scholarly journals Integrin degradation during postmortem cold storage and the level of drip loss in pork

2017 ◽  
Vol 73 (6) ◽  
pp. 325-328
Author(s):  
Magdalena Górska ◽  
Dorota Wojtysiak
Keyword(s):  
Cell Membrane ◽  
Current Knowledge ◽  
Skeletal Muscle Cell ◽  
Matrix Proteins ◽  
Drip Loss ◽  
Main Function ◽  
The Subject ◽  
Transmembrane Fragment ◽  
Muscle Cell Membrane

Integrins are a family of transmembrane adhesion proteins. An integrin molecule is composed of two subunits called α and β, each of which has a large extracellular domain, a transmembrane fragment, and a short cytoplasmic sequence. The main function of integrin is to bind extracellular matrix proteins and the skeletal muscle cell membrane. In addition, integrin as a membrane receptor is involved in signal transduction and cell response to microenvironmental signals, by relaying information about the structure and composition of the cell environment. Postmortem integrin degradation has been the subject of several studies, mainly in pork, where the mechanisms of postmortem integrin degradation are not completely understood. Therefore, the aim of the study was to present current knowledge on the role of integrin in postmortem drip loss in pork. Research to date has shown that postmortem integrin degradation could contribute to the formation of drip channels between the cell body and cell membrane of muscle fibers, which increases the drip loss from pork.

Human Rights Activities as a Function of the Prosecutor’s Office

2020 ◽  
Vol 3 ◽  
pp. 88-93
Author(s):  
K.N. Golikov ◽  
Keyword(s):  
Human Rights ◽  
Civil Rights ◽  
Russian Federation ◽  
The State ◽  
Main Function ◽  
Federal Law ◽  
The Subject ◽  
The Russian Federation ◽  
The Law

The subject of this article is the problems of the nature, essence and purpose of prosecutorial activity. The purpose of the article is to study and justify the role of the human rights function in prosecutorial activities in the concept of a modern legal state. At the heart of prosecutorial activity is the implementation of the main function of the Prosecutor’s office – its rights and freedoms, their protection. This means that any type (branch) of Prosecutor's supervision is permeated with human rights content in relation to a citizen, society, or the state. This is confirmed by the fact that the Federal law “On the Prosecutor's office of the Russian Federation” establishes an independent type of Prosecutor's supervision-supervision over the observance of human and civil rights and freedoms. It is argued that the legislation enshrines the human rights activities of the Prosecutor's office as its most important function. It is proposed to add this to the Law “On the Prosecutor's office of the Russian Federation”.

Social capital in the theory and research of LIS professionals in the light of the literature on the subject. Review of current knowledge

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Maja Dorota Wojciechowska
Keyword(s):  
Social Capital ◽  
Current Knowledge ◽  
Future Research ◽  
Content Type ◽  
Individual Social Capital ◽  
Rural Libraries ◽  
The Subject ◽  
The Moment ◽  
The Impact

Purpose The purpose of the paper is to present the latest scholarly trends in the field of social capital in libraries, to review research concepts published by LIS professionals and to suggest further research possibilities in this area. Design/methodology/approach This paper presents a review and critical analysis of literature associated with research on social capital in libraries to highlight its importance for the development of LIS and its impact on the functioning of environments linked with various types of libraries. The goal of literature analysis was to determine the current condition of research on social capital in libraries. The main trends were identified and the need for further qualitative analyses, which are missing at the moment, was confirmed. Findings It was determined that, so far, LIS professionals have focussed mainly on the role of municipal libraries in developing social capital, the problem of building trust, especially in immigrant circles and the impact of libraries on promoting a civil society. Academic libraries, rural libraries, organisational capital in libraries and individual social capital of librarians were a much less frequent subject of research. The role of libraries in developing social capital in educational (primary and secondary education) and professional (non-university professionals) circles is practically non-existent in research, and it will require in-depth studies and analyses in the coming years. Originality/value This paper constitutes a synthetic review of the latest research concepts concerning social capital in libraries. It identifies the most important research trends and areas that so far have not been explored and suggests research methods to help LIS professionals design future research in this area more effectively.

Isolation of skeletal muscle cell membrane and some of its properties

1961 ◽  
Vol 93 (3) ◽  
pp. 520-533 ◽  
Author(s):  
Tetsuro Kono ◽  
Sidney P. Colowick
Keyword(s):  
Skeletal Muscle ◽  
Cell Membrane ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Muscle Cell Membrane

The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation

2019 ◽  
Vol 287 ◽  
pp. 54-63
Author(s):  
Kuan-Chieh Wang ◽  
Po-Sheng Chen ◽  
Ting-Hsing Chao ◽  
Chawn-Yau Luo ◽  
Hsing-Chun Chung ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Neointima Formation ◽  
Membrane Bound ◽  
Muscle Cell Membrane

Ministers of pagan cult in the religious and political life of the Eastern Slavs (IX-XI centuries)

2019 ◽  
Author(s):  
Mihail Kozlov
Keyword(s):  
Political Life ◽  
Educational Institutions ◽  
Main Function ◽  
School Teachers ◽  
National History ◽  
Old Russian ◽  
Cultural Research ◽  
The Hierarchical Structure ◽  
The Subject

The subject of historical and cultural research in this monograph was the Institute of ancient servants of pagan cult, including both professional priests (Magi, sorcerers and magicians) and wandering buffoons (musicians, storytellers, guides bears, demons). In the first part of the study identified the main function of ancient Ministers of pagan cults, identified key priestly clans, identified the hierarchical structure of the East Slavic priests, its Charter and the basic sources of financing of the ancient pagan temples and their Ministers. The second part is devoted to the place and role of the old Russian Ministers of pagan cult in the religious and political life of the Eastern Slavs of the IX-XI centuries. It is designed for teachers of higher educational institutions, school teachers, students and all those interested in national history and culture.

scholarly journals Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far?

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 683
Author(s):  
Eliana De Luca ◽  
Giuseppe Andrea Sautto ◽  
Paolo Emidio Crisi ◽  
Alessio Lorusso
Keyword(s):  
Current Knowledge ◽  
Domestic Cats ◽  
Stray Cats ◽  
Potential Association ◽  
Clinicopathological Findings ◽  
A Cell ◽  
The Subject ◽  
First Time

Feline morbillivirus (FeMV) was identified for the first time in stray cats in 2012 in Hong Kong and, since its discovery, it was reported in domestic cats worldwide. Although a potential association between FeMV infection and tubulointerstitial nephritis (TIN) has been suggested, this has not been proven, and the subject remains controversial. TIN is the most frequent histopathological finding in the context of feline chronic kidney disease (CKD), which is one of the major clinical pathologies in feline medicine. FeMV research has mainly focused on defining the epidemiology, the role of FeMV in the development of CKD, and its in vitro tropism, but the pathogenicity of FeMV is still not clear, partly due to its distinctive biological characteristics, as well as to a lack of a cell culture system for its rapid isolation. In this review, we summarize the current knowledge of FeMV infection, including genetic diversity of FeMV strains, epidemiology, pathogenicity, and clinicopathological findings observed in naturally infected cats.

scholarly journals Tissue Non-Specific Alkaline Phosphatase and Vascular Calcification: A Potential Therapeutic Target

2019 ◽  
Vol 15 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Daniel Azpiazu ◽  
Sergio Gonzalo ◽  
Ricardo Villa-Bellosta
Keyword(s):  
Alkaline Phosphatase ◽  
Vascular Calcification ◽  
Current Knowledge ◽  
Crystal Deposition ◽  
New Agents ◽  
Vascular Walls ◽  
Nucleotide Pyrophosphatase ◽  
The Subject ◽  
Hydroxyapatite Crystals

Vascular calcification is a pathologic phenomenon consisting of calcium phosphate crystal deposition in the vascular walls. Vascular calcification has been found to be a risk factor for cardiovascular diseases, due to its correlation with cardiovascular events and mortality, and it has been associated with aging, diabetes, and chronic kidney disease. </P><P> Studies of vascular calcification have focused on phosphate homeostasis, primarily on the important role of hyperphosphatemia. Moreover, vascular calcification has been associated with loss of plasma pyrophosphate, one of the main inhibitors of calcification, thus indicating the importance of the phosphate/pyrophosphate ratio. </P><P> Extracellular pyrophosphate can be synthesized from extracellular ATP by ecto-nucleotide pyrophosphatase/ phosphodiesterase, whereas pyrophosphate is hydrolyzed to phosphate by tissuenonspecific alkaline phosphatase, contributing to the formation of hydroxyapatite crystals. </P><P> Over the last decade, vascular calcification has been the subject of numerous reviews and studies, which have revealed new agents and activities that may aid in explaining the complex physiology of this condition. This review summarizes current knowledge about alkaline phosphatase and its role in the process of vascular calcification as a key regulator of the phosphate/pyrophosphate ratio.

scholarly journals Adipoclast: a multinucleated fat-eating macrophage

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Antoni Olona ◽  
Subhankar Mukhopadhyay ◽  
Charlotte Hateley ◽  
Fernando O. Martinez ◽  
Siamon Gordon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Plasma Membrane ◽  
Cell Membrane ◽  
Cell Fusion ◽  
Metabolic Activity ◽  
Current Knowledge ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Current

AbstractCell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic activity resulting from cell fusion. Fusion of macrophages also generates multinucleated giant cells (MGCs) in white adipose tissue (WAT) of obese individuals. For years, our knowledge of MGCs in WAT has been limited to their description as part of crown-like structures (CLS) surrounding damaged adipocytes. However, recent evidence indicates that these cells can phagocytose oversized lipid remnants, suggesting that, as in osteoclasts, cell fusion and multinucleation are required for specialized catabolic functions. We thus reason that WAT MGCs can be viewed as functionally analogous to osteoclasts and refer to them in this article as adipoclasts. We first review current knowledge on adipoclasts and their described functions. In view of recent advances in single cell genomics, we describe WAT macrophages from a ‘fusion perspective’ and speculate on the ontogeny of adipoclasts. Specifically, we highlight the role of CD9 and TREM2, two plasma membrane markers of lipid-associated macrophages in WAT, which have been previously described as regulators of fusion and multinucleation in osteoclasts and MGCs. Finally, we consider whether strategies aiming to target WAT macrophages can be more selectively directed against adipoclasts.

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