scholarly journals Antidiabetic Effects of the Ethanolic Root Extract ofUvaria chamaeP. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Jonathan Emeka Emordi ◽  
Esther Oluwatoyin Agbaje ◽  
Ibrahim Adekunle Oreagba ◽  
Osede Ignis Iribhogbe
Keyword(s):  
Diabetes Mellitus ◽  
Alternative Treatment ◽  
Pancreatic Beta Cells ◽  
Hematological Parameters ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Acacia Senegal ◽  
Cholesterol Levels

Diabetes mellitus has been a menace to mankind from time immemorial. However, a natural product such asU. chamaeP. Beauv (Annonaceae) offers alternative treatment for diabetes mellitus. The study aimed at evaluating antidiabetic activity of the ethanolic root extract ofU. chamaein alloxan-induced diabetic rats. Diabetes was induced in Sprague Dawley rats after overnight fast with 150 mg/kg alloxan intraperitoneally. After 72 h, those with plasma glucose levels >200 mg/dl were classified as diabetic. Five diabetic rats in each group were treated daily for 14 days orally with 100, 250, and 400 mg/kg of the extract, glibenclamide (71 µg/kg) and pioglitazone (429 µg/kg), respectively, while another group was untreated. Control received 0.5 ml ofAcacia senegal. Effects of extract on glucose, other biochemical, and hematological parameters were evaluated.α-amylase andα-glucosidase inhibitory activities of extract and its fractions were also evaluated. Percentage inhibition and IC50values were determined. Diabetic control was achieved on the 7th day of the study with 100, 250, and 400 mg/kg of the extract showing glucose reduction of 72.14%, 78.75%, and 87.71%, respectively. The HDL-cholesterol levels of diabetic rats treated with extracts were significantly increased. Extract and its fractions causedα-amylase andα-glucosidase inhibition. Histologically, pancreas of diabetic rats treated with extract showed regenerated islet cells which were not seen in rats treated with glibenclamide and pioglitazone. This study showed thatU. chamaehas antidiabetic activity which may be throughα-amylase andα-glucosidase inhibition and regeneration of pancreatic beta cells. Also, it may reduce the risk of cardiovascular disease by increasing HDL-cholesterol levels.

scholarly journals In Vivo and In Vitro Antidiabetic Activity of Hydroalcoholic Extract of Dactylorhiza Hatagirea Roots: An Evaluation of Possible Phytoconstituents

2019 ◽  
Vol 9 (6-s) ◽  
pp. 76-81
Author(s):  
Rashmi Choukarya ◽  
Ashish Choursia ◽  
Jagdish Rathi
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Total Protein ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Root Extract ◽  
Test Protocol ◽  
Hydroalcoholic Extract

Diabetes mellitus is one of the most common endocrine disorder which causes microvascular and macrovascular complications. Several synthetic drugs used to treat diabetes have adverse effects on prolonged usage. This has given the impetus to the search for alternative medicines with no or less side effects. The plants of Orchidaceae family have displayed antimicrobial, anti-inflammatory, antioxidant, anticancer and antidiabetic activity. However, their antidiabetic properties are yet to be explored. This study sought to evaluate the antidiabetic potentials of hydroalcoholic extract of root of Dactylorhiza hatagirea (D. hatagirea) in diabetic rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total flavonoids were determined by the well-known test protocol available in the literature and quercetin was detected in hydroalcoholic extract of root of D. hatagirea under study by using RP-HPLC analysis. Percentage inhibition of α-amylase activity by D. hatagirea root extract was estimated with acarbose as the positive control, D. hatagirea extract show dose dependent activity. IC50 value of acarbose and extract was found to 35.33 and 224.45 µg/ml respectively. Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (120 mg/kg; i.p.). The of hydroalcoholic extract of D. hatagirea at a dose of 100 and 200 mg/kg body weight was administrated at a single dose per day to diabetes-induced rats for a period of 15 day. The effect of hydroalcoholic extract of D. hatagirea root on blood glucose, total cholesterol (TR), triglycerides (TG), total protein and body weight were measured in the diabetic rats. The effect of hydroalcoholic extract of D. hatagirea root elicited significant reduction in blood glucose (p<0.001), (p<0.01), lipid parameters (TC, TG, total protein) (p<0.01) and significantly increased body weight at the dose of 200 mg/kg when compared with the diabetic-induced control. For future studies, phytochemcials responsible for various activities can be isolated and modified for pharmacological purpose.This study, therefore, justifies the use of the plant in the treatment of diabetes mellitus. Keywords: Dactylorhiza hatagirea, Phytochemical profile, Quercetin, 

scholarly journals GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS .

2017 ◽  
Vol 10 (6) ◽  
pp. 292
Author(s):  
Kanwar Lal ◽  
Ashok Purohit ◽  
Heera Ram
Keyword(s):  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Serum Biochemistry ◽  
Diabetic Rats ◽  
The Body ◽  
Root Extract ◽  
Standard Drug ◽  
Protective Potential ◽  
Normal Ranges ◽  
Tecomella Undulata

Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs.Conclusion: The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.

scholarly journals Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.

2021 ◽  
Vol 19 (3) ◽  
pp. 02-17
Author(s):  
Aditya Dilipkumar Patil ◽  
Charusheela Dilipkumar Patil ◽  
Dilipkumar Kondiba Patil
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Holistic Approach ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Treatment Of Diabetes

INTRODUCTION – Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathy a science of ultra-molecular doses with a holistic approach is used in treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum, Pancreatinum and Uranium nitricum is used in homeopathy for treatment of Diabetes Mellitus. However no any preclinical studies have been investigated for the anti-diabetic effect and its safety. METHODS – Homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in 6C (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days treatment bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) was measured. RESULTS – After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p

Antidiabetic activity of aqueous extract of leaves of cnestis ferruginea vahl ex DC. (Connaraceae) on alloxan-diabetic induced mice.

2021 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Emile K. Begbin ◽  
Edwige A. Odoh ◽  
Ernest N. Zougrou ◽  
Landry Claude A. Kablan ◽  
Diéneba Kone-Bamba ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Aqueous Extract ◽  
White Blood Cells ◽  
Hdl Cholesterol ◽  
Treated Group ◽  
Antidiabetic Activity ◽  
Metformin Group ◽  
Hematological And Biochemical Parameters ◽  
Group B

Abstract Background: Cnestis ferruginea is a plant species widely used in the traditional african medicine to treat diabetes mellitus. The present study aimed to evaluate the antidiabetic activities of the aqueous extract of the leaves of Cnestis ferruginea (AECF) in diabetic mice. Methods: The mice were grouped into five groups of five animals per group: Group A was not induced with alloxan, Group B animals were induced but not treated, Group C animals were treated with 500 mg / kg of BW of metformin, Group D and E animals were treated with 100, 200 mg/kg BW of AECF respectively. The extracts were administered to the animals orally for 14 days. Fasting blood sugar was measured by a glucometer. Serum concentrations of hematological and biochemical parameters were measured by standard methods. Results: The animals administered with 100 and 200 mg/Kg B.W of extract showed highly significant decrease (P ˂ 0.0001) in blood sugar level compared to the untreated animals. The 100 mg / kg BW dose of AECF produce low significant decrease (P <0.05) of total cholesterol, HDL Cholesterol, AST, ALT, urea, levels of white blood cells, platelets, hematocrit. The 200 mg / kg BW dose of AECF produce in addition significant decrease (P <0.01) of AST and urea. Conclusion: The 200 mg / kg dose of BW of AECF had a greater antidiabetic activity than the dose of 100 mg / kg BW. Keywords: Cnestis ferruginea; antidiabetic activity; alloxan; diabetes mellitus.

scholarly journals Antidiabetic and Antilipidemic Activity of Root Extracts of Salacia oblonga against Streptozotocin-Induced Diabetes in Wistar Rats

Processes ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 301 ◽  
Author(s):  
Kakara Gift Kumar Deepak ◽  
Surekha Challa ◽  
Ganta Suhasin ◽  
Neelapu Nagesewara Rao Reddy ◽  
Hosam O. Elansary ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Wistar Rats ◽  
Type Ii Diabetes Mellitus ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Dependent Manner ◽  
Type Ii ◽  
Root Extracts ◽  
Salacia Oblonga

Salacia oblonga is used to treat diabetes, hypocholesteremia, gonorrhea, rheumatism, asthma, inflammation, oxidative stress, etc. In the present study, the antidiabetic activity of S. oblonga methanolic root extracts collected from three geographical locations, viz., Eleshwaram (Andhra Pradesh), Thoothukudi (Tamil Nadu), and Karwar (Karnataka), was studied in vitro. Among the three extracts, S. oblonga root extracts from Eleshwaram showed maximum α-glucosidase and α-amylase inhibitory activities, indicating better antidiabetic activity. Acute toxicity studies of S. oblonga carried out in Albino Wistar rats showed no toxicity. Further, in vivo studies showed antidiabetic and antilipidemic activities in Albino Wistar rats with induced type II diabetes mellitus. Type II diabetes mellitus was induced in the experimental rats by intraperitoneal injection of nicotinamide and streptozotocin. The rats were orally fed different doses (ranging from 0 to 400 mg/kg body weight) of S. oblonga root extracts from Eleshwaram for 14 days. Blood glucose, lipid, bilirubin, and creatinine levels were analyzed on day 0, 7, and 14. The S. oblonga root extract from Eleshwaram decreased the glucose levels in a dose-dependent manner as well as the lipid, creatinine, and bilirubin levels in diabetic rats. Thus, the present study demonstrates antidiabetic and antilipidemic properties of S. oblonga root extracts.

scholarly journals Evaluation of Antidiabetic Activity of Gymnema sylvestre and Andrographis paniculata in Streptozotocin Induced Diabetic Rats

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Prem Kumar ◽  
Sudha Rani ◽  
B Arunjyothi ◽  
P. Chakrapani ◽  
A Rojarani
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Low Cost ◽  
Diabetic Rats ◽  
Andrographis Paniculata ◽  
Antidiabetic Activity ◽  
Gymnema Sylvestre ◽  
Streptozotocin Induced Diabetes ◽  
Oxidative Effect

Diabetes mellitus is a difficult metabolic disorder that has seriously impact the human health and quality of life. Medicinal plants are being used to control diabetes However, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. Many plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological constituents and many of them are known to be effective against diabetes. Medicinal plants with antihyperglycemic activities are being more desired, owing to lesser sideeffects and low cost. Streptozotocin was induced to all groups of rats at dosage of 35 -55mg/kg except for the normal. Streptozotocin induced diabetes in sprague dawly rats were used to study antidiabetic activity of methonolic extract of two medicinal plants Gymnema sylvestre,Andrographis paniculata methanolic leaf extract was administered orally in graded doses of 30 mg/kg,50mg /kg sprague dawly rats Gymnema sylvestre at a dose of 30mg/kg and Andrographis paniculata at a dose of 50mg/kg showed significant anti-hyperglycemic and anti-oxidative effect which was evident from the 1st week of treatment.

scholarly journals PROTECTIVE EFFECT OF ETHANOLIC ROOT EXTRACT OF COMMIPHORA CAUDATA AGAINST DIABETIC-INDUCED RATS IN HIGH-FAT DIET-STREPTOZOTOCIN MODEL

2019 ◽  
pp. 563-566
Author(s):  
ANITHA K ◽  
SABAPATHI MOHANA LAKSHMI ◽  
SATYANARAYANA SV
Keyword(s):  
High Fat Diet ◽  
Histopathological Examination ◽  
Screening Method ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
High Density Lipoproteins ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
High Fat ◽  
Standard Drug

Objective: The present study was to explore the phytochemical analysis and antidiabetic potential of the root of Commiphora caudata in high-fat diet (HFD) streptozotocin-induced diabetic rats. Methods: The ethanolic root extract of C. caudata at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Glibenclamide (5 mg/kg) was used as standard drug. Results: The data were statistically assessed using one-way ANOVA followed by Dennett’s multiple comparison tests. To unfold the mechanism, we studied all the biochemical parameters glucose, total cholesterol, triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very LDL (VLDL) and histopathological examination of the pancreatic tissue section. The ethanolic extracts of root of C. caudata showed significant reduce of the level of cholesterol, TG, LDL, VLDL, and significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg. Conclusion: Further studies should look into the characterization and isolation of the constituents to know the exact mechanism of hypoglycemic activity. Statistical analyses of this screening method confirm that the proposed method is appropriate and it can be expected to improve basic idea to the researcher who is working in area-like antidiabetic activity.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Hdl Kolesterol Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 1 (4) ◽  
pp. 307-314
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Ikbal Zaenur Ridwan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE AND HDL CHOLESTEROL LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG Background: Hypertension is a major risk factor for type 2 Diabetes Mellitus, hypertension can make cells insensitive to insulin, so blood sugar levels can also be disrupted. Dyslipidemia causes constriction in blood vessels or atherosclerosis which can aggravate hypertension or diabetes mellitus. Meanwhile, the function of HDL in transporting bad cholesterol also causes blood vessels to dilate due to increased NO production. Objective: To find out the relationship between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung, 2020. Method: This type of research used in this research is descriptive-analytic with cross-sectional design. The sampling technique was total sampling. Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020 Results: Based on the results of the chi-square statistical test, it was found that there was no relationship with the results of p = 0.898 (p> 0.05). Conclusion: There is no correlation between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020. Keywords: Diabetes Mellitus type 2, Systolic Blood Pressure, HDL   INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR KOLESTEROL HDL PADA PASIEN DIABETES MELLITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAH Latar Belakang: Hipertensi merupakan faktor risiko utama untuk terjadinya Diabetes Melitus tipe 2, hipertensi dapat membuat sel tidak sensitif terhadap insulin, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidimia menyebabkan terjadinya penyempitan dalam pembuluh darah atau aterosklerosis yang dapat memperberat kondisi hipertensi ataupun diabetes mellitus. Sedangkan fungsi HDL mengangkut kolesterol jahat juga menyebabkan pembuluh darah bisa berdilatasi karena produksi NO yang meningkat.Tujuan: Untuk mengetahui Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah Tahun 2020.Metode: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif analitik dengan desain cross sectional. Teknik pengambilan sampel berupa total sampling. Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah.Hasil: Berdasarkan hasil uji statistic chi-square didapatkan tidak terdapat hubungan dengan hasil p=0,898 (p>0,05).Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020. Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolik, HDL

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