scholarly journals Interleukin 17 Expression in Psoriatic Skin Lesions before and after Treatment with Platelet Rich Plasma (PrP)

2018 ◽  
Vol 86 (6) ◽  
pp. 1447-1456
Author(s):  
ENAS S. MOHAMMED, M.Sc.; MONA A. ATWA, M.D. ◽  
SAHAR F. MANSOUR, M.D.; NADER A. ISMAIL, M.D.
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Interleukin 17 ◽  
Before And After

scholarly journals PSORIASIS IN HIV-INFECTED PATIENTS: CLINICAL AND LABORATORY EVALUATION, APPROACHES TO THERAPY

2017 ◽  
Vol 20 (4) ◽  
pp. 227-231
Author(s):  
Evgeny Yu. Evdokimov ◽  
A. V Sundukov
Keyword(s):  
Practical Interest ◽  
Skin Lesions ◽  
Laboratory Evaluation ◽  
Psoriatic Skin ◽  
Inflammatory Reactions ◽  
Treatment Regimens ◽  
Before And After ◽  
Index Of Severity ◽  
Evaluation Approaches

Clinical and laboratory evaluation of the effectiveness of therapy of psoriasis vulgaris in 78 HIV-infected patients using the two treatment regimens is presented. Peculiarities of clinical course of psoriasis depending on the number of CD4+lymphocytes in the peripheral blood are shown. Histological and histochemical studies of biopsy samples from psoriatic skin lesions and apparently healthy skin in 15 people were performed. The dynamics before and after treatment of CD4+ and CD8+ lymphocytes in biopsies of skin and blood, their relationship with the index of severity of psoriasis (PASI) are presented. This study is of theoretical and practical interest in understanding the value and role of CD4+ and CD8+ lymphocytes in the formation of inflammatory reactions in the skin of patients with psoriasis as a possible option for treatment of psoriasis in HIV-infected patients.

Cyclin D1, B and A expression and cell turnover in psoriatic skin lesions before and after cyclosporin treatment

2000 ◽  
Vol 143 (5) ◽  
pp. 950-956 ◽  
Author(s):  
C. Miracco ◽  
M. Pellegrino ◽  
M.L. Flori ◽  
R. Vatti ◽  
M. Materno ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Cell Turnover ◽  
Cyclosporin Treatment ◽  
Before And After

scholarly journals Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Christian Loesche ◽  
Frank Kolbinger ◽  
Marie-Anne Valentin ◽  
Philip Jarvis ◽  
Melanie Ceci ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Immunohistochemical Analysis ◽  
Neutrophil Infiltration ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Tape Stripping ◽  
Neutrophil Accumulation ◽  
Interleukin 17A ◽  
Before And After ◽  
Invasive Method

Psoriasis is a well characterized interleukin (IL)-17A-driven skin disease with neutrophil infiltration and epidermal hyperkeratosis. Several biomarkers, most prominently β-defensin-2 (BD-2), have been identified using local and systemic invasive measurements as responsive markers of IL-17A-driven skin pathology. We sought to determine whether measurements of epidermal proteins by tape stripping could offer a minimally-invasive method to assess treatment responses. We compared the expression of 170 proteins in the epidermis (tape stripping) and dermis (open flow microperfusion) of 8 psoriatic subjects before and after administration of a single dose of subcutaneous (s.c.) antiIL-17A mAb secukinumab. Proteomic analyses of tape strips revealed a >3-fold decrease in 32 epidermal and inflammatory cell proteins in response to secukinumab. The epidermal proteins with the largest (>10-fold) decreases were: matrix metalloproteinase-8 (MMP-8, 15.68-fold, p<0.05); myeloperoxidase (MPO, 14.72-fold, p<0.005); IL-8 (11.93-fold, p<0.05); MMP-9 (10.81-fold, p<0.005); and IL-1β (10.35-fold, p<0.05). For these proteins, greater-fold protein changes were detected in the epidermis compared to dermis. Immunohistochemical analysis confirmed that neutrophils are the predominant cell type in psoriatic skin lesions that express MPO, MMP-8 and MMP-9, and that secukinumab treatment dramatically decreases neutrophil accumulation. Thus, tape stripping may be used to assess epidermal neutrophils, and protein biomarker responses to anti-IL-17A therapy in psoriasis.

TNFα and its Receptors in Psoriatic Skin, before and after Treatment with Etanercept

2009 ◽  
Vol 22 (4) ◽  
pp. 961-966 ◽  
Author(s):  
G. Caldarola ◽  
C. De Simone ◽  
A. Carbone ◽  
A. Tulli ◽  
P. Amerio ◽  
...  
Keyword(s):  
Psoriatic Skin ◽  
Before And After

Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

2009 ◽  
Vol 160 (2) ◽  
pp. 319-324 ◽  
Author(s):  
C. Johansen ◽  
P.A. Usher ◽  
R.B. Kjellerup ◽  
D. Lundsgaard ◽  
L. Iversen ◽  
...  
Keyword(s):  
Psoriatic Skin ◽  
Interleukin 17 ◽  
Lesional Psoriatic Skin

Split face comparative study of microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Abd Elnaeem Sallam ◽  
Khaled El Zawahry ◽  
Abdul Rahman Muhammed Ali Mustafa
Keyword(s):  
Carbon Dioxide ◽  
Co2 Laser ◽  
Carbon Dioxide Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Significant Difference ◽  
Before And After ◽  
The Face ◽  
Fractional Carbon Dioxide Laser

Abstract Background Acne scars, is a challenge for dermatologists, despite having multiple treatment modalities like microneedling, dermabrasion, Fractional CO2 Laser, dermal fillers, etc. However, monotherapy has been hardly satisfactory because of the polymorphism seen with the scars. Objective Comparison between microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars. Patients and methods This study was carried out in department of dermatology, venereology and andrology, in Kobry El-Kobba Military complex during the period (from September 2018 to July 2020 ) on 20 patients of both sexes aged from 20 to 60 years old presenting with Goodman and Baron Grade II, III, IV acne scars . Results The study revealed a statistically significant difference (p = 0.017) between Goodman and Baron scar grades on the right side of the face before and after treatment indicating that microneedling with platelet rich plasma was effective in improving acne scars. Also, there is a statistically significant difference (p = 0.010) between Goodman and Baron scar grades on the left side of the face before and after treatment, indicating that fractional CO2 laser with platelet rich plasma was effective in improving acne scars. Conclusion and recommendation Further controlled and randomized studies are needed to validate our findings in a larger cohort of patients and longer follow up. Also, number of sessions might be more than 3 sessions.

Histologic evidence that mast cells contribute to local tissue inflammation in peripheral spondyloarthritis by regulating interleukin-17A content

Rheumatology ◽  
2018 ◽  
Vol 58 (4) ◽  
pp. 617-627 ◽  
Author(s):  
Sijia Chen ◽  
Troy Noordenbos ◽  
Iris Blijdorp ◽  
Leonieke van Mens ◽  
Carmen A Ambarus ◽  
...  
Keyword(s):  
Mast Cells ◽  
Synovial Tissue ◽  
In Vitro Study ◽  
Allergic Diseases ◽  
Psoriatic Skin ◽  
Tissue Inflammation ◽  
Interleukin 17A ◽  
Before And After ◽  
Peripheral Spondyloarthritis

Abstract Objectives Synovial mast cells contain IL-17A, a key driver of tissue inflammation in SpA. A recent in vitro study showed that tissue-derived mast cells can capture and release exogenous IL-17A. The present study aimed to investigate if this mechanism could contribute to tissue inflammation in SpA. Methods Potential activation of mast cells by IL-17A was assessed by gene expression analysis of the Laboratory of Allergic Diseases 2 (LAD2) mast cell line. The presence of IL-17A-positive mast cells was assessed by immunohistochemistry in synovial tissue obtained before and after secukinumab treatment, as well as in skin and gut tissues from SpA-related conditions. Results IL-17A did not induce a pro-inflammatory response in human LAD2 mast cells according to the canonical IL-17A signalling pathway. In SpA synovial tissue, the percentage of IL-17A-positive mast cells increased upon treatment with secukinumab. IL-17A-positive mast cells were also readily detectable in non-inflamed barrier tissues such as skin and gut. In non-inflamed dermis and gut submucosa, IL-17A-positive mast cells are the most prevalent IL-17A-positive cells in situ. Compared with non-inflamed tissues, both total mast cells and IL-17A-positive mast cells were increased in psoriatic skin dermis and in submucosa from inflammatory bowel disease gut. In contrast, the proportion of IL-17A-positive mast cells was strikingly lower in the inflamed compared with non-inflamed gut lamina propria. Conclusion IL-17A-positive mast cells are present across SpA target tissues and correlate inversely with inflammation, indicating that their IL-17A content can be regulated. Tissue-resident mast cells may act as IL-17A-loaded sentinel cells, which release IL-17A to amplify tissue inflammation.

scholarly journals El efecto de la terapia acuática en el plasma y la interleucina-12 y 17 en pacientes con esclerosis múltiple

2019 ◽  
Vol 8 (1) ◽  
pp. 89-94
Author(s):  
S. Nejatpour ◽  
M. Fathei ◽  
A. Yaghoubi
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Group ◽  
Interleukin 12 ◽  
Interleukin 17 ◽  
Esclerosis Múltiple ◽  
Intervention Protocol ◽  
Before And After ◽  
Post Test ◽  
Factores De Riesgo ◽  
And Control

Las citocinas como la interleucina-12 (IL-12) y la interleucina-17 (IL-17) influyen en la función del sistema inmune y los diferentes tejidos, siendo estudiadas debido al papel que desempeñan en la Esclerosis Múltiple (EM). El objetivo de este estudio fue investigar el efecto de la terapia acuática en la IL-12 y la IL-17 en pacientes con esclerosis múltiple. Participaron 25 hombres con esclerosis múltiple, los cuales fueron divididos en dos grupos: ejercicio y control. Se tomó una muestra de sangre antes y después de la intervención. El grupo de ejercicio llevó a cabo tres sesiones por semana durante ocho semanas. Las partes inicial y final de cada sesión incluyeron calentamiento y vuelta a la calma, llevadas a cabo en zonas poco profundas. Las actividades fueron diseñadas y llevadas a cabo por un investigador bajo la supervisión de un fisiólogo deportivo y un neurólogo experimentado. Durante las sesiones de entrenamiento, se dedicaban los primeros 10 minutos al calentamiento y los últimos 5 minutos a la vuelta a la calma. La intensidad del ejercicio fue aproximadamente del 75% de la frecuencia cardíaca máxima. Los datos demostraron que tanto IL-12 como IL-17 disminuyeron significativamente entre el pre-test y el post-test. Por tanto, se concluye que la terapia acuática puede reducir los factores de riesgo con respecto a la esclerosis múltiple, incluidas la IL-12 y la IL-17. Cytokines such as Interleukin 12 (IL-12) and Interleukin 17(IL-17) influence the function of the immune system and different tissues and are studied due to the role they play in Multiple Sclerosis (MS). The aim of the study was to investigate the effect of aqua-therapy on plasma IL-12 and IL-17 in patients with MS. 25 men with MS were divided into two groups: exercise and control. Blood sample was taken before and after the intervention protocol. The exercise group carried out three exercise sessions per week during eight weeks. The beginning and final parts of each session included warming up and cool down, and were carried out in shallow areas. These activities were designed and implemented by a researcher under the supervision of a sports physiologist and an experienced neurologist. During the training sessions, the first 10 minutes were for warming up, and the last 5 minutes of training were for cool down. Exercise intensity was approximately 75% of heart rate reserve. The data demonstrated that both IL-12 and IL-17 decreased significantly from pre-test to post-test in the exercise group. We conclude that aqua-training may reduce risk factors regarding multiple sclerosis, including IL-12 and IL-17.

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