scholarly journals Multipathway risk assessment of trihalomethane exposure in drinking water of Lebanon

2007 ◽  
Vol 5 (4) ◽  
pp. 511-522 ◽  
Author(s):  
Lucy Semerjian ◽  
John Dennis
Keyword(s):  
Cancer Risk ◽  
Tap Water ◽  
Inhalation Exposure ◽  
Dermal Absorption ◽  
Cancer Risks ◽  
Oral Ingestion ◽  
Lifetime Cancer Risk ◽  
Exposed Population ◽  
Total Cancer ◽  
Risk Of Cancer

The toxicological risks and lifetime cancer risks of trihalomethanes through oral ingestion, dermal absorption, and inhalation exposure from tap water in selected regions in Lebanon are estimated. Existing trihalomethane concentrations do not pose any non-carcinogenic and developmental risks in the exposed population via oral ingestion. Among the three pathways, residents have a higher risk of cancer through oral ingestion than through the other two pathways. The lifetime cancer risk through oral ingestion for dibromochloromethane makes the highest contribution to total risks, followed by bromodichloromethane, bromoform, and chloroform. The total multipathway cancer risk analysis suggests that no cancer risks exist during the summer and winter seasons; however, in the spring the total cancer risks exceeds the USEPA acceptable level of 10−6 by a factor of 10.7.

scholarly journals Spatial Analysis of Human Health Risk Associated with Trihalomethanes in Drinking Water: A Case Study of Karachi, Pakistan

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Zahida Karim ◽  
Bilal Aslam Qureshi ◽  
Ishtiaq Ghouri
Keyword(s):  
Drinking Water ◽  
Cancer Risk ◽  
Health Risk ◽  
Human Health ◽  
Interpolation Method ◽  
Human Health Risk ◽  
Hazard Index ◽  
Dermal Absorption ◽  
Oral Ingestion ◽  
Lifetime Cancer Risk

The objective of this study was to spatially analyze total trihalomethanes (TTHMs) and health risk associated with TTHMs in drinking water of different densely populated towns of Karachi city. Lifetime cancer risk and hazard index of THMs through oral ingestion and dermal absorption were calculated and mapped using kriging as an interpolation method to evaluate the carcinogenic and noncarcinogenic risk to human health in the study area. Lifetime cancer risk value due to the oral ingestion of TTHMs in different towns of the city was exceeded from1.0×10−6, showing that residents of these towns were expected to be at higher cancer risk. The hazard index for different towns was found to be lower than unity, indicating that no adverse health effects are expected as a result of exposure to THMs.

Prediction of 10-year and lifetime risk of cancer in individual patients with established cardiovascular disease, results from UCC-SMART and CANTOS

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C.C Van 't Klooster ◽  
P.M Ridker ◽  
N.R Cook ◽  
J.G.J.V Aerts ◽  
J Westerink ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Lung Cancer ◽  
Cancer Risk ◽  
Prediction Models ◽  
Funding Source ◽  
Cancer Models ◽  
Total Cancer ◽  
The Cantos ◽  
Risk Of Cancer

Abstract Background As treatment for cardiovascular disease (CVD) has improved substantially over the last decades, more patients survive acute CVD manifestations and are at risk for developing cancer as well as recurrent CVD. Due to similar risk factors, including smoking and obesity, patients with established CVD are at higher risk for cancer. Objectives The aim of this study was to develop and externally validate prediction models for the estimation of 10-year and lifetime risk for total, colorectal, and lung cancer in patients with established CVD. Methods Data from patients with established CVD from the UCC-SMART prospective cohort study (N=7,280) were used for model development, and data from the CANTOS trial (N=9,322) were used for model validation. Predictors were selected based on previously published cancer risk prediction models or cancer risk factors, easy clinical availability, and availability in the derivation dataset (UCC-SMART cohort). A Fine and Gray competing risk-adjusted lifetime model was developed for total, colorectal, and lung cancer. Results Selected predictors were age, sex, smoking status, weight, height, alcohol use, antiplatelet use, diabetes mellitus, and C-reactive protein. External calibration for 4-year risks of the total cancer, colorectal cancer, and lung cancer models was good (Figure 1), and C-statistics were 0.63–0.74 in the CANTOS trial population. Median predicted lifetime risks in CANTOS were 26% (range 1%-52%) for total cancer, 4% (range 0%-13%) for colorectal cancer, and 5% (range 0%-37%) for lung cancer. Conclusions Lifetime and 10-year risk of cancer can be estimated with easy to measure variables in patients with established CVD, showing a wide distribution of predicted lifetime risks for total cancer and lung cancer. Using these lifetime models in clinical practice could increase understanding of cancer risk and aid in emphasizing healthy lifestyle changes. Figure 1. Calibration plots of cancer models Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): University Medical Center; Additional funding: CANTOS trial was funded by Novartis Pharmaceuticals.

scholarly journals Cancer incidence in people with affective disorder: nationwide cohort study in Taiwan, 1997–2010

2014 ◽  
Vol 205 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Yen-Ni Hung ◽  
Shu-Yu Yang ◽  
Ming-Chyi Huang ◽  
For-Wey Lung ◽  
Shih-Ku Lin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Cancer Risk ◽  
Affective Disorders ◽  
Psychiatric Inpatient ◽  
Public Health Problem ◽  
Cancer Risks ◽  
Holistic Approaches ◽  
Risk Of Cancer ◽  
Medical Claims Database

BackgroundCancer is a serious public health problem worldwide, and its relationship with affective disorders is not clear.AimsTo investigate alcohol- and tobacco-related cancer risk among patients with affective disorders in a large Taiwanese cohort.MethodRecords of newly admitted patients with affective disorders from January 1997 through December 2002 were retrieved from the Psychiatric Inpatient Medical Claims database in Taiwan. Cancers were stratified by site and grouped into tobacco- or alcohol-related cancers. Standardised incidence ratios (SIRs) were calculated to compare the risk of cancer between those with affective disorders and the general population.ResultsSome 10 207 patients with bipolar disorder and 9826 with major depression were included. The risk of cancer was higher in patients with major depression (SIR = 2.01, 95% CI 1.85–2.19) than in those with bipolar disorder (SIR 1.39, 95% CI 1.26–1.53). The elevated cancer risk among individuals ever admitted to hospital for affective disorders was more pronounced in tobacco- and/or alcohol-related cancers.ConclusionsElevated cancer risk was found in patients who had received in-patient care for affective disorders. They require holistic approaches to lifestyle behaviours and associated cancer risks.

scholarly journals Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water

2017 ◽  
Vol 6 (4) ◽  
pp. 6 ◽  
Author(s):  
Michael Bamuwamye ◽  
Patrick Ogwok ◽  
Vivian Tumuhairwe ◽  
Richard Eragu ◽  
Henriettah Nakisozi ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Drinking Water ◽  
Cancer Risk ◽  
Environmental Protection Agency ◽  
Tap Water ◽  
Human Health Risk ◽  
Hazard Index ◽  
World Health ◽  
Cancer Risks ◽  
Guideline Values

Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks associated with ingestion of heavy metals (HM) were also assessed for both children and adults. Forty seven water samples obtained from five divisions of Kampala city were analyzed using atomic absorption spectrophotometry. Cancer and non-cancer risks were determined using incremental lifetime cancer risk (ILCR) and non-carcinogenic hazard quotient (HQ), respectively. Lead content was higher than permissible limits (PL) according to East African Standard, World Health Organization, European Union and United States Environmental Protection Agency (USEPA). Arsenic showed minor exceedances above guideline values in tap water and groundwater-fed protected spring, whereas mercury, manganese and nickel were higher than PL. Levels of aluminium, cadmium, chromium, copper, iron, and zinc were below the PL. The lifetime risk of developing cancer through the oral route was greater than the USEPA acceptable level for both children and adults, revealing that exposure to HM in drinking water posed an unacceptable potential cancer risk. Arsenic contributed ca. 90% of the ILCR in tap water and groundwater-fed protected spring. The combined non-cancer risk of the HM expressed as hazard index (HI) was greater than one, with values for children being higher than those for adults. Lead contribution towards HI was in all cases above 90%. These results demonstrate the presence of alarming non-cancer risks for children.

scholarly journals HUMAN HEALTH HAZARD OF POLYCYCLIC AROMATIC HYDROCARBON IN ROAD DUST IN HA NOI METROPOLIS

2018 ◽  
Vol 54 (2A) ◽  
pp. 27
Author(s):  
Vo Thi Le Ha
Keyword(s):  
Cancer Risk ◽  
Health Hazard ◽  
Road Dust ◽  
Gas Chromatography Mass Spectrometry ◽  
Lifetime Cancer Risk ◽  
Total Cancer ◽  
Polycyclic Aromatic ◽  
The Mean ◽  
Potential Cancer ◽  
Human Health Hazard

This study investigates PAHs content in road dust of Hanoi metropolis, Vietnam. The samples were colected from the roads around city and analyzed by gas chromatography mass spectrometry (GC/MS). The total PAHs mass concentration ranges from 33.88 μg/kg to 5588,16 μg/kg, with the mean of 356,24 μg/kg in which HMW accounted up 70 % and LMW made up 30 %. The toxic equivalence factors (TEFs), mutagenic potency equivalent factors (MEFs) and the incremental lifetime cancer risk (ILCR) methodologies were applied to evaluate human exposure to carcinogenic PAHs sources. Carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) were calculated from the potency relative to BaP (TEF) and BaP (MEF). The value of BaP-TEQ for 8 PAHs varied from 1.13 μg/kg to 195.23 μg/kg with mean of 24.34 μg/kg, while the value of BaP-MEQ ranged 1.45 μg/kg to 123.15 μg/kg with mean of 19.96 μg/kg. Basing on ILCRs model, the total cancer risk for children and adults was up to 1.6×10-5 and 3.9×10-5, posing a moderate potential cancer risk, respectively.

scholarly journals Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria

2019 ◽  
Vol 56 (12) ◽  
pp. 838-843 ◽  
Author(s):  
Rosa M Xicola ◽  
Shuwei Li ◽  
Nicolette Rodriguez ◽  
Patrick Reinecke ◽  
Rachid Karam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
Cancer Risk ◽  
Pathogenic Variant ◽  
Age At Diagnosis ◽  
Breast Cancers ◽  
Cancer Risks ◽  
Clinical Criteria ◽  
Gastric Cancers ◽  
Risk Of Cancer

BackgroundThe clinical phenotype of CDH1 pathogenic variant carriers has mostly been studied in families that fulfil criteria of hereditary diffuse gastric cancer (HDGC). We aimed at determining cancer phenotype and cancer risk estimation among families with CDH1 pathogenic variants not selected by HDGC clinical criteria.MethodsPatients were all consecutively identified CDH1 pathogenic variant carriers from a clinical laboratory tested with multigene panel testing and from an academic cancer genetics programme. Clinical and demographic features, cancer phenotypes and genotype–phenotype correlations were determined among CDH1 families. Age-specific cumulative cancer risks (penetrance) were calculated based on 38 families with available pedigrees.ResultsWithin the 113 CDH1 pathogenic variant probands and 476 relatives, 113 had gastric cancer, 177 breast cancer and 196 other cancers. Mean age at diagnosis was 47 for gastric and 54 for breast cancer. Forty-six per cent fulfilled criteria of HDGC. While 36% of families had both gastric and breast cancers, 36% had breast but no gastric cancers and 16% had gastric but not breast cancers. Cumulative risk of cancer by age 80 was 37.2% for gastric and 42.9% for breast cancer.ConclusionIn unselected CDH1 pathogenic variant carrier families, gastric cancer risks were lower and age at diagnosis higher than previously reported in families pre-selected for HDGC criteria. A substantial proportion of families did not present with any gastric cancers and their cancers were limited to breast. Thus, clinical criteria for CDH1 testing should be widened, including breast cancer families only, and a consideration for delayed prophylactic gastrectomy/surveillance should be evaluated.

scholarly journals Assessment of exposure of children swimmers to trihalomethanes in an indoor swimming pool

2020 ◽  
Vol 18 (4) ◽  
pp. 533-544
Author(s):  
Xiaoshuang Wang ◽  
Shaoxia Dong
Keyword(s):  
Environmental Protection Agency ◽  
Inhalation Exposure ◽  
Hazard Index ◽  
Dermal Absorption ◽  
Swimming Pool ◽  
Exposure Model ◽  
Pool Water ◽  
Exposure Pathway ◽  
Indoor Swimming Pool ◽  
Risk Of Cancer

Abstract This study aimed to understand the exposure levels of trihalomethanes (THMs) in an indoor swimming pool and calculate the risks of exposure to THMs, based on the presence of each THM species, of children swimmers aged 6–17, in Beijing, China. We obtained exposure factors for the children through questionnaires and measured THM concentrations through laboratory tests, and we combined the results with an exposure model to calculate the risks, with consideration of different exposure routes (oral ingestion, inhalation and dermal absorption). In terms of exposure factors for the swimmers aged 6–17, the average body weight, exposure duration, exposure frequency, swimming time, shower time, changing time, warm-up exercise and rest time, skin surface area and ingestion rate of pool water were 40.46 kg, 2.70 years, 96 events/year, 64.03 min/event, 17.04 min/event, 15.31 min/event, 12.71 min/event, 1.37 m2 and 48.93 ml/event, respectively. The THM concentrations in swimming pool water, shower water, swimming pool air and locker room air were 67.17 μg/L, 12.64 μg/L, 358.66 μg/m3 and 40.98 μg/m3, respectively. The average cancer risk of THMs was 5.44 × 10−6, which is an unacceptable risk according to the United State Environmental Protection Agency (USEPA) Guidelines. The average hazard index was 0.007, i.e., less than 1, indicating that the noncancer risk was acceptable. Chloroform (TCM) was the main substance in four species of THMs and inhalation exposure was the main exposure pathway. The risk of cancer and noncancer from inhalation exposure to THMs accounts for 97–99% of the total risk. As a result, the disease control authorities and administrative department should pay attention to the health and safety of swimming facilities and, at the same time, establish standards for THMs in the air through further research.

scholarly journals The Cancer Risk among Physicians in Taiwan, a PopulationBased Propensity Score Matched Cohort Study

2021 ◽  
Author(s):  
Hsin-Yi YANG ◽  
Cheng-Ren CHEN ◽  
Shih-Yu LEE ◽  
Wen-Chen TSA ◽  
Yueh-Han HSU
Keyword(s):  
General Population ◽  
Propensity Score ◽  
Cancer Risk ◽  
Job Stress ◽  
Health Insurance System ◽  
Cancer Risks ◽  
Female Physicians ◽  
National Health Insurance System ◽  
Physician Health ◽  
Risk Of Cancer

Background: The field of physician health is gaining increasing attention; however, most research and interventions have concentrated on factors such as job stress, mental health, and substance abuse. The risks of major cancers in physicians remain unclear. We used a propensity score-matched analysis to investigate the risk of cancer in physicians relative to the general population who had no healthcare-related professional background. Methods: Data were obtained from the National Health Insurance system in Taiwan. The physician cohort contained 29,713 physicians, and each physician was propensity score-matched with a person from the general population. Results: The physicians demonstrated a 0.90-fold lower risk of all-cancers (95% confidence interval [CI] = 0.83 – 0.96) when compared with the general population. Female physicians had a higher risk of cancer than male physicians (adjusted hazard ratio [HR] = 1.59; 95% CI = 1.28 – 1.96). Physicians had higher risks of prostate (HR = 1.26; 95% CI = 1.00 – 1.59) and thyroid cancers (HR = 3.16; 95% CI = 1.69 – 5.90) when compared with the general population. Conclusion: Physicians have lower rates of overall cancer risk than the general population. Female physicians have higher cancer risks than male physicians. Male physicians have higher risks of thyroid and prostate cancer relative to the general population.

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