Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes

Abstract Objectives To compare high sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables. Methods We conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity. We recorded anthropometric parameters and studied variables related to diabetes, blood pressure, lipid profile, and HbA1c. HsCRP was measured by ELISA.Results We included 49 children with type 1 diabetes, 46 controls, and 40 children with obesity. hsCRP levels were significantly higher in the group with type 1 diabetes compared to controls and nearly significantly lower than in the group comprising children with obesity. We found no correlation between hsCRP and HbA1C and characteristics of type 1 diabetes with the exception of albuminin creatinine ratio (ACR). Statistically significant association was found between hsCRP and BMI and waist circumference Z-score. Conclusions Children with type 1 diabetes have a higher hsCRP than healthy subjects; this difference is not associated with HbA1c, but is related to waist circumference, BMI, and ACR. Obesity prevention should be a priority when performing follow-up in children with type 1 diabetes.

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Carotid Duplex Study in Correlation with High Sensitivity C-Reactive Protein and Lipid Profile in Children with Type-1 Diabetes Mellitus

Journal of Clinical & Experimental Cardiology ◽

10.4172/2155-9880.1000602 ◽

2018 ◽

Vol 09 (08) ◽

Author(s):

Ashraf Mohamed Abdelfadil ◽

Mohamed Aboul fotouh Mourad ◽

Lamia Hamdy Ali

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Lipid Profile ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Carotid Duplex

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Non-HDL-cholesterol and C-reactive protein in children and adolescents with type 1 diabetes

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0307 ◽

2017 ◽

Vol 30 (3) ◽

Cited By ~ 3

Author(s):

María Mercedes Prado ◽

Teresita Carrizo ◽

Adela Victoria Abregú ◽

Tomás Meroño

Keyword(s):

Risk Factors ◽

Type 1 Diabetes ◽

Cardiovascular Risk ◽

Subgroup Analysis ◽

Hdl Cholesterol ◽

High Sensitivity ◽

C Reactive Protein ◽

Endocrine Diseases ◽

Reactive Protein

AbstractBackground:To what extent high sensitivity C-reactive protein (hsCRP) is associated with known cardiovascular risk factors in children with type 1 diabetes (T1D) has not been fully explored.Methods:Forty-two T1D children (age: 12+/−1 years) without hypertension, retinopathy, hypothyroidism, albuminuria or other endocrine diseases and 20 controls were studied. Out of the 42 T1D patients studied 57% were prepubertal or early pubertal (Tanner I/II), 38% were pubertal (Tanner III/IV) and 5% post-pubertal (Tanner V).Results:Children with T1D showed higher hsCRP than controls [0.51 (0.31–1.71 vs. 0.20 (0.20–0.90) mg/L, p<0.05]. However, hsCRP levels were not different in subgroup analysis [hemoglobin AConclusions:Non-HDL-cholesterol might be more useful than hsCRP to evaluate future cardiovascular risk in children with T1D.

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Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-001424 ◽

2020 ◽

Vol 8 (1) ◽

pp. e001424

Author(s):

Pilar Pérez-Segura ◽

Olaya de Dios ◽

Leticia Herrero ◽

Claudia Vales-Villamarín ◽

Isabel Aragón-Gómez ◽

...

Keyword(s):

Type 1 Diabetes ◽

Waist Circumference ◽

High Sensitivity ◽

Control Group ◽

C Reactive Protein ◽

Anthropometric Parameters ◽

Reactive Protein ◽

Inflammatory State ◽

Design And Methods

IntroductionOur objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables.Research design and methodsWe conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity. We recorded anthropometric parameters and studied variables related to diabetes, blood pressure, lipid profile, and HbA1c. hsCRP was measured by ELISA.ResultsWe included 49 children with type 1 diabetes, 46 controls, and 40 children with obesity. hsCRP levels were significantly higher in the group with type 1 diabetes compared with controls and nearly significantly lower than in the group comprising children with obesity. We found no correlation between hsCRP and HbA1c and characteristics of type 1 diabetes with the exception of albumin to creatinine ratio. Statistically significant association was found between hsCRP and body mass index (BMI) and waist circumference Z-score.ConclusionsThe higher hsCRP levels observed in children with type 1 diabetes compared with a control group with a similar BMI suggest a basal inflammatory state that could increase cardiovascular risk. The main factors related to hsCRP are BMI and waist circumference, so obesity prevention should be a priority when performing follow-up in children with type 1 diabetes.

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Plasma high sensitivity C-reactive protein and its relationship with cytokine levels in children with newly diagnosed type 1 diabetes and ketoacidosis

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2012.05.003 ◽

2012 ◽

Vol 45 (16-17) ◽

pp. 1383-1388 ◽

Cited By ~ 16

Author(s):

Kyriaki Karavanaki ◽

Kostas Kakleas ◽

Soultana Georga ◽

Αnastasia Bartzeliotou ◽

George Mavropoulos ◽

...

Keyword(s):

Type 1 Diabetes ◽

High Sensitivity ◽

Newly Diagnosed ◽

C Reactive Protein ◽

Reactive Protein ◽

Cytokine Levels

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High Sensitivity C-reactive Protein Concentrations, Lipid Status And Duration Of Type-1 Diabetes

10.21203/rs.3.rs-15946/v1 ◽

2020 ◽

Author(s):

HAUWA BAKO ◽

Salisu Babura Mu'azu ◽

Alkali Mohammed ◽

Muhammmad Yalwa Gwarzo ◽

Ibrahim Danjummai Gezawa ◽

...

Keyword(s):

Type 1 Diabetes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Lipoprotein Cholesterol ◽

C Reactive Protein ◽

Reactive Protein ◽

Lipid Status ◽

Hs Crp

Abstract Background: Low-grade inflammation, duration of diabetes, hyperglycemia, and dyslipidemia in the presence of other traditional risk factors have been implicated in the development of vascular, neurologic, musculoskeletal and dermatologic complications observed in type 1 diabetes irrespective of other confounding factors. The study was aimed at assessing the relationship between hs-CRP concentrations, lipid status and duration of type-1 diabetes.Methods: Thirty-four patients aged 15-26 years comprising 14 females and 20 males diagnosed with type 1 diabetes ≤10 years duration, who at first clinical assessment and thorough medical examination presented with any or a combination of the symptoms of ketoacidosis, polyuria, polydipsia, malnutrition, blurred vision, paresthesia, body swelling and frothy urine at the Accident and Emergency Unit of Rasheed Shekoni Specialist Hospital, Jigawa Nigeria were enrolled for the study in a cross-sectional pattern after granting informed consent or obtaining assent from parents or guardians. Blood samples for lipid profile, fasting plasma glucose (FPG) and High sensitivity C - reactive protein (hs-CRP) measurement were collected from all patients through venipuncture after 10 hours overnight fast for biochemical testing. Lipid profile and FPG were assayed using enzymatic methods, hs- CRP via Enzyme Linked immunosorbent Assay (ELISA) technique and Urinalysis with point of care urine test strips. Data obtained was analyzed and presented as Frequency, Percentages, Mean ± SD and Pearson’s correlation with statistical significance at p≤0.05.Results: Patients biochemical characteristics were Fasting Plasma Glucose (9.86 ± 4.44), Total Cholesterol (4.77 ± 2.07), High Density Lipoprotein- Cholesterol (1.35±0.54), Triglycerides (2.17 ± 1.06), Low Density Lipoprotein- Cholesterol (2.29 ±1.49), hs-CRP (6.99 ± 5.44). Correlation matrix showed significant relationship between Triglycerides and hs-CRP (r; 0.378**, p; 0.005), Low Density Lipoprotein-Cholesterol and hs-CRP (r; 0.457*, p; 0.007). hs- CRP concentrations in relation to duration of type-1 diabetes were 1-3 years (3.57±4.10), 3-6 years (6.66±4.39) and 6-10 years (10.06±8.69).Conclusions: Evaluation of hs-CRP concentrations irrespective of lipid status may serve as an inexpensive method of predicting the risk of development of diabetic complications in resource poor settings among patients with established type 1 diabetes as the duration progresses.

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