scholarly journals A quantitative assessment of body iron status and its relationship with glycemic control in patients of type 2 diabetes mellitus in a tertiary care hospital of Kolkata

2021 ◽  
Vol 12 (5) ◽  
pp. 69-74
Author(s):  
Ananya Saha ◽  
Pradip Mukhopadhyay ◽  
Indrajit Nath ◽  
Arun Kumar ◽  
Utpal Kumar Biswas
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Transferrin Saturation ◽  
The Body ◽  
Diabetic Patients ◽  
Type Ii ◽  
Body Iron ◽  
Iron Stores

Background: Diabetes is one of the most common disease which is observed in every household of Indian population. The longevity of the diabetic patients is dependent upon the frequency of complication and comorbidity that they encounter. Serum iron and ferritin, both being the aggravators to the oxidative stress accelerating the development of complications, gives us the reason to venture into the territory exploring the possibility of monitoring the body iron stores and taking prevent measures to control such complication. The current study was designed with an aim to knot the relationship between body iron stores and glycemic control in patients of type-II diabetes mellitus. Aims and Objectives: To measure the levels of serum ferritin, serum Iron, transferrin saturation and HbA1C and finding out the relationship between body iron stores and glycemic control in patients of Type-II Diabetes Mellitus. Materials and Methods: A total of 50 diagnosed cases of type II DM and 50 healthy controls between the age group of 35-65 years were taken following inclusion and exclusion criteria. Body iron stores were assessed by measuring serum ferritin, Serum iron and Transferrin saturation and Glycemic control was assessed by measuring levels of HbA1C. Results: A significant increase in serum ferritin, serum iron and Transferrin saturation (P<0.001) was noted in diabetic patients as compared to controls. There was a positive correlation between serum iron and transferring saturation in the diabetic patients. Conclusion: The co-morbidities and complications in the Diabetic population can be prevented by monitoring Body iron stores as they can significantly contribute to the oxidative stress leading to the complication and decreased life expectancy. Early detection in the abnormality in the body iron store can help us in employing proper measures for a better management of Type-II diabetic patients and thereby improving their survival.

Serum Ferritin Status of Patients with Type 2 DM Attending OPD of BIRDEM General Hospital

2020 ◽  
Vol 11 (1) ◽  
pp. 7-10
Author(s):  
Khadiza Begum ◽  
Fahmida Islam ◽  
Farjana Aktar ◽  
Murshida Aziz ◽  
Tohfa E Ayub Tahiya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Study Groups ◽  
Acute Phase Reactant ◽  
The Body ◽  
Iron Stores ◽  
Normal Healthy Individual ◽  
Diabetes Patients

Background: In recent times much is talked about of serum ferritin, an acute phase reactant a marker of iron stores in the body and its association with diabetes mellitus. Studies implicate that increased body iron stores and subclinical hemochromatosis has been associated with the development of glucose intolerance, type 2 diabetes and its micro as well as macrovascular complications. Material & Methods: This study was carried out to examine and to observe for any relationship between serum ferritin with Type 2 diabetes mellitus. Our study populations were included 163. Among them 81 type 2 diabetes patients as a case (M=49,F=32, mean 44.68 age in years)and 82 normal healthy individual as a control ( M=35, F=47 , mean 34.71 in years). Results: Majority were healthy outpatients who had come for regular checkup and were matched with controls. Serum ferritin and FBS were estimated and other investigations. Results showed that although Serum ferritin was in the normal range value it was increased in type 2 diabetes patients than in controls and was statistically significant, we did get a positive correlation with duration of diabetes. It can be concluded that there were positive associations between serum ferritin and FBG, age, sex among study groups. Conclusion: In conclusion our study shows that there is significant correlation between increased serum ferritin in diabetes compared to individuals with normal blood sugars in this part and hyper ferritinemia may be one of the causes for development of insulin resistance before overt diabetes. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 7-10

scholarly journals EFFECT OF ORAL AZITHROMYCIN AND METRONIDAZOLE AS AN ADJUNCT TO SCALING AND ROOT PLANING ON GLYCEMIC CONTROL IN TYPE II DIABETIC PATIENTS WITH CHRONIC PERIODONTITIS

2017 ◽  
Vol 10 (3) ◽  
pp. 449
Author(s):  
Dhivya K ◽  
Yogarajan K ◽  
Shanmugarajan T S
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Tertiary Care ◽  
Periodontal Therapy ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Type Ii ◽  
Oral Azithromycin

ABSTRACTObjective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixthcomplication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, thepresent study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the levelof serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical andbiochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Packagefor Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than inpatients who received metronidazole and scaling and root planning alone.Conclusion: Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus.Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However,due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.Keywords: Periodontitis, Azithromycin, Metronidazole, Glycemic control, Diabetes mellitus.

scholarly journals Assessment of serum Ferritin level and its correlation with HbA1c in Diabetic Nephropathy

2020 ◽  
Vol 11 (2) ◽  
pp. 46-51
Author(s):  
Madhura Navule Siddappa ◽  
Kowsalya Ramprasad
Keyword(s):  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Pearson Correlation ◽  
The Body ◽  
Control Group ◽  
Type Ii

Background: Serum ferritin levels reflecting the body iron stores, is known to be elevated in type 2 Diabetes Mellitus. However its association with diabetic complications including Diabetic nephropathy (DN), and overall glycemic control needs to be validated. Aims and Objectives: The aim of this study was to find the Serum Ferritin level abnormalities in DM patients with nephropathy in comparison with DM patients without nephropathy and to find correlation of Serum Ferritin (SF) levels with levels of Glycated Hemoglobin (HbA1c) in patients with diabetic nephropathy. Materials and Methods: This is a retrospective study, which included eighty five registered patients with Type 2 DM (44 Type II DM without nephropathy cases and 41 cases of Type II DM with nephropathy). SF and HbA1c was estimated in all cases across both the groups and were compared with age and sex matched controls and analysed. Results: Serum Ferritin levels were higher in diabetics with nephropathy compared to diabetics without nephropathy (p<0.0001). SF levels were higher in diabetic groups compared to control group (p <0.001).The correlation between HbA1c and SF was assessed among all cases of DM with nephropathy group using pearson correlation test and it showed a significantly positive correlation (r=0.431) with a SF (mean = 938±148) and HbA1c (mean = 9.2±2.02). Conclusion: Serum ferritin levels positively correlate with HbA1c levels in Type II DM cases with nephropathy, which suggests that serum Ferritin levels can be used as a surrogate marker of glycemic control in Type II DM with nephropathy.

Interaction Between Genotypes for HFE and TFR2 Genes Mutations and Iron Status in Brazilian Blood Donors

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5382-5382
Author(s):  
Rodolfo D Cancado ◽  
Paulo CJL Santos ◽  
Samuel Rostelato ◽  
Cristiane T Terada ◽  
Iris Gonzales ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Blood Donors ◽  
Binding Capacity ◽  
Iron Status ◽  
Hereditary Hemochromatosis ◽  
Transferrin Saturation ◽  
The Body ◽  
Hfe Gene ◽  
Automation System

Abstract Hereditary hemochromatosis (HH) is a disorder characterized by increased intestinal iron absorption, which leads to a progressive accumulation of iron in the body. This iron overload has been associated with mutations in HFE gene (C282Y, H63D and S65C) and other genes. The objectives of this study were to assess the frequencies of functional mutations in HFE and TFR2 genes and to investigate their relationship with the iron status in a sample of blood donors. Blood donors (n=542) were recruited at the Hemocenter of the Santa Casa Hospital, Sao Paulo, Brazil. The genotypes for HFE (C282Y, H63D and S65C) TFR2 (Y250X and Q690P) gene mutations were evaluated by PCR-RFLP. The concentrations of serum iron and total iron-binding capacity (TIBC) were measured by automation system Advia®(Bayer Diagnostics) and serum ferritin by Axsym System®(Abbott Laboratories). The frequencies of HFE 282Y, HFE 63D and HFE 65C alleles were 2.1, 13.6 and 0.6%, respectively. The frequency C282Y allele (2.1%) in Brazilian blood donors is lower than that observed in blood donors from Northern Europe (5.1 to 8.2%, P&lt;0.05). The TFR2 250X and TFR2 690P alleles were not found in these subjects. The iron status was similar between HFE genotypes in women. However, men carrying HFE 282CY genotype had higher serum ferritin and lower TIBC concentrations when compared to the HFE 282CC genotype carriers. HFE 282CY genotype was also associated with higher transferrin saturation in men who donated blood at the first time. Moreover, male donors with HFE 63DD plus 63HD genotypes had higher serum iron and transferrin saturation when compared to those with HFE 63HH genotype. A relationship between HFE CY/HH/SS haplotype and lower TIBC concentrations was also found in men. The HFE 282Y and HFE 65C alleles were rare while the HFE 63D was frequent in blood donors. The mutations in TFR2 gene were not found in this study. The HFE 282Y and HFE 63D alleles were associated with alterations on iron status only in male blood donors.

ASSOCIATION OF SERUM FERRITIN WITH GLYCEMIC CONTROLAMONG TYPE 2 DIABETIC PATIENTS

2021 ◽  
pp. 34-36
Author(s):  
Mallam Srikanth Goud ◽  
Sohil Sharda ◽  
Gangurde Bhushan Daulatrao
Keyword(s):  
Glycemic Control ◽  
Serum Ferritin ◽  
Blood Donation ◽  
Tertiary Care ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
Strong Positive Correlation ◽  
Good Glycemic Control ◽  
Positive Correlation ◽  
Iron Stores

Introduction: Serum ferritin is a marker for iron stores and is an acute phase reactant. Its role in pathogenesis of Diabetes is suggested by improvement in insulin sensitivity and insulin secretion with frequent blood donation and decreased iron stores. Objective of the present study is to determine correlation of serum ferritin with glycemic control. Material and Methods: This analytical cross sectional study was conducted at a tertiary care centre of southern India, including 50 diabetic patients with good glycemic control and 50 patients with poor glycemic control. Results: Mean serum ferritin level of diabetics was signicantly lower in diabetics with good glycemic control (119.07±58.99 ng/ml) as compared to those with poor glycemic control (331.11±140.69 ng/ml). Serum ferritin showed strong positive correlation (p <0.001)with the duration of diabetes (r = 0.651) and HbA1C (r = 0.828). Conclusion: Serum ferritin levels were higher in diabetic individuals with poor glycemic control and serum ferrition showed strong positive correlation with glycemic control (HbA1C). Serum ferritin may be used as marker for screening poor glycemic control and patients at high risk of developing complications.

scholarly journals Sensorineural hearing loss and type II diabetes mellitus

2018 ◽  
Vol 4 (2) ◽  
pp. 499
Author(s):  
Kavita Sachdeva ◽  
Saima Azim
Keyword(s):  
Diabetes Mellitus ◽  
Hearing Loss ◽  
Glycemic Control ◽  
Sensorineural Hearing Loss ◽  
Hearing Threshold ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Hearing Level ◽  
Type Ii ◽  
Uncontrolled Diabetes

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">The association between Hearing loss and diabetes, first mentioned by Jardao in 1857, had been under continuous research since then; giving both positive and negative results. This study aims to explore the relationship of hearing loss with type II DM and also to evaluate the impact of glycemic control over degree of hearing loss. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">92 patients with type II DM were enrolled in this study, audiometrically evaluated and compared with equal number of age and sex matched non-diabetic controls. Apart from audiological tests, haematological tests like FBS, PPBS, HbA1c, serum creatinine and cholesterol were carried out to assess glycemic control.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">It was observed that 31 (34%) of the diabetic patients had mild to moderate sensorineural hearing loss, while only 12 (13%) of the control group suffered from the same, which is statistically significant (p&lt;0.05). Among these 31 patients, 19 (61%) patients had uncontrolled diabetes (HbA1c &gt;8.5) and 12 (39%) had higher creatinine levels (&gt;2.5 mg/dl). Higher frequencies (4 and 8 kHz) were found to be affected more, both in case and control groups. Low stapedial reflex thresholds were observed in 14% patients of case group and 5.4% of the controls. Speech discrimination scores were not significantly different. Otoacoustic emission showed outer hair cell dysfunction in 85% cases and 66% controls. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">There is a strong correlation between diabetes mellitus and hearing threshold levels especially at higher frequencies. Long duration and uncontrolled diabetes has more implications over hearing threshold. Since the pattern of hearing loss in diabetes and presbycusis is similar, it may be said that hearing level with ageing is significantly impaired earlier in diabetic patients as compared to general population.</span></p>

scholarly journals Covid- 19 and Diabetes Mellitus; An Overview

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Dr Reshna V
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Care ◽  
The Body ◽  
Diabetic Patients ◽  
Good Glycemic Control ◽  
Best Management ◽  
Increased Risk ◽  
Seriously Ill

Diabetes Mellitus (DM) is a long-term metabolic disorder that affects many organs in the body. Diabetes may be linked to a serious type of Coronavirus Disease in 2019 (COVID-19). COVID-19 will make people with diabetes three times more likely to become seriously ill or die. They discovered that advanced age, obesity, and other medical conditions linked to diabetes are also associated with increased risk. In the countries hardest hit by the pandemic, increased morbidity and mortality from COVID-19 in diabetic patients have been observed, and this link, as well as the best management of infected diabetic patients, deserve further investigation. Antidiabetic medications that can minimise inflammation while maintaining good glycemic control are ideal. Patients admitted to the hospital with extreme COVID-19 can need changes to their diabetes care, such as stopping current medications and starting insulin therapy.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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