The use of fibric acid derivatives combined with rosiglitazone appears to decrease HDL cholesterol levels in patients with diabetes mellitus (DM),

2008 ◽  
Vol &NA; (1184) ◽  
pp. 5
Author(s):  
&NA;
Keyword(s):  
Diabetes Mellitus ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Patients With Diabetes

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Hdl Kolesterol Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 1 (4) ◽  
pp. 307-314
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Ikbal Zaenur Ridwan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE AND HDL CHOLESTEROL LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG Background: Hypertension is a major risk factor for type 2 Diabetes Mellitus, hypertension can make cells insensitive to insulin, so blood sugar levels can also be disrupted. Dyslipidemia causes constriction in blood vessels or atherosclerosis which can aggravate hypertension or diabetes mellitus. Meanwhile, the function of HDL in transporting bad cholesterol also causes blood vessels to dilate due to increased NO production. Objective: To find out the relationship between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung, 2020. Method: This type of research used in this research is descriptive-analytic with cross-sectional design. The sampling technique was total sampling. Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020 Results: Based on the results of the chi-square statistical test, it was found that there was no relationship with the results of p = 0.898 (p> 0.05). Conclusion: There is no correlation between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020. Keywords: Diabetes Mellitus type 2, Systolic Blood Pressure, HDL   INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR KOLESTEROL HDL PADA PASIEN DIABETES MELLITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAH Latar Belakang: Hipertensi merupakan faktor risiko utama untuk terjadinya Diabetes Melitus tipe 2, hipertensi dapat membuat sel tidak sensitif terhadap insulin, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidimia menyebabkan terjadinya penyempitan dalam pembuluh darah atau aterosklerosis yang dapat memperberat kondisi hipertensi ataupun diabetes mellitus. Sedangkan fungsi HDL mengangkut kolesterol jahat juga menyebabkan pembuluh darah bisa berdilatasi karena produksi NO yang meningkat.Tujuan: Untuk mengetahui Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah Tahun 2020.Metode: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif analitik dengan desain cross sectional. Teknik pengambilan sampel berupa total sampling. Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah.Hasil: Berdasarkan hasil uji statistic chi-square didapatkan tidak terdapat hubungan dengan hasil p=0,898 (p>0,05).Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020. Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolik, HDL

scholarly journals Antidiabetic Effects of the Ethanolic Root Extract ofUvaria chamaeP. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Jonathan Emeka Emordi ◽  
Esther Oluwatoyin Agbaje ◽  
Ibrahim Adekunle Oreagba ◽  
Osede Ignis Iribhogbe
Keyword(s):  
Diabetes Mellitus ◽  
Alternative Treatment ◽  
Pancreatic Beta Cells ◽  
Hematological Parameters ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Acacia Senegal ◽  
Cholesterol Levels

Diabetes mellitus has been a menace to mankind from time immemorial. However, a natural product such asU. chamaeP. Beauv (Annonaceae) offers alternative treatment for diabetes mellitus. The study aimed at evaluating antidiabetic activity of the ethanolic root extract ofU. chamaein alloxan-induced diabetic rats. Diabetes was induced in Sprague Dawley rats after overnight fast with 150 mg/kg alloxan intraperitoneally. After 72 h, those with plasma glucose levels >200 mg/dl were classified as diabetic. Five diabetic rats in each group were treated daily for 14 days orally with 100, 250, and 400 mg/kg of the extract, glibenclamide (71 µg/kg) and pioglitazone (429 µg/kg), respectively, while another group was untreated. Control received 0.5 ml ofAcacia senegal. Effects of extract on glucose, other biochemical, and hematological parameters were evaluated.α-amylase andα-glucosidase inhibitory activities of extract and its fractions were also evaluated. Percentage inhibition and IC50values were determined. Diabetic control was achieved on the 7th day of the study with 100, 250, and 400 mg/kg of the extract showing glucose reduction of 72.14%, 78.75%, and 87.71%, respectively. The HDL-cholesterol levels of diabetic rats treated with extracts were significantly increased. Extract and its fractions causedα-amylase andα-glucosidase inhibition. Histologically, pancreas of diabetic rats treated with extract showed regenerated islet cells which were not seen in rats treated with glibenclamide and pioglitazone. This study showed thatU. chamaehas antidiabetic activity which may be throughα-amylase andα-glucosidase inhibition and regeneration of pancreatic beta cells. Also, it may reduce the risk of cardiovascular disease by increasing HDL-cholesterol levels.

scholarly journals Metabolic Benefits of Six-month Thiamine Supplementation in Patients with and without Diabetes Mellitus Type 2

2014 ◽  
Vol 7 ◽  
pp. CMED.S13573 ◽  
Author(s):  
Omar Al-Attas ◽  
Nasser Al-Daghri ◽  
Majed Alokail ◽  
Sherif Abd-Alrahman ◽  
Benjamin Vinodson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Total Cholesterol ◽  
Thiamine Deficiency ◽  
Diabetes Mellitus Type 2 ◽  
High Performance ◽  
Hdl Cholesterol ◽  
Diabetes Mellitus Type ◽  
Chronic Hyperglycemia ◽  
Patients With Diabetes

Thiamine deficiency has been documented to be prevalent in patients with diabetes mellitus, and correction of thiamine deficiency in this population may provide beneficial effects in several cardiometabolic parameters, including prevention of impending complications secondary to chronic hyperglycemia. In this interventional study, we aim to determine whether thiamine supplementation is associated with cardiometabolic improvements in patients with diabetes mellitus type 2 (DMT2). A total of 86 subjects (60 DMT2 and 26 age- and BMI-matched controls) were included and were given thiamine supplements (100 mg/day) for six months. Anthropometrics and metabolic profiles were measured routinely. Serum thiamine and its derivatives were measured using high performance liquid chromatography. In all groups, there was a significant decrease in total cholesterol after three months ( p = 0.03) as well as in HDL cholesterol after six months of thiamine supplementation ( p = 0.009). Significant improvements were also observed in the mean serum levels of creatinine ( p = 0.001), as well as thiamine and its derivatives in both serum and urinary levels across follow-up visits ( p-values 0.002 and <0.001, respectively). In the DMT2 group, improvements were observed in lipid profile (mean serum LDL and total cholesterol with ^-values 0.008 and 0.006, respectively), serum thiamine ( p < 0.001), TMP ( p < 0.001), TDP ( p < 0.001), urinary thiamine ( p < 0.001) and serum creatinine ( p < 0.001). Thiamine supplementation is a promising adjuvant therapy for patients with DMT2. Longer clinical trials are needed to determine its protective effect in DMT2 complications.

scholarly journals Efficacy of Lipid-Lowering Therapy During Cardiac Rehabilitation in Patients With Diabetes Mellitus and Coronary Heart Disease

2021 ◽  
Author(s):  
Thomas Wittlinger ◽  
Bernhard Schwaab ◽  
Heinz Voeller ◽  
Christa Bongarth ◽  
Viktoria Heinze ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ldl Cholesterol ◽  
Lipid Lowering ◽  
Diabetic Patients ◽  
Lipid Lowering Therapy ◽  
Cholesterol Levels ◽  
Patients With Diabetes

Abstract BackgroundCardiac rehabilitation (CR) in patients with coronary heart disease (CHD) aims to increase adherence to a healthy lifestyle and to secondary preventive medication. CR is able to improve quality of life and prognosis in CHD patients. This is particularly relevant for CHD patients with diabetes mellitus.DesignA prospective, multicenter registry study with patients from six rehabilitation centers in Germany.MethodsDuring CR, 1100 patients with a minimum age of 18 years and CHD documented by coronary angiography were included in a LLT registry.ResultsIn 369 patients (33.9 %), diabetes mellitus was diagnosed. Diabetic patients were older (65.5 ± 9.0 vs. 62.2 ± 10.9 years, p < 0.001) than nondiabetic patients and more likely to be obese (BMI: 30.2 ± 5.2 kg/m2 vs. 27.8 ± 4.2 kg/m2, p < 0.001). Analysis indicated that diabetic patients were more likely to show LDL cholesterol levels below 55 mg/dL than patients without diabetes at the start of CR (Odds Ratio (OR) 1.9; 95 % CI 1.3 to 2.9) until 3 months of follow-up (OR 1.9; 95 % CI 1.2 to 2.9). During 12 months of follow-up, overall and LDL cholesterol levels decreased within the first 3 months and remained at the lower level thereafter (p < 0.001), irrespective of prevalent diabetes. At the end of the follow-up, LDL cholesterol did not differ significantly between patients with or without diabetes mellitus (p = 0.413).ConclusionWithin 3 months after CR, total and LDL cholesterol were significantly reduced, irrespective of prevalent diabetes mellitus. In addition, CHD patients with diabetes responded faster to LTT than nondiabetic patients, suggesting that diabetic patients benefit more from LLT treatment during CR.

scholarly journals FEATURES OF DYSLIPOPROTEINEMIA IN TYPE 2 DIABETES MELLITUS PATIENTS WITH PRIOR MYOCARDIAL INFARCTION

2020 ◽  
Vol 16 (3) ◽  
pp. 27-32
Author(s):  
N.V. Altunina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Main Group ◽  
Apo B ◽  
Patients With Diabetes ◽  
History Of

Relevance. In diabetes mellitus (DM), atherosclerotic plaques contain more fat, are more inflammatory, and show a higher risk of thrombus formation than in individuals without diabetes. One of the significant factors in the development and progression of atherosclerosis in these patients is atherogenic dyslipidemia, which includes a wide range of disorders and often precedes the onset of diabetes for several years. Therefore, it is relevant to study the features of dyslipidemia in patients with diabetes after myocardial infarction (MI). Objective: to study changes in blood lipid spectrum parameters, including Apolipoproteins (Apo A-1, Apo B) and lipoprotein (a), in postinfarction patients with type 2 DM. Materials and methods. 119 patients (77 men and 42 women; mean age 61.09 ± 0.92 years) were examined, of which 42 were patients with coronary heart disease (CHD) who suffered from MI and type 2 diabetes (main group), 39 patients with a history of MI without concomitant diabetes (comparison group I) and 38 patients with type 2 diabetes without MI (comparison group II). The control group consisted of 30 healthy individuals, comparable in age and sex. Total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDLC) were determined in venous serum by enzymatic colorimetric method. According to the formulas, the level of cholesterol in very-low-density lipoproteins (VLDLC) was calculated; cholesterol in low-density lipoprotein (LDLC), coefficient of atherogenicity (CA). The level of lipoprotein (a) – LP (a), Apo A-1, and Apo B were determined by immunoturbidimetry. Blood sampling in patients was performed on an empty stomach. Results. In the main group, significantly higher rates of TC, TG, LDLC, VLDLC, AF, Apo B, and the ratio of Apo B/Apo A-1, compared with non-diabetic postinfarction patients. At the same time, there was a significantly lower concentration of HDLC, Apo A-1, and LP (a) – in patients with a history of diabetes mellitus. When comparing the indicators of patients in the main group with patients with isolated type 2 diabetes, there were significantly higher levels of LDL cholesterol and CA, as well as significantly lower concentrations of HDL cholesterol and apo A-1 in patients of the main group. The analysis of lipid metabolism in the comparison groups revealed a difference in the level of TG, LDL cholesterol, and Apo B, which have higher levels in patients with isolated type 2 diabetes, and the level of LP (a) – significantly higher in postinfarction patients, in contrast to diabetics. The results indicate deeper disorders of lipid metabolism in post-infarction patients with diabetes than in non-diabetic post-infarction patients, which may be due to insulin resistance, hyperinsulinemia, and hyperglycemia. Conclusions. Dyslipoproteinemia in postinfarction patients with type 2 diabetes is characterized by a decrease in the content of antiatherogenic HDL cholesterol and its protein Apo A-1, moderate hypertriglyceridemia, increased levels of LDL cholesterol, VLDL cholesterol, and Apo B, which causes higher values of cholesterol and increases AF. Elevations in lipid profile parameters such as TG, LDL cholesterol, and Apo B are more associated with diabetes, while higher concentrations of LP (a) are characteristic of postinfarction non-diabetic patients.

Aerobic Exercise Decrease Cholesterol Levels in Type 2 Diabetes Mellitus Patients

2018 ◽  
Vol 13 (1) ◽  
pp. 8
Author(s):  
Cecep Triwibowo ◽  
Evi Nurjannah ◽  
Ikha Fitriyana ◽  
Yulia Fauziyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
T Test ◽  
Group Design ◽  
Cholesterol Levels ◽  
Before And After ◽  
Patients With Diabetes ◽  
Post Test

<p>Elevated  cholesterol  level is one of  the risks  for cardiovascular disease  in diabetes mellitus. Exercise is one of therapy in patients with diabetes mellitus. The purpose of this study is to determine the effect of exercise on decrease cholesterol levels in patients with diabetes mellitus. This study used pre-post test one group design. Twenty-two patients with diabetes mellitus followed the intervention which is a twice a week exercise for 4 weeks. Cholesterol levels were measured before and after exercise. Data were analyzed by  dependent T-test. Cholesterol  levels in patients with  diabetes  mellitus before  the exercise reached 261.18±49.013 mg/dL and after intervention decreased to 224.41±26 mg/dL. Dependent t-test showed differences in cholesterol levels before and after exercise in patients with diabetes mellitus (p&lt;0.05). Exercise can lower cholesterol levels in patients with diabetes mellitus.</p>

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