scholarly journals The effects of weight loss intervention program on serum leptin level, histological and molecular alterations of adipose tissue in rat model with obesity.

2020 ◽  
Vol 16 (1) ◽  
pp. 101-108
Author(s):  
Nearmeen M. Rashad ◽  
Sally E. Sayed ◽  
Mohamed H. Sherif ◽  
Mahmoud Z. Sitohy
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Rat Model ◽  
Intervention Program ◽  
Weight Loss Intervention ◽  
Serum Leptin ◽  
Molecular Alterations

Brown adipose tissue activation in a rat model of Parkinson’s disease

2017 ◽  
Vol 313 (6) ◽  
pp. E731-E736 ◽  
Author(s):  
Wenjuan Wang ◽  
Xiangzhi Meng ◽  
Chun Yang ◽  
Dongliang Fang ◽  
Xuemeng Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Energy Intake ◽  
Rat Model ◽  
Sympathetic Denervation ◽  
Brown Adipose

Loss of body weight and fat mass is one of the nonmotor symptoms of Parkinson’s disease (PD). Weight loss is due primarily to reduced energy intake and increased energy expenditure. Whereas inadequate energy intake in PD patients is caused mainly by appetite loss and impaired gastrointestinal absorption, the underlying mechanisms for increased energy expenditure remain largely unknown. Brown adipose tissue (BAT), a key thermogenic tissue in humans and other mammals, plays an important role in thermoregulation and energy metabolism; however, it has not been tested whether BAT is involved in the negative energy balance in PD. Here, using the 6-hydroxydopamine (6-OHDA) rat model of PD, we found that the activity of sympathetic nerve (SN), the expression of Ucp1 in BAT, and thermogenesis were increased in PD rats. BAT sympathetic denervation blocked sympathetic activity and decreased UCP1 expression in BAT and attenuated the loss of body weight in PD rats. Interestingly, sympathetic denervation of BAT was associated with decreased sympathetic tone and lipolysis in retroperitoneal and epididymal white adipose tissue. Our data suggeste that BAT-mediated thermogenesis may contribute to weight loss in PD.

scholarly journals Effects of a community-based weight loss intervention on adipose tissue circulating factors

2014 ◽  
Vol 8 (4) ◽  
pp. 205-211 ◽  
Author(s):  
Gary D. Miller ◽  
Scott Isom ◽  
Timothy M. Morgan ◽  
Mara Z. Vitolins ◽  
Caroline Blackwell ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Weight Loss Intervention ◽  
Community Based

scholarly journals Weight loss and brown adipose tissue reduction in rat model of sleep apnea

2008 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
Denis Martinez ◽  
Luiz FT Vasconcellos ◽  
Patricia G de Oliveira ◽  
Signorá P Konrad
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Sleep Apnea ◽  
Brown Adipose Tissue ◽  
Rat Model ◽  
Brown Adipose ◽  
Tissue Reduction

Epigenetic Changes in the Methylation Patterns of KCNQ1 and WT1 after a Weight Loss Intervention Program in Obese Stroke Patients

2015 ◽  
Vol 12 (4) ◽  
pp. 321-333 ◽  
Author(s):  
Itziar Abete ◽  
Ana M. Gomez-Uriz ◽  
Maria Mansego ◽  
Ana Arce ◽  
Estibaliz Goyenechea ◽  
...  
Keyword(s):  
Weight Loss ◽  
Intervention Program ◽  
Epigenetic Changes ◽  
Weight Loss Intervention ◽  
Stroke Patients ◽  
Methylation Patterns

Dietary Restriction and Weight Loss Improves the Outcome of Acute Lymphoblastic Leukemia in Diet-Induced Obesity

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3570-3570
Author(s):  
Waseem Alhushki ◽  
Steven Mittelman ◽  
Xia Sheng ◽  
Ehsan Ehsanipour
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Acute Lymphoblastic Leukemia ◽  
Dietary Intervention ◽  
Lymphoblastic Leukemia ◽  
Subcutaneous Fat ◽  
Leukemia Cells ◽  
Weight Loss Intervention ◽  
Obese Mice ◽  
Tissue Explants

Abstract Abstract 3570 Background: Obesity increases the mortality of numerous types of cancer. Furthermore, children over 10 years of age who are obese at diagnosis of acute lymphoblastic leukemia (ALL) have twice the risk of relapse. We have found that obese mice transplanted with leukemia are more likely to relapse after treatment with chemotherapy. We further found that adipose tissue can protect ALL cells from chemotherapy in culture. But it is unclear whether a weight loss intervention after leukemia diagnosis will improve outcome. Hypothesis: A weight loss intervention by dietary modification in diet induced obese mice will decrease the ability of their adipose tissue explants to protect ALL cells from chemotherapy. Methods: Diet-induced obese C57Bl/6 mice (n=7) were switched to a low-fat diet either 3 or 21 days prior to sacrifice at 20 weeks of age. Adipose tissue explants (100 ± 5 mg) from perirenal, visceral, and subcutaneous sites were collected and used in transwell co-cultures with 250 X103 8093 murine pre-B ALL cells. Explants from non-dieted obese mice and lean mice were used as controls. Viable ALL cells were quantified using trypan blue exclusion after a 3-day exposure to 15 nM daunorubicin or 5 nM of vincristine. Results: Dietary intervention significantly reduced body weights in the short (39.2 ± 2.4 grams; P= 0.014) and long (32 ± 2.9 grams; P=0.041) diet groups compared to obese mice (44.5 grams ± 2.6). Leukemia cells were partially protected from daunorubicin by both visceral (21.5±15.7×103 viable cells, p=0.01) and perirenal (28.0±20.7×103, p=0.013) fat explants from obese mice, compared to cultures without adipose tissue (9.4±8.6×103). Fat explants from mice dieted for 3 days prior to collection showed similar protection of ALL cells from daunorubicin (not shown); however, fat explants from mice dieted for 21 days did not protect ALL cells from daunorubicin (visceral: 9.4±8.0×103, p=0.009; perirenal: 7.8±6.3×103, p=0.066 vs. obese). Similar findings were obtained with vincristine. Leukemia cells were protected from vincristine significantly by visceral fat from obese mice (50.8±5.9×103, p=0.01) and marginally by perirenal and subcutaneous fat (93.8±139.1×103, p=0.06 and 113.4±143.7×103, p=0.07 respectively) compared to cultures without adipose tissue (12.4±11.7×103). While short dieting did not restore sensitivity to vincristine, long dieting of obese mice reduced explants leukemia protection to vincristine significantly in visceral (21.8±20.2×103, p=0.004) and marginally in perirenal (34.9±43.3×103, p=0.06) explants compared to the obese group. Conclusions: Dietary intervention and weight loss in diet induced obese mice decreases the ability of adipose tissue ex vivo to protect ALL cells from daunorubicin and vincristine. These results could support a potential role for dietary intervention in improving leukemia outcome in obese patients. Disclosures: No relevant conflicts of interest to declare.

scholarly journals A Weight-Loss Intervention Program Designed for Mexican–American Women: Cultural Adaptations and Results

2012 ◽  
Vol 14 (6) ◽  
pp. 1030-1039 ◽  
Author(s):  
Nangel M. Lindberg ◽  
Victor J. Stevens ◽  
Sonia Vega-López ◽  
Tia L. Kauffman ◽  
Mariana Rosales Calderón ◽  
...  
Keyword(s):  
Weight Loss ◽  
Mexican American ◽  
Intervention Program ◽  
Weight Loss Intervention ◽  
Mexican American Women ◽  
Cultural Adaptations ◽  
American Women

scholarly journals How does adipose tissue fat content change after a weight loss intervention?

2021 ◽  
Vol 10 (1) ◽  
pp. 2-4
Author(s):  
Takashi Abe ◽  
Robert S. Thiebaud ◽  
Jeremy P. Loenneke
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Fat Content ◽  
Weight Loss Intervention ◽  
Content Change
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