scholarly journals Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus

2016 ◽  
pp. 1-6 ◽  
Author(s):  
Melahat Yıldırım ◽  
Esengül Türkyılmaz ◽  
Büşra Demir Cendek ◽  
Gülcan Dauletkazin ◽  
Murta Alışık ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Interchange Reactions

scholarly journals Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ting Chen ◽  
Yufeng Qin ◽  
Minjian Chen ◽  
Yuqing Zhang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Alpha Diversity ◽  
16S Rrna Gene Sequencing ◽  
Maternal Serum ◽  
Rrna Gene ◽  
Child Study ◽  
Mother And Child

Abstract Background Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood. Methods Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE. Results Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicutes and Proteobacteria changed significantly in neonates of GDM mothers. Metabolomic analysis of meconium showed that metabolic pathways including taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis were altered in GDM subjects. Several changed metabolites varying by the similar trend across the maternal serum and neonatal meconium were observed. Conclusion Altogether, these findings suggest that GDM could alter the serum metabolome and is associated with the neonatal meconium microbiota and metabolome, highlighting the importance of maternal factors on early-life metabolism.

scholarly journals Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

2019 ◽  
pp. 1 ◽  
Author(s):  
Emine Arslan ◽  
Umit Gorkem ◽  
Cihan Togrul
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Control Groups ◽  
Diabetes Mellitus Status ◽  
And Control

<p><strong>Objective:</strong> To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status.</p><p><strong>Study Design:</strong> A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment-insulin resistance were assessed.</p><p><strong>Results:</strong> In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p&lt;0.001).</p><p><strong>Conclusion:</strong> No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.</p>

scholarly journals Association of Serum Vitamin D Status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

2021 ◽  
Author(s):  
Caihong Luo ◽  
Zhiju Li ◽  
Yunya Lu ◽  
Fang Wei ◽  
Dongmei Suo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Alkaline Phosphatase ◽  
Maternal Serum ◽  
Thrombin Time ◽  
Laboratory Parameters

Abstract Background: Pregnant women develop certain metabolic alterations and substantial nutrient insufficiency, which may impact fetus development. Reports on the association of serum 25-hydroxy vitamin D (25(OH)D, VD) status with gestational diabetes mellitus (GDM) is still controversial. This study aimed to investigate the association of serum VD status with GDM and other laboratory parameters in early pregnant women.Methods: A total of 1516 pregnant women were enrolled in this study. Maternal serum VD and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. Serum VD level was subsequently correlated with blood glucose and other laboratory parameters.Results: The average VD concentration was 59.12 ± 12.5 nmol/L. None of the study subjects had VD <25 nmol/L; 434 (28.6%) women had VD <50 nmol/L, and 200 women (13.2%) had VD ≥75 nmol/L. There were 264 (17.4%) women diagnosed with GDM. There was not, however, a correlation between serum VD and GDM in early pregnancy. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum VD levels. There was a positive correlation between serum VD and pre-albumin, activated partial thromboplastin time, and a negative correlation between serum VD, creatinine, and thrombin time.Conclusions: There was no correlation between maternal serum VD and GDM in early pregnant women. There were, however, associations between serum VD and parity, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factors, which need further study to explain their pathophysiology and clinical significance.

scholarly journals First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

2019 ◽  
Vol 16 (19) ◽  
pp. 3654 ◽  
Author(s):  
Federica Visconti ◽  
Paola Quaresima ◽  
Eusebio Chiefari ◽  
Patrizia Caroleo ◽  
Biagio Arcidiacono ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Maternal Serum ◽  
Fetal Aneuploidy ◽  
Combined Test ◽  
Β Hcg

Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.

scholarly journals The Correlation of Irisin Levels and Some Trace Element as a Potential Mark Diagnosis of Gestational Diabetes Mellitus

2019 ◽  
Author(s):  
Majid Jawad AL-Ghazali ◽  
Hanaa Addai Ali ◽  
Mohauman Mohammad AL-Rufaie ◽  
Rawaa AddayAli
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Biochemical Parameters ◽  
Serum Levels ◽  
Fast Blood Glucose ◽  
Maternal Serum ◽  
Fasting Insulin ◽  
Control Samples

Abstract- The objective of this project was investigating and comparing changes of serum irisin, and trace levels of the elements (Zn, Cu, Mg) in pregnant women with gestational diabetes mellitus GDM in addition to wholesome pregnant group, examining the correlation among (Zn, Cu, Mg) levels and irisin insulin impedance in GDM pregnant women. Sixty GDM pregnant women and thirty wholesome pregnant women were examined. The pair groups were matched for age, and maternal serum irisin. Insulin levels and gestational age were calculated by the assay for enzyme-linked immune sorbent kit at gestation at 24-28 weeks. The confederation between clinical and biochemical parameters and maternal serum irisin levels were predestined. Serum levels of glucose, body mass index, insulin, OGTT, HOMA IR, HOMAβ, HbA1c, Hb%, irisin, Zn, Cu and Mg were investigated and analyzed for the examined collection as well as control samples. Pregnant women with GDM disease had noteworthy rising fast blood glucose FBG (P=0.004), first-hour OGTT glucose (P=0.001), second-hour OGTT glucose (P=0.001), fasting insulin FI (P=0.001) levels, HOMA IR (P=0.001), HOMAβ (P=0.001), HbA1C (P=0.001), Hb% (P=0.017), as contrasted to healthy women. Levels of irisin serum were significantly minimizing (P=0.001) in women, and sequentially more advanced GDM (mean±SD=71.65±8.03) than healthy pregnant controls (mean±SD 136.54±22.56). Analyses among irisin levels of anthropometric and biochemical values in gestational diabetes patients disclosed that none of the scrupulousness values were remediated with serum irisin level. His present outcomes indicate that the levels of serum irisin might be presented as an incoming GDM marker with decreased irisin levels being GDM symptomatic.

Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

2018 ◽  
Author(s):  
George Simeakis ◽  
Evangelia Vogiatzi ◽  
Panagiota Konstantakou ◽  
Evangelia Zapanti ◽  
Katerina Saltiki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Body Mass ◽  
Thyroid Function

86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 86-LB
Author(s):  
TIANGE SUN ◽  
FANHUA MENG ◽  
RUI ZHANG ◽  
ZHIYAN YU ◽  
SHUFEI ZANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Neutrophil Count ◽  
First Trimester

Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 16 (8) ◽  
pp. 895-899 ◽  
Author(s):  
Shahin Safian ◽  
Farzaneh Esna-Ashari ◽  
Shiva Borzouei
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Free T4 ◽  
Significant Difference ◽  
Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

Do free thyroxine levels influence the relationship between maternal serum ferritin and gestational diabetes mellitus in early pregnancy?

2019 ◽  
Vol 151 ◽  
pp. 114-119 ◽  
Author(s):  
Yanqiong Gu ◽  
Xiujuan Su ◽  
Yuhong Li ◽  
Yuping Tang ◽  
Yirong Bao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Ferritin ◽  
Early Pregnancy ◽  
Maternal Serum ◽  
Free Thyroxine ◽  
The Relationship

Mediators expression in amniotic membrane of pregnant women with and without Gestational Diabetes Mellitus

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e36
Author(s):  
Thiago PB. De Luccia ◽  
Erika Ono ◽  
Karen PT. Pendeloski ◽  
Eloiza LL. Tanabe ◽  
Ana Lúcia M Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Amniotic Membrane
Sign in / Sign up

Export Citation Format

Share Document