market for herbal remedies is due to the preservation and modernization of production capacities for processing of medicinal vegetative raw materials in Ukraine, introduction of modern scientific developments, a large natural resource base of medicinal plants and attracting investments in the development of this industry. The aim of our work was the study of the domestic market of medicines of plant origin, which includes herbal remedies, substances and preparations with the participation of biologically active substances from plants. The object of the study was domestic medicines of plant origin that are registered in Ukraine for 2012–2017. The study used the analytical, statistical methods, and the results of its own resource studies of medicinal plants. Phytopharmaceutical market of Ukraine is actively developing due to the attraction of new types of medicinal plants and expanding the range of medicines. The number of domestic drugs with the participation of biologically active substances from plants has increased by 17.4% compared with 2014. It is established that as of 1 January 2017 in Ukraine was 1 141 the form of medicinal drugs of plant origin. Of them: 645 – domestic products, 496 – foreign. Most of the herbal drugs in the pharmaceutical market of Ukraine are made from wild and cultivated domestic raw materials.

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