scholarly journals The relationship between deficiency of some trace elements, oxidative stress, immunoglobulin E and vitamin A in sheep affected with skin diseases

2020 ◽  
Vol 38 (2) ◽  
pp. 10-16
Author(s):  
Mahmoud Helal
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Vitamin A ◽  
Skin Diseases ◽  
Immunoglobulin E ◽  
The Relationship

Investigation of Some Trace Element Levels in Multiple Sclerosis

2021 ◽  
pp. 1-4
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Blood Samples ◽  
Plasma Iron ◽  
Beneficial Effects ◽  
Iron And Zinc ◽  
Trace Element Levels ◽  
Zinc Levels ◽  
The Relationship ◽  
Homeostatic State

Purpose: In this study, it was aimed to investigate the relationship between MS and the homeostatic state of trace elements, and to reveal the relationship between Fe and Zn in MS pathology Material and Method: Total of 40 (20 patients and 20 control) subjects were participated to this study. Blood samples were taken and analysed plasma iron and zinc levels using an atomic Absorption Spectrophotometer. Kolmogrow-Smirnov Z test used to analyse statistically significance of the data. P<0.05 was accepted as significant. Results: The plasma iron and Zn levels were found to be significantly lower in MS patients compared to control. Conclusion: Considering the important beneficial effects of iron and zinc against neurodegenerative disease and increased oxidative stress, reduced level of these trace elements should be considered in MS treatment.

scholarly journals Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 697
Author(s):  
Oriana Simonetti ◽  
Tiziana Bacchetti ◽  
Gianna Ferretti ◽  
Elisa Molinelli ◽  
Giulio Rizzetto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Lipid Hydroperoxides ◽  
Polymorphonuclear Cells ◽  
Inflammatory Skin Diseases ◽  
Total Antioxidant ◽  
Inflammatory Skin ◽  
Total Antioxidant Potential ◽  
The Relationship

Background: previous studies reported the involvement of reactive oxygen species (ROS) and lipid peroxidation in the pathogenesis of inflammatory skin diseases. The aim of our study was to investigate the relationship between oxidative stress and inflammation in children affected by atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. Methods: levels of lipid hydroperoxides, total antioxidant capacity, and activities of the enzymes myeloperoxidase (MPO), PON1, and PON2/3 were investigated in 56 atopic pediatric patients, and compared with 48 sex-/age-matched healthy controls. Results: significantly higher levels of lipid hydroperoxides and lower values of total antioxidant potential were observed in the serum of AD children compared to that of the controls. Significant lower PON1 activities, and a significant increase in levels of MPO were observed in serum of patients, with a higher serum MPO level/PON1 paraoxonase activity ratio in patients compared to that in the controls. Significantly lower lactonase activity of PON enzymes was observed in polymorphonuclear cells isolated from AD patients. Statistically negative correlation was established between the activity of intracellular PON2/3 activity and ROS levels. Conclusions: our data confirmed that AD is associated with higher oxidative damage and a decrease in antioxidant defense. Moreover, alterations of extracellular and intracellular PON activity can promote lipoprotein dysfunction in AD patients.

scholarly journals Effects of Chronic Kidney Disease on levels of Oxidative Stress and Trace Elements

2021 ◽  
Author(s):  
Xiaojing Zhu ◽  
Yuan Zhang ◽  
Jin Han ◽  
Dan Xiao ◽  
Dan Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Obvious Effect ◽  
The Relationship ◽  
Group Serum ◽  
Lower Expression

Abstract Introduction: The relationship between trace elements and OS in CKD patients is still not completely elucidated. The aim of this work is to determine the serum levels of OS and the trace elements in CKD patients.Methods: A total of 91 patients were enrolled and then divided into 3 groups at the basis of CKD stages. Healthy volunteers were included as a control group. Serum levels of SOD, MDA, Zn, Cu, Ca, Fe, and Mg were determined , and the correlation among these datas were analyzed.Results: The MDA level in the patients’ sera was significantly higher than the controls’ (P<0.05); however, their sera level of SOD was obviously lower (P<0.05). Meanwhile, the creatinine level in CKD patients’ sera was positively correlated with the MDA level (r = 0.534, P<0.01), while negatively with the expression of SOD (r = -0.427, P < 0.01). A lower expression of Zn and Ca values could be seen in the cases’ sera (P<0.05). Besides that, it showed a significant negative correlation between serum levels of MDA and Ca (r=-0.282, P<0.01), MDA and Zn (r=-0.358, P<0.01), while a positive correlation between MDA and Cu (r = 0.236, P=0.022). Adversely, the expression of SOD in the sera of cases was positively related to the levels of Ca (r=0.273, P<0.01) and Zn (r=0.277, P<0.01).Conclusion: Abnormalities of OS and Zn、Ca existed in CKD patients; and elevated OS may play a role in the trace elements imbalance. Dialysis seems to have no obvious effect on plasma trace elements.

The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia

2014 ◽  
Vol 42 (4) ◽  
pp. 329-335 ◽  
Author(s):  
R. da Silva ◽  
E.C. dos Santos-Valente ◽  
F. Burim Scomparini ◽  
R.O. Saccardo Sarni ◽  
B.T. Costa-Carvalho
Keyword(s):  
Oxidative Stress ◽  
Vitamin A ◽  
Nutritional Status ◽  
Ataxia Telangiectasia ◽  
Zinc Levels ◽  
The Relationship ◽  
And Oxidative Stress

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Eleni Koukoulioti ◽  
Ioannis Papoutsis ◽  
Sotirios Athanaselis ◽  
Gerasimos Tsourouflis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Gestational Diabetes ◽  
Oxidative Stress Marker ◽  
Stress Marker

The importance and significance of gene polymorphisms in preeclampsia

2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Early Diagnosis ◽  
Gene Polymorphisms ◽  
Individual Risk ◽  
Extended Study ◽  
Stress Genes ◽  
Detoxification System ◽  
The Individual ◽  
The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

The Relationship between the Blood Plasma Vitamin A Levels of Sows and of their Suckling Pigs

1956 ◽  
Vol 15 (2) ◽  
pp. 400-406
Author(s):  
I. R. Sibbald ◽  
J. P. Bowland ◽  
R. T. Berg
Keyword(s):  
Vitamin A ◽  
Blood Plasma ◽  
Plasma Vitamin ◽  
The Relationship

Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia

2019 ◽  
Vol 70 (8) ◽  
pp. 2822-2825 ◽  
Author(s):  
Cornel Moisa ◽  
Mihnea Alexandru Gaman ◽  
Camelia Cristina Diaconu ◽  
Amelia Maria Gaman
Keyword(s):  
Oxidative Stress ◽  
Essential Thrombocythemia ◽  
Myeloproliferative Neoplasm ◽  
Oxygen Species ◽  
Mutational Status ◽  
Increased Risk ◽  
Stress Levels ◽  
Total Antioxidant ◽  
Thrombotic Complications ◽  
The Relationship

Essential thrombocythemia (ET) is a BCR-ABL1-negative myeloproliferative neoplasm associated with thrombotic and haemorrhagic complications. Reactive oxygen species (ROS) overexpression induces a growth advantage to JAK2V617F-positive clones and, in association with a higher number of immature platelets, leukocytosis, and additional cardiovascular risk factors, leads to an increased risk for thrombotic events. We evaluated oxidative stress by measuring ROS levels and the total antioxidant capacity (TAC) in 62 ET patients and investigated the relationship between oxidative stress, JAK2V617F mutational status and the development of thrombotic events. We found higher oxidative stress levels in JAK2V617F-positive vs. JAK2V617F-negative ET cases with no significant differences between homozygous and heterozygous genotypes. Increased ROS levels and thrombotic events were more frequent in ET patients with old age at diagnosis, higher haematocrit levels or leukocytosis.

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

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